n-acetylneuraminic acid has been researched along with Disease Models, Animal in 131 studies
*Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.53) | 18.7374 |
| 1990's | 7 (5.34) | 18.2507 |
| 2000's | 33 (25.19) | 29.6817 |
| 2010's | 75 (57.25) | 24.3611 |
| 2020's | 14 (10.69) | 2.80 |
| Authors | Studies |
|---|---|
| Crowe, KE; Heller, K; Martin, PT; Nishino, I; Noguchi, S; Rodino-Klapac, L; Zygmunt, DA | 1 |
| Coker, JK; Dhar, C; Gordts, PLSM; Grunddal, KV; Hsiao, J; Kawanishi, K; Varki, A; Varki, N; Zengler, K | 1 |
| Donnelly, B; Malik, A; McNeal, M; Meller, J; Mohanty, SK; Mowery, S; Poling, HM; Temple, H; Tiao, G | 1 |
| Nishino, I; Noguchi, S; Yoshioka, W | 1 |
| Adam, M; Brandis, A; Cahalon, L; Clark, AR; Colaiuta, SP; Croese, T; Gold, O; Greka, A; Habib, N; Itkin, M; Kitsberg, D; Kohnert, E; Malitsky, S; Medina, S; Mehlman, T; Ravid, A; Salame, TM; Schwartz, M; Shapira, I; Slyper, M; Suzzi, S; Vernon, KA | 1 |
| Andelfinger, G; Da Silva, A; Dort, J; Dumont, NA; Ellezam, B; Garozzo, D; Heckel, E; Hinek, A; Huang, S; Joyal, JS; Kho, I; Lefeber, DJ; Messina, A; Molina, T; Morales, CR; Muscarnera, G; Olivos, HJ; Orfi, Z; Pan, X; Pshezhetsky, AV; Romeo, DA; Sturiale, L; van Karnebeek, CDM; van Vliet, PP; Wen, XY; Yamanaka, Y | 1 |
| Alford-Lawrence, BK; Barnard, KN; Holmes, EC; Hood, G; Martínez-Sobrido, L; Nogales, A; Parrish, CR; Voorhees, IEH; Wasik, BR; Weichert, WS | 1 |
| Deng, Y; Ding, J; Hu, Y; Liao, X; Liu, M; Liu, X; Song, Y; Zhao, B; Zhao, D | 1 |
| Boon, L; Boross, P; den Hartog, MT; Eijkelkamp, N; Hack, CE; Huitema, ADR; Lafeber, FPJG; Langenhorst, JB; Meeldijk, J; Popov-Celeketic, J; Prado, J; Steen-Louws, C | 1 |
| Dobrzyńska, I; Figaszewski, ZA; Pędzińska-Betiuk, A; Skrzydlewska, E; Szachowicz-Petelska, B | 1 |
| Barnes, J; Lee, T; Litovsky, SH; Orr, AW; Patel, RP; Peretik, JM; Regal-McDonald, K; Somarathna, M; Traylor, JG | 1 |
| Barendrecht, A; Baumgärtner, W; Boes, M; Boons, GJ; Di Iorio, D; Huskens, J; Jansen, AJG; Kuiken, T; Low, HZ; Maas, C; Osterhaus, A; Rohn, K; Spaan, T; Stittelaar, K; Tieke, M; van Amerongen, G; van den Brand, J; van der Vries, E | 1 |
| Hamaoka, Y; Hayasaka, O; Hokazono, Y; Honda, A; Ikeda, A; Komatsu, M; Kotani, T; Maeda, Y; Okada, K; Shiozaki, K; Takase, R | 1 |
| He-Yang, J; Liu, J; Xue, P; Zhang, W; Zhou, X | 1 |
| Gomer, RH; Karhadkar, TR; Pilling, D | 1 |
| Chen, C; Chen, M; Du, Y; Fan, K; Ji, J; Lu, C; Lv, XL; Qiao, E; Shu, G; Song, J; Sun, J; Wu, F; Xu, M; Xu, X; Yang, W; Zhang, N; Zhao, Z | 1 |
| Akerley, BJ; Jackson, MD; Wong, SM | 1 |
| Chen, X; Huang, P; Jacobson, O; Kim, J; Kim, YH; Liu, Y; Min, KH; Niu, G; Wang, Z; Yung, B; Zhu, G | 1 |
| Beaudry, F; Bernalier-Donadille, A; Garneau, P; Garrivier, A; Gobert, AP; Harel, J; Hay, AG; Jubelin, G; Le Bihan, G; Martin, C; Sicard, JF | 1 |
| Cho, A; Christine, M; Malicdan, V; Miyakawa, M; Nishino, I; Noguchi, S; Nonaka, I | 1 |
| Li, X; Liu, Z; Ma, Y; Yin, D | 1 |
| Huang, X; Kouyoumdjian, H; Mallett, C; Nasr, SH; Ramadan, S; Shapiro, EM; Zhu, DC | 1 |
| Attarian, S; Béhin, A; Marion, S | 1 |
| Deveci, HA; Karapehlivan, M | 1 |
| Ichihara, H; Matsumoto, Y; Motomura, M | 1 |
| Suzuki, A; Tsuda, L; Yamasaki, Y; Yanagisawa, K | 1 |
| Bartsch, YC; Blanchard, V; Braumann, D; Ehlers, M; Eiglmeier, S; Hess, C; Hobusch, J; Holecska, V; Leliavski, A; Lilienthal, GM; Lorenz, AK; Lorenz, FKM; Mertes, MMM; Oefner, CM; Petry, J; Rahmöller, J; Schoen, CT; Steinhaus, M; Stoehr, AD; Winkler, A | 1 |
| Dobrzyńska, I; Figaszewski, ZA; Skrzydlewska, E; Szachowicz-Petelska, B; Weresa, J | 1 |
| Choi, HJ; Choi, JH; Chung, TW; Ha, KT; Han, JH; Kim, CH | 1 |
| Abu Bakar, N; Brand-Arzamendi, K; Da Silva, A; de Brouwer, A; Drögemöller, B; El-Rass, S; Engelke, U; Hoskings, M; Huijben, K; Karbassi, F; Lefeber, DJ; Lehman, AM; Moreland, J; Ng, R; Pan, X; Philip, AM; Pshezhetsky, AV; Rakic, B; Ross, CJ; Selby, K; Tarailo-Graovac, M; Vallance, H; van Karnebeek, CD; van Scherpenzeel, M; Wasserman, WW; Wen, XY; Wevers, RA; Willems, A; Ye, XC; Yun, J; Zijlstra, F | 1 |
| Altmeppen, HC; Bate, C; Chakroun, K; Glatzel, M; Linsenmeier, L; Magnus, T; Piontek, UK; Puig, B; Tatzelt, J; Wegwitz, F | 1 |
| Clarke, P; Hixon, AM; Tyler, KL | 1 |
| Chen, J; Du, YZ; Liu, D; Lu, Y; Qi, J; Shu, GF; Wang, F; Xu, XL; Ying, XY; Zhu, ML | 1 |
| Nimmerjahn, F; Schwab, I | 1 |
| Baltz, T; Coustou, V; Guegan, F; Plazolles, N | 1 |
| Chen, X; Comstock, SS; Donovan, SM; Hester, SN; Kuhlenschmidt, MS; Kuhlenschmidt, TB; Li, M; Monaco, MH | 1 |
| Condon, KH; Ehlers, MD; Hanus, C; Ho, J; Robinson, CG | 1 |
| Gilbert, NM; Lewis, AL; Lewis, WG; Perry, JC; Robinson, LS | 1 |
| Diavatopoulos, DA; Habets, MN; Payne, J; Reading, PC; Short, KR; Wijburg, OL | 1 |
| Adesina, A; Baxter, PA; Blaney, SM; Chintagumpala, M; Hallenbeck, PL; Huang, Y; Hurwitz, M; Hurwitz, RL; Idamakanti, N; Lau, CC; Li, XN; Liu, Z; Mao, H; Perlaky, L; Police, SR; Su, JM; Wadhwa, L; Yu, L; Zhao, X | 1 |
| Aasted, B; Kirkeby, S; Martel, CJ; Vorum, H | 1 |
| Kurniyati, K; Li, C; Zhang, K; Zhang, W | 1 |
| Berghmans, N; Galligan, MC; Harvey, DJ; Madden, SF; Opdenakker, G; Peracaula, R; Pérez-Garay, M; Piccard, H; Rudd, PM; Saldova, R; Struwe, WB | 1 |
| Blackwelder, WC; Cross, AS; Feng, C; Goldblum, SE; Nguyen, C; Vogel, SN; Zhang, L | 1 |
| Brock, LG; Rees, MA; Waldman, JP | 1 |
| Brandenburg, K; Gabriel, G; Heinbockel, L; Hoffmann, J; Reimer, R; Schneider, C | 1 |
| Branch, DR; Campbell, IK; Han, D; Käsermann, F; Lazarus, AH; Leontyev, D; Maraskovsky, E; McKenzie, BS; Miescher, S; Mott, PJ; Neschadim, A; Zuercher, AW | 1 |
| Cho, A; Hayashi, YK; Malicdan, MC; Mine, T; Nishino, I; Noguchi, S; Nonaka, I; Yamamoto, T; Yonekawa, T | 1 |
| Cigsar, G; Citil, M; Karapehlivan, M; Kaya, I; Sozmen, M | 1 |
| Avery, W; Bhatnagar, N; Bosques, CJ; Cochran, E; Garofalo, K; Kaundinya, GV; Lansing, JC; Ling, L; Manning, AM; Meador, JW; Meccariello, R; Medeiros, A; Mekala, D; Nimmerjahn, F; Ortiz, D; Rutitzky, L; Sarvaiya, H; Schultes, BC; Schwab, I; Tyler, S; Washburn, N | 1 |
| Casanova, T; Desmecht, D; Garigliany, MM; Van de Paar, E | 1 |
| Mori-Yoshimura, M; Nishino, I | 1 |
| Béhin, A; Urtizberea, JA | 1 |
| Baskakov, IV; Katorcha, E; Makarava, N; Savtchenko, R | 1 |
| Araoz, B; Bertozzi, CR; Bossi, M; Buscaglia, CA; Camara, Mde L; Campetella, O; Carlevaro, G; Chen, X; Lantos, AB; Mucci, J; Ruiz Diaz, P; Yu, H | 1 |
| Bhushan, S; Christian, P; Galuska, CE; Galuska, SP; Khosravi, F; Meinhardt, A; Michel, V; Pilatz, A; Schuppe, HC | 1 |
| Briles, DE; Hale, JY; Hatcher, BL | 1 |
| Blanchette, KA; Daugherty, SC; Ferreira, DM; Gilley, RP; Gordon, SB; Hinojosa, CA; King, SJ; Kumar, N; McClure, E; Milner, J; Orihuela, CJ; Ott, S; Shenoy, AT; Tallon, LJ; Tettelin, H | 1 |
| Bogner, PN; Buffone, A; Lau, JT; Lugade, A; Manhardt, CT; Nasirikenari, M; Neelamegham, S; Sackstein, R; Thanavala, Y | 1 |
| Henriques-Normark, B; Hentrich, K; Löfling, J; Nizet, V; Pathak, A; Varki, A | 1 |
| García Rodríguez, JC; Maurice, T; Rodríguez Cruz, Y; Rodríguez Obaya, T; Strehaiano, M | 1 |
| Aja, S; Aoki, K; Lei, X; Lopez, PH; Ronnett, GV; Schnaar, RL; Seldin, MM; Wong, GW | 1 |
| da Silva Lopes, TJ; Enya, S; Hasegawa, H; Ito, H; Ito, M; Iwatsuki-Horimoto, K; Kangawa, A; Kawaoka, Y; Kiso, M; Nakajima, N; Otake, M; Sato, Y; Shibata, M; Takahashi, K; Yamayoshi, S | 1 |
| Danner, A; Friedman, K; Gabbard, JD; Howerth, EW; Jones, CA; Kercher, L; Koçer, ZA; Krauss, S; McBride, R; Paulson, JC; Poulson, RL; Seiler, J; Stallknecht, DE; Tompkins, SM; Webster, RG; Wentworth, DE; Zanin, M | 1 |
| Aksu, B; Atukeren, P; Ayvaz, S; Erman, H; Gelisgen, R; Simsek, G; Terzioglu, D; Uslu, L; Uzun, H | 1 |
| Bennmann, D; Bork, K; Horstkorte, R; Kannicht, C; Kohla, G; Kreuzmann, D; Thate, A | 1 |
| Andrew, PW; Kahya, HF; Yesilkaya, H | 1 |
| Cadaoas, J; Chan, YM; Jungles, S; Kakkis, E; Lee, P; Morris, G; Skrinar, A; Vellard, M | 1 |
| Belser, JA; Blixt, O; Busch, J; Chen, LM; Donis, R; Katz, JM; Maines, TR; McBride, R; Pappas, C; Paulson, JC; Tumpey, TM; Van Hoeven, N | 1 |
| Rao, CV; Vijayakumar, M | 1 |
| Crocker, PR; Limb, GA; Perez, MT; Rauch, U; Romero, FJ; Sancho-Pelluz, J; van Veen, T; Wunderlich, KA | 1 |
| Malicdan, MC; Nishino, I; Noguchi, S | 2 |
| Bowlin, TL; Casola, A; Spetch, L | 1 |
| Hayashi, YK; Malicdan, MC; Nishino, I; Noguchi, S; Nonaka, I | 3 |
| Huizing, M; Krasnewich, DM | 1 |
| Hu, MH; Wu, XM; Wu, YH; Zhang, XM; Zhao, Y | 1 |
| Anderson, GG; Goller, CC; Hultgren, SJ; Justice, S; Seed, PC | 1 |
| Figueira, M; Hood, DW; Jenkins, GA; Kumar, GA; Makepeace, K; Moxon, R; Pelton, SI; Sweetman, WA | 1 |
| Amano, M; Aoshima, M; Furukawa, J; Kurogochi, M; Matsushista, T; Nishimura, S; Shinohara, Y | 1 |
| Chan, CC; Chan, JF; Chan, KH; Chen, H; Jin, DY; Leung, VH; Poon, VK; To, KK; Woo, PC; Yuen, KY; Zhang, AJ; Zhang, K; Zheng, B; Zhou, J | 1 |
| Alroy, J; Horak, F; Horak, J; Kolodny, EH; Porter, BF; Torres, PA; Zeng, BJ | 1 |
| Bestebroer, TM; Burke, DF; Chutinimitkul, S; Fouchier, RA; García-Sastre, A; Herfst, S; Jonges, M; Koel, B; Koopmans, M; Kuiken, T; Lowen, AC; Meijer, A; Osterhaus, AD; Perez, DR; Rimmelzwaan, GF; Russell, CA; Schrauwen, EJ; Smith, DJ; Steel, J; Sutherland-Cash, KH; van Riel, D; Wales, DJ; Whittleston, CS; Ye, J | 1 |
| Benirschke, K; Dick, EJ; Strobert, E; Varki, A; Varki, NM | 1 |
| Bi, Y; Gao, H; Guo, X; Hu, Y; Liu, J; Liu, L; Liu, M; Pu, J; Sun, Y; Tan, Y; Wang, J; Xu, Q; Yang, H | 1 |
| Noguchi, S | 1 |
| Ellakany, HF; Hiramatsu, H; Ibrahim, MS; Ikuta, K; Kawashita, N; Mizuike, R; Sriwilaijaroen, N; Suzuki, Y; Takagi, T; Watanabe, Y | 1 |
| Aalberse, RC; Bloem, J; Derksen, NI; Guhr, T; Koenderman, AH; Rispens, T; Wuhrer, M | 1 |
| Altıntas, A; Caliskan-Ak, E; Cetinel, S; Demirci, B; Genc, Z; Pisiriciler, R; Sener, G; Tunali-Akbay, T; Yarat, A | 1 |
| Bian, J; Hu, B; Li, C; Liu, J; Pan, Y; Sun, J; Zhang, W | 1 |
| Carbajo, R; Darvish, B; Darvish, D; Esfandiarifard, S; Kakkis, E; Khokher, Z; No, D; Pietruszka, M; Sinai, P; Valles-Ayoub, Y | 1 |
| Goto, Y; Hayashi, YK; Malicdan, MC; Nishino, I; Noguchi, S; Nonaka, I; Tokutomi, T | 1 |
| Branch, DR; Käsermann, F; Katsman, Y; Leontyev, D; Ma, XZ; Miescher, S | 1 |
| Ciccone, C; Darvish, D; Gahl, WA; Hoogstraten-Miller, S; Huizing, M; Kakani, S; Klootwijk, ED; Kopp, JB; Manoli, I; Niethamer, T; Poling, J; Ten Hagen, KG; Tian, E; Yardeni, T; Zerfas, P | 1 |
| Jones, MB; Lau, JT; Lugade, AA; Nasirikenari, M; Thanavala, Y | 1 |
| Chen, YH; Claflin, K; Davidson, BL; Geoghegan, JC | 1 |
| Kaithwas, G; Ramteke, PW; Renu, N; Saraf, SA | 1 |
| Altinli, E; Apaydin, BB; Aydin, S; Carkman, S; Erginoz, E; Memisoglu, K; Uslu, E; Uzun, H | 1 |
| Alonso, DF; Gabri, MR; Gómez, DE; Ripoll, GV | 1 |
| Bartmess, KC; McCullers, JA | 1 |
| Müller, HE | 1 |
| Bouchet, V; Brisson, JR; Goldstein, R; Hood, DW; Li, J; Li, Z; Martin, A; Moxon, ER; Pelton, SI; Randle, GA; Richards, JC; Schweda, EK | 1 |
| Amano, A; Kuboniwa, M; Nakagawa, I; Nakano, K; Nomura, R; Okahashi, N; Ooshima, T; Yamamura, T | 1 |
| Dal Canto, M; Kumar, AS; Kung, AY; Lipton, HL; Reddi, HV | 1 |
| Güzey, D; Güzey, FK; Oguz, E; Uslu, E | 1 |
| Boudjeltia, KZ; De Backer, D; Nuyens, V; Piagnerelli, M; Su, F; Vanhaeverbeek, M; Vincent, JL; Wang, Z | 1 |
| Baker, HJ; Cox, NR; Dodson, AN; Gentry, AS; Griffin, B; Kennamer, DM; Martin, DR; Morrison, NE; Peck, SL; Rolsma, MD | 1 |
| Cai, FC; Deng, B; Xiang, SL; Zhang, XP; Zhong, M | 1 |
| Figueira, MA; Goldstein, R; Hood, DW; Moxon, ER; Pelton, SI; Ram, S | 1 |
| Angata, T; Broide, DH; Cho, JY; Miller, M; Varki, A; Zhang, M | 1 |
| Bakaletz, LO; Jurcisek, JA | 1 |
| Quaggin, SE | 1 |
| Ciccone, C; Darvish, D; Gahl, WA; Galeano, B; Hoffmann, VJ; Hoogstraten-Miller, S; Huizing, M; Klootwijk, R; Krasnewich, DM; Manoli, I; Starost, MF; Sun, M; Zerfas, PM | 1 |
| Atakisi, O; Citil, M; Erginsoy, S; Karapehlivan, M; Kart, A; Tunca, R; Yapar, K | 1 |
| Barratt, J; Feehally, J; Topham, P | 1 |
| Amano, A; Inaba, H; Ishihara, K; Kato, T; Kawai, S; Kuboniwa, M; Nakano, K; Nomura, R; Ooshima, T | 1 |
| Essien, EM; Inyang, AL; Okpako, D | 1 |
| Haruki, E; Honmura, A; Kaku, H; Mizukawa, H; Nakajima, S; Uchiyama, Y; Yoshida, K | 1 |
| Cifuentes, M; Fernández-Llebrez, P; Grondona, JM; Jiménez, AJ; Pérez, J; Pérez-Fígares, JM; Pérez-Martín, M | 1 |
| Abe, M; Suzuki, O; Tasaki, K; Tominaga, K; Wakasa, H | 1 |
| Claus, H; Frosch, M; Heinze, G; Vogel, U | 1 |
| Alfarone, G; Motlova, J; Nicolini, L; Orefici, G; Parisi, L; Recchia, S; Tissi, L; Volpe, C; VON Hunolstein, C; Wagner, B | 1 |
| Avé, P; Dighiero, G; Dumas, G; Havouis, S; Huerre, M; Pourcel, C; Pritsch, O | 1 |
| Cohn, LA; Kaplan, M; Lory, S; Phillips, T; Smith, A; Weber, A | 1 |
| Hashimoto, K; Hirano, K; Ishii, Y; Kimura, T; Masuyama, K; Morishima, Y; Nomura, A; Sagai, M; Sakamoto, T; Sekizawa, K; Takano, H; Uchida, Y | 1 |
| Abe, Y; Ebina, T; Mori, S; Nakagomi, O; Ohashi, K; Shigeta, S; Takahashi, K; Taniguchi, K; Terada, M | 1 |
| Belce, A; Güzey, D; Güzey, FK; Kucur, M; Uslu, E | 1 |
| Furuya, E; Nishikaze, O | 1 |
| Foster, DM; Klemm, WR | 1 |
11 review(s) available for n-acetylneuraminic acid and Disease Models, Animal
| Article | Year |
|---|---|
Recent advances in establishing a cure for GNE myopathy.
Topics: Animals; Disease Models, Animal; Distal Myopathies; Genetic Therapy; Humans; Mice; Mutation; N-Acetylneuraminic Acid | 2022 |
Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
Topics: Animals; Autoantibodies; Autoimmune Diseases; Cell Adhesion Molecules; Clinical Trials as Topic; Disease Models, Animal; Glycosylation; Histocompatibility Antigens Class I; Humans; Immunocompromised Host; Immunoglobulin Fc Fragments; Immunoglobulin G; Immunoglobulin Variable Region; Immunoglobulins, Intravenous; Immunomodulation; Immunosuppression Therapy; Inflammation; Lectins, C-Type; Lymphocyte Subsets; Mice; Models, Molecular; N-Acetylneuraminic Acid; Protein Conformation; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Fc; Receptors, IgG | 2013 |
[Sialic Acid Replacement Therapy for Distal Myopathy with Rimmed Vacuoles].
Topics: Animals; Disease Models, Animal; Distal Myopathies; Humans; Muscle, Skeletal; N-Acetylneuraminic Acid; Treatment Outcome; Vacuoles | 2015 |
[GNE myopathy].
Topics: Adult; Age of Onset; Animals; Asian People; Bulgaria; Clinical Trials as Topic; Delayed-Action Preparations; Diagnosis, Differential; Disease Models, Animal; Distal Myopathies; Double-Blind Method; Genes, Recessive; Genetic Therapy; Humans; Israel; Japan; Jews; Liposomes; Models, Molecular; Multienzyme Complexes; Muscle, Skeletal; N-Acetylneuraminic Acid; Organ Specificity; Protein Conformation; Registries; United States; Vacuoles | 2015 |
Perspectives on distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy: contributions from an animal model. Lack of sialic acid, a central determinant in sugar chains, causes myopathy?
Topics: Animals; Disease Models, Animal; Distal Myopathies; Humans; Muscle, Skeletal; N-Acetylneuraminic Acid; Vacuoles | 2007 |
Hereditary inclusion body myopathy: a decade of progress.
Topics: Animals; Disease Models, Animal; Humans; Mice; Multienzyme Complexes; Muscle, Skeletal; Mutation, Missense; Myositis, Inclusion Body; N-Acetylneuraminic Acid | 2009 |
[Animal model of distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy and preclinical trial with sugar compounds].
Topics: Administration, Oral; Animals; Disease Models, Animal; Distal Myopathies; Drug Evaluation, Preclinical; Hexosamines; Humans; Inclusion Bodies; Lactose; Mice; Mice, Transgenic; N-Acetylneuraminic Acid; Sialic Acids; Vacuoles | 2010 |
Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology.
Topics: Animal Diseases; Animals; Biological Evolution; Disease Models, Animal; Hominidae; Humans; N-Acetylneuraminic Acid; Species Specificity | 2011 |
[Sialic acid-deficient myopathy].
Topics: Animals; Disease Models, Animal; Distal Myopathies; Humans; Mice; Mice, Knockout; Multienzyme Complexes; Mutation; N-Acetylneuraminic Acid | 2011 |
A spoonful of sugar helps the proteinuria go down?
Topics: Animals; Disease Models, Animal; Humans; Mice; Mice, Knockout; Mutation; Myositis, Inclusion Body; N-Acetylneuraminic Acid; Phosphotransferases (Alcohol Group Acceptor); Proteinuria; Species Specificity | 2008 |
A murine transgenic model of human cold agglutinin disease.
Topics: ABO Blood-Group System; Anemia, Hemolytic, Autoimmune; Animals; Apoptosis; Autoantibodies; Autoimmunity; Ceramides; Clonal Anergy; Clonal Deletion; Cold Temperature; Disease Models, Animal; Erythrocyte Membrane; Genes, Immunoglobulin; H-2 Antigens; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Transgenic; Models, Immunological; Molecular Mimicry; Mycoplasma pneumoniae; N-Acetylneuraminic Acid; Transgenes | 1999 |
120 other study(ies) available for n-acetylneuraminic acid and Disease Models, Animal
| Article | Year |
|---|---|
Visualizing Muscle Sialic Acid Expression in the GNED207VTgGne-/- Cmah-/- Model of GNE Myopathy: A Comparison of Dietary and Gene Therapy Approaches.
Topics: Animals; Diet Therapy; Disease Models, Animal; Distal Myopathies; Genetic Therapy; Humans; Mice; Mice, Transgenic; Multienzyme Complexes; Muscle, Skeletal; N-Acetylneuraminic Acid | 2022 |
Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated With Human-Like Neu5Gc Loss-Brief Report.
Topics: Animal Feed; Animals; Antibodies; Aorta; Aortic Diseases; Atherosclerosis; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Foam Cells; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Mixed Function Oxygenases; N-Acetylneuraminic Acid; Neuraminic Acids; Pan troglodytes; Plaque, Atherosclerotic; Receptors, LDL; Sialadenitis; THP-1 Cells | 2021 |
Rhesus rotavirus receptor-binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia.
Topics: Animals; Animals, Newborn; Biliary Atresia; Binding Sites; Disease Models, Animal; HeLa Cells; Humans; Integrin alpha2beta1; Macaca mulatta; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Rotavirus; Rotavirus Infections; Viral Proteins | 2022 |
N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Animals; Diet, High-Fat; Disease Models, Animal; Humans; Memory Disorders; Mice; Mice, Transgenic; N-Acetylneuraminic Acid; Obesity | 2023 |
Topics: Animals; Disease Models, Animal; Glycoproteins; Humans; Mice; Muscle, Skeletal; N-Acetylneuraminic Acid; Pyruvates; Regeneration; Zebrafish | 2023 |
Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation.
Topics: Animals; Biological Evolution; Disease Models, Animal; Dogs; High-Throughput Nucleotide Sequencing; Host Specificity; Humans; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza, Human; Lung; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Mixed Function Oxygenases; N-Acetylneuraminic Acid; Orthomyxoviridae Infections; Sequence Analysis; Serial Passage; Virulence | 2019 |
Terminating the renewal of tumor-associated macrophages: A sialic acid-based targeted delivery strategy for cancer immunotherapy.
Topics: Amines; Animals; Cell Differentiation; Cell Line, Tumor; Disease Models, Animal; Drug Liberation; Epirubicin; Feasibility Studies; Humans; Immunotherapy; Liposomes; Macrophages; Male; Mice; Monocytes; N-Acetylneuraminic Acid; Nanoconjugates; Neoplasms; Rats; RAW 264.7 Cells; Sialic Acid Binding Immunoglobulin-like Lectins; Tissue Distribution; Tumor Microenvironment | 2019 |
Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation.
Topics: Animals; Anti-Inflammatory Agents; CHO Cells; Cricetulus; Disease Models, Animal; Glycosylation; HEK293 Cells; Humans; Interleukin-10; Interleukin-4; Metabolic Clearance Rate; Mice, Inbred C57BL; N-Acetylneuraminic Acid; Pain; Rats, Wistar; Recombinant Fusion Proteins | 2019 |
Effects of hypertension and FAAH inhibitor treatment of rats with primary and secondary hypertension considering the physicochemical properties of erythrocytes.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Disease Models, Animal; Erythrocyte Membrane; Hypertension; Lipid Peroxidation; Male; N-Acetylneuraminic Acid; Oxidative Stress; Rats; Rats, Inbred SHR | 2020 |
Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunction.
Topics: Adult; Aged; Animals; Arteries; Arteriovenous Shunt, Surgical; Atherosclerosis; Disease Models, Animal; Endothelium, Vascular; Epitopes; Female; Glycosylation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Macrophages; Male; Mannose; Mice; Mice, Knockout, ApoE; Middle Aged; N-Acetylneuraminic Acid; Protein Isoforms; Young Adult | 2020 |
Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity.
Topics: Animals; Blood Platelets; Disease Models, Animal; Ferrets; Host-Pathogen Interactions; Humans; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H5N1 Subtype; Influenza, Human; N-Acetylneuraminic Acid; Orthomyxoviridae Infections; Polysaccharides; Thrombocytopenia; Virus Internalization | 2020 |
Establishment and characterization of Neu1-knockout zebrafish and its abnormal clinical phenotypes.
Topics: Animals; Animals, Genetically Modified; Body Weight; CRISPR-Cas Systems; Disease Models, Animal; Embryo, Nonmammalian; Female; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Glycoproteins; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Male; Mucolipidoses; N-Acetylneuraminic Acid; Neuraminidase; Osteogenesis; Phenotype; Zebrafish; Zebrafish Proteins | 2020 |
Human breast milk oligosaccharides attenuate necrotizing enterocolitis in rats by suppressing mast cell accumulation, DPPI activity and TLR4 expression in ileum tissue, and regulating mitochondrial damage of Caco-2 cells.
Topics: Animals; Animals, Newborn; Caco-2 Cells; Cathepsin C; Cell Cycle; Disease Models, Animal; Enterocolitis, Necrotizing; Glutathione; Humans; Ileum; Mast Cells; Matrix Metalloproteinase 2; Membrane Potential, Mitochondrial; Milk, Human; Mitochondria; N-Acetylneuraminic Acid; Oligosaccharides; Rats, Sprague-Dawley; Toll-Like Receptor 4 | 2020 |
A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet.
Topics: Adipose Tissue; Animals; Cell Adhesion Molecules; Choline Deficiency; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Liver; Inflammation; Lectins, C-Type; Liver; Macrophages; Mice; N-Acetylneuraminic Acid; Neuraminidase; Non-alcoholic Fatty Liver Disease; Receptors, Cell Surface | 2020 |
Sialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Ferric Compounds; Ferritins; Hep G2 Cells; Humans; Indoles; Iron; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Polymers; Transfection | 2021 |
Sialic Acid Protects Nontypeable Haemophilus influenzae from Natural IgM and Promotes Survival in Murine Respiratory Tract.
Topics: Animals; Antibodies, Bacterial; Disease Models, Animal; Haemophilus Infections; Haemophilus influenzae; Immunoglobulin M; Lipopolysaccharides; Mice; Microbial Viability; N-Acetylneuraminic Acid; Respiratory Tract Infections | 2021 |
Development of Sialic Acid-coated Nanoparticles for Targeting Cancer and Efficient Evasion of the Immune System.
Topics: Animals; Breast Neoplasms; Disease Models, Animal; Gold; Immune System; Mice; Molecular Imaging; N-Acetylneuraminic Acid; Nanoparticles; Positron-Emission Tomography; RAW 264.7 Cells; Staining and Labeling | 2017 |
The NAG Sensor NagC Regulates LEE Gene Expression and Contributes to Gut Colonization by
Topics: Acetylglucosamine; Animals; Bacterial Adhesion; Bacteroides thetaiotaomicron; Cell Line; Disease Models, Animal; Enterohemorrhagic Escherichia coli; Epithelial Cells; Escherichia coli O157; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; HCT116 Cells; HeLa Cells; Humans; Intestines; Mice; Mice, Inbred BALB C; Mutation; N-Acetylneuraminic Acid; Operon; Phosphoproteins; Repressor Proteins | 2017 |
Sialic acid deficiency is associated with oxidative stress leading to muscle atrophy and weakness in GNE myopathy.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Distal Myopathies; Humans; Mice; Mice, Knockout; Multienzyme Complexes; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; N-Acetylneuraminic Acid; Oxidative Stress; Reactive Oxygen Species | 2017 |
Targeted cancer imaging and photothermal therapy via monosaccharide-imprinted gold nanorods.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Disease Models, Animal; Drug Screening Assays, Antitumor; Gold; Hep G2 Cells; Humans; Mice; Molecular Imprinting; Monosaccharides; N-Acetylneuraminic Acid; Nanotubes; Neoplasms, Experimental; Phototherapy; Temperature | 2017 |
Detection of β-Amyloid by Sialic Acid Coated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Brain; Contrast Media; Disease Models, Animal; Humans; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mice; Mice, Transgenic; N-Acetylneuraminic Acid; Serum Albumin, Bovine | 2018 |
[GNE myopathy: proven failure of sialic acid supplementation… what's next?]
Topics: Animals; Clinical Trials, Phase II as Topic; Disease Models, Animal; Distal Myopathies; Drug Evaluation, Preclinical; Humans; Mice; Mice, Transgenic; N-Acetylneuraminic Acid; Protein Processing, Post-Translational; Research Design; Treatment Failure | 2017 |
Chlorpyrifos-induced parkinsonian model in mice: Behavior, histopathology and biochemistry.
Topics: Animals; Antioxidants; Aryldialkylphosphatase; Brain; Caffeic Acids; Chlorpyrifos; Disease Models, Animal; Insecticides; Lipid Metabolism; Male; Mice; Motor Activity; N-Acetylneuraminic Acid; Neuroprotective Agents; Parkinsonian Disorders; Phenylethyl Alcohol | 2018 |
Nano-chemotherapy using cationic liposome that strategically targets the cell membrane potential of pancreatic cancer cells with negative charge.
Topics: Animals; Antineoplastic Agents; Cations; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Glycosphingolipids; Humans; Liposomes; Mice; Mice, Inbred BALB C; Molecular Structure; N-Acetylneuraminic Acid; Nanoparticles; Neoplasms, Experimental; Pancreatic Neoplasms; Phosphatidylserines; Structure-Activity Relationship | 2018 |
Induction of ganglioside synthesis in Drosophila brain accelerates assembly of amyloid β protein.
Topics: Acetyltransferases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Membrane; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; G(M1) Ganglioside; Galactosyltransferases; Gangliosides; Humans; N-Acetylneuraminic Acid; Protein Binding; Transgenes | 2018 |
Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Collagen Type II; Disease Models, Animal; Glycosylation; Humans; Immune Tolerance; Lupus Nephritis; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; N-Acetylneuraminic Acid; Receptors, Antigen, B-Cell; Receptors, IgG; Th1 Cells; Th17 Cells | 2018 |
Changes in physicochemical properties of kidney cells membrane as a consequence of hypertension and treatment of hypertensive rats with FAAH inhibitor.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cell Membrane; Chromatography, High Pressure Liquid; Desoxycorticosterone Acetate; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Kidney; Lipid Peroxidation; Male; N-Acetylneuraminic Acid; Phospholipids; Rats; Rats, Inbred SHR; Rats, Wistar | 2019 |
Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis.
Topics: Animals; beta-D-Galactoside alpha 2-6-Sialyltransferase; Cell Line, Tumor; Disease Models, Animal; Endometriosis; Endometrium; Epithelium; Female; Focal Adhesions; Humans; Mice; Mice, Inbred C57BL; N-Acetylneuraminic Acid; Peritoneum; RNA, Small Interfering; Sialic Acid Binding Immunoglobulin-like Lectins; Sialyltransferases; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2018 |
Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function.
Topics: Adult; Animals; Disease Models, Animal; Edema, Cardiac; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Genetic Diseases, Inborn; HEK293 Cells; Hexosamines; Humans; Male; Muscle, Skeletal; Muscular Diseases; Mutation; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Sialic Acid Storage Disease; Young Adult; Zebrafish | 2018 |
GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.
Topics: Animals; Disease Models, Animal; Glycosylphosphatidylinositols; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Acetylneuraminic Acid; Prion Diseases; Prion Proteins; Prions; Protein Sorting Signals; Protein Transport; Proteolysis; PrPC Proteins; Signal Transduction | 2019 |
Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid.
Topics: Animals; Axonal Transport; Cell Adhesion Molecules; Central Nervous System Viral Diseases; Disease Models, Animal; Enterovirus D, Human; Enterovirus Infections; Host-Pathogen Interactions; Humans; Induced Pluripotent Stem Cells; Mice; Motor Neurons; Myelitis; N-Acetylneuraminic Acid; Nerve Tissue Proteins; Neuromuscular Diseases; Paralysis | 2019 |
Highly Integrated Nanoplatform Based on an E-Selectin-Targeting Strategy for Metastatic Breast Cancer Treatment.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dextrans; Disease Models, Animal; Doxorubicin; Drug Carriers; Drug Compounding; Drug Liberation; E-Selectin; Female; Humans; Ligands; Mice; Micelles; N-Acetylneuraminic Acid; Nanoconjugates; Neoplastic Cells, Circulating; Stearic Acids | 2019 |
Erythrophagocytosis of desialylated red blood cells is responsible for anaemia during Trypanosoma vivax infection.
Topics: Amino Acid Sequence; Anemia; Animals; Disease Models, Animal; Erythrocytes; Female; Glycophorins; Glycoproteins; Mice; Mice, Inbred Strains; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Phagocytosis; Trypanosoma vivax; Trypanosomiasis, African | 2013 |
Human milk oligosaccharides inhibit rotavirus infectivity in vitro and in acutely infected piglets.
Topics: Acute Disease; Animals; Diet; Dietary Carbohydrates; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lactose; Milk, Human; N-Acetylneuraminic Acid; Oligosaccharides; RNA, Messenger; Rotavirus; Rotavirus Infections; Species Specificity; Swine; Viral Nonstructural Proteins; Virus Attachment; Virus Replication | 2013 |
The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation.
Topics: Analysis of Variance; Angelman Syndrome; Animals; Animals, Newborn; Bacterial Proteins; Cells, Cultured; Cerebral Cortex; Cytoplasmic Structures; Disease Models, Animal; Embryo, Mammalian; Female; Gene Expression Regulation; Glycine; Golgi Apparatus; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Lectins; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Mutagenesis; N-Acetylneuraminic Acid; Neurons; Protein Transport; RNA, Small Interfering; Spermine; Transfection; Ubiquitin-Protein Ligases; Vesicle-Associated Membrane Protein 2; Viral Proteins | 2013 |
Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis.
Topics: Animals; Bacterial Proteins; Disease Models, Animal; Female; Gardnerella vaginalis; Humans; Mice; Mucous Membrane; N-Acetylneuraminic Acid; Neuraminidase; Proteoglycans; Vaginosis, Bacterial | 2013 |
Influenza A virus induced bacterial otitis media is independent of virus tropism for α2,6-linked sialic acid.
Topics: Animals; Disease Models, Animal; Influenza A virus; Mice; Mice, Inbred C57BL; N-Acetylneuraminic Acid; Orthomyxoviridae Infections; Otitis Media; Pneumococcal Infections; Streptococcus pneumoniae; Viral Tropism; Virus Attachment; Virus Replication | 2013 |
Intravenous injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor-based orthotopic xenograft mouse models of pediatric glioma.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Glioma; Injections, Intravenous; Mice; Mice, SCID; N-Acetylneuraminic Acid; Oncolytic Virotherapy; Oncolytic Viruses; Picornaviridae; Survival Analysis; Xenograft Model Antitumor Assays | 2013 |
Carbohydrate determinants in ferret conjunctiva are affected by infection with influenza H1N1 virus.
Topics: Administration, Intranasal; Animals; Antibodies, Monoclonal; Carbohydrates; Conjunctiva; Conjunctivitis; Disease Models, Animal; Epithelial Cells; Ferrets; Glycosylation; Influenza A Virus, H1N1 Subtype; Meibomian Glands; N-Acetylneuraminic Acid; Orthomyxoviridae Infections; Viral Matrix Proteins | 2013 |
A surface-exposed neuraminidase affects complement resistance and virulence of the oral spirochaete Treponema denticola.
Topics: Animals; Blood Bactericidal Activity; Blood Proteins; Complement System Proteins; Culture Media; Disease Models, Animal; Gene Deletion; Humans; Membrane Proteins; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; N-Acetylneuraminic Acid; Neuraminidase; Survival Analysis; Treponema denticola; Treponemal Infections; Virulence | 2013 |
Increase in sialylation and branching in the mouse serum N-glycome correlates with inflammation and ovarian tumour progression.
Topics: Amylose; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models, Animal; Disease Progression; Female; Glycoproteins; Glycosylation; Humans; Inflammation; Mice; Molecular Weight; N-Acetylneuraminic Acid; Neuraminic Acids; Ovarian Neoplasms; Sialyltransferases; Thioglycolates; Tumor Burden | 2013 |
Neuraminidase reprograms lung tissue and potentiates lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endothelial Cells; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; N-Acetylneuraminic Acid; Neuraminidase; Neutrophils; Proto-Oncogene Proteins c-bcl-2; Pulmonary Edema | 2013 |
A human-specific mutation limits nonhuman primate efficacy in preclinical xenotransplantation studies.
Topics: Animals; Cell Membrane; Disease Models, Animal; Erythrocytes; Gene Expression; Humans; Kupffer Cells; Liver; Macrophages; Mutation; N-Acetylneuraminic Acid; Oxygen; Pan troglodytes; Perfusion; Phagocytosis; Primates; Sialic Acid Binding Ig-like Lectin 1; Species Specificity; Swine; Transplantation, Heterologous | 2014 |
A new class of synthetic anti-lipopolysaccharide peptides inhibits influenza A virus replication by blocking cellular attachment.
Topics: Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Hemagglutination; Humans; Influenza A virus; Influenza A Virus, H7N7 Subtype; Kinetics; Lipopolysaccharides; Mice; N-Acetylneuraminic Acid; Orthomyxoviridae Infections; Peptides; Protein Binding; Receptors, Virus; Virus Attachment; Virus Internalization; Virus Replication | 2014 |
Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils.
Topics: Animals; Arthritis; Basophils; Disease Models, Animal; Immunoglobulin Fc Fragments; Immunoglobulins, Intravenous; Immunologic Factors; Male; Mice; Mice, Inbred NOD; N-Acetylneuraminic Acid | 2014 |
Sialyllactose ameliorates myopathic phenotypes in symptomatic GNE myopathy model mice.
Topics: Aging; Amyloid beta-Peptides; Animals; Body Weight; Cells, Cultured; Creatine Kinase; Disease Models, Animal; Distal Myopathies; Enzyme-Linked Immunosorbent Assay; Hexosamines; Lactose; Mice; Muscle Contraction; Muscle, Skeletal; Mutation; Myoblasts; N-Acetylneuraminic Acid; Peptide Fragments; Phenotype | 2014 |
Investigation of protective effect of L-carnitine on L-asparaginase-induced acute pancreatic injury in male Balb/c mice.
Topics: Acute Disease; Amylases; Animals; Antioxidants; Asparaginase; Biomarkers; Blood Glucose; Carnitine; Cytoprotection; Disease Models, Animal; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Oxidative Stress; Pancreas; Pancreatic Diseases; Triglycerides | 2015 |
Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Blister; Disease Models, Animal; Drug Design; Epidermolysis Bullosa Acquisita; Glycosylation; HEK293 Cells; Humans; Immunoglobulin Fab Fragments; Immunoglobulins, Intravenous; Mice; N-Acetylneuraminic Acid; Purpura, Thrombocytopenic, Idiopathic; Receptors, Fc; Tissue Distribution; Treatment Outcome | 2015 |
Hyporeactivity of Alveolar Macrophages and Higher Respiratory Cell Permissivity Characterize DBA/2J Mice Infected by Influenza A Virus.
Topics: Alveolar Epithelial Cells; Animals; Chemokines; Complement System Proteins; Cytokines; Disease Models, Animal; Disease Resistance; Disease Susceptibility; Gene Expression; Immunohistochemistry; Influenza A virus; Influenza A Virus, H1N1 Subtype; Lung; Macrophages, Alveolar; Mice; Mice, Inbred DBA; N-Acetylneuraminic Acid; Orthomyxoviridae Infections; Respiratory Mucosa; Viral Load | 2015 |
Sialylation of the prion protein glycans controls prion replication rate and glycoform ratio.
Topics: Animals; Brain; Cricetinae; Disease Models, Animal; Glycosylation; Mice; N-Acetylneuraminic Acid; Polysaccharides; Prion Diseases; Prions; Protein Folding; PrPC Proteins; PrPSc Proteins | 2015 |
Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology.
Topics: Animals; Cell-Derived Microparticles; Chagas Disease; Disease Models, Animal; Glycoproteins; Host-Parasite Interactions; Image Processing, Computer-Assisted; Mass Spectrometry; Mice; Mice, Inbred BALB C; Microscopy; Microscopy, Fluorescence; Mucins; N-Acetylneuraminic Acid; Neuraminidase; Trypanosoma cruzi; Virulence | 2016 |
Desialylation of Spermatozoa and Epithelial Cell Glycocalyx Is a Consequence of Bacterial Infection of the Epididymis.
Topics: Animals; Disease Models, Animal; Epididymitis; Glycocalyx; Humans; Male; Mice; N-Acetylneuraminic Acid; Neuraminidase; Spermatozoa; Urinary Tract Infections; Uropathogenic Escherichia coli | 2016 |
Free Sialic Acid Acts as a Signal That Promotes Streptococcus pneumoniae Invasion of Nasal Tissue and Nonhematogenous Invasion of the Central Nervous System.
Topics: Administration, Intranasal; Animals; Bacteremia; Blood-Brain Barrier; Brain; Disease Models, Animal; Female; Meningitis, Pneumococcal; Mice; N-Acetylneuraminic Acid; Nasal Mucosa; Olfactory Bulb; Pneumococcal Infections; Streptococcus pneumoniae | 2016 |
Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization.
Topics: Analysis of Variance; Animals; beta-Galactosidase; Biofilms; Carbohydrate Metabolism; Carbohydrates; Disease Models, Animal; Epithelial Cells; Female; Galactose; Humans; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Nasal Lavage Fluid; Nasal Septum; Nasopharynx; Neuraminidase; Pneumococcal Infections; Streptococcus pneumoniae | 2016 |
Leukocyte-borne α(1,3)-fucose is a negative regulator of β2-integrin-dependent recruitment in lung inflammation.
Topics: Animals; CD18 Antigens; Cell Adhesion; Cell Communication; Disease Models, Animal; Fucose; Fucosyltransferases; Intercellular Adhesion Molecule-1; Leukocytes; Ligands; Lung; Mice; Mice, Inbred C57BL; Models, Biological; N-Acetylneuraminic Acid; Neutrophils; Peritoneum; Pneumonia; Receptors, Interleukin-8B; Selectins; Signal Transduction | 2017 |
Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR.
Topics: Animals; Bacterial Load; Bacterial Proteins; Disease Models, Animal; Gene Expression Regulation, Bacterial; Mice; Mice, Knockout; Mixed Function Oxygenases; N-Acetylneuraminic Acid; Pneumonia, Pneumococcal; Protein Kinases; Streptococcus pneumoniae; Virulence Factors | 2016 |
An Intranasal Formulation of Erythropoietin (Neuro-EPO) Prevents Memory Deficits and Amyloid Toxicity in the APPSwe Transgenic Mouse Model of Alzheimer's Disease.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Disease Models, Animal; Erythropoietin; Hippocampus; Maze Learning; Memory; Memory Disorders; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; N-Acetylneuraminic Acid; Neuroprotective Agents; Nootropic Agents | 2017 |
Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.
Topics: Adipose Tissue; Animals; beta-Galactoside alpha-2,3-Sialyltransferase; Disease Models, Animal; Galactose; Gangliosides; Glucose Tolerance Test; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Metabolism; Mice; Mice, Knockout; N-Acetylneuraminic Acid; Obesity; Sialyltransferases | 2017 |
The Microminipig as an Animal Model for Influenza A Virus Infection.
Topics: Animals; Biomarkers; Disease Models, Animal; Influenza A virus; Male; N-Acetylneuraminic Acid; Orthomyxoviridae Infections; Respiratory Mucosa; Respiratory System; Swine; Swine Diseases; Swine, Miniature; Virus Replication | 2017 |
Potential for Low-Pathogenic Avian H7 Influenza A Viruses To Replicate and Cause Disease in a Mammalian Model.
Topics: Animals; Birds; Disease Models, Animal; Female; Genes, Viral; Genotype; Influenza A virus; Influenza in Birds; Lung; Mammals; Mice; N-Acetylneuraminic Acid; Orthomyxoviridae Infections; Phylogeny; Viral Load; Virus Replication | 2017 |
The Effects of Hyperbaric Oxygen Treatment on Total Antioxidant Capacity and Prolidase Activity after Bile Duct Ligation in Rats.
Topics: Animals; Antioxidants; Biomarkers; Cholestasis; Common Bile Duct; Dipeptidases; Disease Models, Animal; Humans; Hyperbaric Oxygenation; Ligation; Liver; Male; N-Acetylneuraminic Acid; Oxidative Stress; Oxygen; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Spectrophotometry | 2017 |
Increased Polysialylation of the Neural Cell Adhesion Molecule in a Transgenic Mouse Model of Sialuria.
Topics: Age Factors; Animals; Brain; Disease Models, Animal; Feedback, Physiological; Humans; Leukocytes; Liver; Mice; Mice, Transgenic; Multienzyme Complexes; Mutation; N-Acetylneuraminic Acid; Neural Cell Adhesion Molecules; Organ Specificity; Protein Processing, Post-Translational; Sialic Acid Storage Disease | 2017 |
Deacetylation of sialic acid by esterases potentiates pneumococcal neuraminidase activity for mucin utilization, colonization and virulence.
Topics: Acetylation; Animals; Disease Models, Animal; Esterases; Female; Mice; Mucins; Mutagenesis, Site-Directed; N-Acetylneuraminic Acid; Neuraminidase; Pneumonia, Pneumococcal; Real-Time Polymerase Chain Reaction; Streptococcus pneumoniae; Virulence | 2017 |
Substantial deficiency of free sialic acid in muscles of patients with GNE myopathy and in a mouse model.
Topics: Adolescent; Adult; Aged; Animals; Biomarkers; Biopsy; Chromatography, Liquid; Disease Models, Animal; Distal Myopathies; Female; Humans; Male; Mice; Middle Aged; Muscle, Skeletal; N-Acetylneuraminic Acid; Tandem Mass Spectrometry; Young Adult | 2017 |
Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility.
Topics: Animals; Disease Models, Animal; Ferrets; Hemagglutination Tests; Humans; Influenza A Virus, H7N7 Subtype; Influenza in Birds; Influenza, Human; Male; Microarray Analysis; N-Acetylneuraminic Acid; Polysaccharides; Poultry; Receptors, Virus; Virus Attachment; Virus Replication | 2008 |
Effect of quercetin, flavonoids and alpha-tocopherol, an antioxidant vitamin, on experimental reflux oesophagitis in rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Catalase; Collagen; Disease Models, Animal; Esophagitis, Peptic; Esophagus; Gastric Acid; Gastrointestinal Agents; Glutathione; Hexoses; Histamine; Lipid Peroxidation; Male; Malondialdehyde; Mucous Membrane; N-Acetylneuraminic Acid; Omeprazole; Oxidative Stress; Pepsin A; Proton Pump Inhibitors; Quercetin; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2008 |
Sialoadhesin expression in intact degenerating retinas and following transplantation.
Topics: Animals; Animals, Newborn; Antigens, CD; CD11b Antigen; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Genes, MHC Class II; Green Fluorescent Proteins; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Microglia; N-Acetylneuraminic Acid; Receptors, Immunologic; Retina; Retinal Degeneration; Sialic Acid Binding Ig-like Lectin 1 | 2008 |
Effect of NMSO3 treatment in a murine model of human metapneumovirus infection.
Topics: Animals; Cytokines; Disease Models, Animal; Female; Humans; Inflammation; Lipids; Lung; Lung Diseases; Metapneumovirus; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Paramyxoviridae Infections; Virus Replication; Weight Loss | 2008 |
Prophylactic treatment with sialic acid metabolites precludes the development of the myopathic phenotype in the DMRV-hIBM mouse model.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Mice; Muscular Diseases; N-Acetylneuraminic Acid; Phenotype | 2009 |
Effect of Laggera alata on hepatocyte damage induced by carbon tetrachloride in vitro and in vivo.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Asteraceae; Blood Proteins; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Hepatocytes; Hydroxyproline; Male; Mice; Mice, Inbred ICR; N-Acetylneuraminic Acid; Phytotherapy; Plant Extracts; Quinic Acid; Rats; Rats, Sprague-Dawley; Serum Albumin | 2009 |
Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis.
Topics: Animals; Bacterial Capsules; Biofilms; Colony Count, Microbial; Cystitis; Disease Models, Animal; Mice; Mice, Knockout; N-Acetylneuraminic Acid; Signal Transduction; Toll-Like Receptor 4; Urinary Tract Infections; Uropathogenic Escherichia coli; Virulence | 2010 |
Sialic acid mediated transcriptional modulation of a highly conserved sialometabolism gene cluster in Haemophilus influenzae and its effect on virulence.
Topics: Animals; Cell Count; Chinchilla; Colony Count, Microbial; Conserved Sequence; Disease Models, Animal; Haemophilus influenzae; Humans; Lipopolysaccharides; Metabolic Networks and Pathways; Multigene Family; Mutagenesis; N-Acetylneuraminic Acid; Otitis Media; Reverse Transcriptase Polymerase Chain Reaction; Serum; Virulence | 2010 |
Sialic acid-focused quantitative mouse serum glycoproteomics by multiple reaction monitoring assay.
Topics: Amino Acid Sequence; Animals; Carbohydrate Conformation; Carbohydrate Sequence; Chromatography, Liquid; Diabetes Mellitus; Disease Models, Animal; Female; Glycopeptides; Glycosylation; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Molecular Sequence Data; N-Acetylneuraminic Acid; Proteomics | 2010 |
D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Cytokines; Disease Models, Animal; Disease Outbreaks; Female; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Inflammation Mediators; Influenza A Virus, H1N1 Subtype; Influenza, Human; Leucine; Lung; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; N-Acetylneuraminic Acid; Receptors, Virus; Time Factors; Virulence | 2010 |
Tay-Sachs disease in Jacob sheep.
Topics: Animals; Base Sequence; beta-N-Acetylhexosaminidases; Brain Chemistry; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Disease Models, Animal; DNA, Complementary; Female; G(M2) Ganglioside; Heterozygote; Hexosaminidase A; Humans; Lipid Metabolism; Male; Molecular Sequence Data; N-Acetylneuraminic Acid; Point Mutation; Sequence Homology, Nucleic Acid; Sheep; Sheep Diseases; Tay-Sachs Disease; Transfection | 2010 |
Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding.
Topics: Amino Acid Motifs; Amino Acid Substitution; Animals; Binding Sites; Cell Line; Disease Models, Animal; Dogs; Female; Ferrets; Guinea Pigs; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Male; Mice; Mice, Inbred BALB C; Models, Molecular; N-Acetylneuraminic Acid; Pandemics; Receptors, Virus; Turkeys; Virulence; Virus Attachment | 2010 |
Guinea pig model for evaluating the potential public health risk of swine and avian influenza viruses.
Topics: Animals; Birds; Disease Models, Animal; Female; Guinea Pigs; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H1N2 Subtype; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H9N2 Subtype; Influenza in Birds; Influenza, Human; N-Acetylneuraminic Acid; Orthomyxoviridae Infections; Pandemics; Public Health; Respiratory System; Swine | 2010 |
Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt.
Topics: Animals; Cell Line; Cells, Cultured; Chickens; Disease Models, Animal; Ducks; Egypt; Female; Hemagglutinins, Viral; Humans; Influenza A Virus, H5N1 Subtype; Influenza in Birds; Influenza, Human; Mice; Mice, Inbred BALB C; Mutation; N-Acetylneuraminic Acid; Pandemics; Phylogeny; Prevalence; Protein Binding; Receptors, Virus; Respiratory Mucosa; Retrospective Studies; Virus Replication | 2011 |
Enrichment of sialylated IgG by lectin fractionation does not enhance the efficacy of immunoglobulin G in a murine model of immune thrombocytopenia.
Topics: Animals; Chemical Fractionation; Chromatography, Affinity; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glycosylation; Humans; Immunoglobulin G; Immunoglobulins, Intravenous; Immunomodulation; Mass Spectrometry; Mice; N-Acetylneuraminic Acid; Plant Lectins; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Rats; Ribosome Inactivating Proteins | 2011 |
The effect of stinging nettle (Urtica dioica) seed oil on experimental colitis in rats.
Topics: Administration, Oral; Animals; Antioxidants; Cholesterol; Colitis; Colon; Disease Models, Animal; Female; Glutathione; Inflammation; Interleukin-6; L-Lactate Dehydrogenase; Male; Malondialdehyde; N-Acetylneuraminic Acid; Oxidative Stress; Peroxidase; Plant Oils; Rats; Rats, Wistar; Seeds; Superoxide Dismutase; Triglycerides; Trinitrobenzenesulfonic Acid; Urtica dioica | 2011 |
Abrogation of neuraminidase reduces biofilm formation, capsule biosynthesis, and virulence of Porphyromonas gingivalis.
Topics: Amino Acid Sequence; Animals; Bacterial Capsules; Bacteroidaceae Infections; Biofilms; Cryoelectron Microscopy; Disease Models, Animal; Electron Microscope Tomography; Gene Deletion; Histocytochemistry; Human Experimentation; Liver; Lung; Mice; N-Acetylneuraminic Acid; Neuraminidase; Porphyromonas gingivalis; Promoter Regions, Genetic; Sequence Alignment; Survival Analysis; Transcription, Genetic; Virulence | 2012 |
Serum neural cell adhesion molecule is hyposialylated in hereditary inclusion body myopathy.
Topics: Adult; Animals; Blotting, Western; Carbohydrate Epimerases; Disease Models, Animal; Humans; Mice; Middle Aged; Mutation; Myositis, Inclusion Body; N-Acetylneuraminic Acid; Neural Cell Adhesion Molecules; Young Adult | 2012 |
Peracetylated N-acetylmannosamine, a synthetic sugar molecule, efficiently rescues muscle phenotype and biochemical defects in mouse model of sialic acid-deficient myopathy.
Topics: Animals; Disease Models, Animal; Distal Myopathies; Hexosamines; Humans; Mice; Mice, Transgenic; Muscle, Skeletal; N-Acetylneuraminic Acid | 2012 |
Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin.
Topics: Animals; Asparagine; Disease Models, Animal; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunoglobulins, Intravenous; Immunologic Factors; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Plant Lectins; Platelet Count; Polysaccharides; Purpura, Thrombocytopenic, Idiopathic; Receptors, IgG; Ribosome Inactivating Proteins; RNA, Messenger | 2012 |
The Gne M712T mouse as a model for human glomerulopathy.
Topics: Animals; Biomarkers; Carbohydrate Epimerases; Carrier Proteins; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Hexosamines; Humans; Kidney Diseases; Kidney Glomerulus; Membrane Proteins; Mice; Mice, Mutant Strains; Microscopy, Electron; Mutation; N-Acetylneuraminic Acid; Podocytes; Real-Time Polymerase Chain Reaction; Sialoglycoproteins | 2012 |
Anti-inflammatory IgG production requires functional P1 promoter in β-galactoside α2,6-sialyltransferase 1 (ST6Gal-1) gene.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; Blotting, Western; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Haemophilus Infections; Haemophilus influenzae; Immunoglobulin Fc Fragments; Immunoglobulin G; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Acetylneuraminic Acid; Ovalbumin; Pneumonia; Polysaccharides; Promoter Regions, Genetic; Sialyltransferases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Turpentine | 2012 |
Sialic acid deposition impairs the utility of AAV9, but not peptide-modified AAVs for brain gene therapy in a mouse model of lysosomal storage disease.
Topics: Animals; Brain; Capsid Proteins; Dependovirus; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Mice; Mice, Transgenic; Mucopolysaccharidosis VII; N-Acetylneuraminic Acid | 2012 |
Effect of Linum usitatissimum (linseed/flaxseed) fixed oil on experimental esophagitis in albino rats.
Topics: Animals; Collagen; Disease Models, Animal; Esophagitis, Peptic; Linseed Oil; N-Acetylneuraminic Acid; Rats; Rats, Wistar | 2012 |
Effects of gender on stress ulcer formation in rats.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Female; Gastric Mucosa; Hydrogen-Ion Concentration; Male; Malondialdehyde; N-Acetylneuraminic Acid; Probability; Rats; Rats, Wistar; Sensitivity and Specificity; Severity of Illness Index; Sex Factors; Statistics, Nonparametric; Stomach Ulcer; Stress, Physiological; Superoxide Dismutase | 2002 |
Role of cell surface GM3 ganglioside and sialic acid in the antitumor activity of a GM3-based vaccine in the murine B16 melanoma model.
Topics: Animals; Bacterial Outer Membrane Proteins; Cancer Vaccines; Cell Division; Cell Membrane; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; G(M3) Ganglioside; Immunoglobulin G; Immunoglobulin M; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Mice, Inbred C57BL; N-Acetylneuraminic Acid; Neisseria meningitidis | 2002 |
Role of neuraminidase in lethal synergism between influenza virus and Streptococcus pneumoniae.
Topics: Acetamides; Animals; Bacterial Adhesion; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Epithelial Cells; Female; Lung; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Orthomyxoviridae Infections; Oseltamivir; Pneumonia, Pneumococcal; Streptococcus pneumoniae | 2003 |
Lethal synergism between influenza virus and Streptococcus pneumoniae.
Topics: Animals; Disease Models, Animal; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Orthomyxoviridae Infections; Platelet Membrane Glycoproteins; Pneumococcal Infections; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Streptococcus pneumoniae | 2003 |
Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media.
Topics: Animals; Base Sequence; Carbohydrate Sequence; Chinchilla; Disease Models, Animal; DNA, Bacterial; Haemophilus Infections; Haemophilus influenzae; Humans; Lipopolysaccharides; Models, Molecular; Molecular Sequence Data; Mutation; N-Acetylneuraminic Acid; Otitis Media; Phylogeny; Spectrometry, Mass, Electrospray Ionization; Virulence | 2003 |
Comparison of inflammatory changes caused by Porphyromonas gingivalis with distinct fimA genotypes in a mouse abscess model.
Topics: Abscess; Analysis of Variance; Animals; Bacteroidaceae Infections; Cluster Analysis; Disease Models, Animal; Female; Fimbriae Proteins; Genetic Variation; Genotype; Mice; Mice, Inbred BALB C; Mutation; N-Acetylneuraminic Acid; Pili, Sex; Porphyromonas gingivalis; Skin Diseases, Bacterial; Virulence | 2004 |
Virus persistence in an animal model of multiple sclerosis requires virion attachment to sialic acid coreceptors.
Topics: Animals; Animals, Outbred Strains; Capsid; Cardiovirus Infections; Cell Line; Cricetinae; Cytopathogenic Effect, Viral; Disease Models, Animal; Humans; Male; Mice; Multiple Sclerosis; Mutation; N-Acetylneuraminic Acid; Receptors, Virus; Theilovirus; Virion | 2004 |
The effects of ageing on brain tissue sialic acid contents following cold trauma.
Topics: Aging; Animals; Brain; Brain Injuries; Cold Temperature; Disease Models, Animal; Male; N-Acetylneuraminic Acid; Rats; Rats, Wistar; Regeneration; Time Factors | 2004 |
Rapid alterations in transferrin sialylation during sepsis.
Topics: Acute Disease; Adult; Aged; Animals; Blood Pressure; Disease Models, Animal; Electrophoresis, Capillary; Female; Humans; Male; Middle Aged; N-Acetylneuraminic Acid; Sepsis; Sheep; Time Factors; Transferrin | 2005 |
Mutation of the GM2 activator protein in a feline model of GM2 gangliosidosis.
Topics: Aging; Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cats; Central Nervous System; Disease Models, Animal; DNA, Complementary; Female; G(M2) Activator Protein; G(M2) Ganglioside; Gangliosidoses, GM2; Gene Deletion; Hexosaminidases; Liver; Male; Molecular Sequence Data; Mutation; N-Acetylneuraminic Acid; Neurons; Pedigree; Thymus Gland | 2005 |
The sialic acid residue is a crucial component of C. jejuni lipooligosaccharide ganglioside mimicry in the induction Guillain-Barré syndrome.
Topics: Animals; Antibodies; Bacterial Proteins; Campylobacter jejuni; Cholera Toxin; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Gangliosides; Gangliosidosis, GM1; Guillain-Barre Syndrome; Guinea Pigs; Lipopolysaccharides; Male; Microscopy, Electron, Scanning; Molecular Mimicry; N-Acetylneuraminic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Nerve | 2006 |
Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants.
Topics: Animals; Blotting, Western; Chinchilla; Complement Activation; Complement System Proteins; Disease Models, Animal; Ear, Middle; Flow Cytometry; Haemophilus influenzae type b; Lipopolysaccharides; N-Acetylneuraminic Acid; Otitis Media; Virulence | 2007 |
A Gne knockout mouse expressing human V572L mutation develops features similar to distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Disease Models, Animal; Distal Myopathies; Humans; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Electron; Multienzyme Complexes; Muscle Fibers, Skeletal; Mutation, Missense; N-Acetylneuraminic Acid; Oligonucleotides; Vacuoles | 2007 |
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Bronchial Provocation Tests; Disease Models, Animal; Eosinophils; Gene Expression Regulation; Hypersensitivity; Lung Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Acetylneuraminic Acid; Respiratory Mucosa; Sequence Homology; Sialic Acid Binding Ig-like Lectin 3; Sialic Acid Binding Immunoglobulin-like Lectins; T-Lymphocytes | 2007 |
Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein.
Topics: Animals; Biofilms; Chinchilla; Disease Models, Animal; DNA; DNA, Bacterial; Fimbriae Proteins; Fluorescent Antibody Technique; Haemophilus Infections; Haemophilus influenzae; Microscopy, Electron, Scanning; N-Acetylneuraminic Acid | 2007 |
Sizing up sialic acid in glomerular disease.
Topics: Animals; Disease Models, Animal; Female; Hexosamines; Humans; Kidney Diseases; Kidney Glomerulus; Mice; Mice, Mutant Strains; Models, Biological; Multienzyme Complexes; N-Acetylneuraminic Acid; Pregnancy | 2007 |
Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine.
Topics: Animals; Base Sequence; Disease Models, Animal; DNA Primers; Female; Hexosamines; Humans; Kidney Diseases; Kidney Glomerulus; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Microscopy, Electron; Models, Biological; Multienzyme Complexes; N-Acetylneuraminic Acid; Pregnancy; Proteinuria | 2007 |
A Gne knockout mouse expressing human GNE D176V mutation develops features similar to distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy.
Topics: Animals; Disease Models, Animal; Distal Myopathies; Fatigue; Female; Humans; Inclusion Bodies; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Multienzyme Complexes; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation; N-Acetylneuraminic Acid; Vacuoles | 2007 |
Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Carnitine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Antagonism; Glutathione; Hemorrhage; Injections, Intraperitoneal; Liver; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Necrosis; Vitamin B Complex | 2007 |
Heterogenic virulence and related factors among clinical isolates of Porphyromonas gingivalis with type II fimbriae.
Topics: Abscess; Adhesins, Bacterial; Animals; Bacterial Adhesion; Bacterial Capsules; Bacteroidaceae Infections; Cells, Cultured; Cysteine Endopeptidases; Disease Models, Animal; Female; Fimbriae Proteins; Fimbriae, Bacterial; Genetic Heterogeneity; Genotype; Gingipain Cysteine Endopeptidases; Hemagglutinins; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Porphyromonas gingivalis; Random Allocation; Skin Diseases, Bacterial; Virulence | 2008 |
Decrease in platelet survival and total platelet sialic acid concentration in rats infected with Plasmodium bergei bergei.
Topics: Animals; Animals, Suckling; Blood Platelets; Cell Survival; Cellular Senescence; Disease Models, Animal; Malaria; N-Acetylneuraminic Acid; Plasmodium berghei; Platelet Count; Rats; Rats, Wistar; Sialic Acids; Thrombocytopenia; Time Factors | 1995 |
The effect of orengedokuto on experimentally-inflamed rats.
Topics: Animals; Anti-Ulcer Agents; Arthritis, Experimental; Carrageenan; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Glycoproteins; Granuloma; Lipid Peroxides; Male; N-Acetylneuraminic Acid; Rats; Rats, Wistar; Sialic Acids; Vitamin E | 1993 |
Ependymal denudation, aqueductal obliteration and hydrocephalus after a single injection of neuraminidase into the lateral ventricle of adult rats.
Topics: Age Factors; Animals; Astrocytes; Brain Diseases; Cerebral Aqueduct; Disease Models, Animal; Dose-Response Relationship, Drug; Ependyma; Female; Glial Fibrillary Acidic Protein; Hydrocephalus; Immunohistochemistry; Injections, Intraventricular; Male; N-Acetylneuraminic Acid; Neuraminidase; Rats; Rats, Sprague-Dawley; Sialic Acids | 1996 |
Analysis of lectin binding properties on human Burkitt's lymphoma cell lines that show high spontaneous metastasis to distant organs in SCID mice: the binding sites for soybean agglutinin lectin masked by sialylation are closely associated with metastatic
Topics: Animals; Antigens, Tumor-Associated, Carbohydrate; Binding Sites; Burkitt Lymphoma; Cells, Cultured; Clone Cells; Disease Models, Animal; Female; Fluorescein-5-isothiocyanate; Glycine max; Humans; Lectins; Mice; Mice, SCID; N-Acetylneuraminic Acid; Neoplasm Metastasis; Neoplasm Transplantation; Neuraminidase; Plant Lectins; Soybean Proteins; Tumor Cells, Cultured | 1996 |
Role of lipopolysaccharide sialylation in serum resistance of serogroup B and C meningococcal disease isolates.
Topics: Animals; Bacterial Capsules; beta-Galactoside alpha-2,3-Sialyltransferase; Blood Bactericidal Activity; Disease Models, Animal; Humans; Immunity, Innate; Lipopolysaccharides; Meningococcal Infections; Mutagenesis; N-Acetylneuraminic Acid; Neisseria meningitidis; Polysaccharides, Bacterial; Rats; Sialyltransferases; UDPglucose 4-Epimerase | 1999 |
Virulence properties of type VII Streptococcus agalactiae (group B streptococci) and immunochemical analysis of capsular type polysaccharide.
Topics: Animals; Antibody Specificity; Arthritis, Infectious; Bacterial Capsules; Cross Reactions; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immune Sera; Immunodiffusion; Immunoelectrophoresis; Mice; Microscopy, Immunoelectron; N-Acetylneuraminic Acid; Phagocytosis; Polysaccharides, Bacterial; Rabbits; Streptococcal Infections; Streptococcus agalactiae; Virulence | 1999 |
Pseudomonas aeruginosa infection of respiratory epithelium in a cystic fibrosis xenograft model.
Topics: Animals; Colony Count, Microbial; Cystic Fibrosis; Disease Models, Animal; Epitopes; Female; G(M1) Ganglioside; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; N-Acetylneuraminic Acid; Pseudomonas aeruginosa; Pseudomonas Infections; Respiratory Mucosa; Transplantation, Heterologous | 2001 |
Exposure to diesel exhaust exacerbates allergen-induced airway responses in guinea pigs.
Topics: Allergens; Analysis of Variance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; Inflammation; Inhalation Exposure; Leukocyte Count; Mucus; N-Acetylneuraminic Acid; Ovalbumin; Time Factors; Vehicle Emissions | 2001 |
Protective efficacy of a sulfated sialyl lipid (NMSO3) against human rotavirus-induced diarrhea in a mouse model.
Topics: Adsorption; Animals; Antiviral Agents; Binding Sites; Cells, Cultured; Chlorocebus aethiops; Diarrhea; Disease Models, Animal; Humans; Immunity; Lipids; Mice; Mice, Inbred ICR; N-Acetylneuraminic Acid; Rotavirus; Rotavirus Infections; Serotyping; Virus Replication | 2002 |
Tissue and serum sialic acid levels in an animal head injury model.
Topics: Animals; Biomarkers; Brain; Brain Injuries; Disease Models, Animal; Male; N-Acetylneuraminic Acid; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Trauma Severity Indices | 2002 |
Management of inflammation: the parametrical system, its practical and methodological position.
Topics: Alkaline Phosphatase; Amidohydrolases; Animals; Blood Coagulation; Carrageenan; Disease Models, Animal; Inflammation; Lipid Peroxides; Lysosomes; Male; N-Acetylneuraminic Acid; Pancreatic Elastase; Phagocytosis; Rats; Rats, Inbred Strains; Sialic Acids | 1986 |
Effects of chronic alcohol consumption in weanling rats on brain gangliosides.
Topics: Age Factors; Alcoholism; Animals; Brain Chemistry; Disease Models, Animal; Female; Gangliosides; Male; N-Acetylneuraminic Acid; Organ Size; Rats; Rats, Inbred Strains; Sialic Acids | 1986 |