n-acetylneuraminic acid and Alzheimer Disease

n-acetylneuraminic acid has been researched along with Alzheimer Disease in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (11.54)18.2507
2000's8 (30.77)29.6817
2010's8 (30.77)24.3611
2020's7 (26.92)2.80

Authors

AuthorsStudies
Wu, J; Wu, M; Wu, N; Zhan, X; Zhang, H1
Haroutunian, V; Moon, HJ; Zhao, L1
Angiolillo, A; Aniello, F; Di Costanzo, A; Donizetti, A; Febbraio, F; Rendina, A; Tortora, F; Vitale, E1
Adam, M; Brandis, A; Cahalon, L; Clark, AR; Colaiuta, SP; Croese, T; Gold, O; Greka, A; Habib, N; Itkin, M; Kitsberg, D; Kohnert, E; Malitsky, S; Medina, S; Mehlman, T; Ravid, A; Salame, TM; Schwartz, M; Shapira, I; Slyper, M; Suzzi, S; Vernon, KA1
Gaunitz, S; Schedin-Weiss, S; Tjernberg, LO1
Ahmad, K; Garg, RK; Mahdi, AA; Srivastava, S; Verma, AK; Yadav, J1
Chen, X; Li, W; Yang, K; Yang, Z1
Huang, X; Kouyoumdjian, H; Mallett, C; Nasr, SH; Ramadan, S; Shapiro, EM; Zhu, DC1
Suzuki, A; Tsuda, L; Yamasaki, Y; Yanagisawa, K1
Dang, Y; Geng, P; Geng, R; Hu, X; Lei, L; Li, L; Tian, Y; Xu, Z; Zhang, W1
Crisostomo, AC; Finke, JM; Kwon, H; Smalls, HM1
Kikkeri, R; Murthy, RV; Yadav, R1
Liu, J; Liu, Y; Sun, J; Yang, L; Yin, T; Zhou, X1
García Rodríguez, JC; Maurice, T; Rodríguez Cruz, Y; Rodríguez Obaya, T; Strehaiano, M1
Banks, WA; Finke, JM1
Cowan, CB; Good, TA; Patel, DA1
Yamauchi, K1
Baboolal, N; Davis, G; McRae, A; Nayak, S1
Berman, P; de Villiers, N; Hon, D; MacGregor, P; Potocnik, F; van Rensburg, SJ1
Ito, A; Kakuyama, H; Möller, A; Näslund, J; Söderberg, L; Tjernberg, LO; Winblad, B1
Miyatake, T; Saito, F; Saito, K; Sodeyama, N; Yanagisawa, K1
Alafuzoff, I; Miettinen, R; Mikkonen, M; Soininen, H; Tapiola, T1
Ariga, T; Hasegawa, A; Ishida, H; Kiso, M; Kobayashi, K; Miyatake, T1
Berman, PA; Potocnik, FC; Taljaard, JJ; van Rensburg, SJ1
Gong, CX; Grundke-Iqbal, I; Iqbal, K; Liu, F; Merkle, RK; Zaidi, T1
Cosović, C; Drnovsek, V; Heffer-Lauc, M; Kracun, I; Lauc, G; Rosner, H1

Reviews

3 review(s) available for n-acetylneuraminic acid and Alzheimer Disease

ArticleYear
The significance of sialylation on the pathogenesis of Alzheimer's disease.
    Brain research bulletin, 2021, Volume: 173

    Topics: Alzheimer Disease; Animals; Brain; Glycosylation; Humans; N-Acetylneuraminic Acid

2021
Modulators of IgG penetration through the blood-brain barrier: Implications for Alzheimer's disease immunotherapy.
    Human antibodies, 2017, Volume: 25, Issue:3-4

    Topics: Alzheimer Disease; Animals; Antibodies, Bispecific; Antibodies, Monoclonal; Biological Transport; Blood-Brain Barrier; Brain; Carbohydrate Conformation; Gene Expression Regulation; Glycosylation; Histocompatibility Antigens Class I; Humans; Immunoglobulin G; Immunotherapy; N-Acetylneuraminic Acid; Protein Engineering; Receptors, Fc

2017
[Characterization of sialo-apolipoprotein E in human cerebrospinal fluid].
    Rinsho byori. The Japanese journal of clinical pathology, 2009, Volume: 57, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Biological Transport; Brain; Cholesterol; Humans; Lipid Metabolism; Lipoproteins; N-Acetylneuraminic Acid; Particle Size; Protein Binding

2009

Trials

1 trial(s) available for n-acetylneuraminic acid and Alzheimer Disease

ArticleYear
Anti-aβ oligomer IgG and surface sialic acid in intravenous immunoglobulin: measurement and correlation with clinical outcomes in Alzheimer's disease treatment.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Biopolymers; Humans; Immunoglobulin G; Immunoglobulins, Intravenous; N-Acetylneuraminic Acid; Surface Plasmon Resonance; Treatment Outcome

2015

Other Studies

22 other study(ies) available for n-acetylneuraminic acid and Alzheimer Disease

ArticleYear
An Oligomannuronic Acid-Sialic Acid Conjugate Capable of Inhibiting Aβ42 Aggregation and Alleviating the Inflammatory Response of BV-2 Microglia.
    International journal of molecular sciences, 2021, Nov-15, Volume: 22, Issue:22

    Topics: Alginic Acid; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cell Line, Transformed; Cell Proliferation; Cell Survival; Cytokines; Mice; Microglia; N-Acetylneuraminic Acid; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Signal Transduction

2021
Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Aβ interaction and Aβ fibrillation.
    Neurobiology of disease, 2022, Volume: 164

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Apolipoproteins E; Brain; Humans; N-Acetylneuraminic Acid; Protein Isoforms

2022
CD33 rs2455069 SNP: Correlation with Alzheimer's Disease and Hypothesis of Functional Role.
    International journal of molecular sciences, 2022, Mar-26, Volume: 23, Issue:7

    Topics: Alzheimer Disease; Genome-Wide Association Study; Humans; Microglia; N-Acetylneuraminic Acid; Polymorphism, Single Nucleotide; Sialic Acid Binding Ig-like Lectin 3

2022
N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer's disease mouse model.
    Nature communications, 2023, 03-09, Volume: 14, Issue:1

    Topics: Alzheimer Disease; Animals; Diet, High-Fat; Disease Models, Animal; Humans; Memory Disorders; Mice; Mice, Transgenic; N-Acetylneuraminic Acid; Obesity

2023
The N-glycan profile in cortex and hippocampus is altered in Alzheimer disease.
    Journal of neurochemistry, 2021, Volume: 159, Issue:2

    Topics: Acetylglucosamine; Aged; Aged, 80 and over; Alzheimer Disease; Asparagine; Brain Chemistry; Cerebral Cortex; Chromatography, Gel; Chromatography, High Pressure Liquid; Epitopes; Female; Fucose; Galactose; Glycoproteins; Hippocampus; Humans; Male; N-Acetylneuraminic Acid; Polysaccharides; Tandem Mass Spectrometry

2021
Sialic acid associated with oxidative stress and total antioxidant capacity (TAC) expression level as a predictive indicator in moderate to severe Alzheimer's disease.
    Experimental gerontology, 2020, Volume: 141

    Topics: Alzheimer Disease; Antioxidants; Catalase; Female; Glutathione; Glutathione Peroxidase; Humans; Lipid Peroxidation; Male; N-Acetylneuraminic Acid; Oxidative Stress; Superoxide Dismutase

2020
Detection of β-Amyloid by Sialic Acid Coated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer's Disease.
    Small (Weinheim an der Bergstrasse, Germany), 2018, Volume: 14, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Brain; Contrast Media; Disease Models, Animal; Humans; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mice; Mice, Transgenic; N-Acetylneuraminic Acid; Serum Albumin, Bovine

2018
Induction of ganglioside synthesis in Drosophila brain accelerates assembly of amyloid β protein.
    Scientific reports, 2018, 05-29, Volume: 8, Issue:1

    Topics: Acetyltransferases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Membrane; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; G(M1) Ganglioside; Galactosyltransferases; Gangliosides; Humans; N-Acetylneuraminic Acid; Protein Binding; Transgenes

2018
Glycopeptide Nanofiber Platform for Aβ-Sialic Acid Interaction Analysis and Highly Sensitive Detection of Aβ.
    Analytical chemistry, 2019, 07-02, Volume: 91, Issue:13

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cattle; Glycopeptides; Humans; N-Acetylneuraminic Acid; Nanofibers; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Spectrometry, Fluorescence

2019
Sialic Acid Hydroxamate: A Potential Antioxidant and Inhibitor of Metal-Induced β-Amyloid Aggregates.
    Chembiochem : a European journal of chemical biology, 2015, Jul-06, Volume: 16, Issue:10

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cell Survival; Chelating Agents; Free Radical Scavengers; Humans; Hydroxamic Acids; N-Acetylneuraminic Acid; Neuroprotective Agents; Oxidative Stress; Protein Aggregates; Protein Aggregation, Pathological

2015
Sialic acid (SA)-modified selenium nanoparticles coated with a high blood-brain barrier permeability peptide-B6 peptide for potential use in Alzheimer's disease.
    Acta biomaterialia, 2015, Volume: 25

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biological Transport; Blood-Brain Barrier; Coated Materials, Biocompatible; Cytoprotection; Membrane Potential, Mitochondrial; Mice; Microscopy, Confocal; N-Acetylneuraminic Acid; Nanoparticles; Oligopeptides; PC12 Cells; Peptides; Permeability; Protein Aggregates; Rats; Selenium

2015
An Intranasal Formulation of Erythropoietin (Neuro-EPO) Prevents Memory Deficits and Amyloid Toxicity in the APPSwe Transgenic Mouse Model of Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2017, Volume: 55, Issue:1

    Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Disease Models, Animal; Erythropoietin; Hippocampus; Maze Learning; Memory; Memory Disorders; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; N-Acetylneuraminic Acid; Neuroprotective Agents; Nootropic Agents

2017
Exploring the mechanism of beta-amyloid toxicity attenuation by multivalent sialic acid polymers through the use of mathematical models.
    Journal of theoretical biology, 2009, May-21, Volume: 258, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomimetic Materials; Cell Membrane; Cell Survival; Cells, Cultured; Humans; Models, Biological; N-Acetylneuraminic Acid; Neurons; Protein Binding

2009
Sialic acid, homocysteine and CRP: potential markers for dementia.
    Neuroscience letters, 2009, Nov-20, Volume: 465, Issue:3

    Topics: Aged; Alzheimer Disease; Biomarkers; C-Reactive Protein; Dementia; Female; Homocysteine; Humans; Male; N-Acetylneuraminic Acid; Reproducibility of Results; Sensitivity and Specificity

2009
5- and 6-glycosylation of transferrin in patients with Alzheimer's disease.
    Metabolic brain disease, 2004, Volume: 19, Issue:1-2

    Topics: Alcoholism; Alzheimer Disease; Free Radicals; Glycosylation; Heterozygote; Homozygote; Humans; Isoelectric Focusing; N-Acetylneuraminic Acid; Oxidation-Reduction; Transferrin

2004
Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site.
    The Journal of biological chemistry, 2005, Jan-14, Volume: 280, Issue:2

    Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Binding Sites; Cell Line; Circular Dichroism; Glycosylation; Heparin; Humans; Mutagenesis; N-Acetylneuraminic Acid; Non-Fibrillar Collagens; Pepsin A; Protein Binding; Protein Structure, Quaternary; Protein Structure, Tertiary; Recombinant Proteins; Salts

2005
Developmental changes of sialylation of soluble beta/A4 amyloid protein precursor derivatives in human cerebrospinal fluid.
    Brain research. Molecular brain research, 1994, Volume: 27, Issue:2

    Topics: Adult; Age Factors; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Antibodies; Blotting, Western; Child; Humans; Infant; Molecular Weight; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids

1994
Hippocampal plasticity in Alzheimer's disease: changes in highly polysialylated NCAM immunoreactivity in the hippocampal formation.
    The European journal of neuroscience, 1999, Volume: 11, Issue:5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antibody Specificity; Blotting, Western; Dentate Gyrus; Entorhinal Cortex; Female; Humans; Male; Microscopy, Electron; N-Acetylneuraminic Acid; Neural Cell Adhesion Molecules; Neuronal Plasticity; Neurons

1999
Characterization of high-affinity binding between gangliosides and amyloid beta-protein.
    Archives of biochemistry and biophysics, 2001, Apr-15, Volume: 388, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Gangliosides; Humans; N-Acetylneuraminic Acid; Structure-Activity Relationship; Surface Plasmon Resonance

2001
Glycosylation of transferrin in Alzheimer's disease and alcohol-induced dementia.
    Metabolic brain disease, 2000, Volume: 15, Issue:4

    Topics: Adult; Alcoholism; Alzheimer Disease; Glycosylation; Humans; Male; N-Acetylneuraminic Acid; Oligosaccharides; Transferrin

2000
Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease.
    FEBS letters, 2002, Feb-13, Volume: 512, Issue:1-3

    Topics: Acetylglucosamine; Alzheimer Disease; Glycosylation; Hexoses; Humans; N-Acetylneuraminic Acid; Neurofibrillary Tangles; Nucleotidyltransferases; Phosphorylation; Protein Processing, Post-Translational; tau Proteins

2002
Human brain gangliosides in development, aging and disease.
    The International journal of developmental biology, 1991, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Alzheimer Disease; Brain; Brain Chemistry; Child; Child, Preschool; Gangliosides; Humans; Infant; Infant, Newborn; Middle Aged; N-Acetylneuraminic Acid; Sialic Acids

1991