Compounds > n-acetylglucosamine-thiazoline

n-acetylglucosamine-thiazoline and Bacterial-Infections

n-acetylglucosamine-thiazoline has been researched along with Bacterial-Infections* in 1 studies

Other Studies

1 other study(ies) available for n-acetylglucosamine-thiazoline and Bacterial-Infections

ArticleYear
NAG-thiazoline is a potent inhibitor of the Vibrio campbellii GH20 β-N-Acetylglucosaminidase.
    The FEBS journal, 2020, Volume: 287, Issue:22

    Vibrio spp. play a vital role in the recycling of chitin in oceans, but several Vibrio strains are highly infectious to aquatic animals and humans. These bacteria require chitin for growth; thus, potent inhibitors of chitin-degrading enzymes could serve as candidate drugs against Vibrio infections. This study examined NAG-thiazoline (NGT)-mediated inhibition of a recombinantly expressed GH20 β-N-acetylglucosaminidase, namely VhGlcNAcase from Vibrio campbellii (formerly V. harveyi) ATCC BAA-1116. NGT strongly inhibited VhGlcNAcase with an IC

    Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Bacterial Infections; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Humans; Inhibitory Concentration 50; Kinetics; Models, Molecular; Oligosaccharides; Protein Domains; Substrate Specificity; Thermodynamics; Thiazoles; Vibrio

2020