Page last updated: 2024-08-24

n-acetylaspartic acid and Obsessive-Compulsive Disorder

n-acetylaspartic acid has been researched along with Obsessive-Compulsive Disorder in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (5.88)18.2507
2000's17 (50.00)29.6817
2010's15 (44.12)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brandeis, D; Buitelaar, JK; Durston, S; Forde, NJ; Franke, B; Glennon, JC; Lythgoe, DJ; Naaijen, J; Williams, SC; Zwiers, MP1
Jeong, GW; Moon, CM1
Aydın, K; Ertekin, E; Özyıldırım, SŞ; Taravari, V; Tükel, R1
Aydın, K; Barburoğlu, M; Ertekin, E; Özyıldırım, SŞ; Tükel, R1
Choi, NG; Jeong, GW; Park, SE1
Carlsson, A; Carlsson, M; Forssell-Aronsson, E; Ivarsson, T; Jönsson, L; Ljungberg, M; Melin, K; Nilsson, MKL; Starck, G1
Carlsson, A; Carlsson, ML; Ekholm, S; Forssell-Aronsson, E; Ivarsson, T; Jönsson, L; Ljungberg, M; Lundberg, S; Nilsson, M; Ribbelin, S; Starck, G1
Backens, M; Bondy, B; Falkai, P; Gruber, O; Möller, HJ; Reith, W; Scherk, H; Schneider-Axmann, T; Usher, J; Wobrock, T; Zill, P1
Atmaca, M; Koc, M; Ozdemir, H; Ozler, S; Tezcan, E; Yildirim, H1
Chakrabarti, S; Kumar, V; Modi, M; Sahoo, M1
Chen, K; Fan, Q; Li, J; Ross, CA; Tan, L; Wang, J; Wang, X; Xiao, Z; You, C; Zhang, T1
Bédard, MJ; Chantal, S1
Atli, A; Avcu, S; Besiroglu, L; Bora, A; Bulut, MD; Ozbebit, O; Selvi, Y; Sozen, M; Unal, O1
Akın Sarı, B; Güney, E; Işeri, E; Konuş Boyunağa, OL; Oğur, T; Sarıpınar, EG; Sener, S; Yalçın, O1
Andrés, S; Bargalló, N; Castro-Fornieles, J; Falcón, C; Junqué, C; Lázaro, L; Morer, A1
Abramowitz, JS; Port, JD; Whiteside, SP2
Büchel, C; Freyer, T; Hohagen, F; Kordon, A; Kuelz, AK; Voderholzer, U; Wahl, K; Weber-Fahr, W; Zurowski, B1
Aoki, A; Aoki, Y; Suwa, H1
Banerjee, SP; Cortese, B; Ivey, J; Lorch, E; Moore, GJ; Rosenberg, DR; Russell, A1
Alkan, A; Aslan, M; Dogan, S; Emul, M; Kocak, G; Kutlu, R; Sarac, K; Sigirci, A; Yakinci, C1
Banerjee, SP; Bhandari, R; Boyd, C; Ivey, J; Mirza, Y; Moore, GJ; Rose, M; Rosenberg, DR; Russell, A; Smith, JM; Tang, J1
Chung, EC; Ha, TH; Jang, DP; Jang, JH; Kim, IY; Kim, SI; Kwon, JS; Lee, JM; Moon, WJ1
Kimura, T; Kitamura, H; Nakada, T; Ohkubo, M; Shioiri, T; Someya, T1
Harada, M; Kubo, H; Ohmori, T; Sumitani, S1
Baskak, B; Devrimci-Ozguven, H; Munir, KM; Oktem, F; Oner, O; Yagmurlu, B1
Barker, PB; Hoehn-Saric, R; Mohamed, MA; Nestadt, G; Schlund, MW; Smith, MA1
Backens, M; Falkai, P; Gruber, O; Kemmer, C; Kraft, S; Meyer, J; Reith, W; Scherk, H; Schneider-Axmann, T; Usher, J1
Fornito, A; Harrison, BJ; Pantelis, C; Pujol, J; Velakoulis, D; Wellard, RM; Wood, SJ; Yücel, M1
Berger, M; Ebert, D; Hennig, J; Hohagen, F; König, A; Speck, O1
Anderson, G; Bartha, R; Canaran, G; Carr, TJ; Densmore, M; Drost, DJ; Neufeld, RW; Siddiqui, AR; Stein, MB; Williamson, PC1
Rauch, SL1
Fitzgerald, KD; Moore, GJ; Paulson, LA; Rosenberg, DR; Stewart, CM1
Amponsah, A; MacMillan, S; Moore, GJ; Rosenberg, DR; Sullivan, A1

Reviews

1 review(s) available for n-acetylaspartic acid and Obsessive-Compulsive Disorder

ArticleYear
Reduction of N-acetylaspartate in the medial prefrontal cortex correlated with symptom severity in obsessive-compulsive disorder: meta-analyses of (1)H-MRS studies.
    Translational psychiatry, 2012, Aug-14, Volume: 2

    Topics: Aspartic Acid; Basal Ganglia; Humans; Magnetic Resonance Spectroscopy; Obsessive-Compulsive Disorder; Prefrontal Cortex; Severity of Illness Index; Thalamus

2012

Trials

2 trial(s) available for n-acetylaspartic acid and Obsessive-Compulsive Disorder

ArticleYear
Localized functional neurochemical marker abnormalities in dorsolateral prefrontal cortex in pediatric obsessive-compulsive disorder.
    Journal of child and adolescent psychopharmacology, 2003, Volume: 13 Suppl 1

    Topics: Adolescent; Aspartic Acid; Biomarkers; Child; Choline; Creatine; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Obsessive-Compulsive Disorder; Prefrontal Cortex; Psychiatric Status Rating Scales

2003
Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications.
    European journal of radiology, 2004, Volume: 49, Issue:3

    Topics: Adolescent; Analysis of Variance; Aspartic Acid; Basal Ganglia; Child; Child, Preschool; Choline; Chorea; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Reference Values; Rheumatic Fever; Tic Disorders

2004

Other Studies

31 other study(ies) available for n-acetylaspartic acid and Obsessive-Compulsive Disorder

ArticleYear
Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorder.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2018, Volume: 28, Issue:1

    Topics: Adolescent; Aspartic Acid; Autism Spectrum Disorder; Child; Corpus Striatum; Female; Functional Laterality; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Obsessive-Compulsive Disorder; Organ Size; Proton Magnetic Resonance Spectroscopy

2018
Associations of neurofunctional, morphometric and metabolic abnormalities with clinical symptom severity and recognition deficit in obsessive-compulsive disorder.
    Journal of affective disorders, 2018, Volume: 227

    Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Memory, Short-Term; Obsessive-Compulsive Disorder; Proton Magnetic Resonance Spectroscopy

2018
Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for reduced neuronal integrity in the anterior cingulate.
    Psychiatry research, 2014, Dec-30, Volume: 224, Issue:3

    Topics: Adult; Aspartic Acid; Caudate Nucleus; Choline; Creatine; Female; Gyrus Cinguli; Humans; Inositol; Male; Obsessive-Compulsive Disorder; Proton Magnetic Resonance Spectroscopy; Putamen

2014
1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: effects of 12 weeks of sertraline treatment on brain metabolites.
    European archives of psychiatry and clinical neuroscience, 2015, Volume: 265, Issue:3

    Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Follow-Up Studies; Humans; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Protons; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Sertraline; Young Adult

2015
Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive-compulsive disorder: proton magnetic resonance spectroscopy.
    Acta neuropsychiatrica, 2017, Volume: 29, Issue:3

    Topics: Adult; Aspartic Acid; Brain; Choline; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Male; Neuroimaging; Obsessive-Compulsive Disorder; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Young Adult

2017
1H magnetic resonance spectroscopy evidence for occipital involvement in treatment-naive paediatric obsessive-compulsive disorder.
    Acta neuropsychiatrica, 2017, Volume: 29, Issue:3

    Topics: Adolescent; Aspartic Acid; Brain; Child; Choline; Female; Humans; Inositol; Male; Obsessive-Compulsive Disorder; Occipital Lobe; Proton Magnetic Resonance Spectroscopy; Severity of Illness Index

2017
A 1H magnetic resonance spectroscopy study in adults with obsessive compulsive disorder: relationship between metabolite concentrations and symptom severity.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:7

    Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Obsessive-Compulsive Disorder; Principal Component Analysis; Protons; Severity of Illness Index; Surveys and Questionnaires

2008
SNAP-25 genotype influences NAA/Cho in left hippocampus.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:11

    Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; DNA; Female; Genotype; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Schizophrenia; Synaptosomal-Associated Protein 25

2008
Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder.
    Psychiatry and clinical neurosciences, 2009, Volume: 63, Issue:4

    Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Functional Laterality; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales

2009
Late-onset obsessive compulsive disorder associated with possible gliomatosis cerebri.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 2

    Topics: Aged; Anticonvulsants; Aspartic Acid; Brain Neoplasms; Choline; Corpus Callosum; Dominance, Cerebral; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neoplasms, Neuroepithelial; Obsessive-Compulsive Disorder; Parietal Lobe; Temporal Lobe

2009
Increased N-Acetylaspartate/creatine ratio in the medial prefrontal cortex among unmedicated obsessive-compulsive disorder patients.
    Psychiatry and clinical neurosciences, 2010, Volume: 64, Issue:5

    Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Inositol; Interview, Psychological; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Obsessive-Compulsive Disorder; Prefrontal Cortex; Young Adult

2010
Brain magnetic resonance spectroscopy in obsessive-compulsive disorder: the importance of considering subclinical symptoms of anxiety and depression.
    Psychiatry research, 2011, Apr-30, Volume: 192, Issue:1

    Topics: Adult; Anxiety; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Depression; Female; Functional Laterality; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Obsessive-Compulsive Disorder; Statistics as Topic

2011
The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions.
    Acta psychiatrica Scandinavica, 2011, Volume: 124, Issue:2

    Topics: Adult; Aspartic Acid; Choline; Creatine; Diagnostic and Statistical Manual of Mental Disorders; Drug Monitoring; Female; Fluoxetine; Humans; Limbic System; Magnetic Resonance Spectroscopy; Male; Middle Aged; Obsessive Behavior; Obsessive-Compulsive Disorder; Selective Serotonin Reuptake Inhibitors; Treatment Outcome

2011
Comparing brain magnetic resonance spectroscopy findings of pediatric treatment-naive obsessive-compulsive disorder patients with healthy controls.
    Turk psikiyatri dergisi = Turkish journal of psychiatry, 2011,Winter, Volume: 22, Issue:4

    Topics: Adolescent; Aspartic Acid; Brain; Case-Control Studies; Child; Female; Humans; Magnetic Resonance Imaging; Male; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales

2011
Proton magnetic resonance spectroscopy in pediatric obsessive-compulsive disorder: longitudinal study before and after treatment.
    Psychiatry research, 2012, Jan-30, Volume: 201, Issue:1

    Topics: Adolescent; Aspartic Acid; Behavior Therapy; Brain; Child; Choline; Creatine; Female; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Selective Serotonin Reuptake Inhibitors; Treatment Outcome

2012
The effect of behavior therapy on caudate N-acetyl-l-aspartic acid in adults with obsessive-compulsive disorder.
    Psychiatry research, 2012, Jan-30, Volume: 201, Issue:1

    Topics: Adult; Aspartic Acid; Behavior Therapy; Caudate Nucleus; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuroimaging; Obsessive-Compulsive Disorder; Treatment Outcome

2012
Relevance of orbitofrontal neurochemistry for the outcome of cognitive-behavioural therapy in patients with obsessive-compulsive disorder.
    European archives of psychiatry and clinical neuroscience, 2012, Volume: 262, Issue:7

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Cognitive Behavioral Therapy; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Obsessive-Compulsive Disorder; Prefrontal Cortex; Psychiatric Status Rating Scales; Statistics as Topic; Young Adult

2012
Decreased caudate N-acetyl-l-aspartic acid in pediatric obsessive-compulsive disorder and the effects of behavior therapy.
    Psychiatry research, 2012, Apr-30, Volume: 202, Issue:1

    Topics: Adolescent; Aspartic Acid; Behavior Therapy; Caudate Nucleus; Child; Female; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Treatment Outcome

2012
Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2004, Volume: 43, Issue:9

    Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Personality Assessment; Phosphocreatine; Reference Values; Synaptic Transmission

2004
A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder.
    The American journal of psychiatry, 2006, Volume: 163, Issue:7

    Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Choline; Citalopram; Creatine; Female; Frontal Lobe; Gyrus Cinguli; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Personality Inventory; Prefrontal Cortex; Protons; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors

2006
Parietal white matter abnormalities in obsessive-compulsive disorder: a magnetic resonance spectroscopy study at 3-Tesla.
    Acta psychiatrica Scandinavica, 2006, Volume: 114, Issue:2

    Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Nerve Net; Obsessive-Compulsive Disorder; Parietal Lobe; Radiography

2006
Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive-compulsive disorder patients.
    Psychiatry research, 2007, Jan-15, Volume: 154, Issue:1

    Topics: Adult; Antipsychotic Agents; Aspartic Acid; Basal Ganglia; Benzodiazepines; Dominance, Cerebral; Dose-Response Relationship, Drug; Drug Therapy, Combination; Energy Metabolism; Female; Fluvoxamine; Frontal Lobe; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Net; Obsessive-Compulsive Disorder; Olanzapine; Paroxetine; Prefrontal Cortex; Risperidone; Selective Serotonin Reuptake Inhibitors; Treatment Outcome

2007
Proton MR spectroscopy: higher right anterior cingulate N-acetylaspartate/choline ratio in Asperger syndrome compared with healthy controls.
    AJNR. American journal of neuroradiology, 2007, Volume: 28, Issue:8

    Topics: Adolescent; Adult; Aspartic Acid; Asperger Syndrome; Choline; Diagnostic and Statistical Manual of Mental Disorders; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Protons

2007
Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders.
    Psychiatry research, 2007, Nov-15, Volume: 156, Issue:2

    Topics: Adult; Aspartic Acid; Basal Ganglia; Choline; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neural Pathways; Obsessive-Compulsive Disorder; Selective Serotonin Reuptake Inhibitors; Thalamus; Treatment Outcome

2007
Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 2

    Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dominance, Cerebral; Dopamine Plasma Membrane Transport Proteins; Female; Frontal Lobe; Genotype; Gyrus Cinguli; Homozygote; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Minisatellite Repeats; Neurons; Obsessive-Compulsive Disorder; Prefrontal Cortex; Putamen; Reference Values; Young Adult

2009
Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder.
    The Australian and New Zealand journal of psychiatry, 2008, Volume: 42, Issue:6

    Topics: Adult; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Obsessive-Compulsive Disorder; Predictive Value of Tests; Severity of Illness Index; Sex Factors

2008
1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum.
    Psychiatry research, 1997, Jul-04, Volume: 74, Issue:3

    Topics: Adult; Aspartic Acid; Cell Count; Corpus Striatum; Female; Functional Laterality; Gyrus Cinguli; Humans; Hydrogen; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Parietal Lobe; Severity of Illness Index

1997
A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive-compulsive disorder and comparison subjects.
    The American journal of psychiatry, 1998, Volume: 155, Issue:11

    Topics: Adult; Aspartic Acid; Cell Count; Corpus Striatum; Female; Functional Laterality; Humans; Hydrogen; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurons; Obsessive-Compulsive Disorder

1998
Neuroimaging research and the neurobiology of obsessive-compulsive disorder: where do we go from here?
    Biological psychiatry, 2000, Feb-01, Volume: 47, Issue:3

    Topics: Adolescent; Aspartic Acid; Brain Mapping; Cerebral Cortex; Child; Corpus Striatum; Female; Humans; Magnetic Resonance Spectroscopy; Male; Nerve Net; Neural Pathways; Obsessive-Compulsive Disorder; Thalamus

2000
Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder.
    Biological psychiatry, 2000, Feb-01, Volume: 47, Issue:3

    Topics: Adolescent; Aspartic Acid; Brain Mapping; Case-Control Studies; Cerebral Cortex; Child; Choline; Corpus Striatum; Creatine; Dominance, Cerebral; Female; Humans; Magnetic Resonance Spectroscopy; Male; Nerve Net; Neural Pathways; Obsessive-Compulsive Disorder; Phosphocreatine; Reference Values; Thalamus

2000
Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging.
    Journal of child neurology, 2001, Volume: 16, Issue:9

    Topics: Adolescent; Aspartic Acid; Brain Mapping; Case-Control Studies; Child; Choline; Creatine; Cytosol; Dominance, Cerebral; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Reference Values; Thalamus

2001