Page last updated: 2024-08-24

n-acetylaspartic acid and Nerve Degeneration

n-acetylaspartic acid has been researched along with Nerve Degeneration in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (3.03)	18.7374
1990's	17 (25.76)	18.2507
2000's	33 (50.00)	29.6817
2010's	14 (21.21)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cortese, ICM; Ercan, E; Reich, DS; Ronen, I; Sati, P; Wood, ET	1
Arahuetes, RM; de Munck, E; Gil, C; Martínez, A; Miguel, BG; Muñoz-Sáez, E; Ojeda, I; Solas, MT	1
Brandt, AU; Doss, S; Endres, M; Oberwahrenbrock, T; Paul, F; Rinnenthal, JL	1
Abdel-Aziz, K; Altmann, DR; Ciccarelli, O; Day, BL; Peters, AL; Schneider, T; Solanky, BS; Thompson, AJ; Wheeler-Kingshott, CA; Yiannakas, MC	1
Eckhardt, M; Gieselmann, V; Hartmann, D; Maier, H; Wang-Eckhardt, L	1
Bulik, M; Burkon, P; Dobiaskova, M; Hynkova, L; Jancalek, R; Kazda, T; Laack, NN; Pospisil, P; Slampa, P	1
Armitage, PA; Bastin, ME; Chappell, FM; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM	1
Erichsen, AK; Landrø, NI; Sandvik, L; Server, A; Tallaksen, CM	1
Aresi, A; Bizzi, A; Giovagnoli, AR; Gobbo, C; Reati, F; Riva, A	1
Blom, HJ; Bouwman, F; Brundin, L; Dijkstra, CD; Iacobaeus, E; Jakobs, C; Khademi, M; Koel-Simmelink, MJ; Norgren, N; Schepens, M; Teunissen, CE; Twaalfhoven, HA	1
Atmaca, M; Koc, M; Ozdemir, H; Ozler, S; Tezcan, E; Yildirim, H	1
Herrera, JJ; Narayana, PA; Qian, J	1
Altmann, DR; Ciccarelli, O; McLean, MA; Miller, DH; Thompson, AJ; Wheeler-Kingshott, CA; Wimpey, K	1
Geurts, JJ; van Horssen, J	1
Huang, W; Lei, H; Wang, X; Xu, W; Zhan, Y; Zhang, S	1
Hanstock, C; Hui, B; Johnston, W; Kalra, S; Pyra, T; Sudharshan, N	1
Camicioli, R; Choi, C; Johnston, W; Kalra, S; Lynch, M; Sekhon, R; Seres, P; Usman, U	1
Baudrexel, S; Berg, D; Brockmann, K; Csoti, I; Gasser, T; Hattingen, E; Hauser, AK; Hilker, R; Magerkurth, J; Merten, CD; Pilatus, U; Schulte, C; Srulijes, K	1
Boĭko, AN; Davydovskaia, MV; Gusev, EI; Kornienko, VN; Podoprigora, AE; Pronin, IN	1
Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U	1
Alecci, M; Cifelli, A; Jezzard, P; Matthews, PM; Palace, J; Wylezinska, M	1
Ahmed, Z; Baker, D; Croxford, JL; Cuzner, ML; Giovannoni, G; Hankey, DJ; Jackson, SJ; Ledent, C; Petzold, A; Pocock, JM; Pryce, G; Thompson, AJ	1
Barr, J; Bell, JD; Bhakoo, K; Chung, YL; Fraser, JR; Williams, SC	1
Balcar, VJ; Bubeníková, V; Fitzgibbon, T; Pliss, L; Pokorný, J; St'astný, F	1
Al-Semaan, Y; Densmore, M; Drost, DJ; Menon, RS; Neufeld, RW; Rajakumar, N; Schaefer, B; Théberge, J; Williamson, PC	1
Zaffaroni, M	1
Bartolozzi, ML; De Stefano, N; Federico, A; Guidi, L; Stromillo, ML	1
Barbiroli, B; Iotti, S; Lodi, R; Montagna, P; Plazzi, G; Tonon, C; Vignatelli, L	1
Dijkstra, C; Polman, C; Teunissen, CE	1
Ashwal, S; Gross, M; Holshouser, B; Kido, D; Osterdock, R; Serna, T; Tong, K	1
Benner, EJ; Boska, MD; Destache, CJ; Gendelman, HE; Lewis, TB; Mosley, RL; Nelson, JA; Uberti, M	1
Axelson, D; Birmaher, B; Brambilla, P; Keshavan, MS; Nicoletti, MA; Ramos, RT; Ryan, N; Sassi, RB; Soares, JC; Stanley, JA	1
Boucard, CC; Cornelissen, FW; Hoogduin, JM; van der Grond, J	1
Angenstein, F; Debska-Vielhaber, G; Heinze, HJ; Hilfert, L; Kunz, WS; Leibfritz, D; Ludolph, AC; Niessen, HG; Sander, K; Vielhaber, S; Willker, W	1
Blezer, EL; Jongsma, MJ; Olivier, B; Philippens, IH; van Vliet, SA; van Vlieta, SA; Vanwersch, RA	1
Bhattacharjee, MB; Brunetti-Pierri, N; Hunter, J; Potocki, L; Scaglia, F; Wang, ZJ; Wenger, DA	1
Casey, PA; Fiskum, G; McKenna, MC; Robertson, CL; Saraswati, M	1
Kaul, R; Matalon, R; Michals, K	1
Bamonti, F; Rango, M; Scarlato, G; Spagnoli, D; Tomei, G; Zetta, L	1
de Koster, A; Heerschap, A; Horstink, MW; Thijssen, HO; van 't Hof, MA; Zijlmans, JC	1
Bruhn, H; Frahm, J; Hanefeld, F; Kruse, B	1
Choe, BY; Choi, KH; Kang, JK; Park, CK; Shinn, KS; Suh, TS	1
Alger, JR; Barnett, AS; Bertolino, A; Bonavita, S; Campbell, G; Hallett, M; Massaquoi, SG; Patronas, NJ; Tedeschi, G	1
Beal, MF; Brouillet, E; Chen, YC; Jenkins, BG; Kirschner, P; Rosen, BR; Schulz, JB; Storey, E	1
Brooks, DJ; Bryant, DJ; Harding, AE; Marcus, CD; Sargentoni, J; Taylor-Robinson, SD; Weeks, RA	1
Maier, M; Ron, MA	1
Chang, L; Ernst, T; Mehringer, CM; Melchor, R	1
Bertolino, A; Bonavita, S; Hallett, M; Litvan, I; Lundbom, N; Patronas, NJ; Tedeschi, G	1
Deicken, RF; Schuff, N; Weiner, MW; Zhou, L	1
Majors, AW; Mitsumoto, H; Nelson, DR; Ng, TC; Pioro, EP	1
Akimitsu, T; Kitada, K; Kondo, A; Kuramoto, T; Maihara, T; Sasa, M; Serikawa, T; Shigematsu, Y; Yokoi, N	1
Chang, C; Lee, CS; Lee, WT; Pan, YL	1
Antel, J; Arnold, DL; Arnoutelis, R; Jenkinson, M; Matthews, PM; Narayanan, S; Reddy, H	1
Bellacosa, A; Carrara, D; Federico, F; Giannini, P; Liguori, M; Livrea, P; Lucivero, V; Simone, IL; Tortorella, C	1
Barker, GJ; Chard, D; Griffin, CM; Kapeller, P; McLean, MA; Miller, DH; Parker, GJ; Thompson, AJ	1
Bjartmar, C; Trapp, BD	1
Krasnewich, D; Pearl, PL	1
Bard, C; Boulanger, Y; Khiat, A; Lacroix, A; Yared, Z	1
Iidaka, T; Itoh, H; Kado, H; Kimura, H; Kosaka, H; Murata, T; Omori, M; Wada, Y	1
Battistuta, J; Bjartmar, C; Dupree, E; Terada, N; Trapp, BD	1
den Hollander, JA; Luyten, PR; Nauta, JJ; Valk, J; van der Grond, J; van der Knaap, MS	1
Kelley, RI; Stamas, JN	1
Barash, V; Boneh, A; Elpeleg, ON; Flhor, D; Gilon, C; Morag, B	1
Gürçay, O; Onol, B; Ozcan, OE; Renda, Y; Topaloğlu, H; Topçu, M; Yalaz, K	1
Amir, N; Barash, V; Elpeleg, ON; Glick, B; Gross-Tsur, V; Shachar, E; Shapira, Y; Tzelnik, N	1
Divry, P; Mathieu, M	1

Reviews

5 review(s) available for n-acetylaspartic acid and Nerve Degeneration

Article	Year
Biological indicators of the neurodegenerative phase of multiple sclerosis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2003, Volume: 24 Suppl 5 Topics: Aspartic Acid; Axons; Biomarkers; Cytoskeletal Proteins; Humans; Multiple Sclerosis; Nerve Degeneration	2003
Imaging neuronal and axonal degeneration in multiple sclerosis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2003, Volume: 24 Suppl 5 Topics: Aspartic Acid; Atrophy; Axons; Brain; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Nerve Degeneration; Radiography	2003
Biological markers in CSF and blood for axonal degeneration in multiple sclerosis. The Lancet. Neurology, 2005, Volume: 4, Issue:1 Topics: 14-3-3 Proteins; Actins; Amyloid beta-Protein Precursor; Apolipoproteins E; Aspartic Acid; Axons; Biomarkers; Humans; Hydroxycholesterols; Multiple Sclerosis; Nerve Degeneration; Phosphopyruvate Hydratase; Predictive Value of Tests; tau Proteins; Tubulin	2005
Canavan disease: from spongy degeneration to molecular analysis. The Journal of pediatrics, 1995, Volume: 127, Issue:4 Topics: Age of Onset; Aspartic Acid; Brain; Canavan Disease; Child; Diagnosis, Differential; Humans; Jews; Magnetic Resonance Imaging; Male; Muscle Hypotonia; Nerve Degeneration; Prenatal Diagnosis; Survival Rate	1995
Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Current opinion in neurology, 2001, Volume: 14, Issue:3 Topics: Aspartic Acid; Atrophy; Axons; Brain; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Nerve Degeneration; Neurons	2001

Trials

1 trial(s) available for n-acetylaspartic acid and Nerve Degeneration

Article	Year
Mesial prefrontal cortex degeneration in amyotrophic lateral sclerosis: a high-field proton MR spectroscopy study. AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:9 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Female; Frontotemporal Lobar Degeneration; Gliosis; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Prefrontal Cortex; Protons	2011

Article

Year

Mesial prefrontal cortex degeneration in amyotrophic lateral sclerosis: a high-field proton MR spectroscopy study.

AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:9

Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Female; Frontotemporal Lobar Degeneration; Gliosis; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Prefrontal Cortex; Protons

2011

Other Studies

60 other study(ies) available for n-acetylaspartic acid and Nerve Degeneration

Article	Year
Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent NeuroImage. Clinical, 2017, Volume: 15 Topics: Adult; Aged; Aspartic Acid; Axons; Brain; Female; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Young Adult	2017
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS. Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:2 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 3; Choline; Creatinine; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Endoplasmic Reticulum; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Magnetic Resonance Spectroscopy; Male; Mitochondria; Motor Activity; Motor Cortex; Nerve Degeneration; Neurologic Examination; Phenotype; Rats; Rats, Wistar; Spinal Cord; Time Factors	2013
Metabolic evidence for cerebral neurodegeneration in spinocerebellar ataxia type 1. Cerebellum (London, England), 2014, Volume: 13, Issue:2 Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Brain; Cerebral Cortex; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Nerve Fibers, Myelinated; Spinocerebellar Ataxias	2014
Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis. Brain : a journal of neurology, 2015, Volume: 138, Issue:Pt 6 Topics: Adolescent; Adult; Aged; Aspartic Acid; Atrophy; Brain; Case-Control Studies; Cervical Cord; Disability Evaluation; Early Diagnosis; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Nerve Degeneration; Proton Magnetic Resonance Spectroscopy; Spinal Cord; White Matter; Young Adult	2015
N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Oct-28, Volume: 35, Issue:43 Topics: Acetyltransferases; Amidohydrolases; Animals; Aspartic Acid; Axons; Behavior, Animal; Canavan Disease; Enzyme Inhibitors; Female; Genotype; Gliosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Nerve Degeneration; Sphingolipids; Survival Analysis	2015
Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017, Volume: 122, Issue:3 Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Cognitive Dysfunction; Cranial Irradiation; Female; Follow-Up Studies; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Nerve Degeneration; Neuropsychological Tests; Prospective Studies; Quality of Life; Surveys and Questionnaires	2017
Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study. Neurology, 2008, Dec-09, Volume: 71, Issue:24 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Brain Mapping; Cell Death; Diffusion Magnetic Resonance Imaging; Disease Progression; Down-Regulation; Energy Metabolism; Female; Humans; Lactic Acid; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Stroke; Time Factors	2008
Proton magnetic resonance spectroscopy and cognition in patients with spastin mutations. Journal of the neurological sciences, 2009, Feb-15, Volume: 277, Issue:1-2 Topics: Adenosine Triphosphatases; Adult; Aspartic Acid; Biomarkers; Choline; Cognition Disorders; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Nerve Degeneration; Protons; Spastic Paraplegia, Hereditary; Spastin	2009
The neuropsychological and neuroradiological correlates of slowly progressive visual agnosia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2009, Volume: 30, Issue:2 Topics: Agnosia; Aspartic Acid; Atrophy; Brain; Brain Mapping; Disease Progression; Energy Metabolism; Female; Fluorodeoxyglucose F18; Functional Laterality; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Nerve Degeneration; Neuropsychological Tests; Occipital Lobe; Parietal Lobe; Positron-Emission Tomography; Temporal Lobe	2009
Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis. Neurology, 2009, Apr-14, Volume: 72, Issue:15 Topics: Amino Acids; Aspartic Acid; Axons; Biomarkers; Cohort Studies; Disease Progression; Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Neurofilament Proteins; tau Proteins	2009
Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder. Psychiatry and clinical neurosciences, 2009, Volume: 63, Issue:4 Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Functional Laterality; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales	2009
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology. Journal of neurotrauma, 2010, Volume: 27, Issue:3 Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Immunohistochemistry; Magnetic Resonance Spectroscopy; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Wallerian Degeneration	2010
Spinal cord repair in MS: does mitochondrial metabolism play a role? Neurology, 2010, Mar-02, Volume: 74, Issue:9 Topics: Adult; Aspartic Acid; Axons; Cervical Vertebrae; Disease Progression; Female; Follow-Up Studies; Humans; Linear Models; Logistic Models; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Mitochondria; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Organ Size; Reactive Oxygen Species; Spinal Cord; Time Factors	2010
The brake on neurodegeneration: Increased mitochondrial metabolism in the injured MS spinal cord. Neurology, 2010, Mar-02, Volume: 74, Issue:9 Topics: Aspartic Acid; Cervical Vertebrae; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mitochondria; Multiple Sclerosis; Nerve Degeneration; Organ Size; Reactive Oxygen Species; Spinal Cord; Time Factors	2010
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons. Journal of neuroscience research, 2010, Nov-01, Volume: 88, Issue:14 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles	2010
Degeneration of the mid-cingulate cortex in amyotrophic lateral sclerosis detected in vivo with MR spectroscopy. AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Female; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Nerve Degeneration; Neural Pathways; Thalamus	2011
GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure. Neurology, 2012, Jul-17, Volume: 79, Issue:3 Topics: Adenosine Diphosphate; Adult; Age of Onset; Aged; Algorithms; Aspartic Acid; Brain Chemistry; Choline; Creatine; DNA; Energy Metabolism; Female; Glucosylceramidase; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Membranes; Middle Aged; Mitochondria; Nerve Degeneration; Neurons; Parkinson Disease; Phospholipids; Software	2012
[The neurodegenerative process in multiple sclerosis and the possible neuroprotective effect of treatment with Β-interferon 1a (avonex)]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:7 Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Creatine; Female; Humans; Interferon beta-1a; Interferon-beta; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Neuroprotective Agents; Neuropsychological Tests; Retrospective Studies; Young Adult	2012
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease. Journal of neurology, 2003, Volume: 250, Issue:3 Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Progression; Female; Gliosis; Humans; Infant; Inositol; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Radiography	2003
Thalamic neurodegeneration in relapsing-remitting multiple sclerosis. Neurology, 2003, Jun-24, Volume: 60, Issue:12 Topics: Adult; Aspartic Acid; Atrophy; Biomarkers; Body Water; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Nuclear Magnetic Resonance, Biomolecular; Thalamus	2003
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain : a journal of neurology, 2003, Volume: 126, Issue:Pt 10 Topics: Animals; Aspartic Acid; Axons; Benzoxazines; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Agonists; Gene Deletion; Humans; Mice; Mice, Transgenic; Monomeric GTP-Binding Proteins; Morpholines; Multiple Sclerosis; N-Methylaspartate; Naphthalenes; Nerve Degeneration; Nuclear Proteins; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Retina; Saccharomyces cerevisiae Proteins; Spinal Cord; Uveitis	2003
N-acetyl aspartate estimation: a potential method for determining neuronal loss in the transmissible spongiform encephalopathies. Neuropathology and applied neurobiology, 2003, Volume: 29, Issue:5 Topics: Animals; Aspartic Acid; Cell Count; Chromatography, High Pressure Liquid; Hippocampus; Magnetic Resonance Spectroscopy; Mice; Models, Animal; Nerve Degeneration; Neurons; Scrapie	2003
Morphology and ultrastructure of rat hippocampal formation after i.c.v. administration of N-acetyl-L-aspartyl-L-glutamate. Neuroscience, 2003, Volume: 122, Issue:1 Topics: Animals; Aspartic Acid; Cell Count; Cell Death; Dipeptides; DNA Fragmentation; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; In Situ Nick-End Labeling; Injections, Intraventricular; Male; Microscopy, Electron; Nerve Degeneration; Neurons; Neuropeptides; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors	2003
Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS. The American journal of psychiatry, 2003, Volume: 160, Issue:12 Topics: Adult; Antipsychotic Agents; Aspartic Acid; Chronic Disease; Dominance, Cerebral; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Psychiatric Status Rating Scales; Reference Values; Schizophrenia; Thalamus	2003
In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients. Neurology, 2004, Oct-26, Volume: 63, Issue:8 Topics: Adolescent; Adult; Aged; Aspartic Acid; Atrophy; Cataplexy; Creatine; Female; Humans; Hypothalamus; Intracellular Signaling Peptides and Proteins; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Narcolepsy; Nerve Degeneration; Neurons; Neuropeptides; Orexins; Polysomnography	2004
Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury. Journal of neurotrauma, 2004, Volume: 21, Issue:11 Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Injuries; Child; Child, Preschool; Choline; Coma; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Occipital Lobe; Parietal Lobe; Predictive Value of Tests; Recovery of Function; Up-Regulation	2004
Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Feb-16, Volume: 25, Issue:7 Topics: Adoptive Transfer; Animals; Aspartic Acid; Cell Count; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Glatiramer Acetate; Immunization; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Microglia; MPTP Poisoning; Myelin Basic Protein; Nerve Degeneration; Nerve Tissue Proteins; Ovalbumin; Parkinsonian Disorders; Peptides; Substantia Nigra; T-Lymphocyte Subsets; Tyrosine 3-Monooxygenase	2005
Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients. The American journal of psychiatry, 2005, Volume: 162, Issue:11 Topics: Adolescent; Adult; Age Factors; Aspartic Acid; Bipolar Disorder; Child; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Phosphocreatine; Prefrontal Cortex; Recurrence	2005
Occipital proton magnetic resonance spectroscopy (1H-MRS) reveals normal metabolite concentrations in retinal visual field defects. PloS one, 2007, Feb-21, Volume: 2, Issue:2 Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Glaucoma; Humans; Macular Degeneration; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Occipital Lobe; Protons; Scotoma; Visual Fields	2007
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis. The European journal of neuroscience, 2007, Volume: 25, Issue:6 Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Models, Animal; Disease Progression; gamma-Aminobutyric Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Superoxide Dismutase; Time Factors	2007
Exploring the neuroprotective effects of modafinil in a marmoset Parkinson model with immunohistochemistry, magnetic resonance imaging and spectroscopy. Brain research, 2008, Jan-16, Volume: 1189 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Benzhydryl Compounds; Biomarkers; Brain; Callithrix; Disease Models, Animal; Dopamine; Drug Administration Schedule; Immunohistochemistry; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Modafinil; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Phosphocreatine; Predictive Value of Tests; Reproducibility of Results; Substantia Nigra; Treatment Outcome; Tyrosine 3-Monooxygenase	2008
Brain proton magnetic resonance spectroscopy and neuromuscular pathology in a patient with GM1 gangliosidosis. Journal of child neurology, 2008, Volume: 23, Issue:1 Topics: Aspartic Acid; Axons; Biomarkers; Brain; Female; Gangliosidosis, GM1; Gliosis; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Microcirculation; Muscle, Smooth, Vascular; Nerve Degeneration; Nerve Fibers, Myelinated; Neuroglia; Oligosaccharides; Predictive Value of Tests; Schwann Cells; Sensitivity and Specificity	2008
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats. Journal of neurotrauma, 2008, Volume: 25, Issue:6 Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; Choline; Creatine; Disease Progression; Energy Metabolism; Glycolysis; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mitochondria; Nerve Degeneration; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors	2008
Central nervous system trans-synaptic effects of acute axonal injury: a 1H magnetic resonance spectroscopy study. Magnetic resonance in medicine, 1995, Volume: 33, Issue:5 Topics: Animals; Aspartic Acid; Axons; Creatine; Female; Geniculate Bodies; Guinea Pigs; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron; Nerve Degeneration; Optic Nerve; Optic Nerve Injuries; Protons; Superior Colliculi; Synapses	1995
Proton magnetic resonance spectroscopy in suspected vascular ischemic parkinsonism. Acta neurologica Scandinavica, 1994, Volume: 90, Issue:6 Topics: Aged; Aspartic Acid; Brain; Brain Ischemia; Brain Mapping; Energy Metabolism; Female; Humans; Intracranial Arteriosclerosis; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Parkinson Disease; Regional Blood Flow	1994
In vivo proton magnetic resonance spectroscopy of the brain in a patient with L-2-hydroxyglutaric acidemia. Pediatric research, 1994, Volume: 35, Issue:5 Topics: Adolescent; Aspartic Acid; Biomarkers; Brain; Female; Glutarates; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Metabolism, Inborn Errors; Nerve Degeneration	1994
Neuronal dysfunction in patients with closed head injury evaluated by in vivo 1H magnetic resonance spectroscopy. Investigative radiology, 1995, Volume: 30, Issue:8 Topics: Algorithms; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Energy Metabolism; Glasgow Coma Scale; Head Injuries, Closed; Humans; Magnetic Resonance Spectroscopy; Nerve Degeneration; Prognosis; Reference Values	1995
Proton magnetic resonance spectroscopic imaging in patients with cerebellar degeneration. Annals of neurology, 1996, Volume: 39, Issue:1 Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Humans; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Nerve Degeneration; Protons; Severity of Illness Index	1996
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:3 Topics: Aging; Animals; Aspartic Acid; Electron Transport Complex II; Energy Metabolism; Huntington Disease; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Multienzyme Complexes; Nerve Degeneration; Neurochemistry; Neurotoxins; Oxidoreductases; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase	1996
Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory. Movement disorders : official journal of the Movement Disorder Society, 1996, Volume: 11, Issue:2 Topics: Aspartic Acid; Cerebral Cortex; Corpus Striatum; Genetic Carrier Screening; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Imaging; Nerve Degeneration; Reference Values; Synaptic Transmission	1996
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study. Schizophrenia research, 1996, Oct-18, Volume: 22, Issue:1 Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterality; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Degeneration; Schizophrenia	1996
Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy. Radiology, 1997, Volume: 203, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Dementia; Discriminant Analysis; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Hydrogen; Inositol; Lactates; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuroglia; Neurons; Parietal Lobe; Protons; Sensitivity and Specificity; Temporal Lobe	1997
Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration. Brain : a journal of neurology, 1997, Volume: 120 ( Pt 9) Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Parkinson Disease; Phosphocreatine; Protons; Supranuclear Palsy, Progressive; Tissue Distribution	1997
Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia. Schizophrenia research, 1997, Oct-17, Volume: 27, Issue:1 Topics: Adult; Antipsychotic Agents; Aspartic Acid; Brain Mapping; Choline; Creatine; Dominance, Cerebral; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	1997
1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla. Neurology, 1999, Jul-13, Volume: 53, Issue:1 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Female; Glutamic Acid; Glutamine; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Medulla Oblongata; Middle Aged; Nerve Degeneration; Reference Values	1999
Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system. Journal of neurochemistry, 2000, Volume: 74, Issue:6 Topics: Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Blotting, Southern; Central Nervous System; Chromosome Mapping; Cloning, Molecular; Electroencephalography; Epilepsy, Absence; Gene Deletion; Genome; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Nerve Degeneration; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Tremor	2000
Temporal changes of cerebral metabolites and striatal lesions in acute 3-nitropropionic acid intoxication in the rat. Magnetic resonance in medicine, 2000, Volume: 44, Issue:1 Topics: Acetates; Animals; Aspartic Acid; Cerebrovascular Circulation; Corpus Striatum; Image Processing, Computer-Assisted; Male; Nerve Degeneration; Neurotoxins; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; Time Factors	2000
Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis. Brain : a journal of neurology, 2000, Volume: 123 ( Pt 11) Topics: Aspartic Acid; Axons; Fingers; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Motor Cortex; Movement; Multiple Sclerosis; Nerve Degeneration; Nerve Fibers, Myelinated; Neuronal Plasticity; Recovery of Function	2000
Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study. Journal of the neurological sciences, 2001, Jan-01, Volume: 182, Issue:2 Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Tritium	2001
Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study. Journal of neurology, 2001, Volume: 248, Issue:2 Topics: Adult; Aspartic Acid; Brain; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Time Factors	2001
Neurologic course of congenital disorders of glycosylation. Journal of child neurology, 2001, Volume: 16, Issue:6 Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic, Inborn; Child; Child, Preschool; Congenital Disorders of Glycosylation; Developmental Disabilities; Epilepsy; Female; Humans; Infant; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Neurologic Examination; Stroke	2001
Long-term brain metabolic alterations in exogenous Cushing's syndrome as monitored by proton magnetic resonance spectroscopy. Brain research, 2001, Aug-24, Volume: 911, Issue:2 Topics: Adult; Aspartic Acid; Brain; Brain Diseases, Metabolic; Brain Injuries; Cell Membrane; Choline; Creatine; Cushing Syndrome; Drug Administration Schedule; Energy Metabolism; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neurons; Prednisone	2001
MRI white matter hyperintensities, (1)H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early- and late-onset cases. International journal of geriatric psychiatry, 2001, Volume: 16, Issue:12 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy Metabolism; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuropsychological Tests; Reference Values	2001
N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve. Annals of neurology, 2002, Volume: 51, Issue:1 Topics: Age Factors; Animals; Aspartic Acid; Axons; Biomarkers; Cell Division; Dipeptides; Immunohistochemistry; Male; Myelin Proteins; Nerve Degeneration; Oligodendroglia; Optic Nerve; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Stem Cells	2002
1H and 31P magnetic resonance spectroscopy of the brain in degenerative cerebral disorders. Annals of neurology, 1992, Volume: 31, Issue:2 Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Child; Creatine; Demyelinating Diseases; Humans; Hydrogen; Magnetic Resonance Imaging; Nerve Degeneration; Neurons; Phosphorus Isotopes	1992
Quantification of N-acetyl-L-aspartic acid in urine by isotope dilution gas chromatography-mass spectrometry. Journal of inherited metabolic disease, 1992, Volume: 15, Issue:1 Topics: Aspartic Acid; Central Nervous System Diseases; Child; Child, Preschool; Gas Chromatography-Mass Spectrometry; Humans; Infant; Nerve Degeneration; Syndrome	1992
A radiometric assay for aspartoacylase activity in human fibroblasts: application for the diagnosis of Canavan's disease. Clinica chimica acta; international journal of clinical chemistry, 1991, Sep-30, Volume: 201, Issue:3 Topics: Acetates; Amidohydrolases; Aspartic Acid; Cells, Cultured; Clinical Enzyme Tests; Diffuse Cerebral Sclerosis of Schilder; Fibroblasts; Heterozygote; Humans; Kinetics; Nerve Degeneration; Radiometry; Spectrophotometry; Tritium	1991
N-acetylaspartic aciduria in Canavan disease: another proof in two infants. Neuropediatrics, 1990, Volume: 21, Issue:3 Topics: Amidohydrolases; Aspartic Acid; Biopsy; Brain Diseases, Metabolic; Diffuse Cerebral Sclerosis of Schilder; Frontal Lobe; Humans; Infant; Male; Muscle Hypotonia; Nerve Degeneration	1990
Canavan disease and N-acetylaspartic aciduria. Neuropediatrics, 1989, Volume: 20, Issue:4 Topics: Aspartic Acid; Humans; Nerve Degeneration; Nervous System Diseases	1989
Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. American journal of medical genetics, 1989, Volume: 32, Issue:4 Topics: Amidohydrolases; Aspartic Acid; Central Nervous System Diseases; Genes, Recessive; Humans; Metabolism, Inborn Errors; Nerve Degeneration	1989