Page last updated: 2024-08-24

n-acetylaspartic acid and Multiple Sclerosis

n-acetylaspartic acid has been researched along with Multiple Sclerosis in 139 studies

Research

Studies (139)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	35 (25.18)	18.2507
2000's	65 (46.76)	29.6817
2010's	39 (28.06)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bera, G; Bodini, B; Branzoli, F; Didier, M; García-Lorenzo, D; Lehericy, S; Lubetzki, C; Maillart, E; Poirion, E; Ronen, I; Socha, J; Stankoff, B	1
Cortese, ICM; Ercan, E; Reich, DS; Ronen, I; Sati, P; Wood, ET	1
Alkhayer, K; Clements, R; Freeman, E; McDonough, J; Shelestak, J; Singhal, NK	1
Huang, JK; Rosko, L; Smith, VN; Yamazaki, R	1
Grendar, M; Hnilicova, P; Kantorova, E; Kurca, E; Polacek, H; Zelenak, K	1
Cambron, M; D'haeseleer, M; De Keyser, J; Fierens, Y; Hoogduin, JM; Koch, MW; Steen, C; van Osch, MJ	1
Aalto, A; Landtblom, AM; Leinhard, OD; Lundberg, P; Smedby, Ö; Tisell, A; Warntjes, JB	1
Amato, MP; Bartolozzi, ML; Battaglini, M; De Stefano, N; Gasperini, C; Giorgio, A; Hakiki, B; Malentacchi, G; Portaccio, E; Rossi, F; Santangelo, M; Stromillo, ML	1
Bellenberg, B; Busch, M; Chan, A; Gold, R; Lukas, C; Trampe, N	1
Alonso, J; Rovira, A	1
Róg, T; Szafirska, M; Urbanik, A	1
Boyko, AN; Comi, G; De Stefano, N; Filippi, M; Jeffery, D; Kappos, L; Montalban, X; Pagani, E; Rocca, MA	1
Clements, R; Freeman, E; Gregory, R; Li, S; McDonough, J; Sulak, M	1
Bilinska, M; Bladowska, J; Gruszka, E; Podemski, R; Pokryszko-Dragan, A; Sasiadek, M; Slotwinski, K; Zagrajek, M; Zimny, A	1
Blinkenberg, M; Hanson, LG; Mathiesen, HK; Paulson, OB; Skimminge, A; Sorensen, PS; Wu, X	1
Brenneman, D; Cree, BA; Hauser, SL; Kornak, J; Llufriu, S; Nelson, SJ; Oh, J; Pelletier, D; Ratiney, H; Sampat, M	1
Azevedo, CJ; Chu, P; Cree, BA; Hauser, SL; Kornak, J; Nelson, SJ; Okuda, DT; Pelletier, D; Sampat, M	1
Bellini, T; Blankenstein, MA; Comabella, M; Killestein, J; Koel-Simmelink, MJ; Korth, C; Montalban, X; Ottis, P; Roos, B; Rovira, A; Teunissen, CE; Tintoré, M; Trentini, A	1
Denic, A; Rodriguez, M; Warrington, AE; Watzlawik, JO; Wootla, B	1
Alavijeh, SK; Ebrahimzadeh, SA; Faeghi, F; Harirchian, MH; Madadi, A; Rad, HS; Rahimian, N; Vafaeyan, H	1
Alt, J; Hollinger, KR; Kaplin, AI; Riehm, AM; Slusher, BS	1
Beaulieu, C; Giuliani, F; Hanstock, C; Kalra, S; Zaini, WH	1
Botzkowski, D; Gass, A; Kuhle, J; Müller, S; Pardini, M; Putzki, N; Ruberte, E; Tettenborn, B; Valmaggia, C; Vehoff, J; Würfel, J; Yaldizli, Ö	1
Bannerman, P; Burns, T; Clements, R; Daniels, A; Freeman, E; Gadd, J; Guo, F; Huang, H; Kooijman, EE; Li, S; McDonough, J; Pleasure, D; Shriver, L; Singhal, NK	1
Chen, H; Dong, H; Duan, Y; Huang, J; Li, K; Liu, Y; Liu, Z; Ren, Z; Sun, Z; Ye, J	1
Ağildere, M; Arat, Z; Benli, US; Cakir, B; Can, U; Toprak, MK; Ulu, EM	1
Blom, HJ; Bouwman, F; Brundin, L; Dijkstra, CD; Iacobaeus, E; Jakobs, C; Khademi, M; Koel-Simmelink, MJ; Norgren, N; Schepens, M; Teunissen, CE; Twaalfhoven, HA	1
Benedetti, B; Bertolotto, A; Capra, R; Caputo, D; Comi, G; Filippi, M; Martinelli, V; Rocca, MA; Rovaris, M; Zaffaroni, M	1
Babb, JS; Gonen, O; Herbert, J; Kirov, II; Patil, V; Rusinek, H	1
Celda, B; Martínez-Bisbal, MC	1
Geurts, JJ; van Horssen, J	1
De Keyser, J; Hoogduin, JM; Koch, M; Steen, C; Wilczak, N	1
Baranzini, SE; Hauser, SL; Khankhanian, P; Matthews, PM; Nelson, SJ; Oksenberg, JR; Okuda, DT; Pelletier, D; Srinivasan, R	1
Brief, EE; Laule, C; Li, DK; Mackay, AL; Vavasour, IM	1
Babb, JS; Benedetti, B; Falini, A; Filippi, M; Gonen, O; Grossman, RI; Rigotti, DJ	1
Audoin, B; Confort-Gouny, S; Cozzone, PJ; Crespy, L; Faivre, A; Le Fur, Y; Malikova, I; Pelletier, J; Ranjeva, JP; Reuter, F; Rico, A; Soulier, E; Viout, P; Zaaraoui, W	1
Bellmann-Strobl, J; Bock, M; Brandt, AU; Dörr, J; Ittermann, B; Mohr, C; Paul, F; Pfueller, CF; Schubert, F; Schwenteck, T; Waiczies, H; Walaszek, B; Weinges-Evers, N; Wuerfel, JT	1
Achtnichts, L; Amann, M; Babb, JS; Gass, A; Gonen, O; Hirsch, J; Inglese, M; Kappos, L; Naegelin, Y; Rigotti, DJ	1
Chatterjee, S; Kesavadas, C; Saini, J; Thomas, B	1
Bieber, A; Denic, A; Macura, S; Pirko, I; Rodriguez, M; Wootla, B	1
Bagory, M; Comte, JC; Confavreux, C; Cotton, F; Durand-Dubief, F; Hannoun, S; Ibarrola, D; Sappey-Marinier, D	1
Barker, PB; Calabresi, P; Harrison, D; Jones, CK; Reich, DS; Ronen, I; Techawiboonwong, A; Wood, ET	1
Boĭko, AN; Davydovskaia, MV; Gusev, EI; Kornienko, VN; Podoprigora, AE; Pronin, IN	1
Linssen, WH; Pouwels, PJ; van Oosten, BW; Visser, F; Wattjes, MP	1
Brex, PA; Chard, D; Dalton, C; Griffin, CM; Kapeller, P; McLean, MA; Miller, DH; Parker, GJ; Thompson, AJ	1
Alberti, A; Chiarini, P; Gallai, V; Gobbi, G; Pelliccioli, GP; Presciutti, O; Sarchielli, P; Tarducci, R	1
Genain, C; Goodkin, DE; Grenier, D; Lu, Y; Nelson, SJ; Pelletier, D	1
Enzinger, C; Fazekas, F; Hartung, HP; Kapeller, P; Poltrum, B; Ropele, S; Schmidt, H; Schmidt, R; Strasser-Fuchs, S	1
Bozzali, M; Comi, G; Falini, A; Filippi, M; Ghezzi, A; Gonen, O; Grossman, RI; Kesavadas, C; Martinelli, V; Rovaris, M; Scotti, G	1
Arnold, D; Blamire, AM; Corkill, R; Matthews, PM; Narayanan, S; Palace, J; Parry, A; Styles, P	1
Lassmann, H	1
Comi, G; Falini, A; Filippi, M; Ghezzi, A; Martinelli, V; Mezzapesa, DM; Rocca, MA; Scotti, G	1
Harting, I; Meyding-Lamadé, U; Sartor, K; Sellner, J	1
Christodoulou, C; Huang, W; Krupp, LB; Li, L; Li, X; Liang, Z; MacAllister, WS; Melville, P; Morgan, T; Peyster, R; Roche, P; Roque, C; Scherl, WF; Tudorica, LA	1
Antel, JP; Goodkin, DE; Kita, M; Nelson, SJ; Oh, J; Pelletier, D; Zamvil, SS	1
Babb, JS; Gonen, O; Grossman, RI; Inglese, M; Li, BS; Rusinek, H	1
Ahmed, Z; Baker, D; Croxford, JL; Cuzner, ML; Giovannoni, G; Hankey, DJ; Jackson, SJ; Ledent, C; Petzold, A; Pocock, JM; Pryce, G; Thompson, AJ	1
Fukatsu, H; Iijima, M; Ito, T; Mabuchi, N; Sobue, G; Watanabe, H	1
Zaffaroni, M	1
Bartolozzi, ML; De Stefano, N; Federico, A; Guidi, L; Stromillo, ML	1
Arnold, DL; De Stefano, N; Francis, SJ; Lapierre, Y; Narayanan, S; Santos, AC; Tartaglia, MC	1
Mazurek, AA	1
Gamez, J; Johnson, A; Macura, SI; Pirko, I; Rodriguez, M	1
Babb, JS; Ge, Y; Gonen, O; Grossman, RI; Inglese, M; Markowitz, CE	1
Chard, DT; Dalton, CM; Fernando, KT; Gordon, RM; MacManus, DG; McLean, MA; Miller, DH; Miszkiel, KA; Plant, GT; Thompson, AJ	1
Antel, JP; Arnold, DL; Brass, SD; Collins, L; Lapierre, Y; Narayanan, S	1
Huvaj, S; Kendi, AT; Kendi, M; Tan, FU; Tellioğlu, S; Yilmaz, S	1
Dijkstra, C; Polman, C; Teunissen, CE	1
Barkhof, F; Castelijns, JA; Polman, CH; Pouwels, PJ; Uitdehaag, BM; Vrenken, H	1
Antel, JP; Arnold, DL; Biernacki, K; Blain, M; Narayanan, S; Prat, A	1
De Keyser, J; Mostert, JP; Oudkerk, M; Sijens, PE	2
Arnold, DL; Caramanos, Z; Narayanan, S	1
Barkhof, F; Castelijns, JA; Geurts, JJ; Polman, CH; Pouwels, PJ; Reuling, IE; Uitdehaag, BM; Vrenken, H	1
Criste, GA; Trapp, BD	1
Cianfoni, A; Imbesi, SG; Niku, S	1
Barkhof, F; Dijkstra, CD; Eikelenboom, MJ; Jakobs, C; Jasperse, B; Polman, CH; Teunissen, CE; Uitdehaag, BM	1
De Stefano, N; Filippi, M	1
Ali-Cherif, A; Audoin, B; Confort-Gouny, S; Cozzone, PJ; Le Fur, Y; Malikova, I; Pelletier, J; Ranjeva, JP; Soulier, E; Van Au Duong, M; Viout, P	1
Harzheim, M; Klotz, L; Lutterbey, GG; Schild, HH; Träber, F; Wattjes, MP	1
Bagory, M; Confavreux, C; Durand-Dubief, F; Ibarrola, D; Sappey-Marinier, D	1
Bogdanow, M; Harzheim, M; Lutterbey, GG; Schild, HH; Träber, F; Wattjes, MP	1
Bao, F; Caon, C; Khan, O; Latif, Z; Shen, Y; Tselis, A; Zak, I	1
Blaauw, Y; De Keyser, J; Hoogduin, JM; Koch, MW; Kuiper, AJ; Mostert, JP	1
Miller, DH	1
Clark, JB; Davies, SE; McDonald, WI; Newcombe, J; Williams, SR	1
Cohen, JA; Dousset, V; Gonzalez-Scarano, F; Grossman, RI; Hiehle, JF; Lenkinski, RE; Ramer, KN; Schnall, MD	1
Antel, JP; Arnold, DL; Collins, DL; Francis, GS; Matthews, PM; Riess, GT; Wolfson, C	1
de Bie, SH; Fein, G; Goodin, DS; Hugg, JW; Husted, CA; Matson, GB; Maudsley, AA; Tsuruda, JS; Weiner, MW	1
Maudsley, AA; Meyerhoff, DJ; Weiner, MW; Wu, Z	1
Barker, GJ; Brennan, A; Davie, CA; Hawkins, CP; McDonald, WI; Miller, DH; Tofts, PS	1
Barker, GJ; Davie, CA; Harding, AE; McDonald, WI; Miller, DH; Thompson, AJ; Tofts, PS; Webb, S	1
Antel, J; Arnold, DL; De Stefano, N; Francis, G; Fu, L; Matthews, PM; Narayanan, S; Pioro, E; Wolfson, C	1
Adams, D; Hetherington, HP; Mason, GF; Pan, JW; Pohost, GM; Twieg, DB; Vaughn, MJ	1
Hetherington, HP; Mitchell, G; Pan, JW; Pohost, GM; Vaughan, JT; Whitaker, JN	1
Landtblom, AM; Nyland, H; Sjöqvist, L; Söderfeldt, B; Thuomas, KA	1
Gonzalez-Scarano, F; Grossman, RI; Kimura, H; Lenkinski, RE	1
Cabanis, EA; Iba-Zizen, MT; Lyon-Caen, O; Stievenart, JL; Tourbah, A; Zannoli, G	1
Antel, JP; Arnold, DL; Collins, DL; De Stefano, N; Francis, GS; Fu, L; Matthews, PM; Narayanan, S; Pioro, E	1
Arnold, DL; Collins, DL; De Stefano, N; Fu, L; Narayanan, S; Wolfson, C; Worsley, KJ	1
Antel, JP; Arnold, DL; De Stefano, N; Francis, GS; Matthews, PM; Narayanan, S	2
's Gravenmade, EJ; den Boer, JA; Geelen, JA; Minderhoud, JM; Peters, AR; Prevo, RL	1
Doyle, TJ; Lai, D; Narayana, PA; Wolinsky, JS	1
Calabrese, G; Colombo, B; Comi, G; Falini, A; Filippi, M; Lipari, S; Origgi, D; Scotti, G	1
Antel, JP; Arnold, DL; De Stefano, N; Francis, GS; Fu, L; Matthews, PM; Narayanan, S; Wolfson, C; Worsley, KJ	1
Antel, JP; Arnold, DL; De Stefano, N; Francis, GS; Fu, L; Matthews, PM; Narayanan, S; Stanley, J	1
Hetherington, HP; Pan, JW; Twieg, DB	1
Heide, AC; Kraft, GH; Richards, TL	1
Davie, CA; Foong, J; Miller, DH; Ron, MA; Rozewicz, L; Thompson, AJ	1
Alberti, A; Chiarini, P; Gallai, V; Gobbi, G; Pelliccioli, GP; Presciutti, O; Sarchielli, P; Tarducci, R; Vicinanza, F	1
Antel, JP; Arnold, DL; de Stefano, N; Francis, GS; Narayanan, S; Pike, GB	1
Bitsch, A; Brück, W; Bruhn, H; Frahm, J; Lassmann, H; Stringaris, A; Vougioukas, V	1
Blamire, AM; Ho, KH; Lee, MA; Matthews, PM; Mills, KR; Palace, J; Pendlebury, S; Styles, P	1
Babb, JS; Catalaa, I; Ge, Y; Gonen, O; Grossman, RI; Kolson, DL; Mannon, LJ	1
Helms, G; Kivisäkk, P; Link, H; Stawiarz, L	1
Blamire, AM; Lee, MA; Matthews, PM; Pendlebury, ST; Styles, P	1
Barker, GJ; Brex, PA; Leary, SM; MacManus, DG; Miller, DH; Parker, GJ; Thompson, AJ	1
Alonso, J; Cucurella, MG; Montalbán, X; Pedraza, S; Río, J; Rovira, A; Tintoré, MM	1
Barker, GJ; Duncan, JS; McLean, MA; Woermann, FG	1
Antel, J; Arnold, DL; Arnoutelis, R; Jenkinson, M; Matthews, PM; Narayanan, S; Reddy, H	1
Bjartmar, C; Kidd, G; Mörk, S; Rudick, R; Trapp, BD	1
Bellacosa, A; Carrara, D; Federico, F; Giannini, P; Liguori, M; Livrea, P; Lucivero, V; Simone, IL; Tortorella, C	1
Antel, JP; Arnaoutelis, R; Arnold, DL; De Stefano, N; Francis, GS; Matthews, PM; Narayanan, S; Tartaglia, MC	1
Arnold, DL; Bartolozzi, ML; De Stefano, N; Federico, A; Guidi, L; Mortilla, M; Narayanan, S	1
Grodd, W; Klose, U; Mader, I; Melms, A; Naegele, T; Seeger, U; Weissert, R	1
Arnold, DL; De Stefano, N; Matthews, PM; Narayanan, S	1
Bjartmar, C; Trapp, BD	1
Arnold, DL; Matthews, PM	1
Bartolozzi, ML; Comi, G; De Stefano, N; Federico, A; Filippi, M; Guidi, L; Iannucci, G; Mainero, C; Sormani, MP	1
Coyle, PK; Elkins, LE; Krupp, LB; Pan, JW	1
Antel, JP; Arnaoutelis, R; Arnold, DL; Caramanos, Z; Collins, DL; De Stefano, N; Francis, GS; Narayanan, S; Pelletier, D	1
Matthews, PM	1
Antel, JP; Arnold, DL; Francis, GS; Matthews, PM; O'Connor, J	1
Narayana, PA; Wolinsky, JS	1
Christiansen, P; Frederiksen, J; Heltberg, A; Henriksen, O; Jensen, M; Larsson, HB; Olesen, J	1
Richards, TL	1
Baert, AL; Carton, H; Demaerel, P; Johannik, K; Marchal, G; Van Hecke, P; Wilms, G	1
Antel, J; Arnold, DL; Francis, G; Matthews, PM	1

Reviews

18 review(s) available for n-acetylaspartic acid and Multiple Sclerosis

Article	Year
Oligodendrocyte Bioenergetics in Health and Disease. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2019, Volume: 25, Issue:4 Topics: Animals; Aspartic Acid; Axons; Brain; Energy Metabolism; Glucose; Humans; Lactic Acid; Mitochondria; Multiple Sclerosis; Myelin Sheath; Oligodendroglia	2019
1H magnetic resonance spectroscopy in multiple sclerosis and related disorders. Neuroimaging clinics of North America, 2013, Volume: 23, Issue:3 Topics: Aspartic Acid; Biomarkers; Brain; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Protons	2013
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2009, Volume: 53, Issue:6 Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Necrosis; Positron-Emission Tomography; Protons	2009
[Multiple sclerosis: imaging, diagnostic criteria and differential diagnosis]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2003, Volume: 175, Issue:5 Topics: Aspartic Acid; Axons; Brain; Diffusion Magnetic Resonance Imaging; Humans; Image Enhancement; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Nerve Fibers, Myelinated; Reproducibility of Results; Spinal Cord	2003
[Magnetic resonance spectroscopy and its clinical applications in multiple sclerosis]. Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61, Issue:8 Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Protons	2003
Biological indicators of the neurodegenerative phase of multiple sclerosis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2003, Volume: 24 Suppl 5 Topics: Aspartic Acid; Axons; Biomarkers; Cytoskeletal Proteins; Humans; Multiple Sclerosis; Nerve Degeneration	2003
Imaging neuronal and axonal degeneration in multiple sclerosis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2003, Volume: 24 Suppl 5 Topics: Aspartic Acid; Atrophy; Axons; Brain; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Nerve Degeneration; Radiography	2003
Biological markers in CSF and blood for axonal degeneration in multiple sclerosis. The Lancet. Neurology, 2005, Volume: 4, Issue:1 Topics: 14-3-3 Proteins; Actins; Amyloid beta-Protein Precursor; Apolipoproteins E; Aspartic Acid; Axons; Biomarkers; Humans; Hydroxycholesterols; Multiple Sclerosis; Nerve Degeneration; Phosphopyruvate Hydratase; Predictive Value of Tests; tau Proteins; Tubulin	2005
1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review. Brain : a journal of neurology, 2005, Volume: 128, Issue:Pt 11 Topics: Aspartic Acid; Brain; Creatine; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis	2005
N-acetyl-L-aspartate in multiple sclerosis. Advances in experimental medicine and biology, 2006, Volume: 576 Topics: Animals; Aspartic Acid; Axons; Biomarkers; Humans; Magnetic Resonance Imaging; Multiple Sclerosis	2006
MR spectroscopy in multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2007, Volume: 17 Suppl 1 Topics: Aspartic Acid; Brain Chemistry; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis	2007
Magnetic resonance imaging and spectroscopy in multiple sclerosis. Current opinion in neurology, 1995, Volume: 8, Issue:3 Topics: Aspartic Acid; Brain; Disability Evaluation; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Spinal Cord	1995
Correlations of evoked potentials with MR imaging and MR spectroscopy in multiple sclerosis. Physical medicine and rehabilitation clinics of North America, 1998, Volume: 9, Issue:3 Topics: Aspartic Acid; Brain; Choline; Creatine; Evoked Potentials; Evoked Potentials, Somatosensory; Evoked Potentials, Visual; Humans; Lactates; Lipids; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Neural Conduction	1998
Imaging axonal damage in multiple sclerosis by means of MR spectroscopy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2000, Volume: 21, Issue:4 Suppl 2 Topics: Animals; Aspartic Acid; Axons; Central Nervous System; Disability Evaluation; Disease Progression; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis	2000
Proton MR spectroscopy in multiple sclerosis. Neuroimaging clinics of North America, 2000, Volume: 10, Issue:4 Topics: Aspartic Acid; Brain; Choline; Creatine; Disability Evaluation; Disease Progression; Energy Metabolism; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Retrograde Degeneration	2000
Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Current opinion in neurology, 2001, Volume: 14, Issue:3 Topics: Aspartic Acid; Atrophy; Axons; Brain; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Nerve Degeneration; Neurons	2001
Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution. Current opinion in neurology, 2001, Volume: 14, Issue:3 Topics: Aspartic Acid; Axons; Brain; Disability Evaluation; Disease Progression; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Neurologic Examination	2001
Proton MR spectroscopy in multiple sclerosis: value in establishing diagnosis, monitoring progression, and evaluating therapy. AJR. American journal of roentgenology, 1991, Volume: 157, Issue:5 Topics: Animals; Aspartic Acid; Brain; Choline; Humans; Lipid Metabolism; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis	1991

Trials

16 trial(s) available for n-acetylaspartic acid and Multiple Sclerosis

Article	Year
1H-magnetic resonance spectroscopy in diffuse and focal cervical cord lesions in multiple sclerosis. European radiology, 2013, Volume: 23, Issue:12 Topics: Adult; Analysis of Variance; Aspartic Acid; Cervical Vertebrae; Creatine; Cross-Sectional Studies; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Reproducibility of Results; Spinal Cord; Young Adult	2013
Placebo-controlled trial of oral laquinimod in multiple sclerosis: MRI evidence of an effect on brain tissue damage. Journal of neurology, neurosurgery, and psychiatry, 2014, Volume: 85, Issue:8 Topics: Adolescent; Adult; Aspartic Acid; Brain; Creatinine; Disability Evaluation; Endpoint Determination; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Quinolones; Thalamus; Treatment Outcome; Young Adult	2014
The effects of interferon beta-1a on proton MR spectroscopic imaging in patients with multiple sclerosis, a controlled study, preliminary results. The International journal of neuroscience, 2008, Volume: 118, Issue:12 Topics: Adjuvants, Immunologic; Adult; Aspartic Acid; Biomarkers; Brain Mapping; Central Nervous System; Choline; Creatine; Disability Evaluation; Female; Humans; Interferon beta-1a; Interferon-beta; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Nerve Fibers, Myelinated; Outcome Assessment, Health Care; Pilot Projects; Treatment Outcome; Young Adult	2008
Beta-Interferon treatment does not always slow the progression of axonal injury in multiple sclerosis. Journal of neurology, 2003, Volume: 250, Issue:2 Topics: Adult; Aspartic Acid; Axons; Body Water; Brain Chemistry; Cohort Studies; Creatine; Disease Progression; Female; Humans; Interferon Type I; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Recombinant Proteins; Recurrence	2003
Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis. NeuroImage, 2003, Volume: 18, Issue:4 Topics: Adaptation, Physiological; Adult; Aspartic Acid; Axons; Brain; Brain Mapping; Cerebral Cortex; Female; Fingers; Frontal Lobe; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Nerve Net; Nervous System Diseases; Psychomotor Performance; Reference Values; Somatosensory Cortex; Syndrome	2003
Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients. Neurology, 2003, Jun-10, Volume: 60, Issue:11 Topics: Adult; Aspartic Acid; Atrophy; Axons; Biomarkers; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Neuropsychological Tests	2003
Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis. Magnetic resonance in medicine, 2003, Volume: 50, Issue:1 Topics: Adult; Aspartic Acid; Brain; Choline; Corpus Callosum; Creatine; Diffusion; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Nerve Fibers, Myelinated; Recurrence; Remission, Spontaneous; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution	2003
Axonal damage in multiple sclerosis patients with high versus low expanded disability status scale score. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2004, Volume: 31, Issue:2 Topics: Adult; Aspartic Acid; Atrophy; Axons; Biomarkers; Brain; Disability Evaluation; Humans; Magnetic Resonance Imaging; Matched-Pair Analysis; Middle Aged; Multiple Sclerosis; Retrospective Studies; Severity of Illness Index; Spinal Cord	2004
MR spectroscopic evidence for glial increase but not for neuro-axonal damage in MS normal-appearing white matter. Magnetic resonance in medicine, 2005, Volume: 53, Issue:2 Topics: Adolescent; Adult; Aged; Algorithms; Aspartic Acid; Biomarkers; Brain; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neuroglia; Neurons; Neurotransmitter Agents; Tissue Distribution	2005
Fluoxetine increases cerebral white matter NAA/Cr ratio in patients with multiple sclerosis. Neuroscience letters, 2006, Jul-10, Volume: 402, Issue:1-2 Topics: Administration, Oral; Adult; Antidepressive Agents, Second-Generation; Aspartic Acid; Cerebral Cortex; Creatine; Female; Fluoxetine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis	2006
High field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria. Journal of neurology, 2008, Volume: 255, Issue:1 Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Diagnosis, Differential; Encephalitis; Female; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Models, Biological; Multiple Sclerosis; Nerve Fibers, Myelinated; Optic Neuritis; Predictive Value of Tests; Prospective Studies; Protons	2008
Imaging of axonal damage in multiple sclerosis: spatial distribution of magnetic resonance imaging lesions. Annals of neurology, 1997, Volume: 41, Issue:3 Topics: Adult; Aspartic Acid; Axons; Brain; Creatine; Female; Humans; Image Enhancement; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Risk Assessment; Statistics, Nonparametric	1997
Regression analysis of metabolite concentrations estimated from localized proton MR spectra of active and chronic multiple sclerosis lesions. Magnetic resonance in medicine, 2000, Volume: 43, Issue:1 Topics: Acute Disease; Adult; Aged; Aspartic Acid; Brain; Chronic Disease; Contrast Media; Creatine; Female; Humans; Image Enhancement; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Phosphoric Monoester Hydrolases; Reference Values; Regression Analysis	2000
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter. Magnetic resonance in medicine, 2000, Volume: 44, Issue:3 Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; Dipeptides; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Phantoms, Imaging; Regression Analysis; Sensitivity and Specificity	2000
Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis. Brain : a journal of neurology, 2001, Volume: 124, Issue:Pt 5 Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Alanine; Amino Acids; Aspartic Acid; Biomarkers; Choline; Corpus Callosum; Female; Humans; Isoleucine; Leucine; Lipoma; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Proteins; Threonine; Valine	2001
Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b. Journal of neurology, 2001, Volume: 248, Issue:11 Topics: Adjuvants, Immunologic; Adult; Aspartic Acid; Biomarkers; Diffuse Axonal Injury; Female; Humans; Injections, Subcutaneous; Interferon beta-1a; Interferon beta-1b; Interferon-beta; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Recurrence; Treatment Outcome	2001

Other Studies

105 other study(ies) available for n-acetylaspartic acid and Multiple Sclerosis

Article	Year
Dysregulation of energy metabolism in multiple sclerosis measured in vivo with diffusion-weighted spectroscopy. Multiple sclerosis (Houndmills, Basingstoke, England), 2018, Volume: 24, Issue:3 Topics: Adult; Aspartic Acid; Atrophy; Creatine; Diffusion Magnetic Resonance Imaging; Energy Metabolism; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine; Thalamus; White Matter	2018
Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent NeuroImage. Clinical, 2017, Volume: 15 Topics: Adult; Aged; Aspartic Acid; Axons; Brain; Female; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Young Adult	2017
Erythropoietin Upregulates Brain Hemoglobin Expression and Supports Neuronal Mitochondrial Activity. Molecular neurobiology, 2018, Volume: 55, Issue:10 Topics: Animals; Aspartic Acid; Brain; Cell Respiration; Cuprizone; Disease Models, Animal; Electron Transport Complex III; Erythropoietin; Hemoglobins; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Mitochondria; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neurons; Up-Regulation	2018
Increased glutamate and deep brain atrophy can predict the severity of multiple sclerosis. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2019, Volume: 163, Issue:1 Topics: Adult; Aspartic Acid; Atrophy; Disease Progression; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Predictive Value of Tests; Severity of Illness Index; Thalamus; Young Adult	2019
Performance on Paced Auditory Serial Addition Test and cerebral blood flow in multiple sclerosis. Acta neurologica Scandinavica, 2013, Volume: 128, Issue:5 Topics: Adult; Aspartic Acid; Case-Control Studies; Cerebrovascular Circulation; Creatine; Disability Evaluation; Female; Humans; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Statistics, Nonparametric; Tritium	2013
Increased concentrations of glutamate and glutamine in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans. PloS one, 2013, Volume: 8, Issue:4 Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis	2013
Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome. Neurology, 2013, Jun-04, Volume: 80, Issue:23 Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Prodromal Symptoms; Protons; Risk; Syndrome; Young Adult	2013
[The metabolic abnormalities in plaques of multiple sclerosis patients - the assessment in proton MR spectroscopy (1HMRS)]. Przeglad lekarski, 2013, Volume: 70, Issue:5 Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Leukoencephalopathies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Young Adult	2013
Decreased NAA in gray matter is correlated with decreased availability of acetate in white matter in postmortem multiple sclerosis cortex. Neurochemical research, 2013, Volume: 38, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Antimycin A; Aspartic Acid; Autopsy; Axons; Cell Line, Tumor; Female; Humans; Male; Middle Aged; Mitochondria; Motor Cortex; Multiple Sclerosis; Myelin Sheath; Nerve Fibers, Myelinated; Neurons	2013
Magnetic resonance spectroscopy findings as related to fatigue and cognitive performance in multiple sclerosis patients with mild disability. Journal of the neurological sciences, 2014, Apr-15, Volume: 339, Issue:1-2 Topics: Adult; Aspartic Acid; Cognition Disorders; Disabled Persons; Fatigue; Female; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Nerve Fibers, Myelinated; Young Adult	2014
Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. Neurological research, 2014, Volume: 36, Issue:8 Topics: Adult; Aspartic Acid; Cerebral Cortex; Creatine; Disability Evaluation; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Prognosis; Young Adult	2014
Magnetic resonance spectroscopy markers of disease progression in multiple sclerosis. JAMA neurology, 2014, Jul-01, Volume: 71, Issue:7 Topics: Adult; Aspartic Acid; Atrophy; Biomarkers; Case-Control Studies; Disability Evaluation; Disease Progression; Female; Follow-Up Studies; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Predictive Value of Tests; Severity of Illness Index	2014
In vivo evidence of glutamate toxicity in multiple sclerosis. Annals of neurology, 2014, Volume: 76, Issue:2 Topics: Adult; Aspartic Acid; Brain; Female; Follow-Up Studies; Glutamic Acid; History, Ancient; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis	2014
N-acetylaspartate and neurofilaments as biomarkers of axonal damage in patients with progressive forms of multiple sclerosis. Journal of neurology, 2014, Volume: 261, Issue:12 Topics: Adult; Aspartic Acid; Axons; Biomarkers; Disability Evaluation; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multiple Sclerosis; Neurofilament Proteins; Prognosis	2014
A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis. Journal of neuroinflammation, 2015, Apr-29, Volume: 12 Topics: Animals; Antibodies, Monoclonal; Aspartic Acid; Axons; Brain; Brain Stem; Disease Models, Animal; Humans; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Mice; Multiple Sclerosis; Spinal Cord; Statistics, Nonparametric; Theilovirus; Viral Envelope Proteins	2015
Quantification of diagnostic biomarkers to detect multiple sclerosis lesions employing (1)H-MRSI at 3T. Australasian physical & engineering sciences in medicine, 2015, Volume: 38, Issue:4 Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Choline; Creatine; Female; Glutathione; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis	2015
Dose-dependent inhibition of GCPII to prevent and treat cognitive impairment in the EAE model of multiple sclerosis. Brain research, 2016, Mar-15, Volume: 1635 Topics: Animals; Aspartic Acid; Cognition Disorders; Dipeptides; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Glutamate Carboxypeptidase II; Hippocampus; Maze Learning; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Organophosphorus Compounds; Severity of Illness Index	2016
Fatigue in Multiple Sclerosis: Assessing Pontine Involvement Using Proton MR Spectroscopic Imaging. PloS one, 2016, Volume: 11, Issue:2 Topics: Adult; Aspartic Acid; Creatine; Fatigue; Female; Humans; Middle Aged; Multiple Sclerosis; Pons; Proton Magnetic Resonance Spectroscopy	2016
The association between retinal nerve fibre layer thickness and N-acetyl aspartate levels in multiple sclerosis brain normal-appearing white matter: a longitudinal study using magnetic resonance spectroscopy and optical coherence tomography. European journal of neurology, 2016, Volume: 23, Issue:12 Topics: Adult; Aspartic Acid; Axons; Brain; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Retinal Neurons; Sensitivity and Specificity; Tomography, Optical Coherence; White Matter	2016
The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition. Experimental brain research, 2017, Volume: 235, Issue:1 Topics: Acetyltransferases; Animals; Aspartic Acid; Cells, Cultured; Central Nervous System; Chromatography, Liquid; Female; Gene Expression Regulation; Histones; Humans; Ketoglutaric Acids; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; Neurons; Oligodendroglia; Postmortem Changes; Tandem Mass Spectrometry	2017
Metabolic changes in normal-appearing white matter in patients with neuromyelitis optica and multiple sclerosis: a comparative magnetic resonance spectroscopy study. Acta radiologica (Stockholm, Sweden : 1987), 2017, Volume: 58, Issue:9 Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Neuromyelitis Optica; White Matter	2017
Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis. Neurology, 2009, Apr-14, Volume: 72, Issue:15 Topics: Amino Acids; Aspartic Acid; Axons; Biomarkers; Cohort Studies; Disease Progression; Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Neurofilament Proteins; tau Proteins	2009
In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England), 2009, Volume: 15, Issue:7 Topics: Adult; Aspartic Acid; Axons; Biomarkers; Brain; Brain Chemistry; Cell Survival; Cross-Sectional Studies; Disability Evaluation; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Severity of Illness Index; Young Adult	2009
MR spectroscopy indicates diffuse multiple sclerosis activity during remission. Journal of neurology, neurosurgery, and psychiatry, 2009, Volume: 80, Issue:12 Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Neuroglia; Remission Induction; Young Adult	2009
The brake on neurodegeneration: Increased mitochondrial metabolism in the injured MS spinal cord. Neurology, 2010, Mar-02, Volume: 74, Issue:9 Topics: Aspartic Acid; Cervical Vertebrae; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mitochondria; Multiple Sclerosis; Nerve Degeneration; Organ Size; Reactive Oxygen Species; Spinal Cord; Time Factors	2010
Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter. PloS one, 2010, May-25, Volume: 5, Issue:5 Topics: Adenosine Triphosphate; Aspartic Acid; Astrocytes; Brain; Case-Control Studies; Creatine Kinase, BB Form; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Models, Biological; Multiple Sclerosis; Phosphocreatine; Postmortem Changes	2010
Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Brain : a journal of neurology, 2010, Volume: 133, Issue:9 Topics: Adult; Aspartic Acid; Brain; Computer Simulation; Female; Follow-Up Studies; Gene Frequency; Genetic Variation; Genome-Wide Association Study; Genotype; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Models, Genetic; Multiple Sclerosis; Oxidoreductases Acting on Sulfur Group Donors; Polymorphism, Single Nucleotide; Statistics as Topic; Sulfatases	2010
Proton MRS of large multiple sclerosis lesions reveals subtle changes in metabolite T(1) and area. NMR in biomedicine, 2010, Volume: 23, Issue:9 Topics: Aspartic Acid; Choline; Humans; Inositol; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Protons; Water	2010
Global N-acetylaspartate declines even in benign multiple sclerosis. AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:1 Topics: Adolescent; Adult; Aspartic Acid; Brain; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Protons; Tissue Distribution; Young Adult	2011
Occurrence of neuronal dysfunction during the first 5 years of multiple sclerosis is associated with cognitive deterioration. Journal of neurology, 2011, Volume: 258, Issue:5 Topics: Adult; Aspartic Acid; Cognition Disorders; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Neurons; Neuropsychological Tests; Young Adult	2011
Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis. PloS one, 2011, Apr-06, Volume: 6, Issue:4 Topics: Adult; Aspartic Acid; Brain; Demography; Humans; Magnetic Resonance Imaging; Middle Aged; Models, Statistical; Multiple Sclerosis; Nerve Fibers; Retina; Visual Cortex; Young Adult	2011
Multiple Sclerosis Severity Scale and whole-brain N-acetylaspartate concentration for patients' assessment. Multiple sclerosis (Houndmills, Basingstoke, England), 2012, Volume: 18, Issue:1 Topics: Aspartic Acid; Biomarkers; Brain; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Retrospective Studies; Sensitivity and Specificity; Severity of Illness Index	2012
Conventional and advanced magnetic resonance imaging in tumefactive demyelination. Acta radiologica (Stockholm, Sweden : 1987), 2011, Dec-01, Volume: 52, Issue:10 Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Contrast Media; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Gadolinium DTPA; Glutamic Acid; Glutamine; Humans; Image Enhancement; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Young Adult	2011
Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis. Brain pathology (Zurich, Switzerland), 2012, Volume: 22, Issue:5 Topics: Animals; Aspartic Acid; Axons; beta 2-Microglobulin; Brain; Brain Stem; CD8 Antigens; Disease Models, Animal; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Multiple Sclerosis; Recovery of Function; Spinal Cord; Theilovirus; Time Factors	2012
Correlation of diffusion and metabolic alterations in different clinical forms of multiple sclerosis. PloS one, 2012, Volume: 7, Issue:3 Topics: Adult; Aspartic Acid; Choline; Diffusion; Diffusion Tensor Imaging; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Reproducibility of Results; Sensitivity and Specificity	2012
Investigating axonal damage in multiple sclerosis by diffusion tensor spectroscopy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, May-09, Volume: 32, Issue:19 Topics: Adult; Aspartic Acid; Axons; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Female; Humans; Intracellular Fluid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Young Adult	2012
[The neurodegenerative process in multiple sclerosis and the possible neuroprotective effect of treatment with Β-interferon 1a (avonex)]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:7 Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Creatine; Female; Humans; Interferon beta-1a; Interferon-beta; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Neuroprotective Agents; Neuropsychological Tests; Retrospective Studies; Young Adult	2012
Tumefactive multiple sclerosis lesions under fingolimod treatment. Neurology, 2012, Nov-06, Volume: 79, Issue:19 Topics: Aspartic Acid; Brain; Choline; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inositol; Magnetic Resonance Imaging; Multiple Sclerosis; Nerve Fibers, Myelinated; Propylene Glycols; Sphingosine; Young Adult	2012
Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England), 2002, Volume: 8, Issue:3 Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Protons	2002
Localized (1)H magnetic resonance spectroscopy in mainly cortical gray matter of patients with multiple sclerosis. Journal of neurology, 2002, Volume: 249, Issue:7 Topics: Adult; Aspartic Acid; Atrophy; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Occipital Lobe; Parietal Lobe; Recurrence; Water	2002
3-D echo planar (1)HMRS imaging in MS: metabolite comparison from supratentorial vs. central brain. Magnetic resonance imaging, 2002, Volume: 20, Issue:8 Topics: Adult; Aspartic Acid; Brain; Cohort Studies; Corpus Callosum; Cross-Sectional Studies; Echo-Planar Imaging; Female; Humans; Imaging, Three-Dimensional; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Protons; Reproducibility of Results	2002
Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein E epsilon4 allele. Archives of neurology, 2003, Volume: 60, Issue:1 Topics: Adult; Alleles; Apolipoprotein E4; Apolipoproteins E; Aspartic Acid; Brain; Cohort Studies; Female; Follow-Up Studies; Genotype; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Protons	2003
Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain : a journal of neurology, 2003, Volume: 126, Issue:Pt 2 Topics: Adult; Aspartic Acid; Axons; Brain; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Time Factors	2003
Brain damage when multiple sclerosis is diagnosed clinically. Lancet (London, England), 2003, Apr-19, Volume: 361, Issue:9366 Topics: Aspartic Acid; Atrophy; Brain; Brain Damage, Chronic; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis	2003
MRI lesion volume heterogeneity in primary progressive MS in relation with axonal damage and brain atrophy. Journal of neurology, neurosurgery, and psychiatry, 2003, Volume: 74, Issue:7 Topics: Aspartic Acid; Atrophy; Brain; Case-Control Studies; Creatinine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Protons	2003
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain : a journal of neurology, 2003, Volume: 126, Issue:Pt 10 Topics: Animals; Aspartic Acid; Axons; Benzoxazines; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Agonists; Gene Deletion; Humans; Mice; Mice, Transgenic; Monomeric GTP-Binding Proteins; Morpholines; Multiple Sclerosis; N-Methylaspartate; Naphthalenes; Nerve Degeneration; Nuclear Proteins; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Retina; Saccharomyces cerevisiae Proteins; Spinal Cord; Uveitis	2003
The relationship between diffuse axonal damage and fatigue in multiple sclerosis. Archives of neurology, 2004, Volume: 61, Issue:2 Topics: Adult; Aspartic Acid; Axons; Brain Chemistry; Creatine; Cross-Sectional Studies; Fatigue; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Retrospective Studies	2004
Reduced N-acetylaspartate levels and cognitive decline. Archives of neurology, 2004, Volume: 61, Issue:2 Topics: Alleles; Apolipoproteins E; Aspartic Acid; Brain Chemistry; Cognition Disorders; Disease Progression; Humans; Multiple Sclerosis	2004
Disappearing "T1 black holes" in an animal model of multiple sclerosis. Frontiers in bioscience : a journal and virtual library, 2004, May-01, Volume: 9 Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Cardiovirus Infections; Choline; Creatine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Phosphocreatine	2004
Neuronal cell injury precedes brain atrophy in multiple sclerosis. Neurology, 2004, Feb-24, Volume: 62, Issue:4 Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neurons; Severity of Illness Index; Time Factors	2004
Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis. Brain : a journal of neurology, 2004, Volume: 127, Issue:Pt 6 Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine; Prospective Studies; Syndrome	2004
MR spectroscopy of cervical spinal cord in patients with multiple sclerosis. Neuroradiology, 2004, Volume: 46, Issue:9 Topics: Adult; Aspartic Acid; Case-Control Studies; Cervical Vertebrae; Choline; Creatine; Female; Humans; Inositol; Lactic Acid; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Spinal Cord	2004
Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis. Archives of neurology, 2005, Volume: 62, Issue:4 Topics: Adult; Aspartic Acid; Astrocytes; Atrophy; CD3 Complex; Cell Communication; Cells, Cultured; Central Nervous System; Coculture Techniques; Cohort Studies; Disease Progression; Endothelial Cells; Female; Humans; Interferon-beta; Magnetic Resonance Spectroscopy; Male; Microglia; Multiple Sclerosis; Nerve Growth Factor; T-Lymphocytes; Wallerian Degeneration	2005
(1)H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings. European radiology, 2006, Volume: 16, Issue:2 Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mathematical Computing; Middle Aged; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Reference Values; Software	2006
MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis. Magnetic resonance in medicine, 2006, Volume: 55, Issue:3 Topics: Adult; Aged; Aspartic Acid; Cerebral Cortex; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis; Thalamus	2006
Metabolite findings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy. AJNR. American journal of neuroradiology, 2007, Volume: 28, Issue:2 Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differential; Echo-Planar Imaging; Female; Glutamic Acid; Humans; Lactic Acid; Male; Middle Aged; Multiple Sclerosis; Protons	2007
N-acetylaspartic acid in cerebrospinal fluid of multiple sclerosis patients determined by gas-chromatography-mass spectrometry. Journal of neurology, 2007, Volume: 254, Issue:5 Topics: Adult; Aspartic Acid; Female; Gas Chromatography-Mass Spectrometry; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Severity of Illness Index; Statistics, Nonparametric	2007
Relationships between gray matter metabolic abnormalities and white matter inflammation in patients at the very early stage of MS : a MRSI study. Journal of neurology, 2007, Volume: 254, Issue:7 Topics: Adult; Analysis of Variance; Aspartic Acid; Brain Mapping; Case-Control Studies; Choline; Female; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Occipital Lobe; Protons; Thalamus	2007
Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy. AJNR. American journal of neuroradiology, 2007, Volume: 28, Issue:8 Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neuroglia; Osmolar Concentration	2007
"Absolute" quantification in magnetic resonance spectroscopy: validation of a clinical protocol in multiple sclerosis. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2007, Volume: 2007 Topics: Adult; Algorithms; Aspartic Acid; Biomarkers; Brain; Choline; Diagnosis, Computer-Assisted; Female; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Prognosis; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome	2007
Long-term study of brain 1H-MRS study in multiple sclerosis: effect of glatiramer acetate therapy on axonal metabolic function and feasibility of long-Term H-MRS monitoring in multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2008, Volume: 18, Issue:3 Topics: Adult; Aspartic Acid; Axons; Brain; Case-Control Studies; Creatine; Feasibility Studies; Female; Glatiramer Acetate; Humans; Immunosuppressive Agents; Male; Middle Aged; Monitoring, Physiologic; Multiple Sclerosis; Peptides; Statistics, Nonparametric	2008
Reproducibility over a 1-month period of 1H-MR spectroscopic imaging NAA/Cr ratios in clinically stable multiple sclerosis patients. European radiology, 2008, Volume: 18, Issue:8 Topics: Adult; Aspartic Acid; Biomarkers; Creatinine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Protons; Reproducibility of Results; Sensitivity and Specificity	2008
High resolution proton NMR spectroscopy of multiple sclerosis lesions. Journal of neurochemistry, 1995, Volume: 64, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Cadaver; Creatine; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis; Protons; Reference Values	1995
Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis. Magnetic resonance in medicine, 1994, Volume: 32, Issue:3 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Choline; Cohort Studies; Creatine; Demyelinating Diseases; Humans; Hydrogen; Image Enhancement; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis; Phosphocreatine; Signal Processing, Computer-Assisted	1994
Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis. Annals of neurology, 1994, Volume: 36, Issue:1 Topics: Aspartic Acid; Axons; Brain; Creatine; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Pilot Projects; Recurrence; Severity of Illness Index	1994
Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging. Annals of neurology, 1994, Volume: 36, Issue:2 Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine; Phosphorus	1994
Automated processing for proton spectroscopic imaging using water reference deconvolution. Magnetic resonance in medicine, 1994, Volume: 31, Issue:6 Topics: Artifacts; Aspartic Acid; Body Water; Brain; Choline; Creatine; Electronic Data Processing; Fourier Analysis; Humans; Hydrogen; Image Enhancement; Lactates; Lipid Metabolism; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Phosphocreatine; Protons; Water	1994
Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain : a journal of neurology, 1994, Volume: 117 ( Pt 1) Topics: Adult; Aspartic Acid; Creatine; Female; Gadolinium DTPA; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis; Organometallic Compounds; Pentetic Acid	1994
Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain : a journal of neurology, 1995, Volume: 118 ( Pt 6) Topics: Adult; Aged; Aspartic Acid; Axons; Cerebellar Ataxia; Cerebellum; Genes, Dominant; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis	1995
Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy. Brain : a journal of neurology, 1996, Volume: 119 ( Pt 3) Topics: Adult; Aspartic Acid; Brain Diseases; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Time Factors	1996
Quantitative 1H spectroscopic imaging of human brain at 4.1 T using image segmentation. Magnetic resonance in medicine, 1996, Volume: 36, Issue:1 Topics: Aspartic Acid; Basal Ganglia; Brain; Cerebral Cortex; Cerebrospinal Fluid; Choline; Confidence Intervals; Creatine; Gyrus Cinguli; Humans; Hydrogen; Image Enhancement; Linear Models; Lipid Metabolism; Magnetic Resonance Imaging; Multiple Sclerosis; Parietal Lobe; Temporal Lobe; Thalamus	1996
Evaluation of multiple sclerosis by 1H spectroscopic imaging at 4.1 T. Magnetic resonance in medicine, 1996, Volume: 36, Issue:1 Topics: Adult; Aspartic Acid; Astrocytes; Axons; Brain; Cell Membrane; Cerebral Ventricles; Choline; Creatine; Evaluation Studies as Topic; Female; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Recurrence	1996
Proton MR spectroscopy and MR imaging in acute and chronic multiple sclerosis--ringlike appearances in acute plaques. Acta radiologica (Stockholm, Sweden : 1987), 1996, Volume: 37, Issue:3 Pt 1 Topics: Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Inositol; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine	1996
Proton MR spectroscopy and magnetization transfer ratio in multiple sclerosis: correlative findings of active versus irreversible plaque disease. AJNR. American journal of neuroradiology, 1996, Volume: 17, Issue:8 Topics: Adult; Aspartic Acid; Brain; Brain Diseases; Brain Edema; Choline; Chronic Disease; Creatine; Demyelinating Diseases; Encephalitis; Female; Humans; Image Enhancement; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Protons	1996
In vivo localized NMR proton spectroscopy of normal appearing white matter in patients with multiple sclerosis. Journal of neuroradiology = Journal de neuroradiologie, 1996, Volume: 23, Issue:2 Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; Clinical Trials as Topic; Creatine; Discriminant Analysis; Humans; Image Enhancement; Inositol; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis; Protons	1996
Statistics for investigation of multimodal MR imaging data and an application to multiple sclerosis patients. NMR in biomedicine, 1996, Volume: 9, Issue:8 Topics: Aspartic Acid; Brain; Creatine; Disease Progression; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Models, Theoretical; Multiple Sclerosis; Recurrence; Reference Values	1996
Axonal dysfunction and disability in a relapse of multiple sclerosis: longitudinal study of a patient. Neurology, 1997, Volume: 49, Issue:4 Topics: Adult; Aspartic Acid; Axons; Brain; Creatine; Disabled Persons; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Recurrence	1997
A study of multiple sclerosis patients with magnetic resonance spectroscopic imaging. Multiple sclerosis (Houndmills, Basingstoke, England), 1995, Volume: 1, Issue:1 Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis	1995
Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Annals of neurology, 1998, Volume: 43, Issue:1 Topics: Adult; Aspartic Acid; Brain; Choline; Female; Gadolinium; Humans; Image Enhancement; Lipid Metabolism; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis	1998
Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:2 Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neurologic Examination	1998
Imaging axonal damage of normal-appearing white matter in multiple sclerosis. Brain : a journal of neurology, 1998, Volume: 121 ( Pt 1) Topics: Aspartic Acid; Axons; Brain; Creatine; Disability Evaluation; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Models, Neurological; Multiple Sclerosis; Phosphocreatine; Reference Values; Time Factors; Tissue Distribution	1998
Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain : a journal of neurology, 1998, Volume: 121 ( Pt 8) Topics: Aspartic Acid; Axons; Brain; Creatine; Disability Evaluation; Disease Progression; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Recurrence	1998
Quantitative spectroscopic imaging of the human brain. Magnetic resonance in medicine, 1998, Volume: 40, Issue:3 Topics: Aspartic Acid; Brain Chemistry; Brain Mapping; Cerebral Ventricles; Choline; Computer Graphics; Creatine; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Reference Values	1998
Correlates of executive function in multiple sclerosis: the use of magnetic resonance spectroscopy as an index of focal pathology. The Journal of neuropsychiatry and clinical neurosciences, 1999,Winter, Volume: 11, Issue:1 Topics: Adult; Analysis of Variance; Aspartic Acid; Attention; Biomarkers; Case-Control Studies; Chi-Square Distribution; Cognition Disorders; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Memory, Short-Term; Middle Aged; Multiple Sclerosis; Neural Pathways; Neuropsychological Tests; Pattern Recognition, Visual; Volition	1999
Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients. Brain : a journal of neurology, 1999, Volume: 122 ( Pt 3) Topics: Adult; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Phosphocreatine	1999
Combined magnetization transfer and proton spectroscopic imaging in the assessment of pathologic brain lesions in multiple sclerosis. AJNR. American journal of neuroradiology, 1999, Volume: 20, Issue:5 Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine	1999
In vivo evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis. Brain : a journal of neurology, 1999, Volume: 122 ( Pt 10) Topics: Acute Disease; Adult; Aspartic Acid; Axons; Brain; Creatine; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Neural Pathways; Protons; Time Factors	1999
Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR. American journal of neuroradiology, 1999, Volume: 20, Issue:9 Topics: Adult; Aspartic Acid; Axons; Biopsy, Needle; Blood-Brain Barrier; Brain; Cell Division; Choline; Demyelinating Diseases; Diagnosis, Differential; Dominance, Cerebral; Female; Gliosis; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Neuroglia	1999
Axonal injury or loss in the internal capsule and motor impairment in multiple sclerosis. Archives of neurology, 2000, Volume: 57, Issue:1 Topics: Adult; Aged; Aspartic Acid; Axons; Electric Stimulation; Female; Humans; Internal Capsule; Magnetic Resonance Imaging; Magnetics; Male; Middle Aged; Movement Disorders; Multiple Sclerosis; Neural Conduction	2000
Total brain N-acetylaspartate: a new measure of disease load in MS. Neurology, 2000, Jan-11, Volume: 54, Issue:1 Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Cell Survival; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neurons; Reference Values; Reproducibility of Results; Severity of Illness Index	2000
Correlating magnetic resonance imaging markers of axonal injury and demyelination in motor impairment secondary to stroke and multiple sclerosis. Magnetic resonance imaging, 2000, Volume: 18, Issue:4 Topics: Adult; Aged; Aspartic Acid; Axons; Female; Functional Laterality; Humans; Internal Capsule; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Movement Disorders; Multiple Sclerosis; Myelin Sheath; Stroke	2000
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis. Magnetic resonance imaging, 2000, Volume: 18, Issue:4 Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine	2000
Proton magnetic resonance spectroscopy in primary and secondary progressive multiple sclerosis. NMR in biomedicine, 2000, Volume: 13, Issue:2 Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine	2000
Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis. Brain : a journal of neurology, 2000, Volume: 123 ( Pt 11) Topics: Aspartic Acid; Axons; Fingers; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Motor Cortex; Movement; Multiple Sclerosis; Nerve Degeneration; Nerve Fibers, Myelinated; Neuronal Plasticity; Recovery of Function	2000
Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Annals of neurology, 2000, Volume: 48, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Axons; Chronic Disease; Disability Evaluation; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Spinal Cord	2000
Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study. Journal of the neurological sciences, 2001, Jan-01, Volume: 182, Issue:2 Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Tritium	2001
Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability. Archives of neurology, 2001, Volume: 58, Issue:1 Topics: Adult; Aspartic Acid; Atrophy; Axons; Brain; Chromatography, High Pressure Liquid; Creatine; Disability Evaluation; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Severity of Illness Index; Spinal Cord; Time Factors	2001
Correlates of MS disability assessed in vivo using aggregates of MR quantities. Neurology, 2001, May-22, Volume: 56, Issue:10 Topics: Adult; Aspartic Acid; Brain; Creatine; Disability Evaluation; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Models, Neurological; Multiple Sclerosis; Predictive Value of Tests	2001
Cognitive dysfunction lateralizes with NAA in multiple sclerosis. Applied neuropsychology, 2001, Volume: 8, Issue:3 Topics: Adult; Aspartic Acid; Axons; Brain; Cognition Disorders; Disability Evaluation; Female; Functional Laterality; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Severity of Illness Index	2001
Editorial commentary to Narayanan et al. Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b. Journal of neurology, 2001, Volume: 248, Issue:11 Topics: Adjuvants, Immunologic; Aspartic Acid; Clinical Trials as Topic; Diffuse Axonal Injury; Disease Progression; Humans; Interferon beta-1a; Interferon beta-1b; Interferon-beta; Multiple Sclerosis; Reproducibility of Results; Research Design; Treatment Outcome	2001
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Annals of neurology, 1992, Volume: 31, Issue:3 Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differential; Female; Glioma; Humans; Lactates; Lactic Acid; Magnetic Resonance Imaging; Multiple Sclerosis; Tomography, X-Ray Computed	1992
Proton magnetic resonance spectroscopy and multiple sclerosis. Lancet (London, England), 1991, Feb-09, Volume: 337, Issue:8737 Topics: Aspartic Acid; Humans; Lipids; Magnetic Resonance Imaging; Multiple Sclerosis	1991
Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis. Magnetic resonance in medicine, 1991, Volume: 22, Issue:1 Topics: Acute Disease; Adult; Aspartic Acid; Brain; Choline; Chronic Disease; Female; Humans; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis	1991
Human brain proton localized NMR spectroscopy in multiple sclerosis. Magnetic resonance in medicine, 1991, Volume: 18, Issue:1 Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine	1991
Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magnetic resonance in medicine, 1990, Volume: 14, Issue:1 Topics: Aspartic Acid; Brain; Chronic Disease; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Protons	1990