Page last updated: 2024-08-24

n-acetylaspartic acid and Huntington Disease

n-acetylaspartic acid has been researched along with Huntington Disease in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (24.14)	18.2507
2000's	13 (44.83)	29.6817
2010's	9 (31.03)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Casseb, RF; Castellano, G; Cendes, F; D'Abreu, A; Lopes-Cendes, I; Ruocco, HH	1
Aylward, EH; Conley, KE; Laurino, MY; Padowski, JM; Richards, TL; Samii, A; Weaver, KE	1
Adams, W; Beglinger, LJ; Fiedorowicz, J; Gasparovic, C; Jorge, R; Magnotta, VA; Paulsen, J; Yager, JR	1
Dumas, EM; Kan, HE; Roos, RA; Teeuwisse, WM; van Buchem, MA; van den Bogaard, SJ; van der Grond, J; Webb, A	1
Bechtel, N; Bohlen, S; Carter, K; Coleman, AJ; Creighton, S; Dar Santos, R; Decolongon, J; Hayden, MR; Johnson, HJ; Laule, C; Leavitt, BR; Mackay, AL; Milner, RA; Reilmann, R; Sturrock, A; Tabrizi, SJ; Wyper, K	1
Morton, AJ; Sawiak, SJ; Wood, NI	1
Joseph, SA; Mark, LP; Prost, RW; Reynolds, NC	1
Bechtel, N; Coleman, AJ; Creighton, S; Dar Santos, R; Decolongon, J; Hayden, MR; Laule, C; Leavitt, BR; Mackay, AL; Reilmann, R; Sturrock, A; Tabrizi, SJ	1
Ceci, E; de Tommaso, M; Franco, G; Livrea, P; Pica, C; Ruggieri, M; Sciruicchio, V; Serpino, C; Trojano, M	1
Barker, PB; Bassett, SS; Brandt, J; Carass, A; Edden, RA; Liu, X; Margolis, RL; Oishi, K; Redgrave, GW; Ross, CA; Shanahan, M; Unschuld, PG; van Zijl, PC; Wang, X	1
Blamire, AM; Manners, DN; Rajagopalan, B; Schapira, AH; Styles, P; Tabrizi, SJ; Warner, TT	2
Cecil, KM; Doescher, J; Jones, BV; Kiefer, AM; Schapiro, M	1
Mark, LP; Prost, RW; Reynolds, NC	1
Auer, DP; Bender, A; Bender, J; Dose, M; Gasser, T; Klopstock, T; Merl, T; Reilmann, R; Saemann, P; Weindl, A; Yassouridis, A	1
Hanstock, CC; Martin, WR; Wieler, M	1
Cendes, F; Li, LM; Lopes-Cendes, I; Ruocco, HH	1
Ross, BD	1
Beal, MF; Jenkins, BG; Koroshetz, WJ; Rosen, BR	1
Beal, MF; Brouillet, E; Chen, YC; Jenkins, BG; Kirschner, P; Rosen, BR; Schulz, JB; Storey, E	1
Brooks, DJ; Bryant, DJ; Harding, AE; Marcus, CD; Sargentoni, J; Taylor-Robinson, SD; Weeks, RA	1
Harms, L; Ludolph, AC; Meierkord, H; Pfeiffer, L; Timm, G	1
Carter, RE; Coyle, JT; Passani, LA; Vonsattel, JP	1
Blüml, S; Dubowitz, D; Hoang, TQ; Jacques, DB; Kopyov, OV; Lin, A; Ross, BD; Seymour, K; Tan, J	1
Andreassen, OA; Beal, MF; Ferrante, RJ; Jenkins, BG; Klivenyi, P; Kustermann, E; Rosen, BR	1
Andreassen, OA; Beal, MF; Dedeoglu, A; Ferrante, RJ; Hersch, SM; Jenkins, BG; Kaddurah-Daouk, R; Kubilus, JK; Kuemmerle, S	1
Blakemore, C; Cordery, P; Dixon, RM; Hannan, AJ; Styles, P; van Dellen, A; Welch, J; York, D	1
Andreassen, OA; Beal, MF; Borchelt, DR; Browne, SE; Dedeoglu, A; Ferrante, KL; Ferrante, RJ; Friedlich, A; Hersch, SM; Jenkins, BG; Ross, CA; Schilling, G; Thomas, M	1
Dunlop, DS; Lajtha, A; Mc Hale, DM	1

Trials

3 trial(s) available for n-acetylaspartic acid and Huntington Disease

Article	Year
Creatine therapy for Huntington's disease: clinical and MRS findings in a 1-year pilot study. Neurology, 2003, Jul-08, Volume: 61, Issue:1 Topics: Adenosine Triphosphate; Aspartic Acid; Brain; Choline; Creatine; Diarrhea; Dietary Supplements; Dose-Response Relationship, Drug; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Muscle, Skeletal; Nausea; Neuropsychological Tests; Phosphocreatine; Pilot Projects; Reference Values; Safety; Treatment Outcome	2003
Creatine supplementation lowers brain glutamate levels in Huntington's disease. Journal of neurology, 2005, Volume: 252, Issue:1 Topics: Administration, Oral; Adult; Aspartic Acid; Brain; Cerebral Cortex; Creatine; Down-Regulation; Energy Metabolism; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurologic Examination; Neuroprotective Agents; Pilot Projects; Treatment Outcome	2005
High-dose creatine therapy for Huntington disease: a 2-year clinical and MRS study. Neurology, 2005, May-10, Volume: 64, Issue:9 Topics: Administration, Oral; Aspartic Acid; Body Weight; Brain; Creatine; Creatinine; Dose-Response Relationship, Drug; Energy Metabolism; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Neuropsychological Tests; Patient Compliance; Phosphocreatine; Pilot Projects; Treatment Outcome; Up-Regulation	2005

Other Studies

26 other study(ies) available for n-acetylaspartic acid and Huntington Disease

Article	Year
Thalamic metabolic abnormalities in patients with Huntington's disease measured by magnetic resonance spectroscopy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:8 Topics: Adolescent; Adult; Aged; Aspartic Acid; Case-Control Studies; Creatine; Deuterium; Dipeptides; Female; Glycerylphosphorylcholine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Activity; Phosphocreatine; Phosphorylcholine; Thalamic Diseases; Thalamus; Trinucleotide Repeats; Young Adult	2013
Neurochemical correlates of caudate atrophy in Huntington's disease. Movement disorders : official journal of the Movement Disorder Society, 2014, Volume: 29, Issue:3 Topics: Adult; Aged; Aspartic Acid; Atrophy; Caudate Nucleus; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Imaging; Male; Middle Aged; Motor Activity; Mutation; Young Adult	2014
Preliminary study of the association of white-matter metabolite concentrations with disease severity in patients with Huntington's disease. The Journal of neuropsychiatry and clinical neurosciences, 2014,Winter, Volume: 26, Issue:1 Topics: Aspartic Acid; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Nerve Fibers, Myelinated; Protons; Trinucleotide Repeats	2014
Longitudinal metabolite changes in Huntington's disease during disease onset. Journal of Huntington's disease, 2014, Volume: 3, Issue:4 Topics: Adult; Aspartic Acid; Caudate Nucleus; Creatinine; Female; Follow-Up Studies; Humans; Huntington Disease; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Molecular Imaging; Prefrontal Cortex; Putamen	2014
A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers. Movement disorders : official journal of the Movement Disorder Society, 2015, Volume: 30, Issue:3 Topics: Adult; Analysis of Variance; Aspartic Acid; Biomarkers; Brain; Cross-Sectional Studies; Female; Humans; Huntington Disease; Inositol; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Putamen; Statistics as Topic; Time Factors; White Matter	2015
Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy. Journal of Huntington's disease, 2016, 10-01, Volume: 5, Issue:3 Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Disease Progression; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Trinucleotide Repeats	2016
MR-spectroscopic findings in juvenile-onset Huntington's disease. Movement disorders : official journal of the Movement Disorder Society, 2008, Oct-15, Volume: 23, Issue:13 Topics: Adolescent; Aspartic Acid; Brain Mapping; Child; Child, Preschool; Creatine; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Protons; Putamen; Trinucleotide Repeats; Young Adult	2008
Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease. Neurology, 2010, Nov-09, Volume: 75, Issue:19 Topics: Adult; Aspartic Acid; Biomarkers; Cohort Studies; Early Diagnosis; Female; Humans; Huntington Disease; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prospective Studies; Putamen	2010
Serum levels of N-acetylaspartate in Huntington's disease: preliminary results. Movement disorders : official journal of the Movement Disorder Society, 2012, Volume: 27, Issue:2 Topics: Adolescent; Adult; Aged; Aspartic Acid; Case-Control Studies; Female; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged	2012
Brain metabolite alterations and cognitive dysfunction in early Huntington's disease. Movement disorders : official journal of the Movement Disorder Society, 2012, Volume: 27, Issue:7 Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Cognition Disorders; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Regression Analysis; Trinucleotide Repeat Expansion	2012
MR imaging and spectroscopy in juvenile Huntington disease. Pediatric radiology, 2004, Volume: 34, Issue:8 Topics: Aspartic Acid; Brain; Caudate Nucleus; Child; Creatinine; Genetic Testing; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Putamen	2004
Heterogeneity in 1H-MRS profiles of presymptomatic and early manifest Huntington's disease. Brain research, 2005, Jan-07, Volume: 1031, Issue:1 Topics: Adult; Age of Onset; Aged; Aspartic Acid; Early Diagnosis; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Putamen	2005
Is brain lactate increased in Huntington's disease? Journal of the neurological sciences, 2007, Dec-15, Volume: 263, Issue:1-2 Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Huntington Disease; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged	2007
Evidence of thalamic dysfunction in Huntington disease by proton magnetic resonance spectroscopy. Movement disorders : official journal of the Movement Disorder Society, 2007, Oct-31, Volume: 22, Issue:14 Topics: Adult; Age of Onset; Aged; Analysis of Variance; Aspartic Acid; Creatine; Female; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Radionuclide Imaging; Thalamus	2007
Re: Long-term fetal cell transplant in Huntington disease: stayin' alive. Neurology, 2008, Mar-04, Volume: 70, Issue:10 Topics: Aspartic Acid; Cell Differentiation; Corpus Striatum; Fetal Tissue Transplantation; Graft Survival; Growth Cones; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Monitoring, Physiologic; Neural Pathways; Stem Cell Transplantation	2008
Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy. Neurology, 1993, Volume: 43, Issue:12 Topics: Adult; Aspartic Acid; Basal Ganglia; Choline; Creatine; Energy Metabolism; Female; Humans; Huntington Disease; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Protons; Reference Values	1993
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:3 Topics: Aging; Animals; Aspartic Acid; Electron Transport Complex II; Energy Metabolism; Huntington Disease; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Multienzyme Complexes; Nerve Degeneration; Neurochemistry; Neurotoxins; Oxidoreductases; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase	1996
Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory. Movement disorders : official journal of the Movement Disorder Society, 1996, Volume: 11, Issue:2 Topics: Aspartic Acid; Cerebral Cortex; Corpus Striatum; Genetic Carrier Screening; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Imaging; Nerve Degeneration; Reference Values; Synaptic Transmission	1996
Decreased N-acetyl-aspartate/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: a proton magnetic resonance spectroscopy study. Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:1 Topics: Adult; Aged; Aspartic Acid; Choline; Female; Frontal Lobe; Humans; Huntington Disease; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged	1997
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases. Molecular and chemical neuropathology, 1997, Volume: 31, Issue:2 Topics: Alzheimer Disease; Amino Acids; Antigens, Surface; Aspartic Acid; Brain; Case-Control Studies; Cell Count; Dipeptidases; Dipeptides; Glutamate Carboxypeptidase II; Humans; Huntington Disease; Neurons; Neuropeptides; Reference Values	1997
In vivo magnetic resonance spectroscopy of human fetal neural transplants. NMR in biomedicine, 1999, Volume: 12, Issue:4 Topics: Adult; Aspartic Acid; Brain; Fetal Tissue Transplantation; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Parkinson Disease	1999
Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. Journal of neurochemistry, 2000, Volume: 74, Issue:5 Topics: Animals; Aspartic Acid; Blood Glucose; Brain; Glucose; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Neurons; Nonlinear Dynamics; Time Factors	2000
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jun-15, Volume: 20, Issue:12 Topics: Animals; Animals, Genetically Modified; Aspartic Acid; Atrophy; Brain; Corpus Striatum; Creatine; Crosses, Genetic; Dietary Supplements; Female; Humans; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred Strains; Motor Activity; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nuclear Proteins	2000
N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice. Neuroreport, 2000, Nov-27, Volume: 11, Issue:17 Topics: Animals; Aspartic Acid; Biomarkers; Calbindins; Choline; Corpus Striatum; Creatine; Dopamine and cAMP-Regulated Phosphoprotein 32; Huntington Disease; Immunohistochemistry; Magnetic Resonance Imaging; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Phosphoproteins; S100 Calcium Binding Protein G	2000
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiology of disease, 2001, Volume: 8, Issue:3 Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Cell Survival; Creatinine; Disease Models, Animal; Energy Metabolism; Female; Huntingtin Protein; Huntington Disease; Hyperglycemia; Insulin; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Motor Activity; Neostriatum; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Organ Size; Survival Rate	2001
Decreased brain N-acetylaspartate in Huntington's disease. Brain research, 1992, May-15, Volume: 580, Issue:1-2 Topics: Aspartic Acid; Brain; Female; Humans; Huntington Disease; Male	1992