Page last updated: 2024-08-24

n-acetylaspartic acid and Huntington Disease

n-acetylaspartic acid has been researched along with Huntington Disease in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (24.14)18.2507
2000's13 (44.83)29.6817
2010's9 (31.03)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Casseb, RF; Castellano, G; Cendes, F; D'Abreu, A; Lopes-Cendes, I; Ruocco, HH1
Aylward, EH; Conley, KE; Laurino, MY; Padowski, JM; Richards, TL; Samii, A; Weaver, KE1
Adams, W; Beglinger, LJ; Fiedorowicz, J; Gasparovic, C; Jorge, R; Magnotta, VA; Paulsen, J; Yager, JR1
Dumas, EM; Kan, HE; Roos, RA; Teeuwisse, WM; van Buchem, MA; van den Bogaard, SJ; van der Grond, J; Webb, A1
Bechtel, N; Bohlen, S; Carter, K; Coleman, AJ; Creighton, S; Dar Santos, R; Decolongon, J; Hayden, MR; Johnson, HJ; Laule, C; Leavitt, BR; Mackay, AL; Milner, RA; Reilmann, R; Sturrock, A; Tabrizi, SJ; Wyper, K1
Morton, AJ; Sawiak, SJ; Wood, NI1
Joseph, SA; Mark, LP; Prost, RW; Reynolds, NC1
Bechtel, N; Coleman, AJ; Creighton, S; Dar Santos, R; Decolongon, J; Hayden, MR; Laule, C; Leavitt, BR; Mackay, AL; Reilmann, R; Sturrock, A; Tabrizi, SJ1
Ceci, E; de Tommaso, M; Franco, G; Livrea, P; Pica, C; Ruggieri, M; Sciruicchio, V; Serpino, C; Trojano, M1
Barker, PB; Bassett, SS; Brandt, J; Carass, A; Edden, RA; Liu, X; Margolis, RL; Oishi, K; Redgrave, GW; Ross, CA; Shanahan, M; Unschuld, PG; van Zijl, PC; Wang, X1
Blamire, AM; Manners, DN; Rajagopalan, B; Schapira, AH; Styles, P; Tabrizi, SJ; Warner, TT2
Cecil, KM; Doescher, J; Jones, BV; Kiefer, AM; Schapiro, M1
Mark, LP; Prost, RW; Reynolds, NC1
Auer, DP; Bender, A; Bender, J; Dose, M; Gasser, T; Klopstock, T; Merl, T; Reilmann, R; Saemann, P; Weindl, A; Yassouridis, A1
Hanstock, CC; Martin, WR; Wieler, M1
Cendes, F; Li, LM; Lopes-Cendes, I; Ruocco, HH1
Ross, BD1
Beal, MF; Jenkins, BG; Koroshetz, WJ; Rosen, BR1
Beal, MF; Brouillet, E; Chen, YC; Jenkins, BG; Kirschner, P; Rosen, BR; Schulz, JB; Storey, E1
Brooks, DJ; Bryant, DJ; Harding, AE; Marcus, CD; Sargentoni, J; Taylor-Robinson, SD; Weeks, RA1
Harms, L; Ludolph, AC; Meierkord, H; Pfeiffer, L; Timm, G1
Carter, RE; Coyle, JT; Passani, LA; Vonsattel, JP1
Blüml, S; Dubowitz, D; Hoang, TQ; Jacques, DB; Kopyov, OV; Lin, A; Ross, BD; Seymour, K; Tan, J1
Andreassen, OA; Beal, MF; Ferrante, RJ; Jenkins, BG; Klivenyi, P; Kustermann, E; Rosen, BR1
Andreassen, OA; Beal, MF; Dedeoglu, A; Ferrante, RJ; Hersch, SM; Jenkins, BG; Kaddurah-Daouk, R; Kubilus, JK; Kuemmerle, S1
Blakemore, C; Cordery, P; Dixon, RM; Hannan, AJ; Styles, P; van Dellen, A; Welch, J; York, D1
Andreassen, OA; Beal, MF; Borchelt, DR; Browne, SE; Dedeoglu, A; Ferrante, KL; Ferrante, RJ; Friedlich, A; Hersch, SM; Jenkins, BG; Ross, CA; Schilling, G; Thomas, M1
Dunlop, DS; Lajtha, A; Mc Hale, DM1

Trials

3 trial(s) available for n-acetylaspartic acid and Huntington Disease

ArticleYear
Creatine therapy for Huntington's disease: clinical and MRS findings in a 1-year pilot study.
    Neurology, 2003, Jul-08, Volume: 61, Issue:1

    Topics: Adenosine Triphosphate; Aspartic Acid; Brain; Choline; Creatine; Diarrhea; Dietary Supplements; Dose-Response Relationship, Drug; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Muscle, Skeletal; Nausea; Neuropsychological Tests; Phosphocreatine; Pilot Projects; Reference Values; Safety; Treatment Outcome

2003
Creatine supplementation lowers brain glutamate levels in Huntington's disease.
    Journal of neurology, 2005, Volume: 252, Issue:1

    Topics: Administration, Oral; Adult; Aspartic Acid; Brain; Cerebral Cortex; Creatine; Down-Regulation; Energy Metabolism; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurologic Examination; Neuroprotective Agents; Pilot Projects; Treatment Outcome

2005
High-dose creatine therapy for Huntington disease: a 2-year clinical and MRS study.
    Neurology, 2005, May-10, Volume: 64, Issue:9

    Topics: Administration, Oral; Aspartic Acid; Body Weight; Brain; Creatine; Creatinine; Dose-Response Relationship, Drug; Energy Metabolism; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Neuropsychological Tests; Patient Compliance; Phosphocreatine; Pilot Projects; Treatment Outcome; Up-Regulation

2005

Other Studies

26 other study(ies) available for n-acetylaspartic acid and Huntington Disease

ArticleYear
Thalamic metabolic abnormalities in patients with Huntington's disease measured by magnetic resonance spectroscopy.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Case-Control Studies; Creatine; Deuterium; Dipeptides; Female; Glycerylphosphorylcholine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Activity; Phosphocreatine; Phosphorylcholine; Thalamic Diseases; Thalamus; Trinucleotide Repeats; Young Adult

2013
Neurochemical correlates of caudate atrophy in Huntington's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2014, Volume: 29, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Atrophy; Caudate Nucleus; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Imaging; Male; Middle Aged; Motor Activity; Mutation; Young Adult

2014
Preliminary study of the association of white-matter metabolite concentrations with disease severity in patients with Huntington's disease.
    The Journal of neuropsychiatry and clinical neurosciences, 2014,Winter, Volume: 26, Issue:1

    Topics: Aspartic Acid; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Nerve Fibers, Myelinated; Protons; Trinucleotide Repeats

2014
Longitudinal metabolite changes in Huntington's disease during disease onset.
    Journal of Huntington's disease, 2014, Volume: 3, Issue:4

    Topics: Adult; Aspartic Acid; Caudate Nucleus; Creatinine; Female; Follow-Up Studies; Humans; Huntington Disease; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Molecular Imaging; Prefrontal Cortex; Putamen

2014
A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers.
    Movement disorders : official journal of the Movement Disorder Society, 2015, Volume: 30, Issue:3

    Topics: Adult; Analysis of Variance; Aspartic Acid; Biomarkers; Brain; Cross-Sectional Studies; Female; Humans; Huntington Disease; Inositol; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Putamen; Statistics as Topic; Time Factors; White Matter

2015
Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy.
    Journal of Huntington's disease, 2016, 10-01, Volume: 5, Issue:3

    Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Disease Progression; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Trinucleotide Repeats

2016
MR-spectroscopic findings in juvenile-onset Huntington's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2008, Oct-15, Volume: 23, Issue:13

    Topics: Adolescent; Aspartic Acid; Brain Mapping; Child; Child, Preschool; Creatine; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Protons; Putamen; Trinucleotide Repeats; Young Adult

2008
Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease.
    Neurology, 2010, Nov-09, Volume: 75, Issue:19

    Topics: Adult; Aspartic Acid; Biomarkers; Cohort Studies; Early Diagnosis; Female; Humans; Huntington Disease; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prospective Studies; Putamen

2010
Serum levels of N-acetylaspartate in Huntington's disease: preliminary results.
    Movement disorders : official journal of the Movement Disorder Society, 2012, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Case-Control Studies; Female; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged

2012
Brain metabolite alterations and cognitive dysfunction in early Huntington's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2012, Volume: 27, Issue:7

    Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Cognition Disorders; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Regression Analysis; Trinucleotide Repeat Expansion

2012
MR imaging and spectroscopy in juvenile Huntington disease.
    Pediatric radiology, 2004, Volume: 34, Issue:8

    Topics: Aspartic Acid; Brain; Caudate Nucleus; Child; Creatinine; Genetic Testing; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Putamen

2004
Heterogeneity in 1H-MRS profiles of presymptomatic and early manifest Huntington's disease.
    Brain research, 2005, Jan-07, Volume: 1031, Issue:1

    Topics: Adult; Age of Onset; Aged; Aspartic Acid; Early Diagnosis; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Putamen

2005
Is brain lactate increased in Huntington's disease?
    Journal of the neurological sciences, 2007, Dec-15, Volume: 263, Issue:1-2

    Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Huntington Disease; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged

2007
Evidence of thalamic dysfunction in Huntington disease by proton magnetic resonance spectroscopy.
    Movement disorders : official journal of the Movement Disorder Society, 2007, Oct-31, Volume: 22, Issue:14

    Topics: Adult; Age of Onset; Aged; Analysis of Variance; Aspartic Acid; Creatine; Female; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Radionuclide Imaging; Thalamus

2007
Re: Long-term fetal cell transplant in Huntington disease: stayin' alive.
    Neurology, 2008, Mar-04, Volume: 70, Issue:10

    Topics: Aspartic Acid; Cell Differentiation; Corpus Striatum; Fetal Tissue Transplantation; Graft Survival; Growth Cones; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Monitoring, Physiologic; Neural Pathways; Stem Cell Transplantation

2008
Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy.
    Neurology, 1993, Volume: 43, Issue:12

    Topics: Adult; Aspartic Acid; Basal Ganglia; Choline; Creatine; Energy Metabolism; Female; Humans; Huntington Disease; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Protons; Reference Values

1993
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Electron Transport Complex II; Energy Metabolism; Huntington Disease; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Multienzyme Complexes; Nerve Degeneration; Neurochemistry; Neurotoxins; Oxidoreductases; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase

1996
Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory.
    Movement disorders : official journal of the Movement Disorder Society, 1996, Volume: 11, Issue:2

    Topics: Aspartic Acid; Cerebral Cortex; Corpus Striatum; Genetic Carrier Screening; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Imaging; Nerve Degeneration; Reference Values; Synaptic Transmission

1996
Decreased N-acetyl-aspartate/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: a proton magnetic resonance spectroscopy study.
    Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Choline; Female; Frontal Lobe; Humans; Huntington Disease; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged

1997
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases.
    Molecular and chemical neuropathology, 1997, Volume: 31, Issue:2

    Topics: Alzheimer Disease; Amino Acids; Antigens, Surface; Aspartic Acid; Brain; Case-Control Studies; Cell Count; Dipeptidases; Dipeptides; Glutamate Carboxypeptidase II; Humans; Huntington Disease; Neurons; Neuropeptides; Reference Values

1997
In vivo magnetic resonance spectroscopy of human fetal neural transplants.
    NMR in biomedicine, 1999, Volume: 12, Issue:4

    Topics: Adult; Aspartic Acid; Brain; Fetal Tissue Transplantation; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Parkinson Disease

1999
Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice.
    Journal of neurochemistry, 2000, Volume: 74, Issue:5

    Topics: Animals; Aspartic Acid; Blood Glucose; Brain; Glucose; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Neurons; Nonlinear Dynamics; Time Factors

2000
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jun-15, Volume: 20, Issue:12

    Topics: Animals; Animals, Genetically Modified; Aspartic Acid; Atrophy; Brain; Corpus Striatum; Creatine; Crosses, Genetic; Dietary Supplements; Female; Humans; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred Strains; Motor Activity; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nuclear Proteins

2000
N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice.
    Neuroreport, 2000, Nov-27, Volume: 11, Issue:17

    Topics: Animals; Aspartic Acid; Biomarkers; Calbindins; Choline; Corpus Striatum; Creatine; Dopamine and cAMP-Regulated Phosphoprotein 32; Huntington Disease; Immunohistochemistry; Magnetic Resonance Imaging; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Phosphoproteins; S100 Calcium Binding Protein G

2000
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
    Neurobiology of disease, 2001, Volume: 8, Issue:3

    Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Cell Survival; Creatinine; Disease Models, Animal; Energy Metabolism; Female; Huntingtin Protein; Huntington Disease; Hyperglycemia; Insulin; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Motor Activity; Neostriatum; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Organ Size; Survival Rate

2001
Decreased brain N-acetylaspartate in Huntington's disease.
    Brain research, 1992, May-15, Volume: 580, Issue:1-2

    Topics: Aspartic Acid; Brain; Female; Humans; Huntington Disease; Male

1992