n-acetylaspartic acid has been researched along with Disease Models, Animal in 137 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (7.30) | 18.2507 |
| 2000's | 49 (35.77) | 29.6817 |
| 2010's | 75 (54.74) | 24.3611 |
| 2020's | 3 (2.19) | 2.80 |
| Authors | Studies |
|---|---|
| Butterfield, DA; Hinchie, A; Powell, DK; Ren, X; Swomley, A | 1 |
| Gulej, R; Lawrence, B; McKenzie, T; Morton, KA; Saunders, D; Smith, N; Towner, RA | 1 |
| Kashiwaya, Y; King, MT; Pawlosky, RJ; Veech, RL | 1 |
| Bennedsgaard, K; Henriksen, TB; Holm, IE; Kerrn-Jespersen, S; Kyng, KJ; Pedersen, M; Skajaa, T | 1 |
| Krause, BJ; Kuhla, A; Lindner, T; Müller, L; Power Guerra, N; Rühlmann, C; Stenzel, J; Teipel, S; Vollmar, B | 1 |
| Gong, QY; Gu, GJ; Guo, Y; Liu, JH; Wang, MY; Xu, JR; Zhang, B; Zhang, Q; Zhang, W | 1 |
| Azuma, S; Fu, K; Iegaki, N; Ishikawa, Y; Miyamoto, Y; Muramatsu, SI; Nitta, A; Sumi, K; Uno, K | 1 |
| Bongers, A; Cederholm, J; Delerue, F; Don, AS; Fröhlich, D; Harasta, AE; Housley, GD; Ittner, LM; Klugmann, CB; Klugmann, M; McLean, CA; Parley, KE; Pickford, R; Rae, CD; Rowlands, BD; Schneider, M; Spencer, ZHT; Teahan, O; von Jonquieres, G | 1 |
| Choi, CG; Choi, Y; Ha, HK; Ham, SJ; Jeon, SB; Jung, SC; Kim, J; Kim, JK; Kim, KW; Kim, ST; Kwon, JI; Shim, WH; Sung, YS; Woo, CW; Woo, DC | 1 |
| Alkhayer, K; Clements, R; Freeman, E; McDonough, J; Shelestak, J; Singhal, NK | 1 |
| Chitturi, J; Kannurpatti, SS; Li, Y; Santhakumar, V | 1 |
| Akimoto, H; Kobayashi, D; Negishi, A; Nemoto, T; Oshima, S; Sugiyama, T | 1 |
| Cao, Y; Ren, H; Wang, J; Wu, W; Xu, S; Zhang, K; Zhang, M; Zheng, D; Zhong, C | 1 |
| Knedlik, T; Konvalinka, J; Tykvart, J; Vorlova, B | 1 |
| Kantarci, K | 1 |
| Arahuetes, RM; de Munck, E; Gil, C; Martínez, A; Miguel, BG; Muñoz-Sáez, E; Ojeda, I; Solas, MT | 1 |
| Chen, D; Fu, W; Sun, X; Wang, X; Zheng, Z; Zhuang, W | 1 |
| Fang, F; Fang, K; Hou, Z; Lei, H; Lin, X; Liu, M; Liu, S; Meng, H; Sun, B; Zhang, Z | 1 |
| Balayssac, S; Déjean, S; Francés, B; Gilard, V; Halley, H; Lalande, J; Lassalle, JM; Malet-Martino, M; Martino, R | 1 |
| Aoki, I; Barkovich, AJ; Iwasaki, N; Nitta, N; Saito, S; Takanashi, J; Tanaka, R | 1 |
| Francis, JS; Leone, P; Markov, V | 1 |
| Chamberlain, R; Curran, GL; Garwood, M; Jack, CR; Kobayashi, D; Lin, JC; Marjańska, M; Poduslo, JF; Preboske, G; Weigand, SD; Wengenack, TM | 1 |
| Amorini, AM; Belli, A; Di Pietro, V; Lazzarino, G; Logan, A; Signoretti, S; Tavazzi, B; Vagnozzi, R | 1 |
| Liu, X; Peng, D; Ren, M; Wang, L; Wang, Y | 1 |
| Heinze, CR; King, JA; Liso Navarro, AA; Moore, CM; Rogan, RC; Russell, VA; Sikoglu, EM | 1 |
| Chen, G; Cheng, K; Fan, S; Li, J; Li, W; Liu, Z; Tang, G; Xie, P; Yang, D; Yang, Y; Zhang, R; Zhou, J | 1 |
| Bartko, JJ; Choi, C; Ghose, S; Hulsey, K; Mihalakos, P; Morris, SU; Stan, AD; Tamminga, CA; Yanagi, M; Zhao, C | 1 |
| Alt, C; Luong, R; Manning-Bog, A; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Zahr, NM | 1 |
| Cady, EB; Raivich, G; Robertson, NJ; Thayyil, S | 1 |
| Fievisohn, EM; Hardy, WN; Sajja, VS; Vandevord, PJ | 1 |
| Herndon, JG; Komery, A; Li, CX; Li, Y; Mao, H; Novembre, FJ; Zhang, X | 1 |
| Babb, JS; George, AE; Gonen, O; Gonzalez, RG; Kirov, II; Ratai, EM; Tal, A; Wu, WE | 1 |
| Dubovický, M; Kašparová, S; Kucharská, J; Liptaj, T; Lipták, B; Sumbalová, Z; Szomolányi, P; Trattnig, S; Tušková, R; Uličná, O; Vančová, O | 1 |
| Bannerman, P; Burns, T; Freeman, E; Guo, F; Li, S; McDonough, JA; Miers, L; Mills Ko, E; Pleasure, D; Xu, J | 1 |
| Doert, A; Eckert, GP; Müller, WE; Pilatus, U; Zanella, F | 1 |
| Berneman, Z; Daans, J; Guglielmetti, C; Hens, N; Kara, F; Orije, J; Ponsaerts, P; Praet, J; Santermans, E; Van der Linden, A; Verhoye, M | 1 |
| Cohen, Y; Eisenkraft, A; Kadar, T; Kassirer, M; Milk, N; Rosman, Y; Shiyovich, A; Shrot, S; Tauber, M | 1 |
| Denic, A; Rodriguez, M; Warrington, AE; Watzlawik, JO; Wootla, B | 1 |
| Han, L; Hao, S; Hou, Z; Liu, B; Mao, X; Tao, X; Tian, R; Zhang, Q; Zhu, Z | 1 |
| Takanashi, J | 1 |
| Alonso-Alconada, D; Bainbridge, A; Bennett, K; Broad, KD; Ezzati, M; Fierens, I; Fleiss, B; Golay, X; Gressens, P; Hausenloy, DJ; Hristova, M; Jane Hassell, K; Kawano, G; Lebon, S; Oliver-Taylor, A; Robertson, NJ; Rocha-Ferreira, E; Rostami, J; Tachtsidis, I; Yellon, D | 1 |
| Alonso-Alconada, D; Bainbridge, A; Broad, KD; Ezzati, M; Fierens, I; Fleiss, B; Golay, X; Gressens, P; Hassell, J; Kawano, G; Ma, D; Robertson, NJ; Rocha-Ferreira, E; Sanders, RD; Tachtsidis, I | 1 |
| Cordero, MI; Just, N; Poirier, GL; Sandi, C | 1 |
| Chae, SW; Kim, DY; Lee, YT; Park, CR; Yoon, KJ | 1 |
| Kunisawa, N; Kuramoto, T; Kuwamura, M; Nishitani, A; Ohno, Y; Sakuma, T; Shimizu, S; Suzuki, T; Takenaka, S; Tanaka, M; Yamamoto, T; Yokoe, M; Yoshida, Y | 1 |
| Bettschart-Wolfensberger, R; Carrera, I; Mauch, J; Ohlerth, S; Ringer, SK; Spielmann, N; Weiss, M | 1 |
| Morton, AJ; Sawiak, SJ; Wood, NI | 1 |
| Carvalho, F; Carvalho, RA; Cunha, RA; Fonseca, R; Fontes Ribeiro, CA; Jarak, I; Köfalvi, A; Lemos, C; Pereira, FC; Pita, IR; Prediger, RD; Sequeira, AC; Silva, CD | 1 |
| de Lanerolle, N; Kelly, KM; Pan, JW; Pearce, PS; Rapuano, A; Wu, Y | 1 |
| Bannerman, P; Burns, T; Croteau, C; Guo, F; McDonough, JA; Miers, L; Pleasure, D; Singhal, NK; Sohn, J | 1 |
| Gao, G; Gessler, DJ; King, J; Li, D; Matalon, R; Moore, C; Sanmiguel, J; Su, Q; Tuncer, S; Xu, H | 1 |
| Fang, F; Han, D; Hu, L; Lei, H; Liu, H; Liu, M; Xia, SA; Zhu, H | 1 |
| Heiland, S; Poli, S; Schilling, L; Schubert, GA; Thomé, C | 1 |
| Andresen, J; Bjørnerud, A; De Lange, C; Emblem, KE; Hald, JK; Kro, GA; Løberg, EM; Munkeby, BH; Winther-Larssen, EH | 1 |
| Gröhn, H; Gröhn, OH; Immonen, RJ; Kharatishvili, I; Niskanen, JP; Pitkänen, A | 1 |
| Barres, BA; Cerda, SR; Dugas, J; Popko, B; Traka, M; Wollmann, RL | 1 |
| Berger-Sweeney, JE; Kolodny, NH; Nag, N; Ward, BC | 1 |
| Baik, SK; Chang, KH; Cho, BM; Choi, SH; Kim, DH; Kim, HJ; Kim, YW; Lee, JW; Lee, SH | 1 |
| Eyjolfsson, EM; Kondziella, D; Risa, O; Saether, O; Sonnewald, U | 1 |
| de Mattos Dutra, A; Dutra-Filho, CS; Henn, NT; Pederzolli, CD; Rockenbach, FJ; Romagna, EC; Sgaravatti, AM; Wajner, M; Wannmacher, CM; Wyse, AT; Zanin, FR | 1 |
| Baslow, MH; Guilfoyle, DN | 1 |
| Bombardier, JP; González, RG; Greco, JB; Halpern, E; He, J; Joo, CG; Lackner, AA; Lee, V; Lentz, MR; Pilkenton, SJ; Ratai, EM; Turk, KW; Westmoreland, S | 1 |
| Chen, XR; Fulla-Oller, L; Gillet, B; Lescot, T; Marchand-Leroux, C; Meric, P; Plotkine, M; Po, C; Puybasset, L | 1 |
| Ariyannur, PS; Arun, P; Grunberg, NE; Hamilton, K; Ives, JA; Moffett, JR; Namboodiri, AM; Xing, G | 1 |
| Foniok, T; Grieb, P; Jasiński, A; Kirk, D; Labak, M; Rushforth, D; Tomanek, B | 1 |
| Choi, JK; Dedeoglu, A; Jenkins, BG; Küstermann, E | 1 |
| Cohen, Y; Melamed, E; Offen, D; Sadan, O; Shemesh, N | 1 |
| Herrera, JJ; Narayana, PA; Qian, J | 1 |
| Kim, KS; Kim, ST; Lee, BS; Woo, CW | 1 |
| Anikster, Y; Ariyannur, PS; Arun, P; Denu, JM; Gahl, WA; Grunberg, NE; Hallows, WC; Hamilton, K; Madhavarao, CN; Moffett, JR; Mog, S; Namboodiri, AM | 1 |
| Huang, W; Lei, H; Wang, X; Xu, W; Zhan, Y; Zhang, S | 1 |
| Choe, BY; Choi, CB; Choi, WS; Jahng, GH; Kim, HY; Kim, SY; Lee, SH; Ryu, KN; Yang, DM; Yim, SV | 1 |
| Lazzarino, G; Signoretti, S; Tavazzi, B; Vagnozzi, R | 1 |
| Berthet, C; Gruetter, R; Hirt, L; Lei, H | 1 |
| Alexander, M; Becker, A; Bettecken, T; Binder, EB; Bradley, B; Breen, G; Cichon, S; Craig, IW; Czamara, D; Czisch, M; Demirkan, A; Heck, A; Hek, K; Hennings, J; Hoehn, D; Hofman, A; Holsboer, F; Ising, M; Kohli, MA; Lewis, CM; Lucae, S; Maier, W; Menke, A; Müller, MB; Müller-Myhsok, B; Nöthen, MM; Ressler, KJ; Rietschel, M; Ripke, S; Saemann, PG; Salyakina, D; Schmidt, MV; Schramm, J; Schreiber, S; Specht, M; Tiemeier, H; Uhr, M; van Duijn, CM; Wolf, C | 1 |
| Amorini, AM; Barrios, L; Di Pietro, V; Marmarou, A; Marmarou, CR; Pascual, JM; Prieto, R; Tavazzi, B; Taya, K | 1 |
| Cuenod, M; das Neves Duarte, JM; Do, KQ; Gholam-Razaee, MM; Gruetter, R; Kulak, A | 1 |
| Ai, YX; Chen, FY; Li, YG; Liu, LJ; Liu, W; Shu, XJ; Sun, XH; Zhao, H; Zhu, C | 1 |
| Chan, KC; Hui, J; Li, L; Liu, S; Nie, B; Reynolds, GP; Shan, B; Teng, G; Wu, EX; Xi, G; Zhang, X; Zhang, Z | 1 |
| Czisch, M; Holsboer, F; Kaltwasser, SF; Knapman, A; Landgraf, R; Martins-de-Souza, D; Touma, C; Turck, CW | 1 |
| Bieber, A; Denic, A; Macura, S; Pirko, I; Rodriguez, M; Wootla, B | 1 |
| Aoki, I; Barkovich, AJ; Inoue, K; Ito, Y; Saito, S; Takanashi, J | 1 |
| Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW | 1 |
| Cai, Q; Chen, SQ; Shen, YY; Teng, GJ; Wang, PJ; Zang, FC; Zhang, W | 1 |
| Melø, TM; Nilsen, LH; Saether, O; Sonnewald, U; Witter, MP | 1 |
| Cai, K; Crescenzi, R; Hariharan, H; Haris, M; Kogan, F; Nath, K; Reddy, R; Singh, A | 1 |
| Gui-Yun, Z; Jian, H; Qi, L; Xiao-Song, H; Yi-Fang, W | 1 |
| Bainbridge, A; Cady, E; Chandrasekaran, M; Cheong, J; Faulkner, S; Hristova, M; Iwata, O; Iwata, S; Kapetanakis, A; Kato, T; Raivich, G; Robertson, NJ | 1 |
| Angebault, C; Bielicki, G; Boddaert, N; Brabet, P; Cazevieille, C; Chaix, B; Delettre, C; Gueguen, N; Hamel, CP; Lenaers, G; Mausset-Bonnefont, AL; Puel, JL; Renou, JP; Reynier, P; Rigau, V; Sarzi, E; Seveno, M; Wang, J | 1 |
| Alia, A; Nabuurs, RJ; Natté, R; van Buchem, MA; van Duijn, S; van Duinen, SG | 1 |
| Brinker, T; Samii, M; Schuhmann, MU; Skardelly, M; Stiller, D; Thomas, S | 1 |
| Buist, R; Dawood, MR; Hiebert, T; Johnston, JB; Peeling, J; Power, C; Silva, C | 1 |
| Hadjiconstantinou, M; Neff, NH; Podell, M; Smith, MA | 1 |
| Baslow, MH; Berg, MJ; Bhakoo, KK; Duff, K; Gaynor, K; Marks, N; Matsuoka, Y; Saito, M; Suckow, RF | 1 |
| Elger, CE; Feistner, H; Heinze, HJ; Kudin, AP; Kudina, TA; Kunz, WS; Scheich, H; Schoenfeld, A; Stiller, D; Vielhaber, S | 1 |
| Fuller, RA; González, RG; Greco, JB; Halpern, E; He, J; Kim, JP; Lackner, AA; Lentz, MR; Masliah, E; Ratai, E; Sehgal, PK; Westmoreland, SV | 1 |
| Barantin, L; Montharu, J; Nadal-Desbarats, L; Pourcelot, L; Seguin, F; Serriere, S; Vial, F | 1 |
| Beley, A; Demougeot, C; Giroud, M; Marie, C | 1 |
| Jacobsen, H; Künnecke, B; Loetscher, H; Metzger, F; Ozmen, L; Richards, JG; Steiner, G; von Kienlin, M | 1 |
| Cochran, SM; Morris, BJ; Pratt, JA; Reynolds, GP; Reynolds, LM | 1 |
| Anderson, E; Boska, M; Dou, H; Ellison, B; Gelbard, HA; Gendelman, HE; Mellon, M; Nelson, JA; Uberti, M; Xiong, H | 1 |
| During, MJ; Klugmann, M; Leichtlein, CB; Serikawa, T; Symes, CW; Young, D | 1 |
| Francis, J; Freese, A; Hyland, K; Janson, CG; Leone, P; McPhee, SW; Ong, EO; Raghavan, SS; Serikawa, T | 1 |
| Desruisseaux, MS; Kennan, RP; Lee, SC; Machado, FS; Tanowitz, HB; Tsuji, M; Wittner, M | 1 |
| Amorini, AM; Cimatti, M; Delfini, R; Donzelli, S; Lazzarino, G; Signoretti, S; Tavazzi, B; Vagnozzi, R | 1 |
| Cooper, JD; Griffin, JL; Mitchison, HM; Mortishire-Smith, RJ; Pearce, DA; Pears, MR | 1 |
| Beloeil, JC; Dormont, D; Gillet, B; Herzog, C; Lasmézas, C; Méric, P; Provost, F; Vidal, C | 1 |
| Matalon, R; Surendran, S; Tyring, SK | 1 |
| Falkai, P; Maier, W | 1 |
| Harte, MK; Reynolds, GP | 1 |
| Angenstein, F; Debska-Vielhaber, G; Heinze, HJ; Hilfert, L; Kunz, WS; Leibfritz, D; Ludolph, AC; Niessen, HG; Sander, K; Vielhaber, S; Willker, W | 1 |
| Anthony, DC; Blamire, AM; Broom, KA; Griffin, JL; Lowe, JP; Perry, VH; Scott, H; Sibson, NR; Styles, P | 1 |
| Barrios, L; Cerdán, S; López-Larrubia, P; Pascual, JM; Prieto, R; Roda, JM; Solivera, J | 1 |
| de Lanerolle, NC; Gomes, WA; Hetherington, HP; Lado, FA; Pan, C; Takahashi, K | 1 |
| Amorini, AM; Belli, A; Cimatti, M; Delfini, R; Di Pietro, V; Finocchiaro, A; Lazzarino, G; Signoretti, S; Tavazzi, B; Vagnozzi, R | 1 |
| Hiremath, GK; Najm, IM | 1 |
| Blezer, EL; Jongsma, MJ; Olivier, B; Philippens, IH; van Vliet, SA; van Vlieta, SA; Vanwersch, RA | 1 |
| Baek, C; Gwak, M; Jeong, S; Kim, K; Lee, J; Lim, K; Park, P | 1 |
| Bahn, S; Griffin, JL; Holmes, E; Huang, JT; Lan, MJ; Manji, H; McLoughlin, GA; Tsang, TM; Yuan, P | 1 |
| González, RG; Halpern, EF; Lee, V; Lentz, MR; Ratai, EM; Westmoreland, SV | 1 |
| Hanaya, R; Kiura, Y; Kurisu, K; Sakai, N; Sasa, M; Serikawa, T | 1 |
| Li, ZW; Liu, L; Yang, TT; Zheng, N | 1 |
| Nerush, PA; Raevskiĭ, KS | 1 |
| Comair, YG; Hong, SC; Lüders, HO; Najm, IM; Ng, TC; Wang, Y | 1 |
| Cecil, K; Lenkinski, RE; McIntosh, TK; Rubin, Y; Smith, DH; Wehrli, S | 1 |
| Weinberger, DR | 1 |
| Cecil, KM; Lenkinski, RE; McIntosh, TK; Meaney, DF; Smith, DH | 1 |
| Hayakawa, T; Kohmura, E; Nonaka, M; Wakayama, A; Yamashita, T; Yoshimine, T | 1 |
| Klinkosz, B; Mitsumoto, H; Moore, JK; Ng, TC; Pioro, EP; Trapp, BD; Wang, Y | 1 |
| Inagaki, C; Omori, K; Sasa, M | 1 |
| Lüders, HO; Maton, BM; Najm, IM; Ng, TC; Wang, Y | 1 |
| Matalon, R; Michals-Matalon, K | 1 |
| Al-Samsam, RH; Alessandri, B; Bullock, R | 1 |
| Balbo, A; Chikhale, EG; Galdzicki, Z; Huang, W; Rapoport, SI; Schapiro, MB; van Gelderen, P | 1 |
| Beley, A; Bertrand, N; Demougeot, C; Garnier, P; Giroud, M; Marie, C; Mossiat, C | 1 |
| Andreassen, OA; Beal, MF; Borchelt, DR; Browne, SE; Dedeoglu, A; Ferrante, KL; Ferrante, RJ; Friedlich, A; Hersch, SM; Jenkins, BG; Ross, CA; Schilling, G; Thomas, M | 1 |
| Baslow, MH; Hungund, BL; Kitada, K; Serikawa, T; Suckow, RF | 1 |
11 review(s) available for n-acetylaspartic acid and Disease Models, Animal
| Article | Year |
|---|---|
GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antigens, Surface; Aspartic Acid; Biomarkers, Tumor; Brain; Carboxypeptidases; Disease Models, Animal; Glutamate Carboxypeptidase II; Glutamates; Humans; Hydrolysis; Inflammatory Bowel Diseases; Intestine, Small; Jejunum; Male; Mice; Mice, Mutant Strains; Mice, Transgenic; Neuropeptides; Peptide Hydrolases; Phenotype; Prostatic Neoplasms; Rats | 2019 |
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; Diagnosis, Differential; Disease Models, Animal; Disease Progression; Energy Metabolism; Humans; Inositol; Magnetic Resonance Spectroscopy; Mice; Translational Research, Biomedical | 2013 |
Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications.
Topics: Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Biomarkers; Choline; Creatine; Disease Models, Animal; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic Acid; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Pregnancy; Sensitivity and Specificity; Swine | 2014 |
Neurochemistry of Hypomyelination Investigated with MR Spectroscopy.
Topics: Animals; Aspartic Acid; Brain Chemistry; Choline; Creatine; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Pelizaeus-Merzbacher Disease; Proton Magnetic Resonance Spectroscopy | 2015 |
Biochemical and neurochemical sequelae following mild traumatic brain injury: summary of experimental data and clinical implications.
Topics: Animals; Aspartic Acid; Brain; Brain Injuries; Diffuse Axonal Injury; Disease Models, Animal; Humans; Magnetic Resonance Spectroscopy; Oxidative Stress; Rats | 2010 |
N-acetylaspartate: a literature review of animal research on brain ischaemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Chromatography, High Pressure Liquid; Disease Models, Animal; Disease Progression; Magnetic Resonance Spectroscopy; Neurons | 2004 |
[Advances in neurobiological understanding of schizophrenia. Perspectives for new therapeutic concepts].
Topics: Animals; Aspartic Acid; Brain; Carrier Proteins; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Dopamine; Dysbindin; Dystrophin-Associated Proteins; Glutamine; Humans; Intracellular Signaling Peptides and Proteins; Magnetic Resonance Spectroscopy; Nerve Tissue Proteins; Neuregulin-1; Neurons; Neuropil; Risk Factors; Schizophrenia; Synaptic Transmission | 2006 |
Magnetic resonance spectroscopy in animal models of epilepsy.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Choline; Creatine; Disease Models, Animal; Epilepsy; Hydrogen; Immunohistochemistry; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Rats; Sodium Isotopes | 2007 |
The biological basis of schizophrenia: new directions.
Topics: Animals; Aspartic Acid; Brain; Cholecystokinin; Disease Models, Animal; Dopamine; Entorhinal Cortex; gamma-Aminobutyric Acid; Genetic Linkage; Genetic Markers; Glutamic Acid; Humans; RNA, Messenger; Rodentia; Schizophrenia | 1997 |
[Molecular mechanism underlying epileptic seizure: forwards development of novel drugs for untreatable epilepsy].
Topics: Amidohydrolases; Animals; Anticonvulsants; Aspartic Acid; Brain-Derived Neurotrophic Factor; Ceruloplasmin; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Genes, fos; Hippocampus; Humans; Kindling, Neurologic; Mice; Nerve Growth Factors; Potassium Channels; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Receptors, AMPA | 1999 |
Recent advances in Canavan disease.
Topics: Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Child; Diagnosis, Differential; Disease Models, Animal; Genetic Counseling; Genetic Testing; Genotype; Humans; Jews; Magnetic Resonance Imaging; Mutation; Phenotype | 1999 |
126 other study(ies) available for n-acetylaspartic acid and Disease Models, Animal
| Article | Year |
|---|---|
Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Corpus Striatum; Disease Models, Animal; Female; Gene Knockout Techniques; Glutamine; Glutathione; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurodegenerative Diseases; Oxidative Stress; Parkinson Disease; Protein Kinases; Rats; Taurine | 2019 |
Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspartic Acid; Benzenesulfonates; Brain Diseases; Cerebral Cortex; Cerebrovascular Circulation; Choline; Contrast Media; Creatine; Disease Models, Animal; Hippocampus; Imines; Inositol; Lipopolysaccharides; Magnetic Resonance Imaging; Perfusion Imaging; Rats, Sprague-Dawley; Regional Blood Flow | 2019 |
A Dietary Ketone Ester Normalizes Abnormal Behavior in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Brain; Citric Acid Cycle; Diet; Disease Models, Animal; Esters; Glucose; Glutamic Acid; Hippocampus; Ketone Bodies; Ketones; Ketosis; Male; Mice | 2020 |
Short-term outcomes of remote ischemic postconditioning 1 h after perinatal hypoxia-ischemia in term piglets.
Topics: Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Brain; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Female; Hypoxia-Ischemia, Brain; Ischemic Postconditioning; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Sus scrofa; Time Factors | 2021 |
Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animal Nutritional Physiological Phenomena; Animals; Aspartic Acid; Autophagy; Calcium-Binding Proteins; Caloric Restriction; Cerebral Cortex; Creatine; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Hippocampus; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Neurons; Plaque, Amyloid; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals | 2021 |
NSCs promote hippocampal neurogenesis, metabolic changes and synaptogenesis in APP/PS1 transgenic mice.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Cognition Disorders; Creatine; Disease Models, Animal; Glutamic Acid; Hippocampus; Male; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neurogenesis; Synapses | 2017 |
Striatal N-Acetylaspartate Synthetase Shati/Nat8l Regulates Depression-Like Behaviors via mGluR3-Mediated Serotonergic Suppression in Mice.
Topics: Acetyltransferases; Animals; Aspartic Acid; Corpus Striatum; Depression; Dipeptides; Disease Models, Animal; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Hindlimb Suspension; Humans; Interpersonal Relations; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microdialysis; Microinjections; Receptors, Metabotropic Glutamate; Serotonin; Swimming; Transduction, Genetic | 2017 |
Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.
Topics: Acetyltransferases; Amidohydrolases; Animals; Aspartic Acid; Brain; Canavan Disease; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Evoked Potentials, Visual; Female; Genetic Therapy; Humans; Male; Mice, Transgenic; Neurons; Oligodendroglia; Phenotype; RNA, Messenger | 2018 |
The administration of hydrogen sulphide prior to ischemic reperfusion has neuroprotective effects in an acute stroke model.
Topics: Animals; Apoptosis; Aspartic Acid; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Humans; Hydrogen Sulfide; Neuroprotective Agents; Rats; Reperfusion Injury; Stroke; Taurine | 2017 |
Erythropoietin Upregulates Brain Hemoglobin Expression and Supports Neuronal Mitochondrial Activity.
Topics: Animals; Aspartic Acid; Brain; Cell Respiration; Cuprizone; Disease Models, Animal; Electron Transport Complex III; Erythropoietin; Hemoglobins; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Mitochondria; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neurons; Up-Regulation | 2018 |
Early behavioral and metabolomic change after mild to moderate traumatic brain injury in the developing brain.
Topics: Animals; Aspartic Acid; Behavior, Animal; Biomarkers; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Energy Metabolism; Male; Rats; Rats, Sprague-Dawley; Time Factors | 2018 |
Changes in brain metabolites related to stress resilience: Metabolomic analysis of the hippocampus in a rat model of depression.
Topics: Anhedonia; Animals; Aspartic Acid; Biomarkers; Brain-Derived Neurotrophic Factor; Depressive Disorder; Dietary Sucrose; Disease Models, Animal; Disease Susceptibility; Food Preferences; Hippocampus; Male; Metabolomics; Motor Activity; Rats, Wistar; Resilience, Psychological; Stress, Psychological | 2019 |
Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; Glutamate Carboxypeptidase II; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Mice, Knockout; Proton Magnetic Resonance Spectroscopy | 2018 |
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 3; Choline; Creatinine; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Endoplasmic Reticulum; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Magnetic Resonance Spectroscopy; Male; Mitochondria; Motor Activity; Motor Cortex; Nerve Degeneration; Neurologic Examination; Phenotype; Rats; Rats, Wistar; Spinal Cord; Time Factors | 2013 |
Neural metabolite changes in corpus striatum after rat multipotent mesenchymal stem cells transplanted in hemiparkinsonian rats by magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Cell Differentiation; Cell Survival; Choline; Corpus Striatum; Creatine; Disease Models, Animal; Female; Magnetic Resonance Spectroscopy; Male; Mesenchymal Stem Cell Transplantation; Microtubule-Associated Proteins; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine 3-Monooxygenase | 2013 |
Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods.
Topics: Animals; Aspartic Acid; Choline; Corpus Striatum; Creatine; Disease Models, Animal; Frontal Lobe; Functional Laterality; Functional Neuroimaging; Glutamates; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Male; Motor Activity; Oxidopamine; Parietal Lobe; Parkinson Disease, Secondary; Rats; Substantia Nigra; Time Factors | 2014 |
1H NMR metabolomic signatures in five brain regions of the AβPPswe Tg2576 mouse model of Alzheimer's disease at four ages.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cerebellum; Cerebral Cortex; Disease Models, Animal; Genotype; Glutamic Acid; Hippocampus; Magnetic Resonance Spectroscopy; Male; Mesencephalon; Metabolome; Mice; Mice, Transgenic; Tissue Extracts | 2014 |
Neurochemistry in shiverer mouse depicted on MR spectroscopy.
Topics: Amino Acid Transport Systems, Acidic; Analysis of Variance; Animals; Antiporters; Aspartic Acid; Brain; Cerebral Cortex; Choline; Disease Models, Animal; Hereditary Central Nervous System Demyelinating Diseases; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Mice, Neurologic Mutants; Mitochondrial Diseases; Myelin Basic Protein; Neurochemistry; Psychomotor Disorders; Thalamus; White Matter | 2014 |
Dietary triheptanoin rescues oligodendrocyte loss, dysmyelination and motor function in the nur7 mouse model of Canavan disease.
Topics: Adenosine Triphosphate; Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Disease Models, Animal; Mice; Myelin Sheath; Oligodendroglia; Triglycerides | 2014 |
Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Choline; Disease Models, Animal; Humans; Immunization, Passive; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Peptide Fragments; Presenilin-1; Statistics, Nonparametric | 2014 |
The molecular mechanisms affecting N-acetylaspartate homeostasis following experimental graded traumatic brain injury.
Topics: Acetyltransferases; Adenosine Diphosphate; Adenosine Triphosphate; Amidohydrolases; Animals; Aspartic Acid; Brain; Brain Injuries; Disease Models, Animal; Male; Mitochondria; Phosphorylation; Rats; Rats, Wistar | 2014 |
[Effects of estrogen replacement therapy on cognitive function of ovariectomized rats].
Topics: Animals; Aspartic Acid; Cognition; Creatine; Disease Models, Animal; Estradiol; Estrogen Replacement Therapy; Female; Hippocampus; Magnetic Resonance Spectroscopy; Maze Learning; Memory; Menopause; Ovariectomy; Rats; Rats, Sprague-Dawley; Time Factors | 2014 |
Effect of diet on brain metabolites and behavior in spontaneously hypertensive rats.
Topics: Animals; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Brain; Creatine; Dietary Fats; Disease Models, Animal; Energy Metabolism; Fish Oils; Frontal Lobe; Glutamic Acid; Locomotion; Male; Maze Learning; Motor Activity; Proton Magnetic Resonance Spectroscopy; Psychomotor Performance; Rats; Rats, Inbred SHR; Risk-Taking | 2014 |
Amino acid metabolic dysfunction revealed in the prefrontal cortex of a rat model of depression.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; beta-Alanine; Depressive Disorder, Major; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Glycerol; Isoleucine; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Psychological | 2015 |
Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophrenia.
Topics: Adolescent; Adult; Animals; Aspartic Acid; Dentate Gyrus; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Knockout; Middle Aged; Nerve Tissue Proteins; Postmortem Changes; Protons; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction; Young Adult | 2015 |
Associations between in vivo neuroimaging and postmortem brain cytokine markers in a rodent model of Wernicke's encephalopathy.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Creatine; Cytokines; Disease Models, Animal; Liver; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurologic Examination; Rats; Rats, Wistar; Thiamine; Time Factors; Wernicke Encephalopathy | 2014 |
Evaluation of impact-induced traumatic brain injury in the Göttingen Minipig using two input modes.
Topics: Animals; Aspartic Acid; Brain Injuries; Dipeptides; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Swine; Swine, Miniature | 2014 |
Longitudinal cerebral metabolic changes in pig-tailed macaques infected with the neurovirulent virus SIVsmmFGb.
Topics: Animals; Aspartic Acid; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Choline; Corpus Striatum; Creatine; Disease Models, Animal; HIV Infections; Humans; Inositol; Longitudinal Studies; Macaca nemestrina; Male; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Virulence | 2014 |
Early glial activation precedes neurodegeneration in the cerebral cortex after SIV infection: a 3D, multivoxel proton magnetic resonance spectroscopy study.
Topics: Animals; Aspartic Acid; Biomarkers; Central Nervous System Diseases; Cerebral Cortex; Choline; Creatine; Disease Models, Animal; Female; Macaca mulatta; Male; Proton Magnetic Resonance Spectroscopy; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus | 2015 |
Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Dementia; Dipeptides; Disease Models, Animal; Galactose; Inositol; Magnetic Resonance Spectroscopy; Male; Nootropic Agents; Organ Size; Phosphorus Isotopes; Protons; Rats, Wistar; Simvastatin; Spatial Learning; Spatial Memory; Thiobarbituric Acid Reactive Substances; Treatment Outcome; Ubiquinone | 2015 |
Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model.
Topics: Animals; Aspartic Acid; Canavan Disease; Disease Models, Animal; Female; Male; Mice; Mice, Knockout | 2015 |
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Carbon-13 Magnetic Resonance Spectroscopy; Creatine; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Male; Mice, Transgenic; Mutation; Peptide Fragments; Phosphorylcholine; Proton Magnetic Resonance Spectroscopy | 2015 |
Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra.
Topics: Animals; Aspartic Acid; Brain Chemistry; Choline; Creatine; Cuprizone; Demyelinating Diseases; Dipeptides; Disease Models, Animal; Female; Gliosis; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neuroimaging; Oligodendroglia; Phosphocreatine; Proton Magnetic Resonance Spectroscopy | 2015 |
Early brain magnetic resonance imaging can predict short and long-term outcomes after organophosphate poisoning in a rat model.
Topics: Animals; Aspartic Acid; Atropine; Behavior, Animal; Brain; Brain Edema; Choline; Cholinesterase Reactivators; Cognition; Creatine; Disease Models, Animal; Drug Therapy, Combination; Early Diagnosis; Magnetic Resonance Imaging; Male; Maze Learning; Midazolam; Neuroprotective Agents; Obidoxime Chloride; Organophosphate Poisoning; Paraoxon; Predictive Value of Tests; Proton Magnetic Resonance Spectroscopy; Rats, Sprague-Dawley; Scopolamine; Time Factors; Weight Loss | 2015 |
A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.
Topics: Animals; Antibodies, Monoclonal; Aspartic Acid; Axons; Brain; Brain Stem; Disease Models, Animal; Humans; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Mice; Multiple Sclerosis; Spinal Cord; Statistics, Nonparametric; Theilovirus; Viral Envelope Proteins | 2015 |
Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Choline; Creatine; Decompressive Craniectomy; Disease Models, Animal; Lactic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Male; Proton Magnetic Resonance Spectroscopy; Random Allocation; Rats, Sprague-Dawley; Treatment Outcome | 2015 |
Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Brain Mapping; Disease Models, Animal; Electroencephalography; Gene Expression; Gray Matter; Hypoxia-Ischemia, Brain; Immunohistochemistry; Ischemic Postconditioning; KATP Channels; Lactic Acid; Lower Extremity; Magnetic Resonance Spectroscopy; Receptor, Endothelin A; Swine; White Matter | 2016 |
Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia.
Topics: Animals; Animals, Newborn; Argon; Aspartic Acid; Asphyxia Neonatorum; Blood Chemical Analysis; Blood Pressure; Brain; Cell Death; Disease Models, Animal; Heart Rate; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Inhalation; Lactic Acid; Male; Neuroprotection; Random Allocation; Respiration, Artificial; Sus scrofa | 2016 |
Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum.
Topics: Age Factors; Aggression; Animals; Animals, Newborn; Anxiety Disorders; Aspartic Acid; Creatine; Disease Models, Animal; Female; Glutamate Decarboxylase; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Maze Learning; Phosphorylcholine; Rats; Rats, Wistar; Septal Nuclei; Stress, Psychological; Tritium | 2016 |
Effects of anodal transcranial direct current stimulation (tDCS) on behavioral and spatial memory during the early stage of traumatic brain injury in the rats.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain Edema; Brain Injuries, Traumatic; Brain-Derived Neurotrophic Factor; Creatine; Disease Models, Animal; Functional Laterality; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maze Learning; Memory Disorders; Motor Activity; Rats; Time Factors; Transcranial Direct Current Stimulation | 2016 |
Involvement of aspartoacylase in tremor expression in rats.
Topics: Amidohydrolases; Animals; Aspartic Acid; Central Nervous System; Codon, Nonsense; Disease Models, Animal; Epistasis, Genetic; Essential Tremor; Exons; Gene Deletion; Genetic Association Studies; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Mice; Mutation, Missense; Potassium Channels; Rats; Rats, Mutant Strains | 2016 |
Effects of hypotension and/or hypocapnia during sevoflurane anesthesia on perfusion and metabolites in the developing brain of piglets-a blinded randomized study.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain; Choline; Disease Models, Animal; Female; Hypocapnia; Hypotension; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methyl Ethers; Sevoflurane; Single-Blind Method; Swine | 2016 |
Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy.
Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Disease Progression; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Trinucleotide Repeats | 2016 |
Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.
Topics: Anhedonia; Animals; Aspartic Acid; Brain Injuries; Central Nervous System Stimulants; Cerebral Cortex; Disease Models, Animal; Exploratory Behavior; Food Preferences; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Glutamic Acid; Grooming; Male; Maze Learning; Methamphetamine; Mice; Mice, Inbred C57BL; Motor Activity | 2017 |
Metabolic injury in a variable rat model of post-status epilepticus.
Topics: Animals; Aspartic Acid; Cluster Analysis; Creatine; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metabolic Diseases; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2016 |
Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy.
Topics: Animals; Aspartic Acid; Canavan Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons | 2017 |
Redirecting
Topics: Amidohydrolases; Animals; Aspartic Acid; Blood-Brain Barrier; Canavan Disease; Central Nervous System; Dependovirus; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Humans; Mice; Oligodendroglia | 2017 |
Metabolic changes in temporal lobe structures measured by HR-MAS NMR at early stage of electrogenic rat epilepsy.
Topics: Animals; Aspartic Acid; Brain Mapping; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Temporal Lobe; Time Factors | 2008 |
Hypothermia reduces cytotoxic edema and metabolic alterations during the acute phase of massive SAH: a diffusion-weighted imaging and spectroscopy study in rats.
Topics: Acute Disease; Animals; Aspartic Acid; Body Temperature; Brain; Brain Edema; Cerebral Cortex; Creatine; Diffusion; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Energy Metabolism; Hippocampus; Hypothermia, Induced; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage | 2008 |
A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistry; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Hypoxia-Ischemia, Brain; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Microtubule-Associated Proteins; Swine | 2008 |
Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat--11 months follow-up.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Injuries; Creatine; Diffusion Magnetic Resonance Imaging; Dipeptides; Disease Models, Animal; Follow-Up Studies; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Statistics, Nonparametric; Time Factors | 2009 |
Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS.
Topics: Age Factors; Amidohydrolases; Animals; Animals, Newborn; Aspartic Acid; Axons; Behavior, Animal; Canavan Disease; Central Nervous System; Chromosome Mapping; Codon, Nonsense; Disease Models, Animal; Disease Progression; Glutamine; Lipid Metabolism; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Sheath; N-Acylsphingosine Galactosyltransferase; Oligodendroglia | 2008 |
Neurochemical changes in a mouse model of Rett syndrome: changes over time and in response to perinatal choline nutritional supplementation.
Topics: Age Factors; Animals; Animals, Newborn; Aspartic Acid; Brain; Choline; Creatine; Dietary Supplements; Disease Models, Animal; DNA-Binding Proteins; Glutamic Acid; Glutamine; Histone Deacetylases; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Rett Syndrome; Spectrum Analysis | 2009 |
Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.
Topics: Animals; Aspartic Acid; Brain; Cats; Choline; Contrast Media; Creatine; Disease Models, Animal; Disease Progression; Embolism, Fat; Follow-Up Studies; Gadolinium DTPA; Image Enhancement; Intracranial Embolism; Lactic Acid; Lipid Metabolism; Lipids; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Sodium Chloride; Triolein | 2008 |
Gray matter metabolism in acute and chronic hydrocephalus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Creatine; Disease Models, Animal; Glutamic Acid; Hydrocephalus; Image Processing, Computer-Assisted; Inositol; Kaolin; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 2009 |
Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.
Topics: Animals; Antioxidants; Aspartic Acid; Brain Damage, Chronic; Canavan Disease; Catalase; Cerebral Cortex; Dipeptides; Disease Models, Animal; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Injections, Intraventricular; Lipid Peroxidation; Male; Neuropeptides; Neurotoxins; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar | 2009 |
Are astrocytes the missing link between lack of brain aspartoacylase activity and the spongiform leukodystrophy in Canavan disease?
Topics: Amidohydrolases; Animals; Aspartic Acid; Astrocytes; Brain; Canavan Disease; Dipeptides; Disease Models, Animal; Extracellular Fluid; Humans; Myelin Sheath | 2009 |
In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain.
Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Disease Models, Animal; Female; Inositol; Macaca mulatta; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus | 2009 |
Temporal and regional changes after focal traumatic brain injury.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Brain Mapping; Cerebral Cortex; Choline; Creatine; Diffusion; Disease Models, Animal; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Time Factors | 2010 |
Metabolic acetate therapy for the treatment of traumatic brain injury.
Topics: Acetates; Acetic Acid; Acetyl Coenzyme A; Animals; Aspartic Acid; Brain; Brain Injuries; Disease Models, Animal; Energy Metabolism; Lipid Metabolism; Male; Membrane Lipids; Myelin Sheath; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Treatment Outcome; Triacetin; Up-Regulation | 2010 |
Metabolic changes in rat brain following intracerebroventricular injections of streptozotocin: a model of sporadic Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Disease Models, Animal; Electrons; Glucose; Glutathione; Injections, Intraventricular; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Streptozocin | 2010 |
Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Models, Animal; Glutamic Acid; Glutamine; In Vitro Techniques; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Protons; Spectrum Analysis; Superoxide Dismutase | 2009 |
Longitudinal MRI and MRSI characterization of the quinolinic acid rat model for excitotoxicity: peculiar apparent diffusion coefficients and recovery of N-acetyl aspartate levels.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Magnetic Resonance Spectroscopy; Male; Nervous System Diseases; Quinolinic Acid; Rats; Rats, Wistar | 2010 |
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.
Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Immunohistochemistry; Magnetic Resonance Spectroscopy; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Wallerian Degeneration | 2010 |
Correlation between lactate and neuronal cell damage in the rat brain after focal ischemia: An in vivo 1H magnetic resonance spectroscopic (1H-MRS) study.
Topics: Analysis of Variance; Animals; Apoptosis; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Creatinine; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Follow-Up Studies; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Lactic Acid; Lipid Metabolism; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley | 2010 |
Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease.
Topics: Acetates; Animals; Aspartic Acid; Brain; Canavan Disease; Disease Models, Animal; Female; Heterozygote; Lipids; Male; Mutation; Myelin Sheath; Phenotype; Rats; Treatment Outcome | 2010 |
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles | 2010 |
Assessment of metabolic changes in the striatum of a MPTP-intoxicated canine model: in vivo ¹H-MRS study of an animal model for Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Choline; Corpus Striatum; Creatine; Disease Models, Animal; Dogs; Female; Humans; Male; MPTP Poisoning; Tissue Distribution | 2011 |
Early predictive biomarkers for lesion after transient cerebral ischemia.
Topics: Animals; Aspartic Acid; Biomarkers; Disease Models, Animal; Glutamine; Ischemic Attack, Transient; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Predictive Value of Tests; Taurine; Time Factors | 2011 |
The neuronal transporter gene SLC6A15 confers risk to major depression.
Topics: Adult; Amino Acid Transport Systems, Neutral; Analysis of Variance; Animals; Aspartic Acid; Chromosomes, Human, Pair 12; Depressive Disorder, Major; Disease Models, Animal; Female; Gene Expression Regulation; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Germany; Hippocampus; Humans; Linkage Disequilibrium; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Meta-Analysis as Topic; Mice; Middle Aged; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Risk Factors; RNA, Messenger; Stress, Psychological; Tritium; United Kingdom | 2011 |
Brain energy depletion in a rodent model of diffuse traumatic brain injury is not prevented with administration of sodium lactate.
Topics: Adenosine Triphosphate; Animals; Ascorbic Acid; Aspartic Acid; Blood Gas Analysis; Blood Pressure; Brain Chemistry; Brain Injuries; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Energy Metabolism; Glutathione; Male; Models, Biological; NAD; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sodium Lactate | 2011 |
N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development.
Topics: Acetylcysteine; Alanine; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Animal; Free Radical Scavengers; Glutamate-Cysteine Ligase; Glutamic Acid; Glutamine; Glutathione; Inositol; Lactic Acid; Longitudinal Studies; Magnetic Resonance Spectroscopy; Mice; Mice, Knockout; Schizophrenia | 2012 |
Tianeptine reverses stress-induced asymmetrical hippocampal volume and N-acetylaspartate loss in rats: an in vivo study.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Aspartic Acid; Choline; Chromatography, High Pressure Liquid; Corticosterone; Creatine; Disease Models, Animal; Exploratory Behavior; Hippocampus; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Rats, Sprague-Dawley; Statistics as Topic; Stress, Psychological; Thiazepines | 2011 |
Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rat model of depression as measured by 1H-MRS.
Topics: Animals; Aspartic Acid; Behavior, Animal; Citalopram; Creatine; Depression; Disease Models, Animal; Drinking Behavior; Hippocampus; Magnetic Resonance Spectroscopy; Male; Maze Learning; Memory; Organ Size; Protons; Rats; Rats, Sprague-Dawley; Stress, Psychological; Sucrose; Water | 2011 |
Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cognition Disorders; Depressive Disorder, Major; Disease Models, Animal; Energy Metabolism; Hippocampus; Humans; Hypothalamo-Hypophyseal System; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred Strains; Neurons; Pituitary-Adrenal System; Proteome; Stress, Psychological | 2012 |
Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis.
Topics: Animals; Aspartic Acid; Axons; beta 2-Microglobulin; Brain; Brain Stem; CD8 Antigens; Disease Models, Animal; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Multiple Sclerosis; Recovery of Function; Spinal Cord; Theilovirus; Time Factors | 2012 |
Increased N-acetylaspartate in model mouse of Pelizaeus-Merzbacher disease.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dipeptides; Disease Models, Animal; Immunoenzyme Techniques; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Pelizaeus-Merzbacher Disease; Thalamus | 2012 |
Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Aspartic Acid; Brain Mapping; Choline; Creatine; Disease Models, Animal; Epilepsy; Fluorodeoxyglucose F18; Glucose; Hippocampus; Lithium Chloride; Magnetic Resonance Spectroscopy; Male; Pilocarpine; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 2012 |
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Choline; Creatine; Disease Models, Animal; Functional Neuroimaging; Glutamic Acid; Hippocampus; Inositol; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Transgenic; Presenilin-1; Protons | 2012 |
Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Female; Frontal Lobe; gamma-Aminobutyric Acid; Genotype; Glutamic Acid; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Rats, Transgenic | 2012 |
MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Brain Mapping; Choline; Creatine; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Neuroimaging; Presenilin-1; Tritium | 2013 |
Cerebral blood flow and metabolic changes in hippocampal regions of a modified rat model with chronic cerebral hypoperfusion.
Topics: Animals; Aspartic Acid; Cerebrovascular Circulation; Creatine; Disease Models, Animal; Hippocampus; Hypoxia-Ischemia, Brain; Inositol; Laser-Doppler Flowmetry; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 2013 |
Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model.
Topics: Amiloride; Animals; Aspartic Acid; Asphyxia; Brain; Cell Death; Disease Models, Animal; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Microglia; Neuroprotective Agents; Swine | 2013 |
The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.
Topics: Acoustic Stimulation; Age Factors; Aging, Premature; Animals; Aspartic Acid; Chi-Square Distribution; Creatine; Disease Models, Animal; Disease Progression; Electron Transport Chain Complex Proteins; Electron Transport Complex IV; Electroretinography; Evoked Potentials, Auditory, Brain Stem; Evoked Potentials, Visual; Gene Expression Regulation; Glycolysis; GTP Phosphohydrolases; Humans; Lactic Acid; Locomotion; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Diseases; Muscle, Skeletal; Nervous System; Optic Atrophy, Autosomal Dominant; Optic Nerve; Phenotype; Physical Conditioning, Animal; Psychoacoustics; Psychomotor Performance; Reaction Time; Retina; Retinal Ganglion Cells; Sequence Deletion | 2012 |
Longitudinal monitoring of sex-related in vivo metabolic changes in the brain of Alzheimer's disease transgenic mouse using magnetic resonance spectroscopy.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Aspartic Acid; Brain; Creatine; Disease Models, Animal; Female; Glutamic Acid; Humans; Iron; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Presenilin-1 | 2013 |
Long-time in-vivo metabolic monitoring following experimental brain contusion using proton magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Brain Injuries; Disease Models, Animal; Functional Laterality; Glutamic Acid; Hippocampus; Lactates; Magnetic Resonance Imaging; Male; Monitoring, Physiologic; Phosphocreatine; Rats; Rats, Sprague-Dawley; Reference Values; Taurine; Time Factors | 2002 |
Neurovirulence depends on virus input titer in brain in feline immunodeficiency virus infection: evidence for activation of innate immunity and neuronal injury.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain; Cats; CD4-Positive T-Lymphocytes; Cells, Cultured; Choline; Culture Media, Conditioned; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome; Gliosis; Immunity, Innate; Immunodeficiency Virus, Feline; Macrophages; Magnetic Resonance Spectroscopy; Methylamines; Neurons; Virulence | 2002 |
Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Brain; Cats; Choline; Corpus Striatum; Creatine; Disease Models, Animal; Disease Progression; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neurologic Examination; Pargyline; Parkinsonian Disorders; Predictive Value of Tests; Protons; Tyrosine 3-Monooxygenase | 2003 |
Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Brain Diseases; Cell Survival; Cells, Cultured; Disease Models, Animal; Down-Regulation; Fetus; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neuroglia; Neurons; Organ Culture Techniques; Rats; Synaptophysin; Water-Electrolyte Balance | 2003 |
Hippocampal N-acetyl aspartate levels do not mirror neuronal cell densities in creatine-supplemented epileptic rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cell Count; Creatine; Diazepam; Disease Models, Animal; Epilepsy, Temporal Lobe; Food, Formulated; Hippocampus; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Pilocarpine; Rats; Rats, Wistar; Scopolamine; Time Factors | 2003 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creatine; Disease Models, Animal; Disease Progression; Female; Inositol; Longitudinal Studies; Macaca mulatta; Magnetic Resonance Spectroscopy; Male; Predictive Value of Tests; Prospective Studies; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Survival Rate; Viral Load | 2004 |
A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Energy Metabolism; Hydrogen; Hydrogen-Ion Concentration; Hypoxia-Ischemia, Brain; Ischemic Attack, Transient; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Phosphocreatine; Phosphorus Isotopes; Radiopharmaceuticals; Severity of Illness Index; Stroke; Swine | 2004 |
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Disease Models, Animal; Disease Progression; Energy Metabolism; Female; Frontal Lobe; Glutamic Acid; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plaque, Amyloid; Presenilin-2; Spectrum Analysis | 2005 |
Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain.
Topics: Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Corpus Striatum; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Frontal Lobe; Hallucinogens; Hippocampus; Male; Phencyclidine; Psychotic Disorders; Rats; Rats, Long-Evans; Temporal Lobe | 2005 |
Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Aspartic Acid; Brain Mapping; Calcium-Binding Proteins; Capsid Proteins; Choline; Cognition Disorders; Creatine; Disease Models, Animal; Electric Stimulation; Functional Laterality; Glial Fibrillary Acidic Protein; Hippocampus; HIV Infections; HIV-1; Humans; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, SCID; Microfilament Proteins; Microtubule-Associated Proteins; Phosphopyruvate Hydratase; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protons; Time Factors; Vimentin | 2005 |
Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.
Topics: Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Dependovirus; Disease Models, Animal; Female; Gene Expression; Male; Motor Neurons; Myelin Sheath; Rats; Seizures | 2005 |
Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease.
Topics: Amidohydrolases; Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Brain; Canavan Disease; Dependovirus; Disease Models, Animal; Gene Transfer Techniques; Genetic Vectors; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Immunohistochemistry; Locomotion; Phosphopyruvate Hydratase; Psychomotor Performance; Rats; Rats, Mutant Strains; Recombinant Proteins; Tremor | 2005 |
Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria.
Topics: Animals; Aspartic Acid; Axons; Brain; Cerebrovascular Circulation; Disease Models, Animal; Down-Regulation; Magnetic Resonance Imaging; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Plasmodium berghei; Radiography | 2005 |
Hypothesis of the postconcussive vulnerable brain: experimental evidence of its metabolic occurrence.
Topics: Adenosine Triphosphate; Animals; Apyrase; Aspartic Acid; Blood Gas Analysis; Brain; Brain Injuries; Chromatography, High Pressure Liquid; Disease Models, Animal; Energy Metabolism; Male; Rats; Rats, Wistar; Time Factors | 2005 |
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Mice; Mice, Knockout; Models, Biological; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Neurotransmitter Agents; Phenotype; Spectrophotometry; Time Factors | 2005 |
Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Brain; Cattle; Disease Models, Animal; Female; Infections; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Prion Diseases; Scrapie; Time Factors | 2006 |
Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: implications on diabetic neuropathy.
Topics: Amidohydrolases; Animals; Aspartic Acid; Brain; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Duodenum; Hydrolysis; Mice; Mice, Transgenic; Obesity; Up-Regulation | 2006 |
The neuronal pathology of schizophrenia: molecules and mechanisms.
Topics: Animals; Aspartic Acid; Brain; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Neurons; Phencyclidine; Schizophrenia | 2007 |
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Models, Animal; Disease Progression; gamma-Aminobutyric Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Superoxide Dismutase; Time Factors | 2007 |
MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes.
Topics: Animals; Aspartic Acid; Astrocytes; Body Water; Brain; Choline; Creatine; Diffusion; Disease Models, Animal; Disease Progression; Gliosis; Glucose; Glutamic Acid; Hyperkinesis; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Microglia; Prion Diseases | 2007 |
Time course of early metabolic changes following diffuse traumatic brain injury in rats as detected by (1)H NMR spectroscopy.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Injuries; Creatine; Diffuse Axonal Injury; Disease Models, Animal; Disease Progression; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Time Factors; Up-Regulation; Water-Electrolyte Balance | 2007 |
Spectroscopic imaging of the pilocarpine model of human epilepsy suggests that early NAA reduction predicts epilepsy.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Signal Processing, Computer-Assisted | 2007 |
Temporal window of metabolic brain vulnerability to concussions: mitochondrial-related impairment--part I.
Topics: Acetylation; Adenine Nucleotides; Amino Acids; Animals; Aspartic Acid; Brain; Brain Concussion; Coenzymes; Disease Models, Animal; Energy Metabolism; Glutamate Carboxypeptidase II; Male; Mitochondria; NADP; Nicotinic Acids; Rats; Rats, Wistar; Recurrence; RNA, Messenger; Severity of Illness Index; Time Factors | 2007 |
Exploring the neuroprotective effects of modafinil in a marmoset Parkinson model with immunohistochemistry, magnetic resonance imaging and spectroscopy.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Benzhydryl Compounds; Biomarkers; Brain; Callithrix; Disease Models, Animal; Dopamine; Drug Administration Schedule; Immunohistochemistry; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Modafinil; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Phosphocreatine; Predictive Value of Tests; Reproducibility of Results; Substantia Nigra; Treatment Outcome; Tyrosine 3-Monooxygenase | 2008 |
The effects of dantrolene on hypoxic-ischemic injury in the neonatal rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Aspartic Acid; Brain; Carotid Artery, Common; Creatine; Dantrolene; Disease Models, Animal; Hypoxia; Hypoxia-Ischemia, Brain; Injections, Intraventricular; Ligation; Lipid Metabolism; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder.
Topics: Adult; Analysis of Variance; Animals; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Creatine; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Matched-Pair Analysis; Metabolomics; Middle Aged; Prefrontal Cortex; Rats; Rats, Inbred WKY; Reference Values | 2009 |
Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS.
Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Inositol; Linear Models; Macaca mulatta; Magnetic Resonance Spectroscopy; Severity of Illness Index; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus | 2008 |
N-acetyl-L-aspartate activates hippocampal CA3 neurons in rodent slice preparations.
Topics: Animals; Aspartic Acid; Cadmium; Dioxolanes; Disease Models, Animal; Drug Interactions; Electric Stimulation; Glutamates; Glycine; Hippocampus; In Vitro Techniques; Membrane Potentials; Mossy Fibers, Hippocampal; Neurons; Purines; Rats; Rats, Wistar; Tremor | 2008 |
[Estimation of postmortem interval with multivoxel-voxel proton 1H-MR spectroscopy].
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Disease Models, Animal; Embolism, Air; Female; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Postmortem Changes; Protons; Rabbits; Regression Analysis; Time Factors | 2007 |
[The evaluation of the effects of piracetam and N-acetylaspartic acid on memory and the content of mediator amino acids in the brain in a model neurotic state in rats].
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Conditioning, Classical; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Memory; Neurotic Disorders; Piracetam; Rats | 1993 |
Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cell Count; Choline; Creatinine; Dipeptides; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Neuropeptides; Protons; Rats; Rats, Sprague-Dawley; Seizures; Temporal Lobe | 1997 |
High-resolution 1H NMR spectroscopy following experimental brain trauma.
Topics: Animals; Aspartic Acid; Brain Injuries; Disease Models, Animal; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
High-field proton magnetic resonance spectroscopy of a swine model for axonal injury.
Topics: Animals; Aspartic Acid; Axons; Brain; Brain Injuries; Creatine; Disease Models, Animal; Female; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Sensitivity and Specificity; Swine; Swine, Miniature | 1998 |
Changes in brain organic osmolytes in experimental cerebral ischemia.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Creatine; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycerylphosphorylcholine; Magnetic Resonance Spectroscopy; Male; Methylamines; Phosphocreatine; Rats; Rats, Sprague-Dawley; Taurine | 1998 |
Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Axons; Caudate Nucleus; Creatine; Disease Models, Animal; Hippocampus; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Mice, Neurologic Mutants; Motor Neuron Disease; Neocortex; Neurofilament Proteins; Neurons; Phosphocreatine; Putamen; Thalamus; Ubiquitins | 1998 |
Postictal in situ MRS brain lactate in the rat kindling model.
Topics: Animals; Aspartic Acid; Brain Mapping; Creatine; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Hippocampus; Kindling, Neurologic; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley | 1999 |
Extracellular N-acetyl-aspartate as a biochemical marker of the severity of neuronal damage following experimental acute traumatic brain injury.
Topics: Animals; Aspartic Acid; Biomarkers; Blood Gas Analysis; Blood Pressure; Brain; Brain Chemistry; Brain Injuries; Chromatography, High Pressure Liquid; Disease Models, Animal; Extracellular Space; Hydrogen-Ion Concentration; Hypotension; Hypoxia, Brain; Magnetic Resonance Imaging; Male; Neurons; Rats; Rats, Sprague-Dawley | 2000 |
Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Disease Models, Animal; Down Syndrome; Female; Inositol; Lithium; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Mutant Strains; Protons | 2000 |
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.
Topics: 2,2'-Dipyridyl; Acute Disease; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Edema; Brain Ischemia; Carotid Arteries; Cell Death; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Injections, Intra-Arterial; Iron Chelating Agents; Male; Malonates; Microspheres; Mitochondria; Nerve Tissue Proteins; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitro Compounds; Oxidative Stress; Premedication; Propionates; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Succinate Dehydrogenase | 2001 |
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Cell Survival; Creatinine; Disease Models, Animal; Energy Metabolism; Female; Huntingtin Protein; Huntington Disease; Hyperglycemia; Insulin; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Motor Activity; Neostriatum; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Organ Size; Survival Rate | 2001 |
The effects of lithium chloride and other substances on levels of brain N-acetyl-L-aspartic acid in Canavan disease-like rats.
Topics: Animals; Aspartic Acid; Blood-Brain Barrier; Brain; Canavan Disease; Disease Models, Animal; Lithium Chloride; Male; Rats; Rats, Mutant Strains | 2002 |