n-acetylaspartic acid has been researched along with Disease Exacerbation in 142 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 11 (7.75) | 18.2507 |
2000's | 74 (52.11) | 29.6817 |
2010's | 54 (38.03) | 24.3611 |
2020's | 3 (2.11) | 2.80 |
Authors | Studies |
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Blicher, JU; Eskildsen, SF; Figlewski, K; Møller, AT; Near, J; Stærmose, TG | 1 |
Andres-Mach, M; Chudzik, A; Kochalska, K; Kozioł, P; Oakden, W; Orzylowska, A; Pankowska, A; Pietura, R; Rola, R; Stanisz, GJ; Słowik, T; Łazorczyk, A | 1 |
Barkhof, F; Chataway, J; DeAngelis, F; Doshi, A; Gandini Wheeler-Kingshott, CAM; John, NA; MacManus, D; Marshall, I; Monteverdi, A; Parker, RA; Plantone, D; Prados, F; Schneider, T; Solanky, BS; Stutters, J; Weir, CJ | 1 |
Briemberg, H; Eurich, DT; Frayne, R; Genge, AL; Graham, SJ; Hanstock, C; Ishaque, A; Kalra, S; Korngut, L; Luk, C; Seres, P; Srivastava, O; Ta, D; Zinman, L | 1 |
Babb, JS; Davitz, MS; Gonen, O; Herbert, J; Kirov, II; Liu, S; Rusinek, H; Tal, A; Wu, WE | 1 |
Angelini, C; Giacanelli, M; Gurrieri, F; Lispi, L; Luna, R; Neri, G; Petrucci, A | 1 |
Moriya, M; Nojo, T; Waragai, M | 1 |
Bushara, KO; Deelchand, DK; Eberly, LE; Emir, UE; Gomez, CM; Hutter, D; Joers, JM; Lyu, T; Öz, G | 1 |
Grendar, M; Hnilicova, P; Kantorova, E; Kurca, E; Polacek, H; Zelenak, K | 1 |
Gonzales, SS; Kraguljac, NV; Lahti, AC; Morgan, CJ; Sivaraman, S; White, DM | 1 |
Cheong, I; Deelchand, DK; Eberly, LE; Guliani, G; Manousakis, G; Marjańska, M; Öz, G; Walk, D | 1 |
Andersen, CU; Brock, B; Brock, C; Drewes, AM; Frøkjær, JB; Hansen, TM; Jakobsen, PE; Juhl, A; Karmisholt, J; Vorum, H | 1 |
Kantarci, K | 1 |
Algers, J; Brown, M; Buchthal, S; Campbell, T; Cohen, RA; Daar, E; Gongvatana, A; Harezlak, J; Heaton, R; McMahon, D; Mi, D; Navia, B; Robertson, K; Schifitto, G; Singer, E; So, YT; Taylor, M; Yiannoutsos, C; Zhong, J | 1 |
Amato, MP; Bartolozzi, ML; Battaglini, M; De Stefano, N; Gasperini, C; Giorgio, A; Hakiki, B; Malentacchi, G; Portaccio, E; Rossi, F; Santangelo, M; Stromillo, ML | 1 |
Bellenberg, B; Busch, M; Chan, A; Gold, R; Lukas, C; Trampe, N | 1 |
Abe, O; Aoki, Y; Gonoi, W; Inoue, H; Iwashiro, N; Kasai, K; Katsura, M; Koike, S; Natsubori, T; Sasaki, H; Takano, Y; Takao, H; Yahata, N; Yamasue, H | 1 |
Cao, Z; Chen, Y; Dai, H; Li, H; Lin, Y; Pang, L; Wu, R; Yao, J; You, K | 1 |
Blinkenberg, M; Hanson, LG; Mathiesen, HK; Paulson, OB; Skimminge, A; Sorensen, PS; Wu, X | 1 |
Arai, H; Fujii, C; Hata, S; Higuchi, S; Igarashi, K; Ishii, R; Iwai, N; Moriya, M; Ohrui, T; Suzuki, T; Tokuda, T; Uemura, K; Waragai, M; Yoshida, M | 1 |
Brenneman, D; Cree, BA; Hauser, SL; Kornak, J; Llufriu, S; Nelson, SJ; Oh, J; Pelletier, D; Ratiney, H; Sampat, M | 1 |
Anderson, CM; Bayouth, JE; Buatti, JM; Capizzano, AA; Clerkin, PP; Magnotta, V; McGuire, SM; Morris, A; Muruganandham, M; Smith, BJ; Smith, MC | 1 |
Bellini, T; Blankenstein, MA; Comabella, M; Killestein, J; Koel-Simmelink, MJ; Korth, C; Montalban, X; Ottis, P; Roos, B; Rovira, A; Teunissen, CE; Tintoré, M; Trentini, A | 1 |
Fan, Y; Zhou, L | 1 |
Akiguchi, I; Shiino, A; Watanabe, T | 1 |
Almuqbel, M; Anderson, TJ; Dalrymple-Alford, JC; Keenan, RJ; Livingston, L; MacAskill, MR; Melzer, TR; Myall, DJ; Pitcher, TL; Wood, KL | 1 |
Adams, D; Baker, EH; Golas, G; Johnston, J; Kwon, HJ; Latour, Y; Portner, C; Regier, DS; Thomas, S; Tifft, CJ; Vezina, G; Wiggs, E; Yang, S | 1 |
Aleman, A; Bais, L; de Vos, A; Dlabac-De Lange, J; Knegtering, H; Liemburg, E; Opmeer, E; Pijnenborg, G; Sibeijn-Kuiper, A; van der Velde, J; Wunderink, L | 1 |
Audoin, B; Burzykowski, T; Chabrol, B; Galanaud, D; Kaphan, E; Sedel, F; Tourbah, A; Tranchant, C; Vanier, MT | 1 |
Broniscer, A; Edwards, A; Hwang, S; Li, X; Li, Y; Löbel, U; Patay, Z | 1 |
Botzkowski, D; Gass, A; Kuhle, J; Müller, S; Pardini, M; Putzki, N; Ruberte, E; Tettenborn, B; Valmaggia, C; Vehoff, J; Würfel, J; Yaldizli, Ö | 1 |
Morton, AJ; Sawiak, SJ; Wood, NI | 1 |
Bilaniuk, LT; De Vivo, DC; Francis, JS; Gray, SJ; Janson, CG; Leone, P; Markov, V; McCown, TJ; Samulski, RJ; Wang, DJ; Wojtas, I | 1 |
Boonzaier, NR; Larkin, TJ; Matys, T; Price, SJ; van der Hoorn, A; Yan, JL | 1 |
Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG | 1 |
Barres, BA; Cerda, SR; Dugas, J; Popko, B; Traka, M; Wollmann, RL | 1 |
Baik, SK; Chang, KH; Cho, BM; Choi, SH; Kim, DH; Kim, HJ; Kim, YW; Lee, JW; Lee, SH | 1 |
Armitage, PA; Bastin, ME; Chappell, FM; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM | 1 |
Cooper, A; Daly, E; Foy, C; Glover, A; Hye, A; Lovestone, S; Murphy, D; Simmons, A; Thambisetty, M | 1 |
Aresi, A; Bizzi, A; Giovagnoli, AR; Gobbo, C; Reati, F; Riva, A | 1 |
Beaulieu, C; Concha, L; Hanstock, C; Hui, B; Johnston, W; Kalra, S; Pyra, T; Wong, JC | 1 |
Imamura, A; Ito, R; Miyajima, H; Orii, KO | 1 |
Blom, HJ; Bouwman, F; Brundin, L; Dijkstra, CD; Iacobaeus, E; Jakobs, C; Khademi, M; Koel-Simmelink, MJ; Norgren, N; Schepens, M; Teunissen, CE; Twaalfhoven, HA | 1 |
Bazner, S; González, RG; Halpern, EF; Kim, WK; Lee, V; Lentz, MR; Rosenberg, ES; Venna, N; Williams, K | 1 |
Boeve, BF; Jack, CR; Kantarci, K; Knopman, DS; Negash, S; O'Brien, PC; Petersen, RC; Przybelski, SA; Shiung, MM; Weigand, SD; Whitwell, JL | 1 |
Frölich, L; Kratzsch, T; Lais, C; Lanfermann, H; Maurer, K; Pantel, J; Pilatus, U; Rochmont, Adu M; Zanella, FE | 1 |
Benedetti, B; Bertolotto, A; Capra, R; Caputo, D; Comi, G; Filippi, M; Martinelli, V; Rocca, MA; Rovaris, M; Zaffaroni, M | 1 |
Erdinc, O; Gumustas, OG; Kabay, SC; Karaman, HO; Ozden, H | 1 |
Gibikote, S; Kumar, S; Moses, PD; Puliyel, MM; Rose, W | 1 |
Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM | 1 |
Fink, JR; Maravilla, KR; Matsusue, E; Ogawa, T; Rockhill, JK | 1 |
Herrera, JJ; Narayana, PA; Qian, J | 1 |
Bianchi, F; Bongioanni, P; Canapicchi, R; Frijia, F; Hlavata, H; Lombardo, F; Minichilli, F; Montanaro, D; Rossi, B | 1 |
Altmann, DR; Ciccarelli, O; McLean, MA; Miller, DH; Thompson, AJ; Wheeler-Kingshott, CA; Wimpey, K | 1 |
Geurts, JJ; van Horssen, J | 1 |
de Diego-Adeliño, J; Gómez-Ansón, B; Morgan-Ferrando, R; Pérez, V; Pérez-Egea, R; Portella, MJ; Puigdemont, D; Ruscalleda, J; Vives, Y | 1 |
Davies, NP; Davison, JE; Gissen, P; Hendriksz, CJ; Peet, AC; Sun, Y | 1 |
Barton, NW; Fogh, J; Hanson, LG; i Dali, C; Lund, AM; Nair, N | 1 |
Audoin, B; Confort-Gouny, S; Cozzone, PJ; Crespy, L; Faivre, A; Le Fur, Y; Malikova, I; Pelletier, J; Ranjeva, JP; Reuter, F; Rico, A; Soulier, E; Viout, P; Zaaraoui, W | 1 |
Brugger, S; Davis, JM; Leucht, S; Stone, JM | 1 |
Chang, Y; Choi, BS; Jung, C; Kim, JH; Kim, S | 1 |
Fujita, K; Harada, M; Izumi, Y; Kaji, R; Sasaki, M; Yuasa, T | 1 |
Barcikowska, M; Ćwikła, JB; Gabryelewicz, T; Walecki, J | 1 |
Larner, J; Lopes, MB; Nicolasjilwan, M; Schiff, D; Wintermark, M | 1 |
Choi, IY; Lee, P; Smirnova, IV; Wang, WT; Yeh, HW | 1 |
Choi, JY; Hong, YH; Kim, HS; Lee, HY; Lim, TS; Moon, SY | 1 |
Alkan, A; Dogan, DG; Dogan, M; Kahraman, AS; Ozcan, O; Yakinci, C | 1 |
Malik, R; Smith, J; Viola, RE; Wijayasinghe, YS; Zano, S | 1 |
Chen, HC; Lirng, JF; Soong, BW; Wang, PS; Wu, HM; Wu, YT | 1 |
Delfino, M; García-Sánchez, C; Gironell, A; Gómez-Ansón, B; Kulisevsky, J; Llebaria, G; Pagonabarraga, J; Pascual-Sedano, B; Rotger, R; Ruscalleda, J | 1 |
Angebault, C; Bielicki, G; Boddaert, N; Brabet, P; Cazevieille, C; Chaix, B; Delettre, C; Gueguen, N; Hamel, CP; Lenaers, G; Mausset-Bonnefont, AL; Puel, JL; Renou, JP; Reynier, P; Rigau, V; Sarzi, E; Seveno, M; Wang, J | 1 |
Ariaudo, G; Balottin, U; Bastianello, S; Orcesi, S; Pichiecchio, A; Tonduti, D; van der Knaap, MS; Wolf, NI | 1 |
Alberti, A; Chiarini, P; Gallai, V; Gobbi, G; Pelliccioli, GP; Presciutti, O; Sarchielli, P; Tarducci, R | 1 |
Bozzali, M; Comi, G; Falini, A; Filippi, M; Ghezzi, A; Gonen, O; Grossman, RI; Kesavadas, C; Martinelli, V; Rovaris, M; Scotti, G | 1 |
Arnold, D; Blamire, AM; Corkill, R; Matthews, PM; Narayanan, S; Palace, J; Parry, A; Styles, P | 1 |
Hadjiconstantinou, M; Neff, NH; Podell, M; Smith, MA | 1 |
Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U | 1 |
Butman, JA; Floeter, MK; Pagan, F; Statland, J; Zhai, P | 1 |
Confort-Gouny, S; Cozzone, PJ; Denis, B; Lefur, Y; Nicoli, F; Ranjeva, JP | 1 |
Glosser, G; Gonen, O; Grossman, RI; Inglese, M; Kolson, DL; Patel, SH | 1 |
Sener, RN | 1 |
Chen, CY; Chin, SC; Chung, HW; Huang, IJ; Lee, CS; Liou, M; Liu, YJ | 1 |
Mazurek, AA | 1 |
Babb, JS; Ge, Y; Gonen, O; Grossman, RI; Inglese, M; Markowitz, CE | 1 |
Astrakas, LG; Black, PM; Goumnerova, L; Poussaint, TY; Tarbell, NJ; Tzika, AA; Zarifi, MK; Zurakowski, D | 1 |
Fuller, RA; González, RG; Greco, JB; Halpern, E; He, J; Kim, JP; Lackner, AA; Lentz, MR; Masliah, E; Ratai, E; Sehgal, PK; Westmoreland, SV | 1 |
Barker, PB; Bibat, G; Costa Leite, C; Costa, MO; Fatemi, A; Horská, A; Kok, F; Lacerda, MT; Nagae-Poetscher, LM; Naidu, S; Philippart, M; Rosemberg, S | 1 |
Gabreëls, FJ; Heerschap, A; Rotteveel, JJ; Van Der Graaf, M; Van Der Knaap, MS; Van Domburg, PH; Willemsen, MA | 1 |
Alkan, A; Aslan, M; Kutlu, R; Sarac, K; Sigirci, A; Yakinci, C | 1 |
Beley, A; Demougeot, C; Giroud, M; Marie, C | 1 |
Aärimaa, T; Autti, T; Häkkinen, AM; Koillinen, H; Kuusi, T; Linnankivi, T; Lönnqvist, T; Lundbom, N; Pihko, H; Sainio, K; Valanne, L | 1 |
Chan, AA; Chang, SM; Dillon, WP; Larson, D; Lau, A; McDermott, MW; Nelson, SJ; Pirzkall, A; Verhey, LJ | 1 |
Du Pasquier, RA; Katz-Brull, R; Koralnik, IJ; Lenkinski, RE | 1 |
Jacobsen, H; Künnecke, B; Loetscher, H; Metzger, F; Ozmen, L; Richards, JG; Steiner, G; von Kienlin, M | 1 |
Ashwal, S; Gross, M; Holshouser, B; Kido, D; Osterdock, R; Serna, T; Tong, K | 1 |
Abrey, LE; DeAngelis, LM; Koutcher, JA; Lis, E; Panageas, KS; Raizer, JJ; Xu, S; Zakian, KL | 1 |
Bjoraker, KJ; Charnas, LR; Choi, IY; Gruetter, R; Oz, G; Shapiro, EG; Tkác, I | 1 |
Antel, JP; Arnold, DL; Biernacki, K; Blain, M; Narayanan, S; Prat, A | 1 |
Chard, DT; Ingle, GT; McLean, MA; Miller, DH; Ramió-Torrentà, L; Sastre-Garriga, J; Thompson, AJ | 1 |
Banerjee, A; Cha, S; Haas-Kogan, DA; Laprie, A; Le, TP; Lu, Y; McKnight, TR; Nelson, S; Pirzkall, A | 1 |
Cherubini, A; Feliziani, FT; Gobbi, G; Mariani, E; Mecocci, P; Metastasio, A; Pelliccioli, GP; Rinaldi, P; Senin, U; Tarducci, R | 1 |
Battaglini, M; Borsini, W; Bramanti, P; Buchner, S; De Stefano, N; Federico, A; Giorgio, A; Marino, S; Mortilla, M; Stromillo, ML | 1 |
Asano, T; Kato, Z; Kondo, N | 1 |
Bachert, P; Debus, J; Hamprecht, F; Kauczor, HU; Lichy, MP; Schlemmer, HP; Schulz-Ertner, D; Weber, MA | 1 |
Boeve, BF; Gunter, J; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Reyes, D; Shiung, M; Smith, GE; Tangalos, EG; Weigand, SD | 1 |
Appenzeller, S; Cendes, F; Costallat, LT; Li, LM | 1 |
Angenstein, F; Debska-Vielhaber, G; Heinze, HJ; Hilfert, L; Kunz, WS; Leibfritz, D; Ludolph, AC; Niessen, HG; Sander, K; Vielhaber, S; Willker, W | 1 |
Anlar, B | 1 |
Anthony, DC; Blamire, AM; Broom, KA; Griffin, JL; Lowe, JP; Perry, VH; Scott, H; Sibson, NR; Styles, P | 1 |
Barrios, L; Cerdán, S; López-Larrubia, P; Pascual, JM; Prieto, R; Roda, JM; Solivera, J | 1 |
Boscá, I; Casanova, B; Celda, B; Coret, F; Marti-Bonmati, L; Martínez-Bisbal, MC; Martínez-Granados, B; Mir, A; Pascual, AM; Valero, C | 1 |
Ballon, D; Crystal, RG; Dyke, JP; Hackett, NR; Heier, L; Hollmann, C; Kaplitt, MG; Kekatpure, MV; Kosofsky, B; Mao, X; Shungu, D; Sondhi, D; Souweidane, MM; Worgall, S | 1 |
Alimenti, A; de Tribolet, N; Delavelle, J; Dietrich, PY; Lazeyras, F; Lövblad, KO; Yilmaz, H | 1 |
Azevedo, D; Bazzarella, MC; Bottino, CM; Castro, CC; Hototian, SR; Tatsch, M | 1 |
Casey, PA; Fiskum, G; McKenna, MC; Robertson, CL; Saraswati, M | 1 |
Andermann, F; Arnold, DL; Cendes, F; Silver, K | 1 |
Arnold, DL; Collins, DL; De Stefano, N; Fu, L; Narayanan, S; Wolfson, C; Worsley, KJ | 1 |
Alger, JR; Bonavita, S; Di Chiro, G; Duyn, JH; Lundbom, N; Raman, R; Tedeschi, G | 1 |
Chang, S; Day, MR; Dillon, WP; Gutin, PH; Henry, RG; Huhn, SL; Larson, DA; McDermott, M; Nelson, SJ; Noworolski, SE; Prados, MD; Sneed, PK; Vigneron, DB; Wald, LL; Wara, WM | 1 |
Calabrese, G; Colombo, B; Comi, G; Falini, A; Filippi, M; Lipari, S; Origgi, D; Scotti, G | 1 |
Christen, HJ; Frahm, J; Hanefeld, FA; Kruse, B; Pouwels, PJ | 1 |
Antel, JP; Arnold, DL; De Stefano, N; Francis, GS; Fu, L; Matthews, PM; Narayanan, S; Stanley, J | 1 |
Charles, HC; Doraiswamy, PM; Krishnan, KR | 1 |
Abe, K; Fujita, N; Hirabuki, N; Nakamura, M; Terakawa, H; Watanabe, Y; Yanagihara, T | 1 |
Arnold, DL; Cashman, NR; Kalra, S | 1 |
de Mari, M; Federico, F; Ferrari, E; Lamberti, P; Lucivero, V; Mezzapesa, DM; Petruzzellis, M; Simone, IL | 1 |
Babb, JS; Catalaa, I; Ge, Y; Gonen, O; Grossman, RI; Kolson, DL; Mannon, LJ | 1 |
Bendszus, M; Burger, R; Klein, R; Schichor, C; Solymosi, L; Tonn, JC; Warmuth-Metz, M | 1 |
Alonso, J; Cucurella, MG; Montalbán, X; Pedraza, S; Río, J; Rovira, A; Tintoré, MM | 1 |
Adalsteinsson, E; Kleinhans, N; Pfefferbaum, A; Spielman, DM; Sullivan, EV | 1 |
Boeve, BF; Campeau, NG; Ivnik, RJ; Jack, CR; Kantarci, K; Kokmen, E; O'Brien, PC; Petersen, RC; Smith, GE; Tangalos, EG; Xu, YC | 1 |
Goto, H; Hoshi, H; Kato, Z; Kondo, N; Mizuno, S; Takahashi, Y | 1 |
Antel, JP; Arnaoutelis, R; Arnold, DL; De Stefano, N; Francis, GS; Matthews, PM; Narayanan, S; Tartaglia, MC | 1 |
Arnold, DL; Bartolozzi, ML; De Stefano, N; Federico, A; Guidi, L; Mortilla, M; Narayanan, S | 1 |
Block, W; Grothe, C; Karitzky, J; Klockgether, T; Lamerichs, R; Pohl, C; Schild, H; Schmidt, S; Träber, F | 1 |
Arnold, DL; De Stefano, N; Matthews, PM; Narayanan, S | 1 |
Arnold, DL; Matthews, PM | 1 |
Malloy, CR | 1 |
Balestri, P; De Stefano, N; Dotti, MT; Federico, A; Grosso, S; Morgese, G; Mortilla, M | 1 |
Kobayashi, M; Mihara, B; Suga, S; Takayama, H | 1 |
Matthews, PM | 1 |
Dronsky, V; Gelinas, D; Licht, J; Maudsley, AA; Miller, RG; Rule, R; Schuff, N; Suhy, J; Weiner, MW | 1 |
8 review(s) available for n-acetylaspartic acid and Disease Exacerbation
Article | Year |
---|---|
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; Diagnosis, Differential; Disease Models, Animal; Disease Progression; Energy Metabolism; Humans; Inositol; Magnetic Resonance Spectroscopy; Mice; Translational Research, Biomedical | 2013 |
Proton magnetic resonance spectroscopy and illness stage in schizophrenia--a systematic review and meta-analysis.
Topics: Aspartic Acid; Data Interpretation, Statistical; Disease Progression; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Publication Bias; Regression Analysis; Risk; Schizophrenia; Schizophrenic Psychology; Temporal Lobe; Thalamus | 2011 |
N-acetylaspartate: a literature review of animal research on brain ischaemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Chromatography, High Pressure Liquid; Disease Models, Animal; Disease Progression; Magnetic Resonance Spectroscopy; Neurons | 2004 |
Magnetic resonance spectroscopy in the evaluation of central nervous system manifestations of systemic lupus erythematosus.
Topics: Aspartic Acid; Brain; Central Nervous System; Creatine; Disease Progression; Humans; Lupus Vasculitis, Central Nervous System; Magnetic Resonance Spectroscopy; Neurons | 2006 |
Biological markers in the diagnosis and treatment of ALS.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Progression; Electromyography; Humans; Magnetic Resonance Imaging; Monitoring, Physiologic; Neuroprotective Agents; Riluzole; Tomography, Emission-Computed | 1999 |
Imaging axonal damage in multiple sclerosis by means of MR spectroscopy.
Topics: Animals; Aspartic Acid; Axons; Central Nervous System; Disability Evaluation; Disease Progression; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis | 2000 |
Proton MR spectroscopy in multiple sclerosis.
Topics: Aspartic Acid; Brain; Choline; Creatine; Disability Evaluation; Disease Progression; Energy Metabolism; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Retrograde Degeneration | 2000 |
Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution.
Topics: Aspartic Acid; Axons; Brain; Disability Evaluation; Disease Progression; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Neurologic Examination | 2001 |
11 trial(s) available for n-acetylaspartic acid and Disease Exacerbation
Article | Year |
---|---|
NAA is a Marker of Disability in Secondary-Progressive MS: A Proton MR Spectroscopic Imaging Study.
Topics: Adult; Amiloride; Aspartic Acid; Biomarkers; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Disability Evaluation; Disease Progression; Double-Blind Method; Female; Fluoxetine; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Neuroimaging; Neuroprotective Agents; Proton Magnetic Resonance Spectroscopy; Protons; Riluzole | 2020 |
1H-magnetic resonance spectroscopy in diffuse and focal cervical cord lesions in multiple sclerosis.
Topics: Adult; Analysis of Variance; Aspartic Acid; Cervical Vertebrae; Creatine; Cross-Sectional Studies; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Reproducibility of Results; Spinal Cord; Young Adult | 2013 |
Randomized trial of erhuangfang for relapsing multiple sclerosis.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Aspartic Acid; Brain; Creatine; Disability Evaluation; Disease Progression; Drugs, Chinese Herbal; Female; Humans; Magnetic Resonance Spectroscopy; Male; Medicine, Chinese Traditional; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Prospective Studies; Young Adult | 2015 |
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Tamoxifen | 2008 |
Diffusion tensor MRI and MR spectroscopy in long lasting upper motor neuron involvement in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatinine; Diffusion Magnetic Resonance Imaging; Disability Evaluation; Disease Progression; Female; Humans; Male; Middle Aged; Phosphocreatine; Pyramidal Tracts; Reproducibility of Results; Sensitivity and Specificity | 2009 |
Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy.
Topics: Aspartic Acid; Biomarkers; Brain; Child, Preschool; Choline; Cognition; Creatine; Disease Progression; Female; Humans; Leukodystrophy, Metachromatic; Magnetic Resonance Spectroscopy; Male; Movement; Sensitivity and Specificity | 2010 |
Beta-Interferon treatment does not always slow the progression of axonal injury in multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Body Water; Brain Chemistry; Cohort Studies; Creatine; Disease Progression; Female; Humans; Interferon Type I; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Recombinant Proteins; Recurrence | 2003 |
Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study.
Topics: Acute Disease; Adult; Aged; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Diffusion; Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Gadolinium; Humans; Lactic Acid; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Protons; Stroke; Time Factors | 2003 |
Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis.
Topics: Adult; Age of Onset; Aged; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebral Cortex; Choline; Disability Evaluation; Disease Progression; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Nerve Fibers, Myelinated; Neurons; Neuropil; Phosphocreatine; Predictive Value of Tests; Reference Values; Statistics as Topic | 2005 |
Proton spectroscopy in Alzheimer's disease and cognitive impairment no dementia: a community-based study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Atrophy; Brain; Choline; Cognition Disorders; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Predictive Value of Tests; Protons; Residence Characteristics | 2008 |
Longitudinal changes of metabolites in frontal lobes after hemorrhagic stroke of basal ganglia: a proton magnetic resonance spectroscopy study.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Basal Ganglia Hemorrhage; Creatine; Disease Progression; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Predictive Value of Tests; Severity of Illness Index; Stroke; Treatment Outcome | 2001 |
123 other study(ies) available for n-acetylaspartic acid and Disease Exacerbation
Article | Year |
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Short echo-time Magnetic Resonance Spectroscopy in ALS, simultaneous quantification of glutamate and GABA at 3 T.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Choline; Creatine; Disease Progression; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Gray Matter; Hand Strength; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Occipital Lobe; Pilot Projects; Severity of Illness Index; Single-Blind Method | 2019 |
Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Choline; Depressive Disorder; Dietary Supplements; Disease Progression; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Lacticaseibacillus rhamnosus; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Stress, Psychological | 2020 |
Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cognitive Dysfunction; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Prefrontal Cortex; Severity of Illness Index | 2021 |
Proton MR spectroscopy of lesion evolution in multiple sclerosis: Steady-state metabolism and its relationship to conventional imaging.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Cross-Sectional Studies; Disease Progression; Female; Follow-Up Studies; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Male; Multiple Sclerosis, Relapsing-Remitting; Organ Size; Proton Magnetic Resonance Spectroscopy; White Matter; Young Adult | 2017 |
ATP1A3 mutant patient with alternating hemiplegia of childhood and brain spectroscopic abnormalities.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Choline; Disease Progression; Hemiplegia; Humans; Magnetic Resonance Spectroscopy; Male; Mutation; Sodium-Potassium-Exchanging ATPase; Tritium | 2017 |
Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Cognitive Dysfunction; Disease Progression; Female; Follow-Up Studies; Gyrus Cinguli; Humans; Inositol; Lewy Body Disease; Male; Mental Status and Dementia Tests; Parkinson Disease; Prodromal Symptoms; Proton Magnetic Resonance Spectroscopy; Retrospective Studies; Risk Factors | 2017 |
Neurochemical abnormalities in premanifest and early spinocerebellar ataxias.
Topics: Activities of Daily Living; Adult; Aged; Aspartic Acid; Ataxins; Brain; Brain Diseases, Metabolic; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Disease Progression; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Spinocerebellar Ataxias; Young Adult | 2018 |
Increased glutamate and deep brain atrophy can predict the severity of multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Disease Progression; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Predictive Value of Tests; Severity of Illness Index; Thalamus; Young Adult | 2019 |
Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Corpus Striatum; Disease Progression; Dopamine; Female; Glutamic Acid; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizophrenia; Young Adult | 2018 |
Neurochemical correlates of functional decline in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Disease Progression; Female; Glutamic Acid; Humans; Longitudinal Studies; Male; Middle Aged; Motor Cortex; Motor Neurons; Pons; Prognosis; Proton Magnetic Resonance Spectroscopy; Upper Extremity | 2019 |
Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Case-Control Studies; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Peripheral Nerves; Polyneuropathies; White Matter | 2019 |
Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Choline; Cognition; Disease Progression; Female; Glutamic Acid; HIV; Humans; Inositol; Male; Middle Aged; Neuropsychological Tests | 2013 |
Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome.
Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Prodromal Symptoms; Protons; Risk; Syndrome; Young Adult | 2013 |
Reduced frontal glutamate + glutamine and N-acetylaspartate levels in patients with chronic schizophrenia but not in those at clinical high risk for psychosis or with first-episode schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Chronic Disease; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Prodromal Symptoms; Psychotic Disorders; Risk; Schizophrenia; Young Adult | 2014 |
Hippocampal neurochemical changes in senescent mice induced with chronic injection of D-galactose and NaNO₂: an in vitro high-resolution NMR spectroscopy study at 9.4T.
Topics: Amyloid; Animals; Apoptosis; Aspartic Acid; Behavior, Animal; Cell Proliferation; Congo Red; Disease Progression; Galactose; Glutamine; Hippocampus; Inositol; Magnetic Resonance Spectroscopy; Male; Maze Learning; Mice; Neurofibrillary Tangles; Neuroglia; Neurons; Sodium Nitrite; Time Factors | 2014 |
Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis.
Topics: Adult; Aspartic Acid; Cerebral Cortex; Creatine; Disability Evaluation; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Prognosis; Young Adult | 2014 |
Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Brain; Choline; Dementia; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Retrospective Studies; Tritium | 2014 |
Magnetic resonance spectroscopy markers of disease progression in multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Biomarkers; Case-Control Studies; Disability Evaluation; Disease Progression; Female; Follow-Up Studies; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Predictive Value of Tests; Severity of Illness Index | 2014 |
3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy; Choline; Contrast Media; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Gadolinium; Glioblastoma; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Matched-Pair Analysis; Middle Aged; Neoplasm Recurrence, Local; Proportional Hazards Models; Radiotherapy Dosage; Temozolomide; Time Factors | 2014 |
N-acetylaspartate and neurofilaments as biomarkers of axonal damage in patients with progressive forms of multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Biomarkers; Disability Evaluation; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multiple Sclerosis; Neurofilament Proteins; Prognosis | 2014 |
[Prediction of conversion from amnestic mild cognitive impairment to Alzheimer's disease using proton magnetic resonance spectroscopy].
Topics: Aged; Alzheimer Disease; Amnesia; Aspartic Acid; Cognitive Dysfunction; Disease Progression; Female; Forecasting; Hippocampus; Humans; Male; Proton Magnetic Resonance Spectroscopy | 2015 |
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysfunction; Creatine; Dementia; Disease Progression; Female; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Superior Sagittal Sinus | 2016 |
MRI/MRS as a surrogate marker for clinical progression in GM1 gangliosidosis.
Topics: Adolescent; Age of Onset; Aspartic Acid; Atrophy; beta-Galactosidase; Cerebellum; Cerebrum; Child; Child, Preschool; Disease Progression; Female; Gangliosidosis, GM1; Gene Expression; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mobility Limitation; Severity of Illness Index; Speech; Speech Disorders; Young Adult | 2016 |
Prefrontal NAA and Glx Levels in Different Stages of Psychotic Disorders: a 3T 1H-MRS Study.
Topics: Adolescent; Adult; Age Factors; Antipsychotic Agents; Aspartic Acid; Case-Control Studies; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Male; Middle Aged; Neurotransmitter Agents; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Regression Analysis; Risk; Severity of Illness Index; Time Factors | 2016 |
Normalisation of brain spectroscopy findings in Niemann-Pick disease type C patients treated with miglustat.
Topics: 1-Deoxynojirimycin; Adolescent; Adult; Aspartic Acid; Brain; Choline; Disability Evaluation; Disease Progression; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Linear Models; Longitudinal Studies; Male; Niemann-Pick Disease, Type C; Patient Dropouts; Treatment Outcome; Young Adult | 2016 |
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.
Topics: Adolescent; Aging; Aspartic Acid; Biomarkers, Tumor; Brain Stem; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Molecular Imaging; Outcome Assessment, Health Care; Reproducibility of Results; Sensitivity and Specificity; Tumor Burden | 2016 |
The association between retinal nerve fibre layer thickness and N-acetyl aspartate levels in multiple sclerosis brain normal-appearing white matter: a longitudinal study using magnetic resonance spectroscopy and optical coherence tomography.
Topics: Adult; Aspartic Acid; Axons; Brain; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Retinal Neurons; Sensitivity and Specificity; Tomography, Optical Coherence; White Matter | 2016 |
Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy.
Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Disease Progression; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Trinucleotide Repeats | 2016 |
N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.
Topics: Amidohydrolases; Animals; Aspartic Acid; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcription Factors; Brain; Canavan Disease; Child; Child, Preschool; Dependovirus; Disease Progression; Energy Metabolism; Female; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Infant; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Transgenic; Movement Disorders; Myelin Basic Protein; Myelin Sheath; Neurodegenerative Diseases; Oligodendroglia | 2016 |
Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media; Diffusion Tensor Imaging; Disease Progression; Female; Glioblastoma; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Grading; Organometallic Compounds; Prospective Studies; Retrospective Studies | 2017 |
Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS.
Topics: Age Factors; Amidohydrolases; Animals; Animals, Newborn; Aspartic Acid; Axons; Behavior, Animal; Canavan Disease; Central Nervous System; Chromosome Mapping; Codon, Nonsense; Disease Models, Animal; Disease Progression; Glutamine; Lipid Metabolism; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Sheath; N-Acylsphingosine Galactosyltransferase; Oligodendroglia | 2008 |
Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.
Topics: Animals; Aspartic Acid; Brain; Cats; Choline; Contrast Media; Creatine; Disease Models, Animal; Disease Progression; Embolism, Fat; Follow-Up Studies; Gadolinium DTPA; Image Enhancement; Intracranial Embolism; Lactic Acid; Lipid Metabolism; Lipids; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Sodium Chloride; Triolein | 2008 |
Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Brain Mapping; Cell Death; Diffusion Magnetic Resonance Imaging; Disease Progression; Down-Regulation; Energy Metabolism; Female; Humans; Lactic Acid; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Stroke; Time Factors | 2008 |
Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease.
Topics: Aged; alpha-Macroglobulins; Alzheimer Disease; Aspartic Acid; Biomarkers; Complement Factor H; Disease Progression; Electrophoresis, Gel, Two-Dimensional; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Organ Size | 2008 |
The neuropsychological and neuroradiological correlates of slowly progressive visual agnosia.
Topics: Agnosia; Aspartic Acid; Atrophy; Brain; Brain Mapping; Disease Progression; Energy Metabolism; Female; Fluorodeoxyglucose F18; Functional Laterality; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Nerve Degeneration; Neuropsychological Tests; Occipital Lobe; Parietal Lobe; Positron-Emission Tomography; Temporal Lobe | 2009 |
Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion Tensor Imaging; Disease Progression; Female; Humans; Internal Capsule; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Pyramidal Tracts; ROC Curve; Sensitivity and Specificity | 2010 |
Serial MR imaging and 1H-MR spectroscopy in monozygotic twins with Tay-Sachs disease.
Topics: Aspartic Acid; Basal Ganglia; Brain; Cerebral Cortex; Child, Preschool; Choline; Corpus Callosum; Creatine; Disease Progression; Diseases in Twins; DNA Mutational Analysis; Dominance, Cerebral; Energy Metabolism; Epilepsies, Myoclonic; Female; Gangliosidoses, GM2; Hexosaminidase A; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nerve Fibers, Myelinated; Neurologic Examination; Thalamus; Twins, Monozygotic | 2008 |
Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis.
Topics: Amino Acids; Aspartic Acid; Axons; Biomarkers; Cohort Studies; Disease Progression; Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Neurofilament Proteins; tau Proteins | 2009 |
Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Brain; CD4-CD8 Ratio; Disease Progression; Early Diagnosis; Frontal Lobe; Glutamic Acid; HIV Seropositivity; Humans; Immunophenotyping; Magnetic Resonance Spectroscopy; Middle Aged; Neurons; T-Lymphocytes | 2009 |
Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Atrophy; Biomarkers; Brain; Cerebrovascular Disorders; Cognition Disorders; Cohort Studies; Creatine; Dementia; Disease Progression; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Risk Factors | 2009 |
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; Dementia; Disease Progression; Female; Follow-Up Studies; Glutamine; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Parietal Lobe; Prognosis; Severity of Illness Index | 2009 |
In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Biomarkers; Brain; Brain Chemistry; Cell Survival; Cross-Sectional Studies; Disability Evaluation; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Severity of Illness Index; Young Adult | 2009 |
A proton magnetic resonance spectroscopic study in juvenile absence epilepsy in early stages.
Topics: Adolescent; Aspartic Acid; Brain; Child; Choline; Creatine; Disease Progression; Down-Regulation; Electroencephalography; Epilepsy, Absence; Female; Frontal Lobe; Functional Laterality; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Membrane Potentials; Neurotoxins; Predictive Value of Tests; Thalamus | 2010 |
Prolonged neurologic course of familial hemophagocytic lymphohistiocytosis.
Topics: Aspartic Acid; Bone Marrow; Brain; Child; Choline; Diagnosis, Differential; Disease Progression; Fatal Outcome; Female; Ferritins; Fibrinogen; Humans; Lactic Acid; Lymphohistiocytosis, Hemophagocytic; Magnetic Resonance Imaging; Male; Remission Induction; Siblings; Triglycerides | 2009 |
In vivo glutamate decline associated with kainic acid-induced status epilepticus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Disease Progression; Glutamic Acid; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Kainic Acid; Lactic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurons; Organ Size; Rats; Rats, Wistar; Seizures; Status Epilepticus; Time Factors | 2009 |
Distinction between glioma progression and post-radiation change by combined physiologic MR imaging.
Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Follow-Up Studies; Glioma; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Recurrence, Local; Perfusion Imaging; Pilot Projects; Retrospective Studies | 2010 |
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.
Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Immunohistochemistry; Magnetic Resonance Spectroscopy; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Wallerian Degeneration | 2010 |
Spinal cord repair in MS: does mitochondrial metabolism play a role?
Topics: Adult; Aspartic Acid; Axons; Cervical Vertebrae; Disease Progression; Female; Follow-Up Studies; Humans; Linear Models; Logistic Models; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Mitochondria; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Organ Size; Reactive Oxygen Species; Spinal Cord; Time Factors | 2010 |
The brake on neurodegeneration: Increased mitochondrial metabolism in the injured MS spinal cord.
Topics: Aspartic Acid; Cervical Vertebrae; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mitochondria; Multiple Sclerosis; Nerve Degeneration; Organ Size; Reactive Oxygen Species; Spinal Cord; Time Factors | 2010 |
Ventromedial prefrontal spectroscopic abnormalities over the course of depression: a comparison among first episode, remitted recurrent and chronic patients.
Topics: Adult; Age of Onset; Aspartic Acid; Choline; Chronic Disease; Depressive Disorder, Major; Disease Progression; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Prefrontal Cortex | 2011 |
Quantitative in vivo brain magnetic resonance spectroscopic monitoring of neurological involvement in mucopolysaccharidosis type II (Hunter Syndrome).
Topics: Adolescent; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Case-Control Studies; Child; Child, Preschool; Choline; Disease Progression; Enzyme Replacement Therapy; Glutamic Acid; Humans; Iduronate Sulfatase; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mucopolysaccharidosis II; Predictive Value of Tests; Treatment Outcome | 2010 |
Occurrence of neuronal dysfunction during the first 5 years of multiple sclerosis is associated with cognitive deterioration.
Topics: Adult; Aspartic Acid; Cognition Disorders; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Neurons; Neuropsychological Tests; Young Adult | 2011 |
Diffusion-weighted imaging and magnetic resonance spectroscopy of sporadic Creutzfeldt-Jakob disease: correlation with clinical course.
Topics: Aged; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Creutzfeldt-Jakob Syndrome; Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic; Tissue Distribution | 2011 |
Temporal evolution of sporadic Creutzfeldt-Jakob disease monitored by 3-Tesla MR spectroscopy.
Topics: Aged; Aspartic Acid; Choline; Creutzfeldt-Jakob Syndrome; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male | 2011 |
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Temporal Lobe | 2011 |
Subependymal seeding of low-grade oligodendroglial neoplasms: a case series.
Topics: Adult; Aspartic Acid; Creatine; Disease Progression; Ependyma; Fourth Ventricle; Glioma; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mutation; Neoplasm Seeding; Retrospective Studies; Supratentorial Neoplasms; Young Adult | 2012 |
Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo ¹H MR spectroscopy at 9.4 T.
Topics: Acute Disease; Algorithms; Animals; Aspartic Acid; Biological Transport, Active; Blood Glucose; Blood-Brain Barrier; Brain Chemistry; Cerebral Cortex; Chronic Disease; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Progression; Glucose; Glutathione; Hippocampus; Hyperglycemia; Kinetics; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley | 2012 |
Metabolite investigation in both anterior and posterior cingulate gyri in Alzheimer's disease spectrum using 3-tesla MR spectroscopy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Disease Progression; Female; Gyrus Cinguli; Humans; Inositol; Intelligence Tests; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Statistics as Topic | 2012 |
A 9-year follow-up of a girl with pyridoxine (vitamin B6)-dependent seizures: magnetic resonance spectroscopy findings.
Topics: Adolescent; Anticonvulsants; Aspartic Acid; Biomarkers; Brain; Child; Creatinine; Disease Progression; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Predictive Value of Tests; Pyridoxine; Treatment Outcome; Vitamin B Complex | 2012 |
Relationship between enzyme properties and disease progression in Canavan disease.
Topics: Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Catalysis; Disease Progression; Humans; Mutation; Phenotype | 2013 |
Association between proton magnetic resonance spectroscopy measurements and CAG repeat number in patients with spinocerebellar ataxias 2, 3, or 6.
Topics: Adult; Age of Onset; Aged; Aspartic Acid; Case-Control Studies; Cerebellum; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Tissue Proteins; Research Design; Retrospective Studies; Severity of Illness Index; Spinocerebellar Ataxias; Taiwan; Trinucleotide Repeats | 2012 |
Spectroscopic changes associated with mild cognitive impairment and dementia in Parkinson's disease.
Topics: Aged, 80 and over; Aspartic Acid; Brain Chemistry; Cognition; Cognitive Dysfunction; Data Interpretation, Statistical; Dementia; Disease Progression; Executive Function; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Prefrontal Cortex; Psychiatric Status Rating Scales; Psychomotor Performance; Temporal Lobe; Tomography, X-Ray Computed | 2012 |
The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.
Topics: Acoustic Stimulation; Age Factors; Aging, Premature; Animals; Aspartic Acid; Chi-Square Distribution; Creatine; Disease Models, Animal; Disease Progression; Electron Transport Chain Complex Proteins; Electron Transport Complex IV; Electroretinography; Evoked Potentials, Auditory, Brain Stem; Evoked Potentials, Visual; Gene Expression Regulation; Glycolysis; GTP Phosphohydrolases; Humans; Lactic Acid; Locomotion; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Diseases; Muscle, Skeletal; Nervous System; Optic Atrophy, Autosomal Dominant; Optic Nerve; Phenotype; Physical Conditioning, Animal; Psychoacoustics; Psychomotor Performance; Reaction Time; Retina; Retinal Ganglion Cells; Sequence Deletion | 2012 |
Novel hypomyelinating leukoencephalopathy affecting early myelinating structures: clinical course in two brothers.
Topics: Aspartic Acid; Cerebellum; Child; Child, Preschool; Disease Progression; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Fibers, Myelinated; Siblings | 2013 |
Localized (1)H magnetic resonance spectroscopy in mainly cortical gray matter of patients with multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Occipital Lobe; Parietal Lobe; Recurrence; Water | 2002 |
Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Time Factors | 2003 |
Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Brain; Cats; Choline; Corpus Striatum; Creatine; Disease Models, Animal; Disease Progression; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neurologic Examination; Pargyline; Parkinsonian Disorders; Predictive Value of Tests; Protons; Tyrosine 3-Monooxygenase | 2003 |
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease.
Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Progression; Female; Gliosis; Humans; Infant; Inositol; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Radiography | 2003 |
Primary lateral sclerosis: A heterogeneous disorder composed of different subtypes?
Topics: Adult; Aspartic Acid; Atrophy; Brain Stem; Choline; Creatinine; Disease Progression; Evoked Potentials, Motor; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neuron Disease; Muscle Spasticity; Neurons; Psychomotor Performance; Reflex, Abnormal; Reflex, Startle | 2003 |
Whole-brain N-acetylaspartate level and cognitive performance in HIV infection.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Atrophy; Brain; Disease Progression; Energy Metabolism; Female; HIV Seropositivity; HIV-1; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurons; Neuropsychological Tests; Reference Values; Sensitivity and Specificity | 2003 |
Pantothenate kinase-associated neurodegeneration: MR imaging, proton MR spectroscopy, and diffusion MR imaging findings.
Topics: Adolescent; Aspartic Acid; Brain; Cerebellar Nuclei; Choline; Creatine; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Disease Progression; Energy Metabolism; Follow-Up Studies; Globus Pallidus; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurologic Examination; Pantothenate Kinase-Associated Neurodegeneration; Phosphotransferases (Alcohol Group Acceptor); Reference Values; Thalamus | 2003 |
Neuronal damage after ischemic injury in the middle cerebral arterial territory: deep watershed versus territorial infarction at MR perfusion and spectroscopic imaging.
Topics: Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Contrast Media; Diagnosis, Differential; Disease Progression; Female; Humans; Infarction, Middle Cerebral Artery; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurons; Time Factors | 2003 |
Reduced N-acetylaspartate levels and cognitive decline.
Topics: Alleles; Apolipoproteins E; Aspartic Acid; Brain Chemistry; Cognition Disorders; Disease Progression; Humans; Multiple Sclerosis | 2004 |
Neuronal cell injury precedes brain atrophy in multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neurons; Severity of Illness Index; Time Factors | 2004 |
Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors.
Topics: Adolescent; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Child; Child, Preschool; Choline; Disease Progression; Female; Humans; Infant; Magnetic Resonance Angiography; Magnetic Resonance Spectroscopy; Male; Prognosis | 2004 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creatine; Disease Models, Animal; Disease Progression; Female; Inositol; Longitudinal Studies; Macaca mulatta; Magnetic Resonance Spectroscopy; Male; Predictive Value of Tests; Prospective Studies; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Survival Rate; Viral Load | 2004 |
Leukoencephalopathy, cerebral calcifications, and cysts: new observations.
Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Calcinosis; Central Nervous System Cysts; Child; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rare Diseases; Retinal Diseases; Syndrome; Tomography, X-Ray Computed | 2004 |
MR imaging and proton MR spectroscopic studies in Sjögren-Larsson syndrome: characterization of the leukoencephalopathy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Cerebral Ventricles; Child; Child, Preschool; Choline; Creatine; Disease Progression; Energy Metabolism; Female; Humans; Image Processing, Computer-Assisted; Infant; Inositol; Lipid Metabolism; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myelin Sheath; Nerve Fibers, Myelinated; Neurologic Examination; Sjogren-Larsson Syndrome | 2004 |
Subacute sclerosing panencephalitis with fulminating course: follow-up magnetic resonance spectroscopy (MRS) findings.
Topics: Aspartic Acid; Brain; Cerebral Cortex; Child, Preschool; Choline; Creatine; Diagnosis, Differential; Disease Progression; Dominance, Cerebral; Energy Metabolism; Female; Follow-Up Studies; Gliosis; Humans; Image Enhancement; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Myelin Sheath; Neurologic Examination; Neurons; Subacute Sclerosing Panencephalitis | 2004 |
Five new cases of a recently described leukoencephalopathy with high brain lactate.
Topics: Adolescent; Aspartic Acid; Ataxia; Brain Chemistry; Brain Diseases, Metabolic; Brain Stem; Central Nervous System Diseases; Child; Child, Preschool; Choline; Disease Progression; Evoked Potentials, Somatosensory; Female; Finland; Genes, Recessive; Humans; Lactates; Magnetic Resonance Imaging; Male; Muscle Spasticity; Pedigree; Sensation Disorders; Spinal Cord; Tremor | 2004 |
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Creatine; Disease Progression; Energy Metabolism; Female; Glioblastoma; Humans; Image Processing, Computer-Assisted; Lactic Acid; Lipid Metabolism; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neuronavigation; Prognosis; Radiosurgery; Reoperation; Risk; Survival Analysis | 2004 |
Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy.
Topics: Adult; Aspartic Acid; Cerebellum; Cerebral Cortex; Choline; Creatine; Disease Progression; Female; HIV Infections; Humans; Inositol; JC Virus; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Survivors; T-Cell Antigen Receptor Specificity; T-Lymphocytes, Cytotoxic | 2004 |
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Disease Models, Animal; Disease Progression; Energy Metabolism; Female; Frontal Lobe; Glutamic Acid; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plaque, Amyloid; Presenilin-2; Spectrum Analysis | 2005 |
Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Injuries; Child; Child, Preschool; Choline; Coma; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Occipital Lobe; Parietal Lobe; Predictive Value of Tests; Recovery of Function; Up-Regulation | 2004 |
Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Aspartic Acid; Central Nervous System Neoplasms; Choline; Creatine; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Immunocompetence; Lactic Acid; Lipid Metabolism; Lymphoma; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Protons; Survival Analysis | 2005 |
Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients.
Topics: Adolescent; Adrenoleukodystrophy; Aspartic Acid; Brain Chemistry; Child; Child, Preschool; Creatine; Disease Progression; Follow-Up Studies; Glutamine; Hematopoietic Stem Cell Transplantation; Humans; Inositol; Lactates; Lipids; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Prognosis | 2005 |
Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis.
Topics: Adult; Aspartic Acid; Astrocytes; Atrophy; CD3 Complex; Cell Communication; Cells, Cultured; Central Nervous System; Coculture Techniques; Cohort Studies; Disease Progression; Endothelial Cells; Female; Humans; Interferon-beta; Magnetic Resonance Spectroscopy; Male; Microglia; Multiple Sclerosis; Nerve Growth Factor; T-Lymphocytes; Wallerian Degeneration | 2005 |
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy.
Topics: Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression; Feasibility Studies; Female; Glioma; Humans; Lactic Acid; Lipid Metabolism; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neoplasm Recurrence, Local; Pons | 2005 |
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Disease Progression; Female; Functional Laterality; Humans; Inositol; Lateral Ventricles; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Nerve Fibers, Myelinated; Predictive Value of Tests; Protons | 2006 |
Diffuse structural and metabolic brain changes in Fabry disease.
Topics: Adult; alpha-Galactosidase; Aspartic Acid; Axons; Brain; Brain Chemistry; Disease Progression; DNA; Fabry Disease; Female; Heterozygote; Homozygote; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mutation | 2006 |
Inosiplex affects the spectra of proton magnetic resonance spectroscopy in subacute sclerosing panencephalitis.
Topics: Adolescent; Antiviral Agents; Artifacts; Aspartic Acid; Choline; Disease Progression; Dominance, Cerebral; Female; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Inosine Pranobex; Inositol; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neurologic Examination; Reproducibility of Results; Subacute Sclerosing Panencephalitis | 2006 |
[Application of (1)H MR spectroscopic imaging in radiation oncology: choline as a marker for determining the relative probability of tumor progression after radiation of glial brain tumors].
Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Choline; Combined Modality Therapy; Contrast Media; Cranial Irradiation; Diagnosis, Differential; Disease Progression; Female; Follow-Up Studies; Gadolinium DTPA; Glioblastoma; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Oligodendroglioma; Phosphocreatine; Predictive Value of Tests; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Adjuvant; Reference Values; Stereotaxic Techniques | 2006 |
Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Choline; Cognition Disorders; Creatine; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Retrospective Studies | 2007 |
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Models, Animal; Disease Progression; gamma-Aminobutyric Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Superoxide Dismutase; Time Factors | 2007 |
Quantification of neurometabolites in subacute sclerosing panencephalitis by 1H-MRS.
Topics: Aspartic Acid; Brain Chemistry; Confounding Factors, Epidemiologic; Disease Progression; Humans; Inosine Pranobex; Inositol; Magnetic Resonance Spectroscopy; Neurons; Subacute Sclerosing Panencephalitis | 2007 |
MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes.
Topics: Animals; Aspartic Acid; Astrocytes; Body Water; Brain; Choline; Creatine; Diffusion; Disease Models, Animal; Disease Progression; Gliosis; Glucose; Glutamic Acid; Hyperkinesis; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Microglia; Prion Diseases | 2007 |
Time course of early metabolic changes following diffuse traumatic brain injury in rats as detected by (1)H NMR spectroscopy.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Injuries; Creatine; Diffuse Axonal Injury; Disease Models, Animal; Disease Progression; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Time Factors; Up-Regulation; Water-Electrolyte Balance | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis, Relapsing-Remitting; Prospective Studies; Severity of Illness Index | 2007 |
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Age Factors; Age of Onset; Aminopeptidases; Aspartic Acid; Cerebral Cortex; Child; Child, Preschool; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Disease Progression; DNA Mutational Analysis; Endopeptidases; Female; Humans; Magnetic Resonance Imaging; Male; Mutation, Missense; Neurologic Examination; Neuronal Ceroid-Lipofuscinoses; Nuclear Magnetic Resonance, Biomolecular; Ophthalmoscopy; Organ Size; Point Mutation; Retina; Serine Proteases; Severity of Illness Index; Siblings; Tripeptidyl-Peptidase 1 | 2007 |
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Retrospective Studies | 2007 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; Choline; Creatine; Disease Progression; Energy Metabolism; Glycolysis; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mitochondria; Nerve Degeneration; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Imaging of axonal damage in vivo in Rasmussen's syndrome.
Topics: Adolescent; Aspartic Acid; Brain Chemistry; Child; Chronic Disease; Creatine; Disease Progression; Encephalitis; Epilepsies, Partial; Female; Hemiplegia; Humans; Magnetic Resonance Imaging; Male; Status Epilepticus; Syndrome | 1995 |
Statistics for investigation of multimodal MR imaging data and an application to multiple sclerosis patients.
Topics: Aspartic Acid; Brain; Creatine; Disease Progression; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Models, Theoretical; Multiple Sclerosis; Recurrence; Reference Values | 1996 |
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplastic; Choline; Creatine; Deoxyglucose; Disease Progression; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Follow-Up Studies; Glioma; Humans; Hydrogen; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphocreatine; Prognosis; Protons; Radiopharmaceuticals; Tomography, Emission-Computed | 1997 |
Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy.
Topics: Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Contrast Media; Creatine; Disease Progression; Feasibility Studies; Follow-Up Studies; Glioblastoma; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Necrosis; Neoplasm Recurrence, Local; Neoplasm, Residual; Protons; Radiation Injuries; Radiography, Interventional; Retrospective Studies; Stereotaxic Techniques; Supratentorial Neoplasms; Tomography, X-Ray Computed | 1997 |
Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neurologic Examination | 1998 |
Proton magnetic resonance spectroscopy of linear nevus sebaceus syndrome.
Topics: Aspartic Acid; Brain Chemistry; Cerebral Cortex; Child, Preschool; Choline; Creatine; Disease Progression; Hamartoma; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Male; Skin Neoplasms; Syndrome | 1998 |
Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study.
Topics: Aspartic Acid; Axons; Brain; Creatine; Disability Evaluation; Disease Progression; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Recurrence | 1998 |
Prediction of cognitive decline in early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Cognition; Disease Progression; Humans; Magnetic Resonance Spectroscopy; Predictive Value of Tests; Prognosis; Reproducibility of Results | 1998 |
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Disease Progression; Female; Frontal Lobe; Humans; Hydrogen; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple System Atrophy; Neurodegenerative Diseases; Phosphocreatine; Protons; Putamen | 1999 |
Usefulness of proton magnetic resonance spectroscopy in differentiating parkinsonian syndromes.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Diagnosis, Differential; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple System Atrophy; Parkinsonian Disorders; Phosphocreatine; Supranuclear Palsy, Progressive | 1999 |
Total brain N-acetylaspartate: a new measure of disease load in MS.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Cell Survival; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neurons; Reference Values; Reproducibility of Results; Severity of Illness Index | 2000 |
MR spectroscopy in gliomatosis cerebri.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Child; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasms, Neuroepithelial; Prognosis; Stereotaxic Techniques | 2000 |
Proton magnetic resonance spectroscopy in primary and secondary progressive multiple sclerosis.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine | 2000 |
Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurons; Prospective Studies; Sensitivity and Specificity | 2000 |
Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cognition Disorders; Creatine; Disease Progression; Energy Metabolism; Female; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Occipital Lobe; Reference Values; Temporal Lobe | 2000 |
Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis.
Topics: Adult; Age Factors; Aspartic Acid; Case-Control Studies; Child; Child, Preschool; Creatine; Disease Progression; Epilepsy; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Tomography, Emission-Computed, Single-Photon; Tuberous Sclerosis | 2000 |
Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability.
Topics: Adult; Aspartic Acid; Atrophy; Axons; Brain; Chromatography, High Pressure Liquid; Creatine; Disability Evaluation; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Severity of Illness Index; Spinal Cord; Time Factors | 2001 |
Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Phosphocreatine; Reference Values; Severity of Illness Index | 2001 |
Correlation of cerebral metabolites with clinical outcome among patients with severe congestive heart failure.
Topics: Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Disease Progression; Heart Failure; Humans; Inositol; Magnetic Resonance Spectroscopy; Neurons; Predictive Value of Tests | 2001 |
Severe metabolic abnormalities in the white matter of patients with vacuolating megalencephalic leukoencephalopathy with subcortical cysts. A proton MR spectroscopic imaging study.
Topics: Adolescent; Adult; Aspartic Acid; Creatine; Cysts; Dementia, Vascular; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphocreatine | 2001 |
Editorial commentary to Narayanan et al. Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b.
Topics: Adjuvants, Immunologic; Aspartic Acid; Clinical Trials as Topic; Diffuse Axonal Injury; Disease Progression; Humans; Interferon beta-1a; Interferon beta-1b; Interferon-beta; Multiple Sclerosis; Reproducibility of Results; Research Design; Treatment Outcome | 2001 |
Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Reproducibility of Results | 2002 |