Compounds > n-acetylaspartic acid
Page last updated: 2024-08-24

n-acetylaspartic acid and Depression

n-acetylaspartic acid has been researched along with Depression in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (27.27)29.6817
2010's22 (66.67)24.3611
2020's2 (6.06)2.80

Authors

AuthorsStudies
Bajs Janović, M; Erdeljić Turk, V; Foro, T; Henigsberg, N; Hrabač, P; Kalember, P; Ozretić, D; Radoš, M; Šarac, H; Savić, A; Šečić, A1
Li, Z; Liu, J; Liu, X; Ren, Y; Shangguan, J; Wang, C; Wang, J; Zhou, T; Zhou, X1
Castaneda, A; Hakkarainen, A; Lundbom, N; Marttunen, M; Paunio, T; Urrila, AS1
Azuma, S; Fu, K; Iegaki, N; Ishikawa, Y; Miyamoto, Y; Muramatsu, SI; Nitta, A; Sumi, K; Uno, K1
Freed, RD; Gabbay, V; Hollenhorst, CN; Kang, G; Mao, X; Shungu, DC; Weiduschat, N1
Alger, JR; Johnson, MC; London, ED; O'Neill, J; Shen, Z; Tang, J1
Forester, BP; Harper, DG; Jensen, E; Mellen, EJ; Ravichandran, C; Silveri, M1
Baymeeva, NV; Miroshnichenko, II; Safarova, TP; Shipilova, ES; Yakovleva, OB1
Bigler, DC; Bunce, SC; Mack, J; Moore, GJ; Morton, DH; Muelly, ER; Strauss, KA1
Ezzati, A; Katz, MJ; Lipton, RB; Zimmerman, ME1
Boulanger, Y; Chamard, E; Henry, L; Lassonde, M; Théoret, H1
Fuh, JL; Hung, CW; Lirng, JF; Tsai, CF; Wang, SJ1
Gao, S; Peng, GJ; Qin, XM; Shi, BY; Tian, JS1
Duffy, SL; Hermens, DF; Hickie, IB; Jayaweera, HK; Lagopoulos, J; Lewis, SJ; Naismith, SL; Norrie, L1
Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K1
Campbell, SR; Cui, MH; Gao, HX; Gulinello, M; Hee-Hwang, J; Putterman, C; Zong, P1
Babb, JS; Gabbay, V; Gonen, O; Katz, Y; Klein, RG; Liebes, L; Liu, S; Mendoza, S1
Chen, W; Geng, D; Huang, Y; Li, Y; Shi, X; Wu, X1
Atkinson, JH; Clifford, D; Collier, AC; Ellis, RJ; Fennema-Notestine, C; Franklin, D; Gelman, B; Grant, I; Heaton, R; Jernigan, T; Lin, K; Marra, C; McArthur, J; McCutchan, A; Morgello, S; Simpson, D; Taylor, MJ1
Bédard, MJ; Chantal, S1
Li, MH; Li, YH; Lu, J; Sun, XJ; Wang, X; Ye, JL; Zhang, B; Zhao, JG1
Chan, KC; Hui, J; Li, L; Liu, S; Nie, B; Reynolds, GP; Shan, B; Teng, G; Wu, EX; Xi, G; Zhang, X; Zhang, Z1
Bittsansky, M; Dobrota, D; Husarova, V; Kerna, V; Ondrejka, I1
Bora, E; Lubman, DI; MacKenzie, T; Roffel, K; Verdejo-García, A; Vilar-López, R; Yücel, M1
Cookson, MR; Drevets, WC; Gibbs, JR; Goldman, D; Hasler, G; Hodgkinson, C; Neumeister, A; Preuss, N; Salehi, B; Shen, J; Singleton, A; van der Veen, JW; Wendland, JR1
Fredrickson, BE; Grachev, ID; Ramachandran, TS; Szeverenyi, NM; Thomas, PS1
Frey, R; Gruber, S; Heiden, A; Kasper, S; Kemp, GJ; Mlynárik, V; Moser, E; Stadlbauer, A1
Benkelfat, C; Herpertz, SC; Hurley, RA; Johnson, PA; Taber, KH1
Glodzik-Sobanska, L; Kieltyka, A; Kozub, J; Slowik, A; Sobiecka, B; Szczudlik, A; Urbanik, A1
Akdeniz, F; Eker, C; Eker, OD; Gonul, AS; Kitis, O; Ozan, E; Vahip, S1
Faught, RE; Gilliam, FG; Hugg, JW; Kuzniecky, RI; Martin, RC; Maton, BM; Sawrie, SM; Viikinsalo, M1
Cheong, C; Choe, BY; Choi, CB; Hong, KS; Hong, ST; Jeon, YW; Park, C1
Beardslee, WR; Hennen, J; Katic, A; Moore, CM; Moore, JC; Renshaw, PF; Steingard, RJ; Vakili, K; Young, AD; Yurgelun-Todd, DA1

Reviews

1 review(s) available for n-acetylaspartic acid and Depression

ArticleYear
Understanding emotion regulation in borderline personality disorder: contributions of neuroimaging.
    The Journal of neuropsychiatry and clinical neurosciences, 2003,Fall, Volume: 15, Issue:4

    Topics: Aspartic Acid; Borderline Personality Disorder; Brain; Brain Mapping; Choline; Compulsive Personality Disorder; Creatinine; Depression; Electroencephalography; Emotions; Female; Fenfluramine; Humans; Magnetic Resonance Imaging; Nerve Net; Serotonin Agents; Tomography, Emission-Computed; Tryptophan

2003

Trials

2 trial(s) available for n-acetylaspartic acid and Depression

ArticleYear
Cingulate biochemistry in heroin users on substitution pharmacotherapy.
    The Australian and New Zealand journal of psychiatry, 2013, Volume: 47, Issue:3

    Topics: Adult; Aspartic Acid; Buprenorphine; Depression; Dose-Response Relationship, Drug; Female; Functional Neuroimaging; Glutamic Acid; Glutamine; Gyrus Cinguli; Heroin Dependence; Humans; Inositol; Male; Methadone; Opiate Substitution Treatment

2013
The effect of antidepressant treatment on N-acetyl aspartate levels of medial frontal cortex in drug-free depressed patients.
    Progress in neuro-psychopharmacology & biological psychiatry, 2006, Volume: 30, Issue:1

    Topics: Adult; Analysis of Variance; Antidepressive Agents; Aspartic Acid; Brain Mapping; Choline; Creatine; Depression; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male

2006

Other Studies

30 other study(ies) available for n-acetylaspartic acid and Depression

ArticleYear
Choline elevation in amygdala region at recovery indicates longer survival without depressive episode: a magnetic resonance spectroscopy study.
    Psychopharmacology, 2021, Volume: 238, Issue:5

    Topics: Adult; Amygdala; Antidepressive Agents; Aspartic Acid; Brain; Choline; Depression; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Recurrence

2021
Application of
    BMC nephrology, 2020, 06-15, Volume: 21, Issue:1

    Topics: Adult; Aspartic Acid; Choline; Creatine; Depression; Female; Frontal Lobe; Humans; Kidney Failure, Chronic; Male; Prospective Studies; Proton Magnetic Resonance Spectroscopy; Reference Values

2020
Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study.
    Neuropsychobiology, 2017, Volume: 75, Issue:1

    Topics: Adolescent; Aspartic Acid; Creatine; Depression; Female; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Inositol; Male; Proton Magnetic Resonance Spectroscopy; Sleep Wake Disorders

2017
Striatal N-Acetylaspartate Synthetase Shati/Nat8l Regulates Depression-Like Behaviors via mGluR3-Mediated Serotonergic Suppression in Mice.
    The international journal of neuropsychopharmacology, 2017, 12-01, Volume: 20, Issue:12

    Topics: Acetyltransferases; Animals; Aspartic Acid; Corpus Striatum; Depression; Dipeptides; Disease Models, Animal; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Hindlimb Suspension; Humans; Interpersonal Relations; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microdialysis; Microinjections; Receptors, Metabotropic Glutamate; Serotonin; Swimming; Transduction, Genetic

2017
A pilot study of cortical glutathione in youth with depression.
    Psychiatry research. Neuroimaging, 2017, Dec-30, Volume: 270

    Topics: Adolescent; Anhedonia; Aspartic Acid; Case-Control Studies; Child; Choline; Creatine; Depression; Depressive Disorder, Major; Female; Glutathione; Humans; Male; Occipital Lobe; Oxidative Stress; Pilot Projects; Proton Magnetic Resonance Spectroscopy; Young Adult

2017
N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users.
    The international journal of neuropsychopharmacology, 2019, 01-01, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Anxiety; Aspartic Acid; Central Nervous System Stimulants; Cerebral Cortex; Cross-Sectional Studies; Depression; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methamphetamine; Middle Aged; Young Adult

2019
Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019, Volume: 27, Issue:8

    Topics: Aged; Aging; Antipsychotic Agents; Aspartic Acid; Biomarkers; Bipolar Disorder; Cerebral Cortex; Creatine; Depression; Energy Metabolism; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Lamotrigine; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Severity of Illness Index; Treatment Outcome

2019
[The content of N-acetylaspartate in depressed elderly patients during therapy with antidepressants and actovegin].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2019, Volume: 119, Issue:4

    Topics: Aged; Antidepressive Agents; Aspartic Acid; Depression; Female; Heme; Humans; Male

2019
Biochemical correlates of neuropsychiatric illness in maple syrup urine disease.
    The Journal of clinical investigation, 2013, Volume: 123, Issue:4

    Topics: Adolescent; Adult; Affect; Anxiety; Aspartic Acid; Attention; Brain; Case-Control Studies; Child; Child, Preschool; Creatine; Depression; Female; Glutamic Acid; Humans; Impulsive Behavior; Liver Transplantation; Male; Maple Syrup Urine Disease; Prevalence; Psychomotor Agitation; Risk; Young Adult

2013
Hippocampal correlates of depression in healthy elderly adults.
    Hippocampus, 2013, Volume: 23, Issue:12

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Creatine; Depression; Female; Geriatrics; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Statistics as Topic

2013
A follow-up study of neurometabolic alterations in female concussed athletes.
    Journal of neurotrauma, 2014, Feb-15, Volume: 31, Issue:4

    Topics: Aspartic Acid; Athletes; Athletic Injuries; Brain Chemistry; Brain Concussion; Creatine; Depression; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Hippocampus; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Prefrontal Cortex; Young Adult

2014
Differences in brain metabolism associated with agitation and depression in Alzheimer's disease.
    East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan, 2013, Volume: 23, Issue:3

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Depression; Female; Gyrus Cinguli; Humans; Inositol; Male; Neuroimaging; Neuropsychological Tests; Prefrontal Cortex; Psychomotor Agitation

2013
[1H NMR based metabonomics study on the antidepressant effect of genipin in rat hippocampus].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:2

    Topics: Alanine; Animals; Antidepressive Agents; Aspartic Acid; Behavior, Animal; Chronic Disease; Depression; Gardenia; Glutamic Acid; Glycine; Hippocampus; Inositol; Iridoids; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Metabolomics; Plants, Medicinal; Rats; Rats, Sprague-Dawley

2014
Spectroscopic markers of memory impairment, symptom severity and age of onset in older people with lifetime depression: Discrete roles of N-acetyl aspartate and glutamate.
    Journal of affective disorders, 2015, Sep-01, Volume: 183

    Topics: Aged; Aspartic Acid; Case-Control Studies; Cross-Sectional Studies; Depression; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Prefrontal Cortex

2015
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
    Neurological research, 2017, Volume: 39, Issue:4

    Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depression; Disability Evaluation; Fatigue; Female; Glutamic Acid; Humans; Hypothalamus; Inositol; Male; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Severity of Illness Index

2017
Depression is an early disease manifestation in lupus-prone MRL/lpr mice.
    Journal of neuroimmunology, 2009, Feb-15, Volume: 207, Issue:1-2

    Topics: Animals; Aspartic Acid; Autoantibodies; Brain; Cardiolipins; Choline; Chromatin; Creatine; Depression; DNA; Exploratory Behavior; Female; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Mutant Strains; Proteinuria; Psychomotor Performance; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Social Behavior; Swimming

2009
The kynurenine pathway in adolescent depression: preliminary findings from a proton MR spectroscopy study.
    Progress in neuro-psychopharmacology & biological psychiatry, 2010, Feb-01, Volume: 34, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Adolescent; Aspartic Acid; Brain; Brain Mapping; Choline; Depression; Female; Humans; Kynurenine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neural Pathways; Psychiatric Status Rating Scales; Statistics, Nonparametric; Tryptophan; Young Adult

2010
Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: a study using (1)H magnetic resonance spectroscopy.
    Psychiatry research, 2010, Apr-30, Volume: 182, Issue:1

    Topics: Aged; Analysis of Variance; Antidepressive Agents; Aspartic Acid; Brain Mapping; Case-Control Studies; Choline; Depression; Dose-Response Relationship, Drug; Female; Functional Laterality; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Paroxetine; Stroke; Thalamus; Tritium

2010
Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals.
    Journal of clinical and experimental neuropsychology, 2011, Volume: 33, Issue:3

    Topics: Adult; Aspartic Acid; Brain Injuries; Cognition Disorders; Depression; Executive Function; Female; HIV Infections; Humans; Magnetic Resonance Spectroscopy; Male; Memory, Short-Term; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Substance-Related Disorders

2011
Brain magnetic resonance spectroscopy in obsessive-compulsive disorder: the importance of considering subclinical symptoms of anxiety and depression.
    Psychiatry research, 2011, Apr-30, Volume: 192, Issue:1

    Topics: Adult; Anxiety; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Depression; Female; Functional Laterality; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Obsessive-Compulsive Disorder; Statistics as Topic

2011
Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression.
    European archives of psychiatry and clinical neuroscience, 2012, Volume: 262, Issue:1

    Topics: Aged; Aspartic Acid; Brain; Brain Mapping; Creatine; Depression; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Psychiatric Status Rating Scales; Stroke

2012
Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rat model of depression as measured by 1H-MRS.
    PloS one, 2011, Volume: 6, Issue:12

    Topics: Animals; Aspartic Acid; Behavior, Animal; Citalopram; Creatine; Depression; Disease Models, Animal; Drinking Behavior; Hippocampus; Magnetic Resonance Spectroscopy; Male; Maze Learning; Memory; Organ Size; Protons; Rats; Rats, Sprague-Dawley; Stress, Psychological; Sucrose; Water

2011
Hippocampal neurometabolite changes in depression treatment: a (1)H magnetic resonance spectroscopy study.
    Psychiatry research, 2012, Mar-31, Volume: 201, Issue:3

    Topics: Adult; Antidepressive Agents; Aspartic Acid; Choline; Creatine; Depression; Female; Functional Laterality; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Psychiatric Status Rating Scales; Tritium; Young Adult

2012
Age-modulated association between prefrontal NAA and the BDNF gene.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder, Major; Female; Genetic Association Studies; Genotype; Humans; Linear Models; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Polymorphism, Single Nucleotide; Prefrontal Cortex; RNA, Messenger; Young Adult

2013
Association between dorsolateral prefrontal N-acetyl aspartate and depression in chronic back pain: an in vivo proton magnetic resonance spectroscopy study.
    Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:3

    Topics: Adult; Aspartic Acid; Back Pain; Chronic Disease; Depression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Protons; Statistics, Nonparametric

2003
Quantification of metabolic differences in the frontal brain of depressive patients and controls obtained by 1H-MRS at 3 Tesla.
    Investigative radiology, 2003, Volume: 38, Issue:7

    Topics: Adult; Antidepressive Agents; Aspartic Acid; Case-Control Studies; Choline; Creatine; Depression; Female; Frontal Lobe; Humans; Image Enhancement; Inositol; Magnetic Resonance Spectroscopy; Male

2003
Reduced prefrontal N-acetylaspartate in stroke patients with apathy.
    Journal of the neurological sciences, 2005, Nov-15, Volume: 238, Issue:1-2

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Depression; Female; Functional Laterality; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motivation; Prefrontal Cortex; Psychiatric Status Rating Scales; Stroke

2005
Hippocampal 1H-MRSI correlates with severity of depression symptoms in temporal lobe epilepsy.
    Neurology, 2007, Jan-30, Volume: 68, Issue:5

    Topics: Adult; Aspartic Acid; Biomarkers; Creatine; Depression; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Protons; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic

2007
Variation of the choline signal intensity in the dorsolateral prefrontal cortex of rats exposed to the forced swimming test as detected by in vivo 1H MR spectroscopy.
    Journal of neuroscience methods, 2007, Sep-15, Volume: 165, Issue:1

    Topics: Animals; Aspartic Acid; Choline; Creatine; Depression; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Psychological

2007
Increased orbitofrontal cortex levels of choline in depressed adolescents as detected by in vivo proton magnetic resonance spectroscopy.
    Biological psychiatry, 2000, Dec-01, Volume: 48, Issue:11

    Topics: Adolescent; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cytosol; Depression; Female; Frontal Lobe; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Psychiatric Status Rating Scales; Regression Analysis; Severity of Illness Index

2000