Compounds > n-acetylaspartic acid
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n-acetylaspartic acid and Chronic Progressive Multiple Sclerosis

n-acetylaspartic acid has been researched along with Chronic Progressive Multiple Sclerosis in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.56)18.2507
2000's11 (61.11)29.6817
2010's5 (27.78)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Barkhof, F; Chataway, J; DeAngelis, F; Doshi, A; Gandini Wheeler-Kingshott, CAM; John, NA; MacManus, D; Marshall, I; Monteverdi, A; Parker, RA; Plantone, D; Prados, F; Schneider, T; Solanky, BS; Stutters, J; Weir, CJ1
Achtnichts, L; Amann, M; Babb, JS; Bendfeldt, K; Gass, A; Gonen, O; Hirsch, J; Kappos, L; Naegelin, Y; Penner, IK; Rigotti, DJ1
Abdel-Aziz, K; Altmann, DR; Ciccarelli, O; Day, BL; Peters, AL; Schneider, T; Solanky, BS; Thompson, AJ; Wheeler-Kingshott, CA; Yiannakas, MC1
Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K1
Blom, HJ; Bouwman, F; Brundin, L; Dijkstra, CD; Iacobaeus, E; Jakobs, C; Khademi, M; Koel-Simmelink, MJ; Norgren, N; Schepens, M; Teunissen, CE; Twaalfhoven, HA1
Altmann, DR; Ciccarelli, O; McLean, MA; Miller, DH; Thompson, AJ; Wheeler-Kingshott, CA; Wimpey, K1
aufm Kampe, K; Bartsch, A; Bendszus, M; Biller, A; Classen, J; Gentner, R; Rieckmann, P; Schütz, A; Stefan, K; Toyka, KV; Zeller, D1
Bashir, K; Coyle, PK; Hetherington, HP; Krupp, LB; Pan, JW; Whitaker, JN1
Chard, DT; Ingle, GT; McLean, MA; Miller, DH; Ramió-Torrentà, L; Sastre-Garriga, J; Thompson, AJ1
Benedetti, B; Comi, G; Comola, M; Falini, A; Filippi, M; Gallo, A; Rossi, P; Rovaris, M; Scotti, G1
De Keyser, J; Mostert, JP; Oudkerk, M; Sijens, PE1
Behrens, TE; Cader, S; Johansen-Berg, H; Matthews, PM; Palace, J; Smith, S; Wylezinska, M1
Comi, G; Filippi, M; Judica, E; Martinelli, V; Pulizzi, A; Rovaris, M; Sormani, MP1
Ahn, CW; Narayana, PA; Sajja, BR; Wolinsky, JS1
Barker, GJ; Davie, CA; Leary, SM; Miller, DH; Parker, GJ; Stevenson, VL; Thompson, AJ; Wang, L1
Andersson, PB; Capizzano, AA; Goodkin, DE; Maudsley, AA; Rooney, WD; Soher, BJ; Suhy, J; Waubant, E; Weiner, MW1
Hagberg, G; Kappos, L; Mader, I; Radue, EW; Roser, W; Seelig, J; Steinbrich, W1
Bisaga, GN; Odinak, MM; Pozdniakov, AV; Tiutin, LA1

Trials

4 trial(s) available for n-acetylaspartic acid and Chronic Progressive Multiple Sclerosis

ArticleYear
NAA is a Marker of Disability in Secondary-Progressive MS: A Proton MR Spectroscopic Imaging Study.
    AJNR. American journal of neuroradiology, 2020, Volume: 41, Issue:12

    Topics: Adult; Amiloride; Aspartic Acid; Biomarkers; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Disability Evaluation; Disease Progression; Double-Blind Method; Female; Fluoxetine; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Neuroimaging; Neuroprotective Agents; Proton Magnetic Resonance Spectroscopy; Protons; Riluzole

2020
Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis.
    Archives of neurology, 2005, Volume: 62, Issue:4

    Topics: Adult; Age of Onset; Aged; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebral Cortex; Choline; Disability Evaluation; Disease Progression; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Nerve Fibers, Myelinated; Neurons; Neuropil; Phosphocreatine; Predictive Value of Tests; Reference Values; Statistics as Topic

2005
Longitudinal magnetic resonance spectroscopic imaging of primary progressive multiple sclerosis patients treated with glatiramer acetate: multicenter study.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2008, Volume: 14, Issue:1

    Topics: Aspartic Acid; Brain; Choline; Creatine; Glatiramer Acetate; Humans; Immunosuppressive Agents; Longitudinal Studies; Magnetic Resonance Spectroscopy; Models, Theoretical; Multiple Sclerosis, Chronic Progressive; Peptides; Protons

2008
Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques: absolute metabolic values over 2 years during a clinical pharmacological study.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:7

    Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Follow-Up Studies; Guanidines; Humans; Image Enhancement; Immunosuppressive Agents; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting

2000

Other Studies

14 other study(ies) available for n-acetylaspartic acid and Chronic Progressive Multiple Sclerosis

ArticleYear
Global N-acetylaspartate concentration in benign and non-benign multiple sclerosis patients of long disease duration.
    European journal of radiology, 2013, Volume: 82, Issue:12

    Topics: Adult; Aspartic Acid; Biomarkers; Brain Chemistry; Diagnosis, Differential; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis, Chronic Progressive; Protons; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index

2013
Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis.
    Brain : a journal of neurology, 2015, Volume: 138, Issue:Pt 6

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Atrophy; Brain; Case-Control Studies; Cervical Cord; Disability Evaluation; Early Diagnosis; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Nerve Degeneration; Proton Magnetic Resonance Spectroscopy; Spinal Cord; White Matter; Young Adult

2015
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
    Neurological research, 2017, Volume: 39, Issue:4

    Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depression; Disability Evaluation; Fatigue; Female; Glutamic Acid; Humans; Hypothalamus; Inositol; Male; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Severity of Illness Index

2017
Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis.
    Neurology, 2009, Apr-14, Volume: 72, Issue:15

    Topics: Amino Acids; Aspartic Acid; Axons; Biomarkers; Cohort Studies; Disease Progression; Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Neurofilament Proteins; tau Proteins

2009
Spinal cord repair in MS: does mitochondrial metabolism play a role?
    Neurology, 2010, Mar-02, Volume: 74, Issue:9

    Topics: Adult; Aspartic Acid; Axons; Cervical Vertebrae; Disease Progression; Female; Follow-Up Studies; Humans; Linear Models; Logistic Models; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Mitochondria; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Organ Size; Reactive Oxygen Species; Spinal Cord; Time Factors

2010
Rapid-onset central motor plasticity in multiple sclerosis.
    Neurology, 2010, Mar-02, Volume: 74, Issue:9

    Topics: Adult; Aspartic Acid; Creatine; Cross-Sectional Studies; Female; Humans; Learning; Male; Middle Aged; Motor Activity; Motor Cortex; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Neuronal Plasticity; Pyramidal Tracts; Time Factors; Young Adult

2010
Metabolic differences between multiple sclerosis subtypes measured by quantitative MR spectroscopy.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2002, Volume: 8, Issue:3

    Topics: Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting

2002
Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis.
    Archives of neurology, 2005, Volume: 62, Issue:6

    Topics: Adult; Aged; Aspartic Acid; Atrophy; Axons; Biomarkers; Brain; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Radionuclide Imaging

2005
(1)H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings.
    European radiology, 2006, Volume: 16, Issue:2

    Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mathematical Computing; Middle Aged; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Reference Values; Software

2006
Discordant white matter N-acetylasparate and diffusion MRI measures suggest that chronic metabolic dysfunction contributes to axonal pathology in multiple sclerosis.
    NeuroImage, 2007, May-15, Volume: 36, Issue:1

    Topics: Adult; Aspartic Acid; Axons; Brain; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Dominance, Cerebral; Energy Metabolism; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Fibers, Myelinated; Reference Values

2007
Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study.
    Archives of neurology, 2007, Volume: 64, Issue:8

    Topics: Adult; Aged; Anisotropy; Aspartic Acid; Brain; Cohort Studies; Cross-Sectional Studies; Diffusion Magnetic Resonance Imaging; Disability Evaluation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nervous System Diseases; Periaqueductal Gray; Syndrome; Time Factors

2007
1H magnetic resonance spectroscopy of normal appearing white matter in primary progressive multiple sclerosis.
    Journal of neurology, 1999, Volume: 246, Issue:11

    Topics: Adult; Aspartic Acid; Brain; Cohort Studies; Creatine; Dipeptides; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis, Chronic Progressive; Protons; Reference Values

1999
1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2000, Volume: 6, Issue:3

    Topics: Adult; Aspartic Acid; Brain; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Protons; Reference Values

2000
[Proton magnetic-resonance spectroscopy in remitting and secondary-progressive multiple sclerosis].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2001, Volume: 101, Issue:4

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Creatine; Demyelinating Diseases; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Phosphocreatine; Severity of Illness Index

2001