Page last updated: 2024-08-24

n-acetylaspartic acid and Canavan Disease

n-acetylaspartic acid has been researched along with Canavan Disease in 91 studies

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's19 (20.88)18.2507
2000's44 (48.35)29.6817
2010's24 (26.37)24.3611
2020's4 (4.40)2.80

Authors

AuthorsStudies
Baer, CE; Eyles, SJ; Gao, G; Gessler, DJ; Hayward, LJ; Li, D; Lotun, A; Mooney, M; Sanmiguel, J; Strittmatter, L; Su, Q; Tuncer, S; Ulbrich, R; Xu, H1
Burns, T; Guo, F; Hull, V; McDonough, J; Pleasure, D; Sternbach, S; Wang, Y; Zhang, S1
Kocak, A; Yildiz, M1
Bongers, A; Cederholm, J; Delerue, F; Don, AS; Fröhlich, D; Harasta, AE; Housley, GD; Ittner, LM; Klugmann, CB; Klugmann, M; McLean, CA; Parley, KE; Pickford, R; Rae, CD; Rowlands, BD; Schneider, M; Spencer, ZHT; Teahan, O; von Jonquieres, G1
Bannerman, P; Burns, T; Chechneva, O; Guo, F; Hull, V; McDonough, J; Pleasure, D; Wang, Y1
Dahal, GP; Mutthamsetty, V; Viola, RE; Wang, Q1
Ahmed, SS; Gao, G1
Amorini, AM; Cavallari, U; Cavalli, P; Di Pietro, V; Lazzarino, G; Longo, S; Poggiani, C; Tavazzi, B1
Francis, JS; Leone, P; Markov, V1
Banasik, T; Jamroz, E; Kiełtyka, A; Konopka, M; Paprocka, J; Skorupa, A; Sokół, M; Wicher, M1
Drenckhahn, A; Knierim, E; Schuelke, M1
Bannerman, P; Burns, T; Freeman, E; Guo, F; Li, S; McDonough, JA; Miers, L; Mills Ko, E; Pleasure, D; Xu, J1
Buono, S; De Bernardo, G; Giordano, M; Sordino, D1
Eckhardt, M; Gieselmann, V; Hartmann, D; Maier, H; Wang-Eckhardt, L1
Boespflug-Tanguy, O; Rodriguez, D; Sarret, C1
Bilaniuk, LT; De Vivo, DC; Francis, JS; Gray, SJ; Janson, CG; Leone, P; Markov, V; McCown, TJ; Samulski, RJ; Wang, DJ; Wojtas, I1
Bannerman, P; Burns, T; Croteau, C; Guo, F; McDonough, JA; Miers, L; Pleasure, D; Singhal, NK; Sohn, J1
Anogianakis, G; Bostantjopoulou, S; Geroukis, T; Kapina, V; Kazis, D; Kimiskidis, VK; Koutsonikolas, D; Kouvatsou, Z; Papagiannopoulos, S; Papaliagkas, V; Tsatsali-Foroglou, E; Zafeiriou, D1
Gao, G; Gessler, DJ; King, J; Li, D; Matalon, R; Moore, C; Sanmiguel, J; Su, Q; Tuncer, S; Xu, H1
Barres, BA; Cerda, SR; Dugas, J; Popko, B; Traka, M; Wollmann, RL1
Ahmad, AM; Al-Dirbashi, OY; Al-Nemer, M; Al-Sayed, M; Imtiaz, F; Kurdi, W; Rashed, MS; Tulbah, M1
de Mattos Dutra, A; Dutra-Filho, CS; Henn, NT; Pederzolli, CD; Rockenbach, FJ; Romagna, EC; Sgaravatti, AM; Wajner, M; Wannmacher, CM; Wyse, AT; Zanin, FR1
Baslow, MH; Guilfoyle, DN2
Attwell, D; Hamilton, NB; Káradóttir, R; Kolodziejczyk, K; Wade, A1
Hamaguchi, H; Hoshino, H; Kubota, M; Mizuguchi, K1
Assadi, M; Bilaniuk, L; Goldfarb, O; Janson, C; Leone, P; Suri, N; Wang, DJ1
de Souza Streck, E; Deckmann, KB; Dutra-Filho, CS; Magnusson, AS; Mescka, CP; Pederzolli, CD; Sgaravatti, AM; Sgarbi, MB; Wajner, M; Wannmacher, CM; Wyse, AT1
Anikster, Y; Ariyannur, PS; Arun, P; Denu, JM; Gahl, WA; Grunberg, NE; Hallows, WC; Hamilton, K; Madhavarao, CN; Moffett, JR; Mog, S; Namboodiri, AM1
Surendran, S1
Francis, JS; Leone, P; Markov, V; Strande, L1
Purushothaman, KK; Sreenivasan, P1
Malik, R; Smith, J; Viola, RE; Wijayasinghe, YS; Zano, S1
Assadi, M; Bilaniuk, LT; During, MJ; Francis, JS; Freese, A; Goldfarb, O; Goldman, HW; Janson, CG; Kolodny, EH; Leone, P; McPhee, SW; Samulski, RJ; Shera, D; Wang, DJ; Young, D1
Jacobowitz, DM; Kallarakal, AT; Kirmani, BF; Namboodiri, MA1
Faehnle, CR; Le Coq, J; Moore, RA; Viola, RE1
Baslow, MH4
Bamforth, FJ; Chan, A; Goodman, SI; Matalon, R; Surendran, S; Tyring, SK1
Inoue, Y; Kuhara, T1
Bembeeva, RTs; Bukina, AM; Fedoniuk, ID; Il'ina, ES; Mikhaĭlova, SV; Petrukhin, AS; Pokrovskaia, AIa; Zakharova, EIu1
Arun, P; Garbern, J; Hristova, D; Jiang, W; Johnson, A; Madhavarao, CN; Matalon, R; Moffett, JR; Namboodiri, MA; Surendran, S; Szucs, S1
During, MJ; Klugmann, M; Leichtlein, CB; Serikawa, T; Symes, CW; Young, D1
Francis, J; Freese, A; Hyland, K; Janson, CG; Leone, P; McPhee, SW; Ong, EO; Raghavan, SS; Serikawa, T1
Chen, V1
Bal, D; Gradowska, W; Gryff-Keller, A1
Arun, P; Madhavarao, CN; Mathew, R; Moffett, JR; Namboodiri, MA1
Amorini, AM; Bellia, F; Ceccarelli, L; Di Pietro, V; Donzelli, S; Francis, JS; Giardina, B; Janson, CG; Lazzarino, G; Leone, P; Tavazzi, B1
Assadi, M; Bilaniuk, L; Francis, J; Janson, CG; Leone, P; Shera, D1
Benbir, G; Jakobs, C; Karaarslan, E; Rolland, MO; Salomons, GS; van der Knaap, MS; Yalcinkaya, C1
Assadi, M; Bilaniuk, L; Freese, A; Goldfarb, O; Janson, CG; Kolodny, EH; Leone, P; McPhee, S; Pastores, G; Raghavan, S; Saslow, B; Shera, D; Torres, P; Wang, DJ; Zeng, BJ1
Hershfield, J; Madhavarao, CN; Mathew, R; Moffett, JR; Namboodiri, AM; Peethambaran, A; Sambhu, PA1
Moffett, JR; Namboodiri, AM1
Arun, P; Hershfield, J; Jacobowitz, DM; Kirmani, B; Madhavarao, CN; Mathew, R; Moffett, JR; Namboodiri, AM; Namboodiri, S; Potti, A1
Bhattacharya, P; Harris, K; Lin, A; Ross, B; Tran, T; Wong, W1
Assadi, M; Bilaniuk, L; Francis, J; Freese, A; Haselgrove, J; Hurh, P; Janson, CG; Leone, P; McPhee, SW; Shera, D; Wang, DJ1
Bingman, CA; Bitto, E; McCoy, JG; Phillips, GN; Wesenberg, GE1
Boughamoura, L; Chaabane, F; Chabchoub, I; Essoussi, AS; Kabachi, N; Tilouche, S; Tlili, K; Yacoub, M1
Viola, RE1
Arun, P; Madhavarao, CN; Moffett, JR; Namboodiri, AM; Ross, B1
Al-Dirbashi, OY; Al-Mokhadab, MA; Al-Qahtani, K; Al-Sayed, MA; Kurdi, W; Rashed, MS1
Styles, J; Velinov, M; Wisniewski, K; Zellers, N1
Engelbrecht, V; Gärtner, J; Kahn, T; Mödder, U; Rassek, M1
Kaul, R; Matalon, R; Michals, K1
Anikster, Y; Elpeleg, ON; Jakobs, C; Shaag, A1
Burlina, AB; Burlina, AP; Ferrari, V; Leon, A; Mazza, MR; Skaper, SD1
Christensen, E; Geiss-Holtorff, R; Hennig, J; Lehnert, W; Lou, HC; Müller-Forell, W; Ott, D; Pryds, O; Rolland, MO; Toft, PB1
Bennett, MJ; Divry, P; Elpeleg, ON; Gibson, KM; Jakobs, C; Rinaldo, P; Rolland, MO; Sherwood, WG1
Kelley, RI1
Baslow, MH; Resnik, TR1
Breslau, J1
Duhaime, AC; Gripp, KW; Molloy, PT; Muenke, M; Rorke, LB; Schut, L; Tucker, SH; Wang, ZJ; Zackai, EH; Zimmerman, RA1
Blüml, S1
Anastasiou, AL; Augoustidou-Savvopoulou, P; Fagan, E; Kleijer, WJ; Kontopoulos, EE; Maroupoulos, G; Papadopoulou, F; Payne, S; Zafeiriou, DI1
Besley, GT; Elpeleg, ON; Jakobs, C; Manning, NJ; Shaag, A; Walter, JH1
Elpeleg, ON; Shaag, A1
Matalon, R1
Matalon, R; Michals-Matalon, K2
Matalon, R; Penzien, JM; Rady, PL; Tyring, SK; Vargas, T1
Corigliano-Murphy, A; Jiang, G; Namboodiri, MA; Provencio, I; Rollag, M1
Baslow, MH; Hungund, BL; Suckow, RF1
Blüml, S; Moreno, A; Ross, BD1
Chakraborty, G; Ledeen, RW; Mekala, P; Wu, G; Yahya, D1
Gordon, N1
Kobayashi, K; Tsujino, S1
Harting, I; Seitz, A1
During, MJ; Janson, CG; Leone, P; McPhee, SJ1
Baslow, MH; Hungund, BL; Kitada, K; Serikawa, T; Suckow, RF1

Reviews

16 review(s) available for n-acetylaspartic acid and Canavan Disease

ArticleYear
Brain N-acetylaspartate as a molecular water pump and its role in the etiology of Canavan disease: a mechanistic explanation.
    Journal of molecular neuroscience : MN, 2003, Volume: 21, Issue:3

    Topics: Animals; Aspartic Acid; Brain; Canavan Disease; Extracellular Fluid; Humans; Hydrostatic Pressure; Membrane Transport Proteins; Neurons; Oligodendroglia; Water-Electrolyte Balance

2003
Canavan disease and the role of N-acetylaspartate in myelin synthesis.
    Molecular and cellular endocrinology, 2006, Jun-27, Volume: 252, Issue:1-2

    Topics: Aging; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Humans; Mice; Mice, Knockout; Myelin Basic Protein

2006
Preface: a brief review of N-acetylaspartate.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Animals; Aspartic Acid; Canavan Disease; Dipeptides; Energy Metabolism; Humans; Magnetic Resonance Spectroscopy; Myelin Sheath; Neurons; Osmolar Concentration

2006
Defective myelin lipid synthesis as a pathogenic mechanism of Canavan disease.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Acetates; Acetyltransferases; Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Humans; Lipid Metabolism; Myelin Sheath

2006
N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology.
    Progress in neurobiology, 2007, Volume: 81, Issue:2

    Topics: Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Energy Metabolism; Humans; Lipid Metabolism; Metabolic Networks and Pathways

2007
Canavan disease: from spongy degeneration to molecular analysis.
    The Journal of pediatrics, 1995, Volume: 127, Issue:4

    Topics: Age of Onset; Aspartic Acid; Brain; Canavan Disease; Child; Diagnosis, Differential; Humans; Jews; Magnetic Resonance Imaging; Male; Muscle Hypotonia; Nerve Degeneration; Prenatal Diagnosis; Survival Rate

1995
Canavan disease. Analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms.
    Journal of molecular neuroscience : MN, 1997, Volume: 9, Issue:2

    Topics: Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Female; Fetal Diseases; Histidine; Humans; Pregnancy

1997
Molecular water pumps and the aetiology of Canavan disease: a case of the sorcerer's apprentice.
    Journal of inherited metabolic disease, 1999, Volume: 22, Issue:2

    Topics: Aspartic Acid; Body Water; Canavan Disease; Humans

1999
Canavan disease: diagnosis and molecular analysis.
    Genetic testing, 1997, Volume: 1, Issue:1

    Topics: Amidohydrolases; Aspartic Acid; Canavan Disease; Cloning, Molecular; Diagnosis, Differential; Female; Gene Frequency; Genetic Carrier Screening; Genetic Testing; Humans; Jews; Male; Mutation; Pregnancy; Prenatal Diagnosis

1997
Recent advances in Canavan disease.
    Advances in pediatrics, 1999, Volume: 46

    Topics: Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Child; Diagnosis, Differential; Disease Models, Animal; Genetic Counseling; Genetic Testing; Genotype; Humans; Jews; Magnetic Resonance Imaging; Mutation; Phenotype

1999
Molecular basis of Canavan disease.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 1998, Volume: 2, Issue:2

    Topics: Alleles; Amidohydrolases; Aspartic Acid; Canavan Disease; DNA Mutational Analysis; Humans; Incidence; Jews; Life Expectancy; Magnetic Resonance Imaging; Mutation; United States

1998
Canavan's spongiform leukodystrophy: a clinical anatomy of a genetic metabolic CNS disease.
    Journal of molecular neuroscience : MN, 2000, Volume: 15, Issue:2

    Topics: Aspartic Acid; Astrocytes; Axons; Brain; Canavan Disease; Humans

2000
Canavan disease: a review of recent developments.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2001, Volume: 5, Issue:2

    Topics: Amidohydrolases; Aspartic Acid; Canavan Disease; Female; Genetic Therapy; Humans; Infant; Infant, Newborn; Pregnancy; Prenatal Diagnosis; Prognosis

2001
[Canavan disease (aspartoacylase deficiency)].
    Ryoikibetsu shokogun shirizu, 2001, Issue:36

    Topics: Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Diagnosis, Differential; Humans; Mutation; Prognosis

2001
Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease.
    Current opinion in molecular therapeutics, 1999, Volume: 1, Issue:4

    Topics: Acetates; Acetazolamide; Amidohydrolases; Animals; Aspartic Acid; Brain; Brain Edema; Calcium Compounds; Canavan Disease; Child; Child, Preschool; Cholesterol; Combined Modality Therapy; Cytomegalovirus; Dependovirus; DNA, Recombinant; Female; Fetal Diseases; Genetic Therapy; Genetic Vectors; Glycerophospholipids; Humans; Infant; Injections, Intraventricular; Liposomes; Male; Mitochondria; Nerve Tissue Proteins; Osmotic Pressure; Phosphatidylethanolamines; Prenatal Diagnosis; Primates; Promoter Regions, Genetic; Protamines; Rats

1999
Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review.
    Neurochemistry international, 2002, Volume: 40, Issue:4

    Topics: Adolescent; Adult; Amidohydrolases; Aquaporins; Aspartic Acid; Body Water; Brain; Canavan Disease; Cell Compartmentation; Child; Child, Preschool; Energy Metabolism; Glucose; Humans; Ion Channel Gating; Membrane Potentials; Nerve Fibers, Myelinated; Nerve Tissue Proteins; Neurons; Osmolar Concentration

2002

Trials

1 trial(s) available for n-acetylaspartic acid and Canavan Disease

ArticleYear
Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13)C]glucose infusion.
    Journal of neurochemistry, 2001, Volume: 77, Issue:1

    Topics: Adult; Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Carbon Isotopes; Child, Preschool; Glucose; Glutamic Acid; Humans; Infusions, Intravenous; Intubation, Gastrointestinal; Magnetic Resonance Spectroscopy; Predictive Value of Tests

2001

Other Studies

74 other study(ies) available for n-acetylaspartic acid and Canavan Disease

ArticleYear
Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism.
    Progress in neurobiology, 2023, Volume: 226

    Topics: Animals; Canavan Disease; Cell Lineage; Central Nervous System; Epigenesis, Genetic; Mammals; Mice; Myelin Sheath; Oligodendroglia

2023
Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice.
    Annals of neurology, 2020, Volume: 87, Issue:3

    Topics: Acetyltransferases; Amidohydrolases; Animals; Aspartic Acid; Ataxia; Atrophy; Canavan Disease; Cerebellum; Female; Gene Knockdown Techniques; Infusions, Intraventricular; Male; Mice; Mutation; Oligonucleotides, Antisense; Purkinje Cells; Rotarod Performance Test; Thalamus; Vacuoles

2020
Docking, molecular dynamics and free energy studies on aspartoacylase mutations involved in Canavan disease.
    Journal of molecular graphics & modelling, 2017, Volume: 74

    Topics: Amidohydrolases; Aspartic Acid; Canavan Disease; Catalytic Domain; Humans; Hydrogen Bonding; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation, Missense; Protein Binding; Thermodynamics

2017
Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.
    Acta neuropathologica, 2018, Volume: 135, Issue:1

    Topics: Acetyltransferases; Amidohydrolases; Animals; Aspartic Acid; Brain; Canavan Disease; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Evoked Potentials, Visual; Female; Genetic Therapy; Humans; Male; Mice, Transgenic; Neurons; Oligodendroglia; Phenotype; RNA, Messenger

2018
Pathophysiology and Treatment of Canavan Disease.
    Neurochemical research, 2020, Volume: 45, Issue:3

    Topics: Acetyltransferases; Amidohydrolases; Animals; Aspartic Acid; Astrocytes; Canavan Disease; Cerebellum; Gene Knockout Techniques; Humans; Mice; Oligodendroglia; RNA, Small Interfering; Symporters; Transduction, Genetic

2020
Development of bisubstrate analog inhibitors of aspartate N-acetyltransferase, a critical brain enzyme.
    Chemical biology & drug design, 2020, Volume: 95, Issue:1

    Topics: Acetyltransferases; Aspartic Acid; Binding Sites; Brain; Canavan Disease; Drug Discovery; Enzyme Inhibitors; Humans; Maltose; Protein Binding; Recombinant Fusion Proteins

2020
Gene therapy for Canavan's disease takes a step forward.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2013, Volume: 21, Issue:3

    Topics: Amidohydrolases; Aspartic Acid; Canavan Disease; Dependovirus; Genetic Therapy; Genetic Vectors; Humans; Recombination, Genetic

2013
New T530C mutation in the aspartoacylase gene caused Canavan disease with no correlation between severity and N-acetylaspartate excretion.
    Clinical biochemistry, 2013, Volume: 46, Issue:18

    Topics: Amidohydrolases; Aspartic Acid; Canavan Disease; Child, Preschool; Homozygote; Humans; Infant; Magnetic Resonance Imaging; Mutation, Missense

2013
Dietary triheptanoin rescues oligodendrocyte loss, dysmyelination and motor function in the nur7 mouse model of Canavan disease.
    Journal of inherited metabolic disease, 2014, Volume: 37, Issue:3

    Topics: Adenosine Triphosphate; Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Disease Models, Animal; Mice; Myelin Sheath; Oligodendroglia; Triglycerides

2014
Four-and-one-half years' experience in monitoring of reproducibility of an MR spectroscopy system--application of in vitro results to interpretation of in vivo data.
    Journal of applied clinical medical physics, 2014, 05-08, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Algorithms; Aspartic Acid; Biomarkers; Brain; Canavan Disease; Child; Child, Preschool; Diagnosis, Computer-Assisted; Female; Humans; In Vitro Techniques; Longitudinal Studies; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Reproducibility of Results; Sensitivity and Specificity; Translational Research, Biomedical; Young Adult

2014
Leukodystrophy with multiple beaded periventricular cysts: unusual cranial MRI results in Canavan disease.
    Journal of inherited metabolic disease, 2015, Volume: 38, Issue:5

    Topics: Amidohydrolases; Aspartic Acid; Brain; Brain Diseases; Canavan Disease; Central Nervous System Cysts; Child, Preschool; Humans; Magnetic Resonance Imaging; Male; Skull

2015
Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model.
    Annals of neurology, 2015, Volume: 77, Issue:5

    Topics: Animals; Aspartic Acid; Canavan Disease; Disease Models, Animal; Female; Male; Mice; Mice, Knockout

2015
Early diagnosis of Canavan syndrome: how can we get there?
    BMJ case reports, 2015, Aug-05, Volume: 2015

    Topics: Aspartic Acid; Canavan Disease; Early Diagnosis; Genetic Therapy; Humans; Infant; Magnetic Resonance Spectroscopy

2015
N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Oct-28, Volume: 35, Issue:43

    Topics: Acetyltransferases; Amidohydrolases; Animals; Aspartic Acid; Axons; Behavior, Animal; Canavan Disease; Enzyme Inhibitors; Female; Genotype; Gliosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Nerve Degeneration; Sphingolipids; Survival Analysis

2015
Atypical clinical and radiological course of a patient with Canavan disease.
    Metabolic brain disease, 2016, Volume: 31, Issue:2

    Topics: Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Child; Female; Humans; Magnetic Resonance Imaging

2016
N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.
    Neurobiology of disease, 2016, Volume: 96

    Topics: Amidohydrolases; Animals; Aspartic Acid; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcription Factors; Brain; Canavan Disease; Child; Child, Preschool; Dependovirus; Disease Progression; Energy Metabolism; Female; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Infant; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Transgenic; Movement Disorders; Myelin Basic Protein; Myelin Sheath; Neurodegenerative Diseases; Oligodendroglia

2016
Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017, 01-11, Volume: 37, Issue:2

    Topics: Animals; Aspartic Acid; Canavan Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons

2017
Investigation of the motor system in two siblings with Canavan's disease: a combined transcranial magnetic stimulation (TMS) - diffusion tensor imaging (DTI) study.
    Metabolic brain disease, 2017, Volume: 32, Issue:2

    Topics: Adult; Aspartic Acid; Canavan Disease; Diffusion Tensor Imaging; Efferent Pathways; Evoked Potentials, Motor; Female; Humans; Internal Capsule; Pyramidal Tracts; Siblings; Thalamus; Transcranial Magnetic Stimulation

2017
Redirecting
    JCI insight, 2017, 02-09, Volume: 2, Issue:3

    Topics: Amidohydrolases; Animals; Aspartic Acid; Blood-Brain Barrier; Canavan Disease; Central Nervous System; Dependovirus; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Humans; Mice; Oligodendroglia

2017
Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Nov-05, Volume: 28, Issue:45

    Topics: Age Factors; Amidohydrolases; Animals; Animals, Newborn; Aspartic Acid; Axons; Behavior, Animal; Canavan Disease; Central Nervous System; Chromosome Mapping; Codon, Nonsense; Disease Models, Animal; Disease Progression; Glutamine; Lipid Metabolism; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Sheath; N-Acylsphingosine Galactosyltransferase; Oligodendroglia

2008
Reliable prenatal diagnosis of Canavan disease by measuring N-acetylaspartate in amniotic fluid using liquid chromatography tandem mass spectrometry.
    Prenatal diagnosis, 2009, Volume: 29, Issue:5

    Topics: Amidohydrolases; Amniotic Fluid; Aspartic Acid; Canavan Disease; Case-Control Studies; Chromatography, Liquid; Female; Gestational Age; Humans; Mutation; Pregnancy; Prenatal Diagnosis; Reproducibility of Results; Risk Factors; Tandem Mass Spectrometry

2009
Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.
    Metabolic brain disease, 2009, Volume: 24, Issue:2

    Topics: Animals; Antioxidants; Aspartic Acid; Brain Damage, Chronic; Canavan Disease; Catalase; Cerebral Cortex; Dipeptides; Disease Models, Animal; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Injections, Intraventricular; Lipid Peroxidation; Male; Neuropeptides; Neurotoxins; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar

2009
Are astrocytes the missing link between lack of brain aspartoacylase activity and the spongiform leukodystrophy in Canavan disease?
    Neurochemical research, 2009, Volume: 34, Issue:9

    Topics: Amidohydrolases; Animals; Aspartic Acid; Astrocytes; Brain; Canavan Disease; Dipeptides; Disease Models, Animal; Extracellular Fluid; Humans; Myelin Sheath

2009
The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes.
    Brain : a journal of neurology, 2009, Volume: 132, Issue:Pt 6

    Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Canavan Disease; Cerebellum; Dipeptides; Evoked Potentials; Glutamic Acid; Hydrolysis; Oligodendroglia; Patch-Clamp Techniques; Pelizaeus-Merzbacher Disease; Rats; Receptors, N-Methyl-D-Aspartate; Tissue Culture Techniques

2009
[Long term clinical course of Canavan disease--a rare Japanese case].
    No to hattatsu = Brain and development, 2009, Volume: 41, Issue:5

    Topics: Adult; Amidohydrolases; Asian People; Aspartic Acid; Biomarkers; Canavan Disease; Female; Humans; Magnetic Resonance Spectroscopy; Mutation; Time Factors; Young Adult

2009
Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2010, Volume: 14, Issue:4

    Topics: Aspartic Acid; Basal Ganglia; Canavan Disease; Cerebral Cortex; Choline; Citrates; Creatine; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Male; Severity of Illness Index

2010
N-acetylaspartic acid impairs enzymatic antioxidant defenses and enhances hydrogen peroxide concentration in rat brain.
    Metabolic brain disease, 2010, Volume: 25, Issue:2

    Topics: Animals; Antioxidants; Aspartic Acid; Brain; Canavan Disease; Catalase; Drug Administration Schedule; Female; Glutathione Peroxidase; Hydrogen Peroxide; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Up-Regulation

2010
Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease.
    Journal of inherited metabolic disease, 2010, Volume: 33, Issue:3

    Topics: Acetates; Animals; Aspartic Acid; Brain; Canavan Disease; Disease Models, Animal; Female; Heterozygote; Lipids; Male; Mutation; Myelin Sheath; Phenotype; Rats; Treatment Outcome

2010
Upregulation of N-acetylaspartic acid resulting nitric oxide toxicity induces aspartoacylase mutations and protein interaction to cause pathophysiology seen in Canavan disease.
    Medical hypotheses, 2010, Volume: 75, Issue:6

    Topics: Amidohydrolases; Aspartic Acid; Canavan Disease; Humans; Mutation; Nitric Oxide; Nitric Oxide Synthase Type II; Up-Regulation

2010
Aspartoacylase supports oxidative energy metabolism during myelination.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012, Volume: 32, Issue:9

    Topics: Amidohydrolases; Animals; Aspartic Acid; Biomarkers; Canavan Disease; Cells, Cultured; Chromatography, High Pressure Liquid; Demyelinating Diseases; Dependovirus; Energy Metabolism; Glucose; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mutation; Myelin Sheath; Oligodendroglia; Oxidation-Reduction; Oxidative Stress

2012
Radiological clue to diagnosis of Canavan disease.
    Indian journal of pediatrics, 2013, Volume: 80, Issue:1

    Topics: Aspartic Acid; Brain; Canavan Disease; Humans; Infant; Magnetic Resonance Imaging; Male

2013
Relationship between enzyme properties and disease progression in Canavan disease.
    Journal of inherited metabolic disease, 2013, Volume: 36, Issue:1

    Topics: Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Catalysis; Disease Progression; Humans; Mutation; Phenotype

2013
Canavan disease, a rare early-onset human spongiform leukodystrophy: insights into its genesis and possible clinical interventions.
    Biochimie, 2013, Volume: 95, Issue:4

    Topics: Acetates; Animals; Aspartic Acid; Brain; Canavan Disease; Extracellular Fluid; Humans; Myelin Sheath; Osmosis; Signal Transduction; Water; Water-Electrolyte Balance

2013
Long-term follow-up after gene therapy for canavan disease.
    Science translational medicine, 2012, Dec-19, Volume: 4, Issue:165

    Topics: Aspartic Acid; Brain; Canavan Disease; Child; Child, Preschool; Genetic Therapy; Humans; Infant; Prospective Studies

2012
Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease.
    Brain research. Molecular brain research, 2002, Nov-15, Volume: 107, Issue:2

    Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Cytoplasm; Mesencephalon; Myelin Sheath; Nerve Fibers, Myelinated; Oligodendroglia; Prosencephalon; Rats; Rats, Sprague-Dawley; Rhombencephalon; RNA, Messenger

2002
Purification and preliminary characterization of brain aspartoacylase.
    Archives of biochemistry and biophysics, 2003, May-01, Volume: 413, Issue:1

    Topics: Amidohydrolases; Amino Acid Substitution; Animals; Aspartic Acid; Brain; Canavan Disease; Cobalt; Humans; In Vitro Techniques; Kinetics; Mice; Mutagenesis, Site-Directed; Point Mutation; Protein Processing, Post-Translational; Recombinant Proteins; Substrate Specificity; Zinc

2003
Mild elevation of N-acetylaspartic acid and macrocephaly: diagnostic problem.
    Journal of child neurology, 2003, Volume: 18, Issue:11

    Topics: Adolescent; Aspartic Acid; Brain; Canavan Disease; Humans; Male

2003
Rapid and sensitive screening for and chemical diagnosis of Canavan disease by gas chromatography-mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Jun-25, Volume: 806, Issue:1

    Topics: Aspartic Acid; Canavan Disease; Case-Control Studies; Child; Child, Preschool; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Infant, Newborn; Neonatal Screening; Pilot Projects

2004
[A case of Canavan-Van Bogaert-Bertrand leukodystrophy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2004, Volume: 104, Issue:4

    Topics: Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Child, Preschool; Humans; Magnetic Resonance Imaging; Male

2004
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Apr-05, Volume: 102, Issue:14

    Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Humans; Lipids; Male; Mice; Mice, Knockout; Models, Neurological; Myelin Sheath; Rats

2005
Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2005, Volume: 11, Issue:5

    Topics: Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Dependovirus; Disease Models, Animal; Female; Gene Expression; Male; Motor Neurons; Myelin Sheath; Rats; Seizures

2005
Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease.
    Brain research. Molecular brain research, 2005, Apr-27, Volume: 135, Issue:1-2

    Topics: Amidohydrolases; Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Brain; Canavan Disease; Dependovirus; Disease Models, Animal; Gene Transfer Techniques; Genetic Vectors; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Immunohistochemistry; Locomotion; Phosphopyruvate Hydratase; Psychomotor Performance; Rats; Rats, Mutant Strains; Recombinant Proteins; Tremor

2005
Dietary treatment proposed for Canavan's disease.
    The Lancet. Neurology, 2005, Volume: 4, Issue:5

    Topics: Acetates; Amidohydrolases; Animals; Aspartic Acid; Brain; Canavan Disease; Dietary Supplements; Food, Formulated; Humans; Lipids; Mice; Myelin Sheath; Oligodendroglia

2005
Absolute configuration of N-acetylaspartate in urine from patients with Canavan disease.
    Journal of inherited metabolic disease, 2005, Volume: 28, Issue:4

    Topics: Aspartic Acid; Canavan Disease; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Stereoisomerism

2005
Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:1

    Topics: Acetates; Animals; Aspartic Acid; Brain; Calcium Compounds; Canavan Disease; Liver; Male; Mice; Mice, Inbred C57BL

2005
Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.
    Clinical biochemistry, 2005, Volume: 38, Issue:11

    Topics: Adolescent; Adult; Amino Acids; Amniotic Fluid; Aspartic Acid; Canavan Disease; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Humans; Infant; Mass Screening; Metabolism, Inborn Errors; Middle Aged; Prenatal Diagnosis; Purines; Pyrimidines; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet

2005
Lithium citrate for Canavan disease.
    Pediatric neurology, 2005, Volume: 33, Issue:4

    Topics: Aspartic Acid; Brain; Canavan Disease; Citrates; Female; Humans; Infant; Magnetic Resonance Spectroscopy; Myelin Sheath

2005
Atypical MRI findings in Canavan disease: a patient with a mild course.
    Neuropediatrics, 2005, Volume: 36, Issue:5

    Topics: Aspartic Acid; Bacterial Proteins; Canavan Disease; Child, Preschool; Chromosomes, Human, Pair 7; Cysteine; Female; Globus Pallidus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mutation; Serine Endopeptidases; Tyrosine

2005
Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene.
    Annals of neurology, 2006, Volume: 59, Issue:2

    Topics: Adult; Alanine; Amidohydrolases; Aspartic Acid; Canavan Disease; DNA Mutational Analysis; Female; Glycine; Humans; Magnetic Resonance Imaging; Middle Aged; Point Mutation; Siblings

2006
Regulation of NAA-synthesis in the human brain in vivo: Canavan's disease, Alzheimer's disease and schizophrenia.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Alzheimer Disease; Aspartic Acid; Brain; Canavan Disease; Child; Glutamic Acid; Humans; Magnetic Resonance Imaging; Molecular Structure; Schizophrenia

2006
Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI.
    Neuropediatrics, 2006, Volume: 37, Issue:4

    Topics: Age Factors; Aspartic Acid; Atrophy; Brain; Canavan Disease; Case-Control Studies; Child, Preschool; Confidence Intervals; Diffusion Magnetic Resonance Imaging; Dipeptides; Female; Humans; Infant; Magnetic Resonance Spectroscopy; Male; Protons; Reference Values

2006
Structure of aspartoacylase, the brain enzyme impaired in Canavan disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Jan-09, Volume: 104, Issue:2

    Topics: Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Catalytic Domain; Child; Crystallography, X-Ray; Humans; Models, Molecular; Mutation, Missense; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Rats; Recombinant Proteins; Static Electricity; Substrate Specificity; Zinc

2007
[Canavan disease or N-acetyl aspartic aciduria: a case report].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2007, Volume: 14, Issue:2

    Topics: Aspartic Acid; Brain; Canavan Disease; Diagnosis, Differential; Gas Chromatography-Mass Spectrometry; Humans; Infant; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male

2007
The impact of structural biology on neurobiology.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Jan-09, Volume: 104, Issue:2

    Topics: Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Humans; Molecular Structure; Mutation; Neurobiology; Rats; Substrate Specificity

2007
Quantification of N-acetylaspartic acid in urine by LC-MS/MS for the diagnosis of Canavan disease.
    Journal of inherited metabolic disease, 2007, Volume: 30, Issue:4

    Topics: Aspartic Acid; Canavan Disease; Child; Child, Preschool; Chromatography, Liquid; Female; Humans; Hydrolysis; Infant; Infant, Newborn; Male; Mass Spectrometry; Models, Chemical; Reference Values; Urinalysis

2007
Homozygosity for mutation G212A of the gene for aspartoacylase is associated with atypical form of Canavan's disease.
    Clinical genetics, 2008, Volume: 73, Issue:3

    Topics: Alanine; Amidohydrolases; Amino Acid Substitution; Aspartic Acid; Canavan Disease; Child, Preschool; Female; Glycine; Homozygote; Humans; Magnetic Resonance Imaging; Mutation

2008
[Magnetic resonance tomography and localized proton spectroscopy in 2 siblings with Canavan's disease].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1995, Volume: 163, Issue:3

    Topics: Aspartic Acid; Brain; Canavan Disease; Child, Preschool; Choline; Chromatography, Gas; Creatine; Humans; Infant; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphocreatine

1995
Prenatal detection of Canavan disease (aspartoacylase deficiency) by DNA analysis.
    Journal of inherited metabolic disease, 1994, Volume: 17, Issue:6

    Topics: Amidohydrolases; Amniotic Fluid; Aspartic Acid; Base Sequence; Canavan Disease; DNA; Female; Humans; Molecular Sequence Data; Pregnancy; Prenatal Diagnosis

1994
N-acetylaspartylglutamate selectively inhibits neuronal responses to N-methyl-D-aspartic acid in vitro.
    Journal of neurochemistry, 1994, Volume: 63, Issue:3

    Topics: Animals; Aspartic Acid; Canavan Disease; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Dipeptides; Kainic Acid; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neurons

1994
Magnetic resonance imaging in juvenile Canavan disease.
    European journal of pediatrics, 1993, Volume: 152, Issue:9

    Topics: Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Child; Child, Preschool; Choline; Corpus Striatum; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Myelin Proteins

1993
Reliable prenatal diagnosis of Canavan disease (aspartoacylase deficiency): comparison of enzymatic and metabolite analysis.
    Journal of inherited metabolic disease, 1993, Volume: 16, Issue:5

    Topics: Amniotic Fluid; Aspartic Acid; Canavan Disease; Female; Fetal Diseases; Humans; Pregnancy; Prenatal Diagnosis

1993
Prenatal detection of Canavan disease by measurement of N-acetyl-L-aspartate in amniotic fluid.
    Journal of inherited metabolic disease, 1993, Volume: 16, Issue:5

    Topics: Adult; Amniotic Fluid; Aspartic Acid; Canavan Disease; Female; Humans; Pregnancy; Prenatal Diagnosis

1993
Case 15-1998: elevated N-acetylaspartic acid activity in Canavan's disease.
    The New England journal of medicine, 1998, Aug-27, Volume: 339, Issue:9

    Topics: Aspartic Acid; Canavan Disease; Humans

1998
Imaging studies in a unique familial dysmyelinating disorder.
    AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:7

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Canavan Disease; Cerebellar Diseases; Cerebral Cortex; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differential; Female; Genes, Dominant; Humans; Hydrocephalus; Infant; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged

1998
In vivo quantitation of cerebral metabolite concentrations using natural abundance 13C MRS at 1.5 T.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 1999, Volume: 136, Issue:2

    Topics: Aspartic Acid; Brain; Canavan Disease; Carbon Isotopes; Child; Child, Preschool; Glutamic Acid; Glutamine; Humans; Hydrogen Bonding; Infant; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Sensitivity and Specificity; Spin Labels; Synaptic Transmission

1999
Protracted course of N-acetylaspartic aciduria in two non-Jewish siblings: identical clinical and magnetic resonance imaging findings.
    Brain & development, 1999, Volume: 21, Issue:3

    Topics: Aspartic Acid; Brain; Canavan Disease; Child, Preschool; Ethnicity; Evoked Potentials, Auditory, Brain Stem; Evoked Potentials, Motor; Evoked Potentials, Visual; Female; Humans; Jews; Magnetic Resonance Imaging; Neural Conduction

1999
Prenatal diagnosis of Canavan disease--problems and dilemmas.
    Journal of inherited metabolic disease, 1999, Volume: 22, Issue:3

    Topics: Amidohydrolases; Amniotic Fluid; Aspartic Acid; Canavan Disease; Female; Fetal Diseases; Humans; Infant; Male; Polymerase Chain Reaction; Pregnancy; Prenatal Diagnosis

1999
The spectrum of mutations of the aspartoacylase gene in Canavan disease in non-Jewish patients.
    Journal of inherited metabolic disease, 1999, Volume: 22, Issue:4

    Topics: Amidohydrolases; Aspartic Acid; Canavan Disease; Humans; Jews; Mutation

1999
Novel splice site mutation of aspartoacylase gene in a Turkish patient with Canavan disease.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2000, Volume: 4, Issue:1

    Topics: Amidohydrolases; Aspartic Acid; Canavan Disease; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Consanguinity; Exons; Female; Genes, Recessive; Humans; Introns; Mutation; Pedigree; Polymorphism, Restriction Fragment Length; RNA Splicing; Sequence Analysis, DNA

2000
Murine aspartoacylase: cloning, expression and comparison with the human enzyme.
    Brain research. Molecular brain research, 2000, May-05, Volume: 77, Issue:2

    Topics: Acetylation; Amides; Amidohydrolases; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Canavan Disease; Chromatography, Affinity; Cloning, Molecular; Humans; Hydrolysis; Mice; Molecular Sequence Data; Recombinant Fusion Proteins; Sequence Alignment; Substrate Specificity

2000
Effects of ethanol and of alcohol dehydrogenase inhibitors on the reduction of N-acetylaspartate levels of brain in mice in vivo: a search for substances that may have therapeutic value in the treatment of Canavan disease.
    Journal of inherited metabolic disease, 2000, Volume: 23, Issue:7

    Topics: Alcohol Dehydrogenase; Animals; Aspartic Acid; Brain; Canavan Disease; Enzyme Inhibitors; Ethanol; Male; Mice; Pyrazoles

2000
Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase.
    Journal of neurochemistry, 2001, Volume: 78, Issue:4

    Topics: Amidohydrolases; Animals; Aspartic Acid; Axonal Transport; Brain; Canavan Disease; Carbon Radioisotopes; Cell Fractionation; Eye; Lipids; Myelin Sheath; Neurons; Optic Nerve; Rats; Visual Pathways

2001
[Canavan disease].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2001, Volume: 173, Issue:10

    Topics: Aspartic Acid; Brain; Canavan Disease; Consanguinity; Humans; Infant; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male

2001
The effects of lithium chloride and other substances on levels of brain N-acetyl-L-aspartic acid in Canavan disease-like rats.
    Neurochemical research, 2002, Volume: 27, Issue:5

    Topics: Animals; Aspartic Acid; Blood-Brain Barrier; Brain; Canavan Disease; Disease Models, Animal; Lithium Chloride; Male; Rats; Rats, Mutant Strains

2002