Page last updated: 2024-08-24

n-acetylaspartic acid and Amyotrophic Lateral Sclerosis

n-acetylaspartic acid has been researched along with Amyotrophic Lateral Sclerosis in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	15 (26.79)	18.2507
2000's	21 (37.50)	29.6817
2010's	19 (33.93)	24.3611
2020's	1 (1.79)	2.80

Authors

Authors	Studies
Blicher, JU; Eskildsen, SF; Figlewski, K; Møller, AT; Near, J; Stærmose, TG	1
Briemberg, H; Eurich, DT; Frayne, R; Genge, AL; Graham, SJ; Hanstock, C; Ishaque, A; Kalra, S; Korngut, L; Luk, C; Seres, P; Srivastava, O; Ta, D; Zinman, L	1
Atassi, N; Cernasov, P; Keil, B; Lawson, R; Long, CJ; Murphy, A; Paganoni, S; Ratai, EM; Ratti, E; Rosen, B; Salibi, N; Seethamraju, R; Triantafyllou, C; Xu, M	1
Cheong, I; Deelchand, DK; Eberly, LE; Guliani, G; Manousakis, G; Marjańska, M; Öz, G; Walk, D	1
Arahuetes, RM; de Munck, E; Gil, C; Martínez, A; Miguel, BG; Muñoz-Sáez, E; Ojeda, I; Solas, MT	1
Brunetti, A; Cervo, A; Cocozza, S; Giorgio, SMDA; Marsili, A; Morra, VB; Palma, V; Quarantelli, M; Saccà, F; Tedeschi, E; Vacca, G	1
Abe, T; Harada, M; Izumi, Y; Kaji, R; Sako, W	1
Blanquer, M; García Santos, JM; Gómez Espuch, J; Iniesta, F; Inuggi, A; María Moraleda, J; Martínez, S; Vázquez, C	1
Chen, W; Li, X; Lin, H; Luo, J; Sun, G; Wang, Y; Wang, Z; Xu, Y	1
Beaulieu, C; Concha, L; Hanstock, C; Hui, B; Johnston, W; Kalra, S; Pyra, T; Wong, JC	1
Choi, JK; Dedeoglu, A; Jenkins, BG; Küstermann, E	1
Govind, V; Maudsley, AA; Schuff, N; Sharma, K; Studholme, C; Young, K	1
Bianchi, F; Bongioanni, P; Canapicchi, R; Frijia, F; Hlavata, H; Lombardo, F; Minichilli, F; Montanaro, D; Rossi, B	1
Bittšanský, M; Dobrota, D; Grofik, M; Kurča, E; Nosál', V; Poláček, H; Sivák, S; Turčanová-Koprušáková, M	1
Hanstock, C; Hui, B; Johnston, W; Kalra, S; Pyra, T; Sudharshan, N	1
Camicioli, R; Choi, C; Johnston, W; Kalra, S; Lynch, M; Sekhon, R; Seres, P; Usman, U	1
Andersen, PM; Benatar, M; Carew, JD; Gronka, S; Hu, X; Nair, G; Wuu, J	1
Capozzo, R; Ceci, E; D'Errico, E; Leo, A; Livrea, P; Logroscino, G; Mastrapasqua, M; Ruggieri, M; Simone, IL; Tortelli, R; Zoccolella, S	1
Callaghan, BC; Chenevert, TL; Edden, RA; Feldman, EL; Foerster, BR; Petrou, M	1
Arheart, KL; Govind, V; Maudsley, AA; Saigal, G; Sharma, KR; Sheriff, S	1
Jenkinson, M; Knight, S; Maudsley, AA; Stagg, CJ; Talbot, K; Turner, MR	1
Chawla, S; Elman, LB; Grossman, M; Maudsley, AA; McCluskey, LF; Melhem, ER; Poptani, H; Sheriff, S; Verma, G; Wang, S; Woo, JH	1
Arnold, DL; Caramanos, Z; Cashman, NR; Genge, A; Kalra, S	1
Arnold, DL; Genge, A; Kalra, S	1
Cai, Y; Gao, Y; Guo, X; Li, D; Liang, Y; Lim, CC; Ma, L; Yin, H	1
Arnold, DL; Kalra, S	1
Gelinas, DF; Miller, RG; Rule, RR; Schuff, N; Suhy, J; Weiner, MW	1
Desiderio, LM; Elman, LB; Krejza, J; McCluskey, LF; Melhem, ER; Poptani, H; Wang, S; Woo, JH	1
Chao, L; Laxer, K; Meyerhoff, DJ; Mueller, S; Sacrey, DT; Schuff, N; Weiner, MW	1
Arnold, DL; Cashman, NR; Genge, A; Kalra, S; Vitale, A	1
Chen, L; Huang, H; Liu, Y; Tan, K; Wang, H; Xi, H; Xue, Y; Zhang, F; Zhang, J	1
Kassubek, J; Ludolph, AC; Unrath, A	1
Angenstein, F; Debska-Vielhaber, G; Heinze, HJ; Hilfert, L; Kunz, WS; Leibfritz, D; Ludolph, AC; Niessen, HG; Sander, K; Vielhaber, S; Willker, W	1
Battista, V; Chan, S; Dashnaw, S; Floyd, AG; Gooch, CL; Gordon, PH; Hayes, S; Hays, AP; Hirsch, J; Kaufmann, P; Levin, B; Mao, X; Mitsumoto, H; Montes, J; Pullman, SL; Rowland, LP; Shungu, DC; Tang, MX; Ulug, AM	1
Coutinho, CM; Gatt, JA; Gunawardena, WJ; Jones, AP; Mitchell, JD; Shaw, IC	1
Constantakakis, E; Plaitakis, A	1
Jones, AP; Knight, JM; Redmond, JP; Shaw, IC	1
Gredal, O; Karlsborg, M; Rosenbaum, S; Strange, P; Topp, S; Werdelin, L	1
Fujii, H; Ichijo, M; Ikeda, K; Irimajiri, S; Iwasaki, Y; Kinoshita, M; Matsuoka, Y	1
Gelinas, D; Maudsley, AA; Miller, RG; Rooney, WD; Schuff, N; Weiner, MW	1
Arnold, DL; Cashman, NR; Genge, A; Kalra, S	1
Andrews, C; Dawson, JM; Ellis, CM; Leigh, PN; Simmons, A; Williams, SC	1
Klinkosz, B; Mitsumoto, H; Moore, JK; Ng, TC; Pioro, EP; Trapp, BD; Wang, Y	1
Majors, AW; Mitsumoto, H; Nelson, DR; Ng, TC; Pioro, EP	1
Arnold, DL; Cashman, NR; Kalra, S	1
Chan, S; Douglas-Akinwande, A; Lange, DJ; Rowland, LP; Shungu, DC	1
Bowen, BC; Bradley, WG; Pattany, PM; Rotta, F	1
Block, W; Grothe, C; Karitzky, J; Klockgether, T; Lamerichs, R; Pohl, C; Schild, H; Schmidt, S; Träber, F	1
Hahn, D; Kenn, W; Ochs, G; Pabst, TA	1
Abe, K; Fujita, N; Hirabuki, N; Takanashi, M; Tanaka, H; Watanabe, Y; Yanagihara, T	1
Block, W; Grothe, C; Klockgether, T; Pels, H; Pohl, C; Schild, HH; Schmidt, S; Träber, F	1
Elger, CE; Feistner, H; Heinze, HJ; Kanowski, M; Kaufmann, J; Kunz, WS; Sailer, M; Tempelmann, C; Vielhaber, S	1
Dronsky, V; Gelinas, D; Licht, J; Maudsley, AA; Miller, RG; Rule, R; Schuff, N; Suhy, J; Weiner, MW	1
Cwik, VA; Hanstock, CC; Martin, WR	1
Coyle, JT; Hedreen, JC; Kuncl, R; Rothstein, JD; Sim, L; Stauch-Slusher, B; Tsai, GC	1
Clawson, L; Cornblath, DR; Coyle, JT; Drachman, DB; Kuncl, RW; Pestronk, A; Rothstein, JD; Stauch, BL; Tsai, G	1

Reviews

3 review(s) available for n-acetylaspartic acid and Amyotrophic Lateral Sclerosis

Article	Year
ALS surrogate markers. MRS. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2004, Volume: 5 Suppl 1 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Creatine; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Motor Cortex	2004
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Advances in experimental medicine and biology, 2006, Volume: 576 Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; Choline; Cocaine; Creatine; Epilepsy; Ethanol; HIV Infections; Humans; Magnetic Resonance Imaging; Neurodegenerative Diseases; Neurons; Stress Disorders, Post-Traumatic	2006
Biological markers in the diagnosis and treatment of ALS. Journal of the neurological sciences, 1999, Volume: 165 Suppl 1 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Progression; Electromyography; Humans; Magnetic Resonance Imaging; Monitoring, Physiologic; Neuroprotective Agents; Riluzole; Tomography, Emission-Computed	1999

Trials

6 trial(s) available for n-acetylaspartic acid and Amyotrophic Lateral Sclerosis

Article	Year
The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis. European journal of radiology, 2015, Volume: 84, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multimodal Imaging; Pyramidal Tracts; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity	2015
Diffusion tensor MRI and MR spectroscopy in long lasting upper motor neuron involvement in amyotrophic lateral sclerosis. Archives italiennes de biologie, 2009, Volume: 147, Issue:3 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatinine; Diffusion Magnetic Resonance Imaging; Disability Evaluation; Disease Progression; Female; Humans; Male; Middle Aged; Phosphocreatine; Pyramidal Tracts; Reproducibility of Results; Sensitivity and Specificity	2009
Mesial prefrontal cortex degeneration in amyotrophic lateral sclerosis: a high-field proton MR spectroscopy study. AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:9 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Female; Frontotemporal Lobar Degeneration; Gliosis; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Prefrontal Cortex; Protons	2011
A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2003, Volume: 4, Issue:1 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain Chemistry; Brain-Derived Neurotrophic Factor; Feasibility Studies; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neurons; Placebos; Prospective Studies; Sensitivity and Specificity; Treatment Outcome	2003
Preliminary results of proton magnetic resonance spectroscopy in motor neurone disease (amytrophic lateral sclerosis). Journal of the neurological sciences, 1995, Volume: 129 Suppl Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged	1995
Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport, 1998, Jun-01, Volume: 9, Issue:8 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Excitatory Amino Acid Antagonists; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Motor Neurons; Riluzole	1998

Other Studies

47 other study(ies) available for n-acetylaspartic acid and Amyotrophic Lateral Sclerosis

Article	Year
Short echo-time Magnetic Resonance Spectroscopy in ALS, simultaneous quantification of glutamate and GABA at 3 T. Scientific reports, 2019, 11-26, Volume: 9, Issue:1 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Choline; Creatine; Disease Progression; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Gray Matter; Hand Strength; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Occipital Lobe; Pilot Projects; Severity of Illness Index; Single-Blind Method	2019
Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study. Neurology, 2021, 08-24, Volume: 97, Issue:8 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cognitive Dysfunction; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Prefrontal Cortex; Severity of Illness Index	2021
Ultra high-field (7tesla) magnetic resonance spectroscopy in Amyotrophic Lateral Sclerosis. PloS one, 2017, Volume: 12, Issue:5 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neurons	2017
Neurochemical correlates of functional decline in amyotrophic lateral sclerosis. Journal of neurology, neurosurgery, and psychiatry, 2019, Volume: 90, Issue:3 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Disease Progression; Female; Glutamic Acid; Humans; Longitudinal Studies; Male; Middle Aged; Motor Cortex; Motor Neurons; Pons; Prognosis; Proton Magnetic Resonance Spectroscopy; Upper Extremity	2019
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS. Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:2 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 3; Choline; Creatinine; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Endoplasmic Reticulum; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Magnetic Resonance Spectroscopy; Male; Mitochondria; Motor Activity; Motor Cortex; Nerve Degeneration; Neurologic Examination; Phenotype; Rats; Rats, Wistar; Spinal Cord; Time Factors	2013
The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2016, Volume: 27 Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Cell Death; Cross-Sectional Studies; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neurons	2016
Spinal cord infusion of stem cells in amyotrophic lateral sclerosis: Magnetic resonance spectroscopy shows metabolite improvement in the precentral gyrus. Cytotherapy, 2016, Volume: 18, Issue:6 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell- and Tissue-Based Therapy; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Neurons; Pilot Projects; Spinal Cord; Stem Cell Transplantation; Stem Cells	2016
Detecting neuronal dysfunction of hand motor cortex in ALS: A MRSI study. Somatosensory & motor research, 2017, Volume: 34, Issue:1 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Creatine; Female; Functional Laterality; Hand; Humans; Image Processing, Computer-Assisted; Linear Models; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Statistics, Nonparametric	2017
Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010, Volume: 11, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion Tensor Imaging; Disease Progression; Female; Humans; Internal Capsule; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Pyramidal Tracts; ROC Curve; Sensitivity and Specificity	2010
Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation. The European journal of neuroscience, 2009, Volume: 30, Issue:11 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Models, Animal; Glutamic Acid; Glutamine; In Vitro Techniques; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Protons; Spectrum Analysis; Superoxide Dismutase	2009
Multivariate statistical mapping of spectroscopic imaging data. Magnetic resonance in medicine, 2010, Volume: 63, Issue:1 Topics: Adult; Algorithms; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Choline; Creatinine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Reproducibility of Results; Sensitivity and Specificity	2010
Proton magnetic resonance spectroscopy in patients with early stages of amyotrophic lateral sclerosis. Neuroradiology, 2010, Volume: 52, Issue:12 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Creatinine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reproducibility of Results; Sensitivity and Specificity	2010
Degeneration of the mid-cingulate cortex in amyotrophic lateral sclerosis detected in vivo with MR spectroscopy. AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Female; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Nerve Degeneration; Neural Pathways; Thalamus	2011
Presymptomatic spinal cord neurometabolic findings in SOD1-positive people at risk for familial ALS. Neurology, 2011, Oct-04, Volume: 77, Issue:14 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Family Health; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mutation; Risk Factors; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Tritium	2011
Serum N-acetylaspartate level in amyotrophic lateral sclerosis. Archives of neurology, 2011, Volume: 68, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Chromatography, Liquid; Female; Humans; Italy; Logistic Models; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Middle Aged; Protons	2011
Decreased motor cortex γ-aminobutyric acid in amyotrophic lateral sclerosis. Neurology, 2012, May-15, Volume: 78, Issue:20 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cross-Sectional Studies; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Protons; Radionuclide Imaging; Young Adult	2012
Comprehensive evaluation of corticospinal tract metabolites in amyotrophic lateral sclerosis using whole-brain 1H MR spectroscopy. PloS one, 2012, Volume: 7, Issue:4 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Choline; Creatine; Humans; Hydrogen; Magnetic Resonance Imaging; Male; Middle Aged; Pyramidal Tracts; Severity of Illness Index	2012
Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS. Neurology, 2013, Feb-12, Volume: 80, Issue:7 Topics: Aged; Amyotrophic Lateral Sclerosis; Anisotropy; Aspartic Acid; Brain; Case-Control Studies; Creatine; Diffusion Magnetic Resonance Imaging; Disability Evaluation; Disabled Persons; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged	2013
Whole-brain analysis of amyotrophic lateral sclerosis by using echo-planar spectroscopic imaging. Radiology, 2013, Volume: 267, Issue:3 Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Echo-Planar Imaging; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; Retrospective Studies	2013
Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy. AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:3 Topics: Acetates; Aged; Amines; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cell Survival; Creatine; Cyclohexanecarboxylic Acids; Energy Metabolism; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Parietal Lobe; Reference Values; Treatment Outcome	2003
Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis. Journal of neurology, 2004, Volume: 251, Issue:10 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain Mapping; Case-Control Studies; Creatine; Diffusion Magnetic Resonance Imaging; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pyramidal Tracts; Spinocerebellar Degenerations	2004
Reduced NAA in motor and non-motor brain regions in amyotrophic lateral sclerosis: a cross-sectional and longitudinal study. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2004, Volume: 5, Issue:3 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Cross-Sectional Studies; Female; Functional Laterality; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Reference Values; Tritium	2004
Amyotrophic lateral sclerosis: diffusion-tensor and chemical shift MR imaging at 3.0 T. Radiology, 2006, Volume: 239, Issue:3 Topics: Adult; Age Factors; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Forecasting; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Internal Capsule; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Neuron Disease; Phosphocreatine; Prospective Studies; Pyramidal Tracts	2006
Cerebral degeneration predicts survival in amyotrophic lateral sclerosis. Journal of neurology, neurosurgery, and psychiatry, 2006, Volume: 77, Issue:11 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Survival	2006
MR spectroscopy evaluation and short-term outcome of olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2007, Volume: 21, Issue:1 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cell Transplantation; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Olfactory Bulb; Prospective Studies; Protons; Recovery of Function	2007
Brain metabolites in definite amyotrophic lateral sclerosis. A longitudinal proton magnetic resonance spectroscopy study. Journal of neurology, 2007, Volume: 254, Issue:8 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Analysis of Variance; Aspartic Acid; Choline; Creatine; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Statistics, Nonparametric; Time Factors	2007
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis. The European journal of neuroscience, 2007, Volume: 25, Issue:6 Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Models, Animal; Disease Progression; gamma-Aminobutyric Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Superoxide Dismutase; Time Factors	2007
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS. Neurology, 2007, Apr-24, Volume: 68, Issue:17 Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Creatine; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neuron Disease; Motor Neurons; Muscular Atrophy, Spinal; Neural Conduction; Prospective Studies; Transcranial Magnetic Stimulation	2007
Altered metabolism of excitatory amino acids, N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in amyotrophic lateral sclerosis. Brain research bulletin, 1993, Volume: 30, Issue:3-4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Dipeptides; Humans; Middle Aged; Spinal Cord	1993
Identification of brain metabolites by magnetic resonance spectroscopy in MND/ALS. Journal of the neurological sciences, 1996, Volume: 139 Suppl Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Chemistry; Creatine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy	1996
Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectroscopy. Neurology, 1997, Volume: 48, Issue:4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebellum; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Muscular Atrophy, Spinal; Protons; Reference Values	1997
Quantification of brain metabolites in ALS by localized proton magnetic spectroscopy. Neurology, 1998, Volume: 50, Issue:2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Creatine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Motor Cortex; Organ Specificity; Reference Values	1998
Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS. Neurology, 1998, Volume: 50, Issue:6 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Pyramidal Tracts; Reference Values; Tissue Distribution	1998
A proton magnetic resonance spectroscopic study in ALS: correlation with clinical findings. Neurology, 1998, Volume: 51, Issue:4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatinine; Humans; Magnetic Resonance Imaging; Middle Aged; Motor Cortex; Occipital Lobe; Parietal Lobe; Phosphocreatine; Protons	1998
Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry. Neuroreport, 1998, Sep-14, Volume: 9, Issue:13 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Axons; Caudate Nucleus; Creatine; Disease Models, Animal; Hippocampus; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Mice, Neurologic Mutants; Motor Neuron Disease; Neocortex; Neurofilament Proteins; Neurons; Phosphocreatine; Putamen; Thalamus; Ubiquitins	1998
1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla. Neurology, 1999, Jul-13, Volume: 53, Issue:1 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Female; Glutamic Acid; Glutamine; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Medulla Oblongata; Middle Aged; Nerve Degeneration; Reference Values	1999
Motor neuron diseases: comparison of single-voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain. Radiology, 1999, Volume: 212, Issue:3 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neuron Disease; Motor Neurons; Pyramidal Tracts; Sensitivity and Specificity	1999
1H-magnetic resonance spectroscopy in amyotrophic lateral sclerosis. Journal of the neurological sciences, 1999, Oct-31, Volume: 169, Issue:1-2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain Chemistry; Creatine; Humans; Magnetic Resonance Spectroscopy; Middle Aged	1999
Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyotrophic lateral sclerosis. Archives of neurology, 2001, Volume: 58, Issue:5 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Phosphocreatine; Reference Values; Severity of Illness Index	2001
1H spectroscopy in patients with amyotrophic lateral sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2001, Volume: 11, Issue:3 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Statistics, Nonparametric	2001
Decrease in N-acetylaspartate/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis. Neuroradiology, 2001, Volume: 43, Issue:7 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Neurons	2001
Proton magnetic resonance spectroscopy and transcranial magnetic stimulation for the detection of upper motor neuron degeneration in ALS patients. Journal of the neurological sciences, 2001, Sep-15, Volume: 190, Issue:1-2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Electric Stimulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neurons; Neural Conduction; Peripheral Nerves; Predictive Value of Tests; Pyramidal Cells; Transcranial Magnetic Stimulation	2001
Effect of creatine supplementation on metabolite levels in ALS motor cortices. Experimental neurology, 2001, Volume: 172, Issue:2 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondria, Muscle; Motor Cortex; Reference Values	2001
Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI. Neurology, 2002, Mar-12, Volume: 58, Issue:5 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Reproducibility of Results	2002
Reduction in metabolite transverse relaxation times in amyotrophic lateral sclerosis. Journal of the neurological sciences, 2002, Jun-15, Volume: 198, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain Stem; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Osmolar Concentration; Reference Values	2002
Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS. Brain research, 1991, Aug-09, Volume: 556, Issue:1 Topics: Amino Acids; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Dipeptides; Glutamates; Glutamic Acid; Humans; Motor Cortex; Reference Values; Spinal Cord	1991
Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Annals of neurology, 1990, Volume: 28, Issue:1 Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Dipeptides; Female; Glutamates; Humans; Male; Middle Aged; Spinal Cord	1990