Compounds > n-acetylaspartic acid
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n-acetylaspartic acid and Aging

n-acetylaspartic acid has been researched along with Aging in 115 studies

Research

Studies (115)

TimeframeStudies, this research(%)All Research%
pre-19902 (1.74)18.7374
1990's23 (20.00)18.2507
2000's43 (37.39)29.6817
2010's46 (40.00)24.3611
2020's1 (0.87)2.80

Authors

AuthorsStudies
Bohsali, A; Crosson, B; Fleischer, CC; Goldstein, F; Hone-Blanchet, A; John, SE; Krishnamurthy, LC; Lah, J; Levey, A; Lin, Q; Loring, D; Qiu, D; Shahid, S; Zhao, L1
Deelchand, DK; Grant, A; Hemmy, LS; Hodges, J; Marjańska, M; McCarten, JR; Terpstra, M1
Banzer, W; Deichmann, R; Engeroff, T; Fleckenstein, J; Füzéki, E; Hellweg, R; Matura, S; Pantel, J; Pilatus, U; Schwarz, S; Vogt, L1
Forester, BP; Harper, DG; Jensen, E; Mellen, EJ; Ravichandran, C; Silveri, M1
Bolo, NR; Fried, PJ; Pascual-Leone, A1
Gallinat, J; Hädel, S; Rapp, M; Schubert, F; Wirth, C1
Andrade-Valença, LP; Menezes, TL; Valença, MM1
Balogová, Z; Dezortová, M; Hájek, M; Profant, O; Syka, J; Wagnerová, D1
Chan, Q; Chang, RC; Chiu, PW; Chu, LW; Mak, HK; Yau, KK1
Aoki, A; Aoki, Y; Inokuchi, R; Suwa, H1
De Beaumont, L; Henry, LC; Lassonde, M; Poirier, J; Théoret, H; Tremblay, S1
Goji, A; Harada, M; Ito, H; Kagami, S; Kurosawa, K; Miyazaki, M; Mori, K; Mori, T1
Deelchand, DK; Emir, UE; Marjańska, M; Terpstra, M1
Balayssac, S; Déjean, S; Francés, B; Gilard, V; Halley, H; Lalande, J; Lassalle, JM; Malet-Martino, M; Martino, R1
Brooks, WM; Choi, IY; Hui, D; Lee, P; Michaelis, EK; Wang, WT; Wang, X1
Ito, D; Kitagawa, M; Ono, K; Tanaka, N; Watari, T1
Alvarez-Linera, J; Frank, A; García-Álvarez, R; Hernández-Tamames, JA; Loureiro, JP; Mato Abad, V; Quirós, A1
Chaddock-Heyman, L; Erickson, KI; Kramer, AF; Leckie, RL; McAuley, E; Prakash, RS; Radchenkova, P; Sutton, BP; Voss, MW; Weinstein, AM1
Goetz, R; Gonen, O; Lazar, M; Malaspina, D; Mazgaj, R; Messinger, JW; Rothman, K; Tal, A1
Gong, QY; Quan, H; Sun, HQ; Tan, QY; Tan, ZJ; Xing, HY; Yang, ZY; Yue, Q1
Ellingson, BM; Hardy, AJ; Holly, LT; Salamon, N1
Abe, T; Harada, M; Izumi, Y; Kaji, R; Sako, W1
Barker, PB; Brandt, AS; Churchill, G; Edden, RA; Harris, AD; Hua, J; Lim, IA; Margolis, RL; Pradhan, S; Ross, CA; Unschuld, PG; van Zijl, PC1
Bronzlik, P; Ding, XQ; Kahl, KG; Lanfermann, H; Maudsley, AA; Sabati, M; Schmitz, B; Schütze, M; Sheriff, S1
Broniscer, A; Edwards, A; Hwang, S; Li, X; Li, Y; Löbel, U; Patay, Z1
Brickman, AM; Gietl, AF; Griffith, EY; Henning, A; Hock, C; Kirchner, T; Leh, SE; Meier, I; Michels, L; Nitsch, RM; Pruessmann, KP; Quevenco, FC; Schreiner, SJ; Steininger, SC; Unschuld, PG; Van Bergen, JMG; Wyss, M1
Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K1
Ariagno, RL; Augustine, EM; Barnes, PD; Clayton, DB; Dermon, JD; Mirmiran, M; Spielman, DM; Sutcliffe, TL1
Fleysher, L; Fleysher, R; Gonen, O; Kirov, II; Liu, S; Patil, V1
Kubas, B; Kulak, W; Otapowicz, D; Smigielska-Kuzia, J; Sobaniec, W; Zawada, B1
Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM1
Barker, PB; Bibat, G; Farage, L; Horská, A; Kaufmann, WE; Nagae, LM; Naidu, S1
Chen, CS; Chiang, IC; Hsieh, TJ; Kuo, YT; Li, CW; Lin, HF; Lin, WC; Liu, GC; Lu, CY1
Gybina, AA; Prohaska, JR; Tkac, I1
Fan, X; Jain, S; Killiany, R; Kim, DS; Murray, D; Ronen, I; Rosene, D; Schettler, S1
Behar, KL; Boumezbeur, F; Cline, GW; de Graaf, RA; Mason, GF; Petersen, KF; Rothman, DL; Shulman, GI1
Alger, JR; Asarnow, RF; Babikian, T; Cazalis, F; Copeland, S; Giza, CC; Hilleary, SM; Kernan, CL; Marion, SD; Mink, R; Newman, N; O'Neill, J; Vu, JA1
Mattsson, P; Raininko, R1
Nakada, T1
Akiguchi, I; Shiino, A; Watanabe, T1
Huang, W; Lei, H; Wang, X; Xu, W; Zhan, Y; Zhang, S1
Baird, G; Bolton, P; Conroy, RM; Curran, S; Daly, E; Foy, C; Hallahan, B; Murphy, DG; Murphy, KC; O'Brien, FM; O'Gorman, RL; Page, L; Robertson, D; Sharma, A1
Achten, E; Acou, M; Audenaert, K; Claeys, T; De Deene, Y; Deblaere, K; Goethals, I; Reyngoudt, H; Verleden, S; Vlerick, L1
Ceci, E; Di Bitonto, G; Livrea, P; Mastrapasqua, M; Paolicelli, D; Pica, C; Ruggieri, M; Solfrizzi, V; Tortorella, C; Trojano, M1
Essig, M; Schröder, J; Schuster, L1
Babb, JS; George, IC; Gonen, O; Jayawickrama, N; Kirov, II; Perry, NN1
Arheart, KL; Govind, V; Maudsley, AA1
Mullins, ME1
Fang, J; Liu, ZH; Wang, XY; Zhang, J; Zheng, DD1
Achtnichts, L; Amann, M; Babb, JS; Gass, A; Glodzik, L; Gonen, O; Hirsch, J; Monsch, AU; Sollberger, M; Wu, WE1
Cai, Q; Chen, SQ; Shen, YY; Teng, GJ; Wang, PJ; Zang, FC; Zhang, W1
Abe, O; Aoki, Y; Gonoi, W; Inoue, H; Iwashiro, N; Kasai, K; Kato, N; Katsura, M; Kawakubo, Y; Kunimatsu, A; Kuwabara, H; Matsuzaki, H; Murakami, M; Natsubori, T; Nippashi, Y; Sasaki, H; Takano, Y; Takao, H; Tsuchiya, KJ; Yahata, N; Yamasue, H1
Cookson, MR; Drevets, WC; Gibbs, JR; Goldman, D; Hasler, G; Hodgkinson, C; Neumeister, A; Preuss, N; Salehi, B; Shen, J; Singleton, A; van der Veen, JW; Wendland, JR1
Horita, DA; Kleven, GA; Morgan, JJ; Olson, J; Ronca, AE; Tulbert, CD1
Bertolino, A; Lipska, BK; Olson, A; Roffman, JL; van Gelderen, P; Weinberger, DR1
Breteler, MM; den Heijer, T; Hofman, A; Origgi, D; Oudkerk, M; Sijens, PE; Vermeer, SE1
Graham, S; Jones, M; Rae, C; Sachdev, P; Shnier, R; Valenzuela, MJ; Wen, W1
Georgieff, MK; Gruetter, R; Rao, R; Tkac, I; Townsend, EL1
Baumgartner, RN; Brooks, WM; Driscoll, I; Hamilton, DA; Petropoulos, H; Sutherland, RJ; Yeo, RA1
Chang, L; Ernst, T1
Düzel, E; Guderian, S; Heinze, HJ; Kaufmann, J; Münte, TF; Schiltz, K; Szentkuti, A1
Aleman, A; de Haan, EH; de Vries, R; de Winter, CF; Drent, ML; Kenemans, JL; Koppeschaar, HP; Lijffijt, M; van Dam, PS; van der Grond, J1
Cashdollar, N; Kaiser, LG; Schuff, N; Weiner, MW1
Deus, J; Iranzo, A; Moreno-Torres, A; Pujol, J; Santamaria, J; Soriano-Mas, C1
Cooper, JD; Griffin, JL; Mitchison, HM; Mortishire-Smith, RJ; Pearce, DA; Pears, MR1
Chapon, F; Confort-Gouny, S; Cozzone, P; Fogliarini, C; Fur, YL; Girard, N; Levrier, O; Viola, A; Viout, P1
Brodaty, H; Ross, AJ; Sachdev, PS; Wen, W1
Hershfield, J; Madhavarao, CN; Mathew, R; Moffett, JR; Namboodiri, AM; Peethambaran, A; Sambhu, PA1
Chao, L; Laxer, K; Meyerhoff, DJ; Mueller, S; Sacrey, DT; Schuff, N; Weiner, MW1
Chaumoitre, K; Cozzone, PJ; D'Ercole, C; Figarella-Branger, D; Girard, N; Gire, C; Gouny, SC; Le Fur, Y; Viola, A; Viout, P1
Charlton, RA; Howe, FA; Markus, HS; McIntyre, DJ; Morris, RG1
Baumgartner, C; Bittsanský, M; Gruber, S; Kaya, M; Lehner-Baumgartner, E; Mlynárik, V; Moser, E; Riederer, F; Serles, W1
Bittsanský, M; Bodamer, O; Chmelík, M; Frey, R; Gruber, S; Mlynárik, V; Moser, E; Pinker, K; Riederer, F; Serles, W; Stadlbauer, A1
Charlton, RA; Howe, FA; Markus, HS; McIntyre, DJ1
Nakas, CT; Navia, BA; Yiannoutsos, CT1
Buschke, H; Derby, CA; Hetherington, HP; Katz, MJ; Lipton, RB; Pan, JW; Verghese, J; Zimmerman, ME1
Casey, PA; Fiskum, G; McKenna, MC; Robertson, CL; Saraswati, M1
Kakimoto, Y; Miyake, M; Sorimachi, M1
Kakimoto, Y; Miyake, M1
Chang, C; Jang, T1
Boyko, OB; Charles, HC; Doraiswamy, PM; Krishnan, KR; Lazeyras, F; McDonald, WM; Patterson, LJ1
Constans, JM; Fein, G; MacKay, S; Meyerhoff, DJ; Norman, D; Van Dyke, C; Weiner, MW1
Christiansen, P; Henriksen, O; Larsson, HB; Stubgaard, M; Toft, P1
Chiarini, P; Gobbi, G; Lowenthal, DT; Palumbo, B; Palumbo, R; Parnetti, L; Pelliccioli, GP; Presciutti, O; Senin, U; Tarducci, R1
Beal, MF; Brouillet, E; Chen, YC; Jenkins, BG; Kirschner, P; Rosen, BR; Schulz, JB; Storey, E1
Bhakoo, KK; Florian, CL; Noble, MD; Williams, SR1
Maier, M; Ron, MA1
Lim, KO; Spielman, DM1
Doi, W; Fukuzako, H; Hashiguchi, T; Okamura, H; Sakamoto, Y; Takenouchi, K; Takigawa, M1
Brooks, WM; Garry, PJ; Kodituwakku, PW; Rosenberg, GA; Wesley, MH1
Bachevalier, J; Bertolino, A; Frank, JA; Mattay, VS; Saunders, RC; Weinberger, DR1
Constantinidis, I; Herndon, JG; Moss, MB1
Adalsteinsson, E; Lim, KO; Pfefferbaum, A; Spielman, D; Sullivan, EV1
Bascaramurty, S; Kozlowski, P; Malisza, KL; Ning, G; Tuor, UI1
Brown, MM; Griffiths, JR; Howe, FA; Saunders, DE; van den Boogaart, A1
Achten, E; Breteler, MM; de Groot, JC; de Leeuw, FE; Heijboer, R; Hofman, A; Oudkerk, M; Sijens, PE1
Caserta, MT; Wyrwicz, AM; Yao, FS1
Barker, GJ; Brex, PA; Leary, SM; MacManus, DG; Miller, DH; Parker, GJ; Thompson, AJ1
Ito, M; Kato, T; Nishina, M; Takashima, S1
Brodaty, H; Gillies, D; Sachdev, PS; Shnier, R; Valenzuela, MJ; Wen, W1
Apkarian, AV; Grachev, ID2
Angelie, E; Bonmartin, A; Boudraa, A; Gonnaud, PM; Mallet, JJ; Sappey-Marinier, D1
Horinouchi, T; Kadota, T; Kuroda, C1
Apkarian, AV; Grachev, ID; Ramachandran, TS; Swarnkar, A; Szeverenyi, NM1
Amend, DL; Capizzano, AA; Ezekiel, F; Gamst, AC; Maudsley, AA; Schuff, N; Weiner, MW1
Brooks, JC; Gosney, MA; Kemp, GJ; Lye, M; Roberts, N; Whitehouse, GH1
Harada, M; Miyoshi, H; Nishitani, H; Otsuka, H; Uno, M1
Catani, M; Cherubini, A; Gobbi, G; Howard, R; Mecocci, P; Pelliccioli, GP; Piccirilli, M; Senin, U; Tarducci, R1
Harada, M; Nagahiro, S; Uno, M1
Deck, MD; Filippi, CG; Heier, LA; Uluğ, AM; Zimmerman, RD1
Hida, K; Kwee, IL; Nakada, T1
Burri, R; Herschkowitz, N; Steffen, C1
Bigler, P; Burri, R; Colombo, JP; Herschkowitz, N; Posse, S; Straehl, P1
Faber, JA; Valk, J; van der Grond, J; van der Knaap, MS; van Rijen, PC; Willemse, K1

Reviews

4 review(s) available for n-acetylaspartic acid and Aging

ArticleYear
Age-related change of neurochemical abnormality in attention-deficit hyperactivity disorder: a meta-analysis.
    Neuroscience and biobehavioral reviews, 2013, Volume: 37, Issue:8

    Topics: Age Factors; Aging; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Humans; Magnetic Resonance Spectroscopy; Prefrontal Cortex

2013
Conversion of brain cytosol profile from fetal to adult type during the perinatal period: taurine-NAA exchange.
    Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2010, Volume: 86, Issue:6

    Topics: Adult; Aging; Animals; Aspartic Acid; Brain; Cytosol; Fetus; Humans; Magnetic Resonance Spectroscopy; Taurine

2010
Canavan disease and the role of N-acetylaspartate in myelin synthesis.
    Molecular and cellular endocrinology, 2006, Jun-27, Volume: 252, Issue:1-2

    Topics: Aging; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Humans; Mice; Mice, Knockout; Myelin Basic Protein

2006
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; Choline; Cocaine; Creatine; Epilepsy; Ethanol; HIV Infections; Humans; Magnetic Resonance Imaging; Neurodegenerative Diseases; Neurons; Stress Disorders, Post-Traumatic

2006

Trials

6 trial(s) available for n-acetylaspartic acid and Aging

ArticleYear
Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adult; Aged; Aging; Aspartic Acid; Choline; Creatinine; Diffusion Tensor Imaging; Female; Gait Disorders, Neurologic; Humans; Linear Models; Male; Middle Aged; Neck Pain; Nerve Fibers; Paresthesia; Prospective Studies; Proton Magnetic Resonance Spectroscopy; Spinal Cord; Spinal Cord Compression; Spinal Stenosis; Spondylosis; Young Adult

2015
The aging hippocampus: cognitive, biochemical and structural findings.
    Cerebral cortex (New York, N.Y. : 1991), 2003, Volume: 13, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Choline; Cognition; Creatine; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurons; Organ Size; Sex Factors; Statistics as Topic; Visual Perception

2003
Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate.
    Psychoneuroendocrinology, 2005, Volume: 30, Issue:4

    Topics: Adolescent; Adult; Age of Onset; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; Cognition Disorders; Female; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Magnetic Resonance Spectroscopy; Male; Neurons; Neuropsychological Tests

2005
Proton spectroscopy of human brain: effects of age and sex.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Sex Characteristics

1994
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 76, Issue:2

    Topics: Adult; Age Factors; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values

2001
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 77, Issue:1

    Topics: Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Net; Organ Specificity

2001

Other Studies

105 other study(ies) available for n-acetylaspartic acid and Aging

ArticleYear
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
    Neurobiology of aging, 2022, Volume: 109

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Cognition; Creatine; Female; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Peptide Fragments; tau Proteins

2022
Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using
    Neuroscience, 2017, 06-23, Volume: 354

    Topics: Aged; Aged, 80 and over; Aging; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Creatine; Dipeptides; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Phosphocreatine; Tritium; Young Adult

2017
Lifespan leisure physical activity profile, brain plasticity and cognitive function in old age.
    Aging & mental health, 2019, Volume: 23, Issue:7

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Aspartic Acid; Attention; Brain; Brain-Derived Neurotrophic Factor; Choline; Energy Metabolism; Executive Function; Exercise; Female; Humans; Leisure Activities; Magnetic Resonance Spectroscopy; Male; Memory; Memory, Short-Term; Neuronal Plasticity

2019
Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019, Volume: 27, Issue:8

    Topics: Aged; Aging; Antipsychotic Agents; Aspartic Acid; Biomarkers; Bipolar Disorder; Cerebral Cortex; Creatine; Depression; Energy Metabolism; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Lamotrigine; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Severity of Illness Index; Treatment Outcome

2019
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019, Volume: 130, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Intolerance; Glutamic Acid; Glutamine; Glutathione; Glycerylphosphorylcholine; Humans; Inositol; Insulin Resistance; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neuronal Plasticity; Phosphocreatine; Phosphorylcholine; Prediabetic State; Theta Rhythm; Transcranial Magnetic Stimulation

2019
Effects of age and sex on the concentrations of glutamate and glutamine in the human brain.
    Journal of magnetic resonance imaging : JMRI, 2013, Volume: 38, Issue:6

    Topics: Adult; Aging; Aspartic Acid; Choline; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurotransmitter Agents; Reproducibility of Results; Sensitivity and Specificity; Sex Factors; Young Adult

2013
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
    Arquivos de neuro-psiquiatria, 2013, Volume: 71, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Diagnosis, Differential; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Male; Mental Status Schedule; Severity of Illness Index

2013
Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy.
    Experimental gerontology, 2013, Volume: 48, Issue:8

    Topics: Adult; Aged; Aging; Aspartic Acid; Audiometry, Pure-Tone; Auditory Cortex; Case-Control Studies; Female; Glutamates; Humans; Lactates; Magnetic Resonance Spectroscopy; Male; Presbycusis

2013
Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T.
    Age (Dordrecht, Netherlands), 2014, Volume: 36, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; China; Choline; Creatine; Female; Gyrus Cinguli; Humans; Imaging, Three-Dimensional; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons

2014
Motor system alterations in retired former athletes: the role of aging and concussion history.
    BMC neurology, 2013, Aug-26, Volume: 13

    Topics: Age Factors; Aged; Aging; Analysis of Variance; Apolipoproteins E; Aspartic Acid; Brain; Brain Concussion; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Motor Activity; Motor Cortex; Neuropsychological Tests; Photic Stimulation; Protons; Reaction Time; Regression Analysis; Surveys and Questionnaires

2013
Age-related changes in a patient with Pelizaeus-Merzbacher disease determined by repeated 1H-magnetic resonance spectroscopy.
    Journal of child neurology, 2014, Volume: 29, Issue:2

    Topics: Aging; Aspartic Acid; Case-Control Studies; Child, Preschool; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Male; Parietal Lobe; Pelizaeus-Merzbacher Disease

2014
Faster metabolite (1)H transverse relaxation in the elder human brain.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Adolescent; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cellular Microenvironment; Choline; Creatine; Humans; Nuclear Magnetic Resonance, Biomolecular; Occipital Lobe

2013
1H NMR metabolomic signatures in five brain regions of the AβPPswe Tg2576 mouse model of Alzheimer's disease at four ages.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:1

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cerebellum; Cerebral Cortex; Disease Models, Animal; Genotype; Glutamic Acid; Hippocampus; Magnetic Resonance Spectroscopy; Male; Mesencephalon; Metabolome; Mice; Mice, Transgenic; Tissue Extracts

2014
Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.
    Neurochemical research, 2014, Volume: 39, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Corpus Striatum; Glutamate Dehydrogenase; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Receptors, Glutamate; Synapses

2014
Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs.
    American journal of veterinary research, 2014, Volume: 75, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Creatine; Dogs; Female; Lactic Acid; Magnetic Resonance Spectroscopy; Male

2014
The partial volume effect in the quantification of 1H magnetic resonance spectroscopy in Alzheimer's disease and aging.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 42, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Cognitive Dysfunction; Female; Functional Laterality; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons

2014
Education mitigates age-related decline in N-Acetylaspartate levels.
    Brain and behavior, 2015, Volume: 5, Issue:3

    Topics: Aged; Aging; Aspartic Acid; Cognitive Reserve; Educational Status; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male

2015
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
    Brain imaging and behavior, 2016, Volume: 10, Issue:1

    Topics: Adult; Aging; Aspartic Acid; Creatine; Female; Gliosis; Gyrus Cinguli; Humans; Inositol; Intelligence Tests; Male; Memory Disorders; Memory, Short-Term; Middle Aged; Neuropsychological Tests; Proton Magnetic Resonance Spectroscopy; Retrospective Studies; Schizophrenia; Schizophrenic Psychology; Sex Characteristics; Young Adult

2016
A quantitative analysis of (1)H-MR spectroscopy at 3.0 T of three brain regions from childhood to middle age.
    The British journal of radiology, 2015, Volume: 88, Issue:1052

    Topics: Adolescent; Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Child; Creatinine; Female; Glutamic Acid; Glutamine; Healthy Volunteers; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Matrix Metalloproteinase 9; Middle Aged; Young Adult

2015
The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2016, Volume: 27

    Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Cell Death; Cross-Sectional Studies; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neurons

2016
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
    Schizophrenia research, 2016, Volume: 172, Issue:1-3

    Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Gyrus Cinguli; Humans; Inositol; Male; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizophrenia

2016
Physiological neuronal decline in healthy aging human brain - An in vivo study with MRI and short echo-time whole-brain (1)H MR spectroscopic imaging.
    NeuroImage, 2016, Aug-15, Volume: 137

    Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Imaging; Proton Magnetic Resonance Spectroscopy; Reference Values; Reproducibility of Results; Sensitivity and Specificity; White Matter; Young Adult

2016
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.
    Neuroradiology, 2016, Volume: 58, Issue:10

    Topics: Adolescent; Aging; Aspartic Acid; Biomarkers, Tumor; Brain Stem; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Molecular Imaging; Outcome Assessment, Health Care; Reproducibility of Results; Sensitivity and Specificity; Tumor Burden

2016
Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: a
    Neurobiology of aging, 2016, Volume: 48

    Topics: Aged; Aging; Aspartic Acid; Energy Metabolism; Female; Gray Matter; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Memory, Episodic; Mitochondria

2016
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
    Neurological research, 2017, Volume: 39, Issue:4

    Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depression; Disability Evaluation; Fatigue; Female; Glutamic Acid; Humans; Hypothalamus; Inositol; Male; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Severity of Illness Index

2017
Can magnetic resonance spectroscopy predict neurodevelopmental outcome in very low birth weight preterm infants?
    Journal of perinatology : official journal of the California Perinatal Association, 2008, Volume: 28, Issue:9

    Topics: Aging; Aspartic Acid; Basal Ganglia; Child Development; Choline; Cohort Studies; Follow-Up Studies; Humans; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Magnetic Resonance Spectroscopy; Nervous System; Predictive Value of Tests; Thalamus

2008
Age dependence of regional proton metabolites T2 relaxation times in the human brain at 3 T.
    Magnetic resonance in medicine, 2008, Volume: 60, Issue:4

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Tissue Distribution

2008
An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study.
    Journal of child neurology, 2009, Volume: 24, Issue:1

    Topics: Adolescent; Aging; Aspartic Acid; Basal Ganglia; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Sex Characteristics; Statistics, Nonparametric

2009
N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:10

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Female; Humans; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Fibers, Myelinated; Neuropsychological Tests; Thalamus

2008
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
    Annals of neurology, 2009, Volume: 65, Issue:1

    Topics: Adolescent; Aging; Analysis of Variance; Aspartic Acid; Case-Control Studies; Child; Child, Preschool; Creatine; Female; Frontal Lobe; Genotype; Glutamic Acid; Glutamine; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Methyl-CpG-Binding Protein 2; Mutation; Protons; Rett Syndrome; Severity of Illness Index

2009
Proton magnetic resonance spectroscopy of late-life major depressive disorder.
    Psychiatry research, 2009, Jun-30, Volume: 172, Issue:3

    Topics: Aged; Aging; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Choline; Cognition; Creatine; Depressive Disorder, Major; Dominance, Cerebral; Female; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Psychiatric Status Rating Scales

2009
Copper deficiency alters the neurochemical profile of developing rat brain.
    Nutritional neuroscience, 2009, Volume: 12, Issue:3

    Topics: Aging; Animals; Ascorbic Acid; Aspartic Acid; Brain; Brain Chemistry; Cerebellum; Citric Acid; Copper; Creatine; Female; Hippocampus; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mitochondria; Phosphocreatine; Rats

2009
Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy.
    Neurobiology of aging, 2011, Volume: 32, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Humans; Image Processing, Computer-Assisted; Inositol; Macaca mulatta; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Statistics as Topic

2011
Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:1

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Brain Chemistry; Female; Glucose Tolerance Test; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mitochondria

2010
Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI.
    Journal of neurotrauma, 2010, Volume: 27, Issue:3

    Topics: Adolescent; Age Factors; Aging; Anisotropy; Aspartic Acid; Axons; Biomarkers; Brain Injuries; Child; Choline; Cognition Disorders; Corpus Callosum; Diffuse Axonal Injury; Diffusion Tensor Imaging; Female; Humans; Magnetic Resonance Spectroscopy; Male; Wallerian Degeneration

2010
Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myelin Sheath; Reference Values; Young Adult

2010
Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging.
    Dementia and geriatric cognitive disorders, 2010, Volume: 30, Issue:1

    Topics: Aged; Aging; Alzheimer Disease; Amnesia; Analysis of Variance; Aspartic Acid; Biomarkers; Brain Chemistry; Choline; Cognition Disorders; Diagnosis, Differential; Female; Hippocampus; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Prospective Studies

2010
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
    Journal of neuroscience research, 2010, Nov-01, Volume: 88, Issue:14

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles

2010
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging.
    Psychiatry research, 2010, Nov-30, Volume: 184, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aging; Amygdala; Aspartic Acid; Asperger Syndrome; Brain Mapping; Child; Choline; Creatine; Female; Hippocampus; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphocreatine

2010
Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study.
    European journal of radiology, 2012, Volume: 81, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Choline; Creatine; Female; Gyrus Cinguli; Hippocampus; Humans; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged

2012
Age-related changes of serum N-acetyl-aspartate in healthy controls.
    Age and ageing, 2011, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Preschool; Chromatography, Liquid; Cohort Studies; Female; Humans; Infant; Male; Mass Spectrometry; Middle Aged; Sex Factors; Young Adult

2011
[Normal aging and imaging correlations].
    Der Radiologe, 2011, Volume: 51, Issue:4

    Topics: Aging; Aspartic Acid; Brain; Humans; Magnetic Resonance Imaging; Reference Values; Statistics as Topic

2011
Longitudinal inter- and intra-individual human brain metabolic quantification over 3 years with proton MR spectroscopy at 3 T.
    Magnetic resonance in medicine, 2012, Volume: 67, Issue:1

    Topics: Aging; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Spectroscopy; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution

2012
Associations of age, gender and body mass with 1H MR-observed brain metabolites and tissue distributions.
    NMR in biomedicine, 2012, Volume: 25, Issue:4

    Topics: Adult; Aged; Aging; Aspartic Acid; Body Mass Index; Brain; Choline; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reproducibility of Results; Sensitivity and Specificity; Sex Factors; Statistics as Topic; Tissue Distribution

2012
Daydreaming about our metaphorical tool belt.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:3

    Topics: Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male

2012
The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:3

    Topics: Adult; Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male; Reproducibility of Results; Sensitivity and Specificity

2012
Whole brain N-acetylaspartate concentration is conserved throughout normal aging.
    Neurobiology of aging, 2012, Volume: 33, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Atrophy; Biomarkers; Brain; Brain Chemistry; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Organ Size

2012
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
    Behavioural brain research, 2012, Nov-01, Volume: 235, Issue:1

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Choline; Creatine; Disease Models, Animal; Functional Neuroimaging; Glutamic Acid; Hippocampus; Inositol; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Transgenic; Presenilin-1; Protons

2012
Absence of age-related prefrontal NAA change in adults with autism spectrum disorders.
    Translational psychiatry, 2012, Oct-23, Volume: 2

    Topics: Adult; Age Factors; Aging; Aspartic Acid; Asperger Syndrome; Autistic Disorder; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multivariate Analysis; Prefrontal Cortex

2012
Age-modulated association between prefrontal NAA and the BDNF gene.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder, Major; Female; Genetic Association Studies; Genotype; Humans; Linear Models; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Polymorphism, Single Nucleotide; Prefrontal Cortex; RNA, Messenger; Young Adult

2013
Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development.
    NMR in biomedicine, 2013, Volume: 26, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Dipeptides; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Prosencephalon; Rats; Rats, Sprague-Dawley; Taurine

2013
Reduced N-acetylaspartate in prefrontal cortex of adult rats with neonatal hippocampal damage.
    Cerebral cortex (New York, N.Y. : 1991), 2002, Volume: 12, Issue:9

    Topics: Age Factors; Aging; Animals; Animals, Newborn; Aspartic Acid; Female; Hippocampus; Male; Motor Activity; Neurons; Nuclear Magnetic Resonance, Biomolecular; Prefrontal Cortex; Pregnancy; Rats; Rats, Sprague-Dawley

2002
Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men.
    Radiology, 2003, Volume: 226, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Linear Models; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values; Sex Factors

2003
Memory training alters hippocampal neurochemistry in healthy elderly.
    Neuroreport, 2003, Jul-18, Volume: 14, Issue:10

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; Brain Mapping; Cerebral Cortex; Choline; Creatine; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Memory; Mental Recall; Middle Aged; Practice, Psychological; Water

2003
Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus.
    The Journal of nutrition, 2003, Volume: 133, Issue:10

    Topics: Aging; Animals; Aspartic Acid; Body Weight; Brain; Brain Chemistry; Creatine; Ethanolamines; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Iron; Iron Deficiencies; Liver; Magnetic Resonance Spectroscopy; Male; Myocardium; Organ Size; Phosphocreatine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Taurine

2003
Effect of aging on brain metabolism in antiretroviral-naive HIV patients.
    AIDS (London, England), 2004, Jan-01, Volume: 18 Suppl 1

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Female; Frontal Lobe; HIV Seropositivity; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged

2004
Quantitative MR analyses of the hippocampus: unspecific metabolic changes in aging.
    Journal of neurology, 2004, Volume: 251, Issue:11

    Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Attention; Brain Chemistry; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Functional Laterality; Hippocampus; Humans; Image Processing, Computer-Assisted; Learning; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Problem Solving; Reproducibility of Results; Statistics as Topic; Verbal Behavior; Weights and Measures

2004
Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T.
    Neurobiology of aging, 2005, Volume: 26, Issue:5

    Topics: Adult; Aged; Aging; Analysis of Variance; Aspartic Acid; Brain Chemistry; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Protons; Statistics as Topic

2005
Age-related metabolic changes in the upper brainstem tegmentum by MR spectroscopy.
    Neurobiology of aging, 2005, Volume: 26, Issue:7

    Topics: Adult; Aged; Aging; Analysis of Variance; Aspartic Acid; Brain Mapping; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mesencephalon; Middle Aged; Pons; Reference Values

2005
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
    The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52

    Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Mice; Mice, Knockout; Models, Biological; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Neurotransmitter Agents; Phenotype; Spectrophotometry; Time Factors

2005
MRS of normal and impaired fetal brain development.
    European journal of radiology, 2006, Volume: 57, Issue:2

    Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Fetus; gamma-Aminobutyric Acid; Humans; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Taurine

2006
Longitudinal changes during aging using proton magnetic resonance spectroscopy.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Chi-Square Distribution; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Protons; Time Factors

2006
Assessment of normal fetal brain maturation in utero by proton magnetic resonance spectroscopy.
    Magnetic resonance in medicine, 2006, Volume: 56, Issue:4

    Topics: Aging; Algorithms; Aspartic Acid; Brain; Brain Chemistry; Female; Fetal Development; Gestational Age; Humans; Linear Models; Magnetic Resonance Spectroscopy; Pregnancy

2006
The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.
    Brain research, 2007, Aug-20, Volume: 1164

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Cognition; Cognition Disorders; Cross-Sectional Studies; Female; Humans; Intelligence; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Middle Aged; Nerve Fibers, Myelinated; Neuropsychological Tests; Predictive Value of Tests; Wallerian Degeneration

2007
Decrease of NAA with aging outside the seizure focus in mesial temporal lobe epilepsy--a proton-MRS study at 3 Tesla.
    Brain research, 2007, Nov-07, Volume: 1179

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Drug Resistance; Epilepsy, Temporal Lobe; Female; Functional Laterality; Humans; Magnetic Resonance Spectroscopy; Male; Memory; Neuropsychological Tests; Protons; Seizures; Temporal Lobe; Verbal Learning

2007
Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy.
    European journal of radiology, 2008, Volume: 68, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Imaging, Three-Dimensional; Magnetic Resonance Spectroscopy; Male; Middle Aged; Retrospective Studies

2008
Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.
    Journal of magnetic resonance imaging : JMRI, 2007, Volume: 26, Issue:6

    Topics: Aged; Aged, 80 and over; Aging; Artifacts; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons

2007
Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injury.
    NeuroImage, 2008, Mar-01, Volume: 40, Issue:1

    Topics: Adult; Aging; AIDS Dementia Complex; Algorithms; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistry; Choline; Creatinine; Female; HIV Infections; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Predictive Value of Tests; ROC Curve

2008
Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults.
    Neurology, 2008, Apr-29, Volume: 70, Issue:18

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory; Memory Disorders; Neuropsychological Tests; Organ Size; Sampling Studies; Verbal Behavior

2008
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
    Journal of neurotrauma, 2008, Volume: 25, Issue:6

    Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; Choline; Creatine; Disease Progression; Energy Metabolism; Glycolysis; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mitochondria; Nerve Degeneration; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors

2008
A gas chromatographic method for the determination of N-acetyl-L-aspartic acid, N-acetyl-alpha-aspartylglutamic acid and beta-citryl-L-glutamic acid and their distributions in the brain and other organs of various species of animals.
    Journal of neurochemistry, 1981, Volume: 36, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Brain Chemistry; Carps; Chickens; Chromatography, Gas; Citrates; Columbidae; Dipeptides; Glutamates; Guinea Pigs; Male; Nervous System; Rabbits; Ranidae; Rats; Species Specificity; Turtles

1981
Developmental changes of N-acetyl-L-aspartic acid, N-acetyl-alpha-aspartylglutamic acid and beta-citryl-L-glutamic acid in different brain regions and spinal cords of rat and guinea pig.
    Journal of neurochemistry, 1981, Volume: 37, Issue:4

    Topics: Aging; Animals; Aspartic Acid; Brain; Dipeptides; Glutamates; Guinea Pigs; Organ Specificity; Rats; Rats, Inbred Strains; Species Specificity; Spinal Cord

1981
Age-dependent neurotoxicity of striatal lesions produced by aminooxyacetic acid: quantitative in vitro 1H NMR spectroscopic studies.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Aging; Alanine; Animals; Aspartic Acid; Corpus Striatum; Creatine; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; In Vitro Techniques; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mitochondria; Rats; Rats, Sprague-Dawley

1995
Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging.
    Annals of neurology, 1994, Volume: 36, Issue:1

    Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Axons; Brain; Cerebral Cortex; Cerebral Ventricles; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged

1994
The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium.
    Magnetic resonance imaging, 1993, Volume: 11, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Phosphocreatine

1993
1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease.
    Journal of the American Geriatrics Society, 1996, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Case-Control Studies; Diagnosis, Differential; Female; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Middle Aged; Organotechnetium Compounds; Oximes; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon

1996
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:3

    Topics: Aging; Animals; Aspartic Acid; Electron Transport Complex II; Energy Metabolism; Huntington Disease; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Multienzyme Complexes; Nerve Degeneration; Neurochemistry; Neurotoxins; Oxidoreductases; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase

1996
Regional and developmental variations in metabolite concentration in the rat brain and eye: a study using 1H NMR spectroscopy and high performance liquid chromatography.
    Neurochemical research, 1996, Volume: 21, Issue:9

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Callosum; Dipeptides; Eye; gamma-Aminobutyric Acid; Glutamic Acid; Hydrogen; Magnetic Resonance Spectroscopy; Olfactory Bulb; Oligodendroglia; Optic Nerve; Organ Specificity; Rats; Stem Cells

1996
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.
    Schizophrenia research, 1996, Oct-18, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterality; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Degeneration; Schizophrenia

1996
Estimating NAA in cortical gray matter with applications for measuring changes due to aging.
    Magnetic resonance in medicine, 1997, Volume: 37, Issue:3

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Female; Humans; Magnetic Resonance Spectroscopy

1997
Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects.
    Psychiatry and clinical neurosciences, 1997, Volume: 51, Issue:4

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain Mapping; Creatine; Energy Metabolism; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurons; Phosphocreatine; Reference Values; Temporal Lobe

1997
1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderly.
    Stroke, 1997, Volume: 28, Issue:10

    Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Intracranial Arteriosclerosis; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reference Values

1997
Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study.
    Cerebral cortex (New York, N.Y. : 1991), 1997, Volume: 7, Issue:8

    Topics: Aging; Amygdala; Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Choline; Creatine; Entorhinal Cortex; Female; Functional Laterality; Hippocampus; Macaca mulatta; Magnetic Resonance Spectroscopy; Male; Neurons; Phosphocreatine; Prefrontal Cortex; Reference Values

1997
Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study.
    Neuroreport, 1998, Jun-22, Volume: 9, Issue:9

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; Creatine; Female; Inositol; Macaca mulatta; Magnetic Resonance Imaging; Male

1998
In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging.
    Magnetic resonance in medicine, 1999, Volume: 41, Issue:2

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged

1999
Metabolite changes in neonatal rat brain during and after cerebral hypoxia-ischemia: a magnetic resonance spectroscopic imaging study.
    NMR in biomedicine, 1999, Volume: 12, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Ischemia; Cerebral Infarction; Female; Hypoxia, Brain; Lactic Acid; Magnetic Resonance Imaging; Pregnancy; Protons; Rats; Rats, Wistar

1999
Aging of the adult human brain: in vivo quantitation of metabolite content with proton magnetic resonance spectroscopy.
    Journal of magnetic resonance imaging : JMRI, 1999, Volume: 9, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values

1999
1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men.
    Magnetic resonance in medicine, 1999, Volume: 42, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Blood Glucose; Brain; Choline; Creatine; Energy Metabolism; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values; Sex Factors

1999
In vitro proton and phosphorus NMR spectroscopic analysis of murine (C57Bl/6J) brain development.
    NMR in biomedicine, 1999, Volume: 12, Issue:7

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Chloroform; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Magnetic Resonance Spectroscopy; Methanol; Mice; Mice, Inbred C57BL; Phosphatidylcholines; Phosphatidylinositols; Phosphorus; Protons; Taurine

1999
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
    Magnetic resonance imaging, 2000, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Phosphocreatine

2000
In vitro high resolution proton magnetic resonance study of human cerebellar development during the period from the fetus to childhood.
    Physiological chemistry and physics and medical NMR, 1999, Volume: 31, Issue:2

    Topics: Aging; Amino Acids; Aspartic Acid; Cerebellum; Child; Child, Preschool; Creatinine; Dipeptides; Embryonic and Fetal Development; Fetus; Humans; Infant; Magnetic Resonance Spectroscopy

1999
Dual voxel proton magnetic resonance spectroscopy in the healthy elderly: subcortical-frontal axonal N-acetylaspartate levels are correlated with fluid cognitive abilities independent of structural brain changes.
    NeuroImage, 2000, Volume: 12, Issue:6

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Cognition; Energy Metabolism; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Net; Neuropsychological Tests; Reference Values

2000
Chemical mapping of anxiety in the brain of healthy humans: an in vivo 1H-MRS study on the effects of sex, age, and brain region.
    Human brain mapping, 2000, Volume: 11, Issue:4

    Topics: Adult; Aging; Anxiety; Aspartic Acid; Brain; Brain Chemistry; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Orbit; Osmolar Concentration; Reference Values; Sex Characteristics; Tissue Distribution

2000
Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:1

    Topics: Adult; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values; Tissue Distribution

2001
Development and aging of the cerebrum: assessment with proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values; Sex Characteristics; Tissue Distribution

2001
Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging.
    Magnetic resonance in medicine, 2001, Volume: 45, Issue:5

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Female; Humans; Hydrogen; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Signal Processing, Computer-Assisted

2001
A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations.
    Cerebral cortex (New York, N.Y. : 1991), 2001, Volume: 11, Issue:7

    Topics: Adult; Aged; Aging; Aspartic Acid; Cerebrospinal Fluid; Choline; Creatinine; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Water

2001
Multivariate analysis of regional metabolic differences in normal ageing on localised quantitative proton MR spectroscopy.
    Neuroradiology, 2001, Volume: 43, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Cerebrospinal Fluid; Corpus Striatum; Dementia; Female; Frontal Lobe; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values

2001
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
    Neuroreport, 2001, Aug-08, Volume: 12, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognition Disorders; Creatine; Diagnosis, Differential; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Protons

2001
Quantitative evaluation of cerebral metabolites and cerebral blood flow in patients with carotid stenosis.
    Neurological research, 2001, Volume: 23, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Basal Ganglia; Brain Ischemia; Carotid Stenosis; Cerebral Cortex; Cerebrovascular Circulation; Choline; Creatine; Endarterectomy, Carotid; Energy Metabolism; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Recovery of Function; Tomography, Emission-Computed, Single-Photon; Treatment Outcome

2001
Developmental delay in children: assessment with proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 2002, Volume: 23, Issue:5

    Topics: Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatine; Developmental Disabilities; Female; Frontal Lobe; Humans; Infant; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Parietal Lobe; Reference Values; Tissue Distribution

2002
In vivo 1H and 31P NMR spectroscopy of the developing rat brain.
    Magnetic resonance in medicine, 1992, Volume: 23, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Hydrogen; Magnetic Resonance Spectroscopy; Phosphocreatine; Phosphorus; Rats; Rats, Inbred Strains

1992
N-acetyl-L-aspartate is a major source of acetyl groups for lipid synthesis during rat brain development.
    Developmental neuroscience, 1991, Volume: 13, Issue:6

    Topics: Acetyltransferases; Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Injections, Intraventricular; Lipids; Nerve Tissue Proteins; Rats; Rats, Inbred Strains

1991
Brain development: 1H magnetic resonance spectroscopy of rat brain extracts compared with chromatographic methods.
    Neurochemical research, 1990, Volume: 15, Issue:10

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Creatine; Hydrogen; Magnetic Resonance Spectroscopy; Rats; Rats, Inbred Strains

1990
Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain.
    Radiology, 1990, Volume: 176, Issue:2

    Topics: Adenosine Triphosphate; Adolescent; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Female; Humans; Infant; Magnetic Resonance Spectroscopy; Male; Organophosphates; Phosphocreatine; Phosphorus; Protons

1990