n-acetyl-beta-glucosaminyl-n-acetylmuramyl-alanylisoglutamine and Lung-Neoplasms

The influence of a new, liposome-encapsulated muramyldipeptide analog--GMDP--on Lewis lung carcinoma spreading was studied in mice in which primary tumor had been removed. The drug was found to significantly decrease the extent and number of lung metastases, as compared to mice which had not received GMDP. This was matched by recovery of alveolar and splenic macrophages functional activity, as assessed by adenosine deaminase and 5'-nucleotidase levels in these cells.

Topics: 5'-Nucleotidase; Acetylmuramyl-Alanyl-Isoglutamine; Adenosine Deaminase; Adjuvants, Immunologic; Animals; Combined Modality Therapy; Liposomes; Lung Neoplasms; Macrophages; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Nucleotidases

N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine (GMDP), a new liposome-encapsulated muramyl dipeptide analog, was studied for its effect on the Lewis lung carcinoma metastatic spreading as well as on the adenosine deaminase (ADA) and 5'-nucleotidase (5-N) activity in the alveolar and peritoneal mice macrophages. The drug administration was found to cause a sharp dose-dependent decrease in the lung metastases volume and number as compared to those in mice not treated with GMDP. The antimetastatic effect of GMDP is accompanied by an increase in the functional macrophage activity determined by ADA and 5-N level in these cells.

Topics: 5'-Nucleotidase; Acetylmuramyl-Alanyl-Isoglutamine; Adenosine Deaminase Inhibitors; Animals; Drug Carriers; Female; Liposomes; Lung Neoplasms; Macrophages; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Nucleotidases

Topics: 5'-Nucleotidase; Acetylmuramyl-Alanyl-Isoglutamine; Adenosine Deaminase; Adjuvants, Immunologic; Animals; Lung Neoplasms; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Nucleotidases; Pulmonary Alveoli