Compounds > n-acetyl-4-benzoquinoneimine
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n-acetyl-4-benzoquinoneimine and Liver Dysfunction

n-acetyl-4-benzoquinoneimine has been researched along with Liver Dysfunction in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's1 (12.50)18.2507
2000's5 (62.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ando, Y; Fukuhara, K; Ohno, A; Okuda, H; Yamoto, T1
Kalhorn, TF; Slattery, JT; Zhao, P1
Clement, YN; Williams, AF1
Allard, JL; Court, MH; Duan, SX; Gonzalez, FJ; Gorman, N; Greenblatt, DJ; Hao, Q; Hunt, JA; Jeffery, EH; Kostrubsky, V; Sinclair, JF; Sinclair, PR; Szakacs, JG; von Moltke, LL; Walton-Strong, BW; Wolf, KK; Wood, SG; Wrighton, SA1
Jaw, S; Jeffery, EH1
Bement, JL; Bement, WJ; Gonzalez, FJ; Jeffery, EH; Sinclair, JF; Sinclair, PR; Szakacs, JG; Walton, HS; Wood, SG; Wrighton, SA1
Hanioka, K; Hojo, M; Miyata, M; Yamazoe, Y1
de Vries, J; Debets, AJ; van de Straat, R; Vermeulen, NP1

Other Studies

8 other study(ies) available for n-acetyl-4-benzoquinoneimine and Liver Dysfunction

ArticleYear
A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.
    Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glutathione; Imines; Liver; Liver Diseases; Magnetic Resonance Imaging; Male; Metabolomics; Oxidation-Reduction; Oxidative Stress; Phenobarbital; Rats; Rats, Inbred F344

2011
Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver.
    Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Central Nervous System Depressants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Synergism; Ethanol; Glutathione; Imines; In Vitro Techniques; Liver; Liver Diseases; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley

2002
Protection against paracetamol-induced hepatic injury by prazosin pre-treatment in CD-1 mice.
    Mutation research, 2005, Nov-11, Volume: 579, Issue:1-2

    Topics: Acetaminophen; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Glucuronosyltransferase; Glutathione; Imines; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Prazosin; Protective Agents

2005
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:7

    Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Ethanol; Glucuronides; Glutathione; Hydroxylation; Imines; Liver; Liver Diseases; Male; Mice; Mice, Knockout; Pentanols; Severity of Illness Index; Testosterone; Troleandomycin

2007
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
    Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3

    Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzoquinones; beta-Naphthoflavone; Biotransformation; Caffeine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Activation; Female; Imines; Isoenzymes; Kinetics; Liver Diseases; Mice; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital

1993
Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.
    Toxicology and applied pharmacology, 2000, Oct-15, Volume: 168, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Synergism; Ethanol; Fatty Liver, Alcoholic; Female; Imines; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Pentanols; Sex Factors

2000
Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose.
    Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:9

    Topics: Acetaminophen; Alanine Transaminase; Allopurinol; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Inhibitors; Fructose; Glucose; Imines; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Portal Vein; Rats; Rats, Sprague-Dawley; Sucrose; Xanthine Oxidase

2000
The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.
    Biochemical pharmacology, 1987, Jul-01, Volume: 36, Issue:13

    Topics: Acetaminophen; Animals; Benzoquinones; Carmustine; Chemical and Drug Induced Liver Injury; Glutathione; Imines; Lipid Peroxides; Liver; Liver Diseases; Male; Maleates; Oxidation-Reduction; Quinones; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1987