Page last updated: 2024-08-23

n-acetyl-4-benzoquinoneimine and Drug Overdose

n-acetyl-4-benzoquinoneimine has been researched along with Drug Overdose in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's3 (27.27)29.6817
2010's4 (36.36)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; Isoardi, KZ; Page, C; Ress, K; Stathakis, P1
Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; James, LP; McArdle, K; Pickering, JW1
Akakpo, JY; Du, K; Jaeschke, H; Nguyen, NT; Ramachandran, A; Umbaugh, DS1
Aubrecht, J; Bohler, S; Briedé, JJ; Caiment, F; Kleinjans, JCS; Krauskopf, J; Liu, X; Nicolaes, GAF1
Alonso, EM; James, LP; Squires, RH; Zhang, S1
Marshall, DC; Webb, TE1
Heard, K; Yip, L1
Capparelli, E; Davern, TJ; Hinson, JA; James, LP; Lee, WM; Letzig, L; Roberts, DW; Simpson, PM1
Marx, J1
Good, AM; Johnson, DW; Juurlink, DN; Sivilotti, ML; Yarema, MC1
Kirsch, RE; Pillans, P; Robson, SC; Spearman, CW1

Trials

1 trial(s) available for n-acetyl-4-benzoquinoneimine and Drug Overdose

ArticleYear
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
    Journal of hepatology, 2020, Volume: 72, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Australia; Benzoquinones; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Imines; Liver; Male; Middle Aged; Prospective Studies; Treatment Outcome; Young Adult

2020

Other Studies

10 other study(ies) available for n-acetyl-4-benzoquinoneimine and Drug Overdose

ArticleYear
Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7).
    Clinical pharmacology and therapeutics, 2023, Volume: 113, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Retrospective Studies

2023
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
    Toxicology letters, 2021, Mar-01, Volume: 338

    Topics: Acetaminophen; Animals; Benzoquinones; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytosol; Disease Models, Animal; Drug Overdose; Enzyme Activation; Hepatocytes; Imines; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Proteins; Oxidative Stress; Protein Transport; Superoxides; Time Factors

2021
Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease.
    Clinical and translational science, 2019, Volume: 12, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Benzoquinones; Circulating MicroRNA; Crystallography, X-Ray; Cytochrome P-450 CYP3A; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drosophila Proteins; Drug Overdose; Female; Humans; Imines; Male; Middle Aged; Models, Animal; Molecular Docking Simulation; Molecular Structure; Parkinson Disease; Risk Factors; Sequence Alignment; Substantia Nigra; Young Adult

2019
Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure.
    Journal of pediatric gastroenterology and nutrition, 2015, Volume: 61, Issue:1

    Topics: Acetaminophen; Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Benzoquinones; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Overdose; Female; Humans; Imines; Infant; Liver; Liver Failure, Acute; Male; Prognosis; Proteins

2015
Immobilised UGT1A9 may be used to treat paracetamol overdose.
    Medical hypotheses, 2015, Volume: 85, Issue:6

    Topics: Acetaminophen; Benzoquinones; Drug Overdose; Enzymes, Immobilized; Glucuronosyltransferase; Hepatocytes; Humans; Imines; Liver, Artificial; UDP-Glucuronosyltransferase 1A9

2015
Potential adjunct treatment for high-risk acetaminophen overdose.
    Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:5

    Topics: Acetaminophen; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibitors; Drug Overdose; Fomepizole; Humans; Imines; Liver; Pyrazoles

2016
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:8

    Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquinones; Biomarkers; Biotransformation; Databases as Topic; Drug Overdose; Female; Half-Life; Humans; Imines; Liver Failure, Acute; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Models, Statistical; Nonlinear Dynamics; Young Adult

2009
Toxicology. Protecting liver from painkiller's lethal dose.
    Science (New York, N.Y.), 2002, Oct-11, Volume: 298, Issue:5592

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Androstanols; Animals; Benzoquinones; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Drug Overdose; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imines; Isoenzymes; Liver; Liver Failure, Acute; Mice; Mice, Transgenic; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Transcription Factors

2002
A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure.
    Clinical toxicology (Philadelphia, Pa.), 2005, Volume: 43, Issue:4

    Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Benzoquinones; Chemical and Drug Induced Liver Injury; Computer Simulation; Drug Overdose; Glutathione; Humans; Imines; Models, Statistical; Predictive Value of Tests

2005
Paracetamol poisoning.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1993, Volume: 83, Issue:11

    Topics: Acetaminophen; Acetylcysteine; Benzoquinones; Chemical and Drug Induced Liver Injury; Clinical Protocols; Drug Overdose; Humans; Imines

1993