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n-acetyl-4-benzoquinoneimine and Disease Models, Animal

n-acetyl-4-benzoquinoneimine has been researched along with Disease Models, Animal in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Akakpo, JY; Du, K; Jaeschke, H; Nguyen, NT; Ramachandran, A; Umbaugh, DS1
Blomgren, A; Grundemar, L; Högestätt, ED; Nilsson, JLÅ; Nilsson, UJ1
Bi, H; Chen, P; Fan, X; Gonzalez, FJ; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H1
Iguchi, T; Mikamoto, K; Mori, K; Niino, N; Sakurai, K; Sayama, A; Shimoda, H; Takasaki, W; Tamai, S1
Allard, JL; Court, MH; Duan, SX; Gonzalez, FJ; Gorman, N; Greenblatt, DJ; Hao, Q; Hunt, JA; Jeffery, EH; Kostrubsky, V; Sinclair, JF; Sinclair, PR; Szakacs, JG; von Moltke, LL; Walton-Strong, BW; Wolf, KK; Wood, SG; Wrighton, SA1

Other Studies

5 other study(ies) available for n-acetyl-4-benzoquinoneimine and Disease Models, Animal

ArticleYear
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
    Toxicology letters, 2021, Mar-01, Volume: 338

    Topics: Acetaminophen; Animals; Benzoquinones; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytosol; Disease Models, Animal; Drug Overdose; Enzyme Activation; Hepatocytes; Imines; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Proteins; Oxidative Stress; Protein Transport; Superoxides; Time Factors

2021
N,N'-Bis(2-mercaptoethyl)isophthalamide Binds Electrophilic Paracetamol Metabolites and Prevents Paracetamol-Induced Liver Toxicity.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Benzene Derivatives; Benzoquinones; Chelating Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Imines; Mice; Sulfhydryl Compounds

2018
Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 143, Issue:1

    Topics: Acetaminophen; Activation, Metabolic; Animals; Apoptosis Regulatory Proteins; Benzoquinones; Binding Sites; Biomarkers; Catalytic Domain; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytoprotection; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Imines; Lignans; Liver; Liver Regeneration; Male; Membrane Proteins; Mice, Inbred C57BL; Mitochondria, Liver; Molecular Docking Simulation; Protein Binding; Protein Conformation; Signal Transduction

2015
A monkey model of acetaminophen-induced hepatotoxicity; phenotypic similarity to human.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:1

    Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Humans; Imines; Liver; Macaca fascicularis; Male; MicroRNAs; Phenotype

2017
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:7

    Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Ethanol; Glucuronides; Glutathione; Hydroxylation; Imines; Liver; Liver Diseases; Male; Mice; Mice, Knockout; Pentanols; Severity of Illness Index; Testosterone; Troleandomycin

2007