n-acetyl-4-benzoquinoneimine has been researched along with Chemical and Drug Induced Liver Injury in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.00) | 18.7374 |
| 1990's | 5 (10.00) | 18.2507 |
| 2000's | 10 (20.00) | 29.6817 |
| 2010's | 22 (44.00) | 24.3611 |
| 2020's | 9 (18.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y; Ge, W; Song, W; Yan, R | 1 |
| Bai, ZF; Dai, WZ; He, TT; Li, Q; Xiao, XH; Zhan, XY; Zhao, J | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; Isoardi, KZ; Page, C; Ress, K; Stathakis, P | 1 |
| Bertheux, H; Clausznitzer, D; Coghlan, H; Copple, IM; Fenwick, SW; Fisher, CP; Gardner, I; Goldring, CE; Jenkins, RE; Johnson, RL; Jones, AR; Kunnen, SJ; Liguori, MJ; Livoti, LA; Reddyhoff, D; Rehman, AH; Russomanno, G; Simonin, G; Sison-Young, R; Stevens, JL; Vermeil De Conchard, G; Weaver, RJ | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; James, LP; McArdle, K; Pickering, JW | 1 |
| Annexstad, EJ; Hovda, KE; Jacobsen, D; Kringen, MK; Lao, YE; Molden, E; Saeverud, HA | 1 |
| Ding, CH; Zhu, H | 1 |
| Chen, Y; Jiang, X; Li, R; Wang, L; Wang, T; Yang, Y; Zhang, X | 1 |
| Akakpo, JY; Du, K; Jaeschke, H; Nguyen, NT; Ramachandran, A; Umbaugh, DS | 1 |
| Hara, A; Kanno, SI; Tomizawa, A; Yomogida, S | 1 |
| Blomgren, A; Grundemar, L; Högestätt, ED; Nilsson, JLÅ; Nilsson, UJ | 1 |
| Heruth, DP; Li, DY; Qing Ye, S; Shortt, K; Zhang, LQ; Zhang, N | 1 |
| Kubo, T; Lee, SH; Oe, T; Ozawa, M | 1 |
| Arnér, ES; Capecchi, MR; Eriksson, S; Iverson, SV; Meade, ES; Meade, TA; Prigge, JR; Schmidt, EE; Talago, EA; Xu, J | 1 |
| Aziz, AT; Rehman, H; Saggu, S; Sakeran, MI; Zidan, N | 1 |
| Cavar, I; Kelava, T | 1 |
| Howell, BA; Siler, SQ; Watkins, PB | 1 |
| Fromenty, B; Michaut, A; Moreau, C; Robin, MA | 1 |
| Alder, NN; Boelsterli, UA; Chamberland, SR; Imaizumi, N; Lee, KK | 1 |
| Bi, H; Chen, P; Fan, X; Gonzalez, FJ; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H | 1 |
| Challa, SR; Pawar, AK; Pingili, RB | 1 |
| Alonso, EM; James, LP; Squires, RH; Zhang, S | 1 |
| Heard, K; Yip, L | 1 |
| Iguchi, T; Mikamoto, K; Mori, K; Niino, N; Sakurai, K; Sayama, A; Shimoda, H; Takasaki, W; Tamai, S | 1 |
| Chan, EC; New, LS; Tan, SC | 1 |
| Batzler, AJ; Chai, Y; Fridley, BL; Jenkins, GD; Ji, Y; Kalari, KR; Moyer, AM; Nordgren, KK; Pelleymounter, LL; Weinshilboum, RM | 1 |
| Ando, Y; Fukuhara, K; Ohno, A; Okuda, H; Yamoto, T | 1 |
| Aponte, AM; Bourdi, M; Chen, Y; Gucek, M; Li, JH; Lombard, DB; Lu, Z; Pohl, LR; Sack, MN | 1 |
| Aninat, C; Bois, FY; Brochot, C; Bunescu, A; Corlu, A; Dumas, ME; Elena-Herrmann, B; Griscom, L; Leclerc, E; Legallais, C; Prot, JM; Razan, F; Snouber, LC | 1 |
| Andersen, ME; Clewell, HJ; Harrill, AH; Howell, BA; Siler, SQ; Watkins, PB; Woodhead, JL; Yang, Y | 1 |
| Arakawa, S; Atsumi, R; Fujimoto, K; Maejima, T; Sugiura, T; Yagi, M; Yamaguchi, T; Yamazoe, Y | 1 |
| Ahn, BH; Choi, HS; Han, J; Heo, JY; Kim, SH; Kweon, G; Lee, JU; Park, JH; Seo, KS; Shong, M; Song, MS; Tadi, S; Yim, YH | 1 |
| Kalhorn, TF; Slattery, JT; Zhao, P | 1 |
| Good, AM; Johnson, DW; Juurlink, DN; Sivilotti, ML; Yarema, MC | 1 |
| Clement, YN; Williams, AF | 1 |
| Devaki, T; Raghavendran, HB; Sathivel, A | 1 |
| Ikeda, T | 1 |
| Aleksunes, LM; Kardas, MJ; Klaassen, CD; Manautou, JE; Moffit, JS; Slitt, AL | 1 |
| Allard, JL; Court, MH; Duan, SX; Gonzalez, FJ; Gorman, N; Greenblatt, DJ; Hao, Q; Hunt, JA; Jeffery, EH; Kostrubsky, V; Sinclair, JF; Sinclair, PR; Szakacs, JG; von Moltke, LL; Walton-Strong, BW; Wolf, KK; Wood, SG; Wrighton, SA | 1 |
| Blair, IA; Huggett, A | 1 |
| Kirsch, RE; Pillans, P; Robson, SC; Spearman, CW | 1 |
| Jaw, S; Jeffery, EH | 1 |
| Bement, JL; Bement, WJ; Gonzalez, FJ; Jeffery, EH; Sinclair, JF; Sinclair, PR; Szakacs, JG; Walton, HS; Wood, SG; Wrighton, SA | 1 |
| Hanioka, K; Hojo, M; Miyata, M; Yamazoe, Y | 1 |
| Adamson, GM; Harman, AW; Papadimitriou, JM | 1 |
| Benson, RW; Hinson, JA; Pumford, NR; Roberts, DW | 1 |
| Nelson, SD | 1 |
| Moldéus, P; Moore, G; Moore, M; Nelson, S; Orrenius, S; Thor, H | 1 |
| Fischer, V; Mason, RP | 1 |
| de Vries, J; Debets, AJ; van de Straat, R; Vermeulen, NP | 1 |
5 review(s) available for n-acetyl-4-benzoquinoneimine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Genetic Association of Single Nucleotide Polymorphisms with Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Glutathione; Humans; Imines; Liver; Polymorphism, Single Nucleotide | 2018 |
Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Humans; Imines; Mice; Mitochondria; Non-alcoholic Fatty Liver Disease; Obesity, Abdominal; Rats | 2014 |
[Drug-induced liver injury].
Topics: Acetaminophen; Anesthetics, General; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 CYP2E1; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Genetic Predisposition to Disease; Humans; Hypoglycemic Agents; Imines; NADP; Pharmacogenetics; Thiazolidinediones; Troglitazone | 2006 |
Molecular mechanisms of the hepatotoxicity caused by acetaminophen.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Imines; Liver | 1990 |
Free radicals of acetaminophen: their subsequent reactions and toxicological significance.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Free Radicals; Horseradish Peroxidase; Hydrogen Peroxide; Imines; Lactoperoxidase; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Peroxidases; Superoxides | 1986 |
1 trial(s) available for n-acetyl-4-benzoquinoneimine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Australia; Benzoquinones; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Imines; Liver; Male; Middle Aged; Prospective Studies; Treatment Outcome; Young Adult | 2020 |
44 other study(ies) available for n-acetyl-4-benzoquinoneimine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Metabolic Competency of Larval Zebrafish in Drug-Induced Liver Injury: A Case Study of Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glutathione; Imines; Larva; Liver; Mammals; Sulfates; Zebrafish | 2022 |
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Liver; Mice; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction | 2022 |
Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7).
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Retrospective Studies | 2023 |
A systems approach reveals species differences in hepatic stress response capacity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver; Mice; Oxidative Stress; Proteomics; Rats; Species Specificity; Systems Analysis | 2023 |
Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes.
Topics: Acetaminophen; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Glucuronosyltransferase; Glutathione; Humans; Imines; Liver; Liver Failure; Male; Muscular Dystrophy, Duchenne; Pharmacogenomic Testing | 2020 |
Isatidis Folium alleviates acetaminophen-induced liver injury in mice by enhancing the endogenous antioxidant system.
Topics: Acetaminophen; Animals; Antioxidants; Benzoquinones; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cytochrome P-450 CYP1A2; Glutathione; Imines; Liver; Male; Mice; Plant Extracts; Plant Leaves | 2020 |
Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway.
Topics: Abietanes; Acetaminophen; Analgesics, Non-Narcotic; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Benzoquinones; Chemical and Drug Induced Liver Injury; Imines; Liver; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; RNA, Long Noncoding; Signal Transduction | 2020 |
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Topics: Acetaminophen; Animals; Benzoquinones; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytosol; Disease Models, Animal; Drug Overdose; Enzyme Activation; Hepatocytes; Imines; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Proteins; Oxidative Stress; Protein Transport; Superoxides; Time Factors | 2021 |
Glutathione peroxidase 3 is a protective factor against acetaminophen‑induced hepatotoxicity in vivo and in vitro.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Female; Glutathione Peroxidase; Hepatocytes; Humans; Imines; K562 Cells; Male; Mice | 2017 |
N,N'-Bis(2-mercaptoethyl)isophthalamide Binds Electrophilic Paracetamol Metabolites and Prevents Paracetamol-Induced Liver Toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Benzene Derivatives; Benzoquinones; Chelating Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Imines; Mice; Sulfhydryl Compounds | 2018 |
LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cysteine; Edema; Exanthema; Glutathione; Humans; Imines; Male; Protein Binding; Serum Albumin; Skin Diseases; Tandem Mass Spectrometry | 2019 |
A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Glutathione; Glycogen; Hepatocytes; Imines; Inactivation, Metabolic; Lipogenesis; Liver; Mice; Thioredoxin Reductase 1; Thioredoxins | 2013 |
Abrogation by Trifolium alexandrinum root extract on hepatotoxicity induced by acetaminophen in rats.
Topics: Acetaminophen; Animals; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Evaluation, Preclinical; Imines; Lipid Peroxidation; Liver; Liver Function Tests; Methanol; Phytotherapy; Plant Extracts; Plant Roots; Rats; Solvents; Trifolium; Water | 2014 |
Hepatoprotective action of Panaxatriol saponins against acetaminophen-induced liver injury: what is the mechanism?
Topics: Acetaminophen; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Ginsenosides; Humans; Imines; Thioredoxins; Tumor Necrosis Factor-alpha | 2014 |
Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.
Topics: Acetaminophen; Acetanilides; Animals; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; Computer Simulation; Cytochrome P-450 CYP2E1; Imines; Isomerism; Liver; Mice; Models, Biological; Systems Biology | 2014 |
Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Electron Transport Complex II; Enzyme Inhibitors; Hepatocytes; Imines; Liver; Male; Methylene Blue; Mice, Inbred C57BL; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Succinate Dehydrogenase | 2015 |
Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.
Topics: Acetaminophen; Activation, Metabolic; Animals; Apoptosis Regulatory Proteins; Benzoquinones; Binding Sites; Biomarkers; Catalytic Domain; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytoprotection; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Imines; Lignans; Liver; Liver Regeneration; Male; Membrane Proteins; Mice, Inbred C57BL; Mitochondria, Liver; Molecular Docking Simulation; Protein Binding; Protein Conformation; Signal Transduction | 2015 |
Systemic exposure of Paracetamol (acetaminophen) was enhanced by quercetin and chrysin co-administration in Wistar rats and in vitro model: risk of liver toxicity.
Topics: Acetaminophen; Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Drug Interactions; Flavonoids; Imines; Intestinal Absorption; Male; Quercetin; Rats; Rats, Wistar | 2015 |
Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Benzoquinones; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Overdose; Female; Humans; Imines; Infant; Liver; Liver Failure, Acute; Male; Prognosis; Proteins | 2015 |
Potential adjunct treatment for high-risk acetaminophen overdose.
Topics: Acetaminophen; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibitors; Drug Overdose; Fomepizole; Humans; Imines; Liver; Pyrazoles | 2016 |
A monkey model of acetaminophen-induced hepatotoxicity; phenotypic similarity to human.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Humans; Imines; Liver; Macaca fascicularis; Male; MicroRNAs; Phenotype | 2017 |
Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Data Interpretation, Statistical; Glutathione; Humans; Imines; Isoxazoles; Leflunomide; Mass Spectrometry; Mice; Microsomes, Liver; Phenacetin; Recombinant Proteins | 2008 |
Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.
Topics: Acetaminophen; Benzoquinones; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Genome-Wide Association Study; Glutathione; Humans; Imines; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Predictive Value of Tests; RNA, Messenger | 2011 |
A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glutathione; Imines; Liver; Liver Diseases; Magnetic Resonance Imaging; Male; Metabolomics; Oxidation-Reduction; Oxidative Stress; Phenobarbital; Rats; Rats, Inbred F344 | 2011 |
SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylation; Alanine Transaminase; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Imines; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Protein Binding; Sirtuin 3 | 2011 |
Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytoprotection; Gene Expression Profiling; Hep G2 Cells; Humans; Imines; Metabolomics; Microfluidic Analytical Techniques; Oxidative Stress; Proteomics | 2012 |
An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Benzoquinones; Chemical and Drug Induced Liver Injury; Cohort Studies; Computer Simulation; Hepatocytes; Humans; Imines; Infusions, Intravenous; Liver; Prescription Drug Misuse; Risk Factors | 2012 |
Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Benzoquinones; Blotting, Western; Chemical and Drug Induced Liver Injury; Female; Glutathione; Glutathione Transferase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Imines; JNK Mitogen-Activated Protein Kinases; Liver; Male; MAP Kinase Kinase 4; Mice; Mice, Knockout; Phosphorylation | 2012 |
An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice.
Topics: Acetaminophen; Animals; Antioxidants; Benzoquinones; Cell Death; Chemical and Drug Induced Liver Injury; Hepatocytes; Imines; JNK Mitogen-Activated Protein Kinases; Male; Mice; Organic Chemicals; Phosphorylation; Reactive Nitrogen Species; Reactive Oxygen Species | 2013 |
Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Central Nervous System Depressants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Synergism; Ethanol; Glutathione; Imines; In Vitro Techniques; Liver; Liver Diseases; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley | 2002 |
A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Benzoquinones; Chemical and Drug Induced Liver Injury; Computer Simulation; Drug Overdose; Glutathione; Humans; Imines; Models, Statistical; Predictive Value of Tests | 2005 |
Protection against paracetamol-induced hepatic injury by prazosin pre-treatment in CD-1 mice.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Glucuronosyltransferase; Glutathione; Imines; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Prazosin; Protective Agents | 2005 |
Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytochrome-B(5) Reductase; Endoplasmic Reticulum; Imines; Inactivation, Metabolic; Liver; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron; Microsomes, Liver; Mitochondria; NADP; NADPH-Ferrihemoprotein Reductase; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Sargassum; Tumor Necrosis Factor-alpha | 2006 |
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Blotting, Western; Chemical and Drug Induced Liver Injury; Clofibrate; Drug Interactions; Enzyme Inhibitors; Hepatocytes; Imines; Indolequinones; L-Lactate Dehydrogenase; Male; Mice; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); Peroxisome Proliferators | 2007 |
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Ethanol; Glucuronides; Glutathione; Hydroxylation; Imines; Liver; Liver Diseases; Male; Mice; Mice, Knockout; Pentanols; Severity of Illness Index; Testosterone; Troleandomycin | 2007 |
The mechanism of paracetamol-induced hepatotoxicity: implications for therapy.
Topics: Acetaminophen; Antidotes; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; Humans; Imines; Inactivation, Metabolic; Oxidation-Reduction | 1983 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Benzoquinones; Chemical and Drug Induced Liver Injury; Clinical Protocols; Drug Overdose; Humans; Imines | 1993 |
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzoquinones; beta-Naphthoflavone; Biotransformation; Caffeine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Activation; Female; Imines; Isoenzymes; Kinetics; Liver Diseases; Mice; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital | 1993 |
Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Synergism; Ethanol; Fatty Liver, Alcoholic; Female; Imines; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Pentanols; Sex Factors | 2000 |
Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose.
Topics: Acetaminophen; Alanine Transaminase; Allopurinol; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Inhibitors; Fructose; Glucose; Imines; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Portal Vein; Rats; Rats, Sprague-Dawley; Sucrose; Xanthine Oxidase | 2000 |
Postnatal mice have low susceptibility to paracetamol toxicity.
Topics: Acetaminophen; Age Factors; Animals; Animals, Newborn; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Disease Susceptibility; Female; Glutathione; Imines; Inactivation, Metabolic; Liver; Liver Function Tests; Male; Metabolic Clearance Rate; Mice; Necrosis | 1991 |
Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen protein adducts in subcellular liver fractions following a hepatotoxic dose of acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Cell Membrane; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cysteine; Cytosol; Fluorescent Antibody Technique; Imines; Kinetics; Liver; Male; Mice; Microsomes, Liver; Mitochondria, Liver; Quinones | 1990 |
The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.
Topics: Acetaminophen; Animals; Benzoquinones; Calcium; Calcium-Transporting ATPases; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytosol; Homeostasis; Imines; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NAD; Oxidation-Reduction; Phosphorylase a; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1985 |
The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.
Topics: Acetaminophen; Animals; Benzoquinones; Carmustine; Chemical and Drug Induced Liver Injury; Glutathione; Imines; Lipid Peroxides; Liver; Liver Diseases; Male; Maleates; Oxidation-Reduction; Quinones; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1987 |