n-(n-(3-5-difluorophenacetyl)alanyl)phenylglycine-tert-butyl-ester and Diabetic-Nephropathies

Growth hormone (GH) plays a significant role in normal renal function and overactive GH signaling has been implicated in proteinuria in diabetes and acromegaly. Previous results have shown that the glomerular podocytes, which play an essential role in renal filtration, express the GH receptor, suggesting the direct action of GH on these cells. However, the exact mechanism and the downstream pathways by which excess GH leads to diabetic nephropathy is not established. In the present article, using immortalized human podocytes

Topics: Animals; Cells, Cultured; Cytokines; Diabetic Nephropathies; Dipeptides; Epithelial-Mesenchymal Transition; Growth Hormone; Humans; Male; Mice; Podocytes; Proteinuria; Receptor, Notch1; Signal Transduction