n-(cyclobutylmethyl)-8-beta-methyl-6-methylenemorphinan-3-ol and Substance-Related-Disorders

Xorphanol is a new mixed agonist-antagonist from the morphinan class of analgesics. On the basis of animal experiments, the physical dependence liability of xorphanol is predicted to be of a low order in man. Conceptually, xorphanol is of interest since in vitro experiments have revealed anti-naloxone properties and resistance to antagonism by opioid antagonists. At the practical level, xorphanol is a well tolerated, orally active analgesic that provides effective pain relief clinically.

Topics: Animals; Chemical Phenomena; Chemistry; Humans; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Pain; Rats; Rats, Inbred Strains; Substance-Related Disorders; Time Factors; Urination

Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Haplorhini; Humans; Mice; Morphinans; Morphine; Narcotic Antagonists; Rats; Substance-Related Disorders; Time Factors