n-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide and Spinal-Cord-Injuries
n-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide has been researched along with Spinal-Cord-Injuries* in 1 studies
Other Studies
1 other study(ies) available for n-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide and Spinal-Cord-Injuries
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Rehabilitation Decreases Spasticity by Restoring Chloride Homeostasis through the Brain-Derived Neurotrophic Factor-KCC2 Pathway after Spinal Cord Injury.
Activity-based therapy is routinely integrated in rehabilitation programs to facilitate functional recovery after spinal cord injury (SCI). Among its beneficial effects is a reduction of hyperreflexia and spasticity, which affects ∼75% of the SCI population. Unlike current anti-spastic pharmacological treatments, rehabilitation attenuates spastic symptoms without causing an active depression in spinal excitability, thus avoiding further interference with motor recovery. Understanding how activity-based therapies contribute to decrease spasticity is critical to identifying new pharmacological targets and to optimize rehabilitation programs. It was recently demonstrated that a decrease in the expression of KCC2, a neuronal Cl Topics: Animals; Brain-Derived Neurotrophic Factor; Chlorides; Female; H-Reflex; Homeostasis; K Cl- Cotransporters; Muscle Spasticity; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Injuries; Symporters; Thiazoles; Thioglycolates; Thoracic Vertebrae | 2020 |