n-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide has been researched along with Alcoholism* in 1 studies
1 other study(ies) available for n-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide and Alcoholism
| Article | Year |
|---|---|
Role of KCC2 in the Regulation of Brain-Derived Neurotrophic Factor on Ethanol Consumption in Rats.
Alcohol use disorder (AUD) is a common and complex disorder resulting from repetitive alcohol drinking. The mesocorticolimbic dopamine (DA) system, originating from the ventral tegmental area (VTA) in the midbrain, is involved in the rewarding effect of ethanol. The γ-aminobutyric acid (GABA) neurons in VTA appear to be key substrates of acute and chronic ethanol, which regulates DA neurotransmission indirectly in the mesocorticolimbic system. Despite significant research on the relationship between brain-derived neurotrophic factor (BDNF) and reduced alcohol consumption in male rats involving tropomyosin-related kinase B (TrkB), the mechanisms of BDNF-TrkB regulating alcohol behavior remain scarce. K Topics: Alcohol Drinking; Alcoholism; Animals; Brain-Derived Neurotrophic Factor; Ethanol; Male; Rats; Substance Withdrawal Syndrome; Symporters; Ventral Tegmental Area | 2023 |