Compounds > n-(4-fluorobenzyl)-8-hydroxy-1-6-naphthyridine-7-carboxamide

n-(4-fluorobenzyl)-8-hydroxy-1-6-naphthyridine-7-carboxamide and HIV-Infections

n-(4-fluorobenzyl)-8-hydroxy-1-6-naphthyridine-7-carboxamide has been researched along with HIV-Infections* in 1 studies

Other Studies

1 other study(ies) available for n-(4-fluorobenzyl)-8-hydroxy-1-6-naphthyridine-7-carboxamide and HIV-Infections

Article	Year
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore. Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6 A series of HIV-1 integrase inhibitors containing a novel metal binding motif consisting of the 8-hydroxy-1,6-naphthyridine core and either an oxadiazole or triazole has been identified. The design of the key structural components was based on a two-metal coordination pharmacophore. This report presents initial structure-activity data that shows the new chelation architecture delivers potent inhibition in both enzymatic and antiviral assays. Topics: Amino Acid Motifs; Anti-HIV Agents; Chelating Agents; Chemistry, Pharmaceutical; Drug Design; HIV Infections; HIV Integrase Inhibitors; Humans; Models, Chemical; Molecular Structure; Naphthyridines; Oxadiazoles; Structure-Activity Relationship; Triazoles; Virus Replication	2009

Article

Year

The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.

Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6

A series of HIV-1 integrase inhibitors containing a novel metal binding motif consisting of the 8-hydroxy-1,6-naphthyridine core and either an oxadiazole or triazole has been identified. The design of the key structural components was based on a two-metal coordination pharmacophore. This report presents initial structure-activity data that shows the new chelation architecture delivers potent inhibition in both enzymatic and antiviral assays.

Topics: Amino Acid Motifs; Anti-HIV Agents; Chelating Agents; Chemistry, Pharmaceutical; Drug Design; HIV Infections; HIV Integrase Inhibitors; Humans; Models, Chemical; Molecular Structure; Naphthyridines; Oxadiazoles; Structure-Activity Relationship; Triazoles; Virus Replication

2009