Compounds > n-(4-carboxyphenyl)retinamide

n-(4-carboxyphenyl)retinamide and Esophageal-Neoplasms

n-(4-carboxyphenyl)retinamide has been researched along with Esophageal-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for n-(4-carboxyphenyl)retinamide and Esophageal-Neoplasms

Article	Year
Retinoids prevent epithelial carcinogenesis induced by N-nitroso compounds. IARC scientific publications, 1991, Issue:105 Two new retinoic acid esters and retinamides synthesized in China, N-(4-ethoxycarbophenyl)retinamide (RI) and N-(4-carboxyphenyl)retinamide (RII), significantly inhibited carcinogenesis induced in the epithelium of the forestomach of mice by N-nitrososarcosine ethyl ester. RI also markedly inhibited carcinogenesis induced in the epithelium of the oesophagus and forestomach in rats by this ester. No sign of hypervitaminosis was noticed with doses as high as six times the therapeutic dose. RI also inhibited precancerous and cancerous lesions in the nasal cavity and nasopharynx and oesophagus of rats induced by dinitrosopiperazine. In a malignant oesophageal epithelial cell line from rats, RE25-3, established in our laboratory, RI and RII inhibited mitosis, proliferation rate, chromosomal aberrations and incorporation of 3H-thymidine into DNA. The ability to form colonies on agar plates was also inhibited by these two compounds. Topics: Animals; Antineoplastic Agents; Carcinogens; Esophageal Neoplasms; Female; Mice; Nitrosamines; Rats; Rats, Inbred Strains; Stomach Neoplasms; Tretinoin; Tumor Cells, Cultured	1991
[Effects of N-(P-carboxylpheyl)-retinamide on ECa109-C3 cells in vitro--observation with transmission electron microscopy]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 1986, Volume: 8, Issue:1 The effect of retinamide on the subcellular structure of esophageal cancer epithelial cells(ECa109-C3) was observed by transmission electron microscope. Cells, treated with 10 micrograms/ml retinamide for 1, 2, 3, 4 and 5 days, gave the following changes: 1. The number of the microvilli decreased. 2. The number of the tonofilaments and desmosomes increased. 3. polyribosome decreased in amount or disappeared. 4. The ratio of the nucleus/cytoplasm reduced. These changes varied with the time of retinamide treatment. In the early stage, the structural changes, resembling that in ECa109-C3 cells treated with DMSO, showed some characteristics of the normal esophageal epithelial cells. These results show that the retinamide can induce the differentiation of the esophageal epithelial cancer cells. In the late stage, the retinamide caused the swelling of mitochondria, blurring of cristae, dispersion of Golgi complexes, appearance of more lysosomes and degeneration of cancer cells. Topics: Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Epithelium; Esophageal Neoplasms; Humans; Tretinoin	1986

Article

Year

Retinoids prevent epithelial carcinogenesis induced by N-nitroso compounds.

IARC scientific publications, 1991, Issue:105

Two new retinoic acid esters and retinamides synthesized in China, N-(4-ethoxycarbophenyl)retinamide (RI) and N-(4-carboxyphenyl)retinamide (RII), significantly inhibited carcinogenesis induced in the epithelium of the forestomach of mice by N-nitrososarcosine ethyl ester. RI also markedly inhibited carcinogenesis induced in the epithelium of the oesophagus and forestomach in rats by this ester. No sign of hypervitaminosis was noticed with doses as high as six times the therapeutic dose. RI also inhibited precancerous and cancerous lesions in the nasal cavity and nasopharynx and oesophagus of rats induced by dinitrosopiperazine. In a malignant oesophageal epithelial cell line from rats, RE25-3, established in our laboratory, RI and RII inhibited mitosis, proliferation rate, chromosomal aberrations and incorporation of 3H-thymidine into DNA. The ability to form colonies on agar plates was also inhibited by these two compounds.

Topics: Animals; Antineoplastic Agents; Carcinogens; Esophageal Neoplasms; Female; Mice; Nitrosamines; Rats; Rats, Inbred Strains; Stomach Neoplasms; Tretinoin; Tumor Cells, Cultured

1991

[Effects of N-(P-carboxylpheyl)-retinamide on ECa109-C3 cells in vitro--observation with transmission electron microscopy].

Zhonghua zhong liu za zhi [Chinese journal of oncology], 1986, Volume: 8, Issue:1

The effect of retinamide on the subcellular structure of esophageal cancer epithelial cells(ECa109-C3) was observed by transmission electron microscope. Cells, treated with 10 micrograms/ml retinamide for 1, 2, 3, 4 and 5 days, gave the following changes: 1. The number of the microvilli decreased. 2. The number of the tonofilaments and desmosomes increased. 3. polyribosome decreased in amount or disappeared. 4. The ratio of the nucleus/cytoplasm reduced. These changes varied with the time of retinamide treatment. In the early stage, the structural changes, resembling that in ECa109-C3 cells treated with DMSO, showed some characteristics of the normal esophageal epithelial cells. These results show that the retinamide can induce the differentiation of the esophageal epithelial cancer cells. In the late stage, the retinamide caused the swelling of mitochondria, blurring of cristae, dispersion of Golgi complexes, appearance of more lysosomes and degeneration of cancer cells.

Topics: Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Epithelium; Esophageal Neoplasms; Humans; Tretinoin

1986