n-(3-bromo-4-(3-(18f)fluoro-propoxy)benzyl)guanidine and Cardiomyopathies

Cardiac sympathetic nervous system molecular imaging has demonstrated prognostic value. Compared with meta-[. Blood sampling was performed on 20 participants concurrent to FBBG PET imaging (healthy = NORM, non-ischemic cardiomyopathy = NICM, ischemic cardiomyopathy = ICM, post-traumatic stress disorder = PTSD). Image-derived blood time-activity curves were transformed to plasma input functions using cohort-specific corrections for plasma protein binding, plasma-to-whole blood distribution, and metabolism.. The plasma-to-whole blood ratio was 0.78 ± 0.06 for NORM, 0.64 ± 0.06 for PTSD and 0.60 ± 0.14 for (N)ICM after 20 minutes. 22 ± 4% of FBBG was bound to plasma proteins. Metabolism of FBBG in (N)ICM was delayed, with a parent fraction of 0.71 ± 0.05 at 10 minutes post-injection compared to 0.53 ± 0.03 for PTSD/NORM. While there were variations in metabolic rate, metabolite-corrected plasma input functions were similar across all cohorts.. Rapid plasma clearance of FBBG limits the impact of disease-specific corrections of the blood input function for tracer kinetic modeling.

Topics: Cardiomyopathies; Guanidines; Heart; Humans; Positron-Emission Tomography

Topics: Aged; Cardiomyopathies; Ephedrine; Fluorobenzenes; Guanidines; Humans; Male; Myocardial Ischemia; Positron Emission Tomography Computed Tomography; Risk; ST Elevation Myocardial Infarction; Sympathetic Nervous System