n-(3-(aminomethyl)benzyl)acetamidine has been researched along with Inflammation in 17 studies
N-(3-(aminomethyl)benzyl)acetamidine: structure in first source
N-[3-(aminomethyl)benzyl]acetamidine : An aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we examined the role of NO in lipopolysaccharide (LPS)-induced inflammation in an ovalbumin (OVA)-challenged mouse asthma model." | 3.81 | Nitric oxide suppresses LPS-induced inflammation in a mouse asthma model by attenuating the interaction of IKK and Hsp90. ( Chiang, CP; Huang, CF; Lee, MY; Liu, HY; Sun, GH; Sun, KH; Tang, SJ; Tsou, YC, 2015) |
| " It was found that in the carrageenin-induced pleurisy, a single intrapleural injection of the selective inducible NO inhibitors S-(2-aminoethyl) isothiourea (AE-ITU; 3 and 10 mg/kg) and N-(3-(aminomethyl)-benzyl) acetamidine (1400W; 10 mg/kg) or the selective endothelial cell NOS inhibitor L-N(5)(1-iminoethyl)-ornithine (10 mg/kg) not only exacerbated inflammation at the very early stages of the lesion (1-6 h), but also prevented inflammatory resolution." | 3.71 | Nitric oxide synthase inhibitors have opposite effects on acute inflammation depending on their route of administration. ( Gilroy, DW; Paul-Clark, MJ; Tomlinson, A; Willis, D; Willoughby, DA, 2001) |
| "The biology of harlequin ichthyosis (HI), a devastating skin disorder caused by loss-of-function mutations in the gene ABCA12, is poorly understood, and to date, no satisfactory treatment has been developed." | 1.56 | 3D model of harlequin ichthyosis reveals inflammatory therapeutic targets. ( Caley, MP; Dewan, P; Enjalbert, F; Enright, AJ; Jones, EM; Kelsell, DP; Morse, MA; O'Toole, EA, 2020) |
| " These data suggest that the compound has been administered using an appropriate dosing regimen for iNOS inhibition in the rat lung." | 1.32 | Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation. ( Battram, CH; Belvisi, MG; Birrell, MA; Foster, ML; Haddad, el-B; McCluskie, K; Webber, SE; Yacoub, MH, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Molina, P | 1 |
| Tárraga, A | 1 |
| Gonzalez-Tejero, A | 1 |
| Rioja, I | 1 |
| Ubeda, A | 1 |
| Terencio, MC | 1 |
| Alcaraz, MJ | 1 |
| Timonen, JM | 1 |
| Nieminen, RM | 1 |
| Sareila, O | 1 |
| Goulas, A | 1 |
| Moilanen, LJ | 1 |
| Haukka, M | 1 |
| Vainiotalo, P | 1 |
| Moilanen, E | 1 |
| Aulaskari, PH | 1 |
| Enjalbert, F | 1 |
| Dewan, P | 1 |
| Caley, MP | 1 |
| Jones, EM | 1 |
| Morse, MA | 1 |
| Kelsell, DP | 1 |
| Enright, AJ | 1 |
| O'Toole, EA | 1 |
| Davies, AL | 1 |
| Desai, RA | 1 |
| Bloomfield, PS | 1 |
| McIntosh, PR | 1 |
| Chapple, KJ | 1 |
| Linington, C | 1 |
| Fairless, R | 1 |
| Diem, R | 1 |
| Kasti, M | 1 |
| Murphy, MP | 1 |
| Smith, KJ | 1 |
| Maher, A | 1 |
| El-Sayed, NS | 1 |
| Breitinger, HG | 1 |
| Gad, MZ | 1 |
| Katada, K | 1 |
| Bihari, A | 1 |
| Badhwar, A | 1 |
| Yoshida, N | 1 |
| Yoshikawa, T | 1 |
| Potter, RF | 1 |
| Cepinskas, G | 1 |
| Ban, K | 1 |
| Santora, R | 1 |
| Kozar, RA | 1 |
| Birrell, MA | 2 |
| McCluskie, K | 2 |
| Haddad, el-B | 1 |
| Battram, CH | 1 |
| Webber, SE | 1 |
| Foster, ML | 1 |
| Yacoub, MH | 1 |
| Belvisi, MG | 2 |
| Wong, S | 1 |
| Sakaguchi, Y | 1 |
| Shirahase, H | 1 |
| Ichikawa, A | 1 |
| Kanda, M | 1 |
| Nozaki, Y | 1 |
| Uehara, Y | 1 |
| Nicholson, TE | 1 |
| Dibb, S | 1 |
| Renton, KW | 1 |
| Tang, Q | 1 |
| Svensson, CI | 1 |
| Fitzsimmons, B | 1 |
| Webb, M | 1 |
| Yaksh, TL | 1 |
| Hua, XY | 1 |
| Hu, A | 1 |
| Jiao, X | 1 |
| Gao, E | 1 |
| Li, Y | 1 |
| Sharifi-Azad, S | 1 |
| Grunwald, Z | 1 |
| Ma, XL | 1 |
| Sun, JZ | 1 |
| Paul-Clark, MJ | 1 |
| Gilroy, DW | 1 |
| Willis, D | 1 |
| Willoughby, DA | 1 |
| Tomlinson, A | 1 |
| Lee, MY | 1 |
| Sun, KH | 1 |
| Chiang, CP | 1 |
| Huang, CF | 1 |
| Sun, GH | 1 |
| Tsou, YC | 1 |
| Liu, HY | 1 |
| Tang, SJ | 1 |
| Wu, J | 1 |
| Wadsworth, RM | 1 |
| Kennedy, S | 1 |
| Gresa-Arribas, N | 1 |
| Viéitez, C | 1 |
| Dentesano, G | 1 |
| Serratosa, J | 1 |
| Saura, J | 1 |
| Solà, C | 1 |
1 trial available for n-(3-(aminomethyl)benzyl)acetamidine and Inflammation
| Article | Year |
|---|---|
Neurological deficits caused by tissue hypoxia in neuroinflammatory disease.
Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental | 2013 |
16 other studies available for n-(3-(aminomethyl)benzyl)acetamidine and Inflammation
| Article | Year |
|---|---|
Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives.
Topics: Alkaloids; Animals; Brassicaceae; Cells, Cultured; Chromatography, Thin Layer; Dinoprostone; Free Ra | 2001 |
Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Line; Crystallography, X-Ray; Cyclooxygen | 2011 |
3D model of harlequin ichthyosis reveals inflammatory therapeutic targets.
Topics: Amidines; ATP-Binding Cassette Transporters; Benzylamines; Cell Culture Techniques; Cells, Cultured; | 2020 |
Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: modulation by NOS inhibitors.
Topics: Alzheimer Disease; Amidines; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2014 |
Hindlimb ischemia/reperfusion-induced remote injury to the small intestine: role of inducible nitric-oxide synthase-derived nitric oxide.
Topics: Amidines; Animals; Benzylamines; E-Selectin; Enzyme Inhibitors; Epithelial Cells; Hindlimb; Inflamma | 2009 |
Enteral arginine modulates inhibition of AP-1/c-Jun by SP600125 in the postischemic gut.
Topics: Amidines; Animals; Anthracenes; Arginine; Benzylamines; DNA; Enteral Nutrition; Gene Silencing; Infl | 2011 |
Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation.
Topics: Amidines; Animals; Benzylamines; Bronchi; Cytokines; Dexamethasone; Dextrans; Disease Models, Animal | 2003 |
Nitric oxide as a noninvasive biomarker of lipopolysaccharide-induced airway inflammation: possible role in lung neutrophilia.
Topics: Amidines; Animals; Benzylamines; Biomarkers; Bronchial Diseases; Dexamethasone; Drug Interactions; G | 2004 |
Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice.
Topics: Amidines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Arthritis, Experimental; Ben | 2004 |
Nitric oxide mediates an LPS-induced depression of cytochrome P450 (CYP1A) activity in astrocytes.
Topics: Amidines; Animals; Astrocytes; Benzylamines; Cells, Cultured; Cytochrome P-450 CYP1A1; Enzyme Inhibi | 2004 |
Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation.
Topics: Amidines; Animals; Benzylamines; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Dr | 2007 |
Tonic beta-adrenergic drive provokes proinflammatory and proapoptotic changes in aging mouse heart.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Amidines; Animals; Apoptosis; Benzylam | 2008 |
Nitric oxide synthase inhibitors have opposite effects on acute inflammation depending on their route of administration.
Topics: Acute Disease; Amidines; Animals; Antioxidants; Benzylamines; Carrageenan; Disease Models, Animal; D | 2001 |
Nitric oxide suppresses LPS-induced inflammation in a mouse asthma model by attenuating the interaction of IKK and Hsp90.
Topics: Animals; Asthma; Cells, Cultured; Cytokines; Disease Models, Animal; Female; HSP90 Heat-Shock Protei | 2015 |
Inhibition of inducible nitric oxide synthase promotes vein graft neoadventitial inflammation and remodelling.
Topics: Animals; Carotid Arteries; Connective Tissue; Endothelium, Vascular; Enzyme Inhibitors; Imines; Infl | 2011 |
Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Coculture Techniques; Cyclooxygenase 2; Gene Expressio | 2012 |