n-(3-(aminomethyl)benzyl)acetamidine and Disease Models, Animal

Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Micronutrients; Organophosphorus Compounds; Oxygen; Rats; Recovery of Function; Severity of Illness Index; Single-Blind Method; Spinal Cord Diseases; Ubiquinone

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Amacrine Cells; Amidines; Animals; Apoptosis; Benzylamines; Cell Hypoxia; Disease Models, Animal; Humans; Microglia; Neuroprotection; Neuroprotective Agents; Nitric Oxide Synthase Type II; Organ Culture Techniques; Retina; Retinal Diseases; Retinal Ganglion Cells; Swine

Topics: Adaptation, Physiological; Amidines; Angiotensin II; Animals; Arterioles; Benzylamines; Constriction; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Humans; Ischemia; Kidney; Membrane Potentials; Nitric Oxide; Nitric Oxide Synthase Type II; Pericytes; Rats, Sprague-Dawley; Renal Artery; Renal Circulation; Vasoconstriction; Vasoconstrictor Agents

Topics: Amidines; Animals; Benzylamines; Cytokines; Disease Models, Animal; Male; Neuralgia; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Wistar

Topics: Amidines; Animals; Benzylamines; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Functional Laterality; In Vitro Techniques; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Patch-Clamp Techniques; Postural Balance; Recognition, Psychology; RNA, Messenger; Time Factors; Up-Regulation

Topics: Amidines; Animals; Benzylamines; Brain; Disease Models, Animal; Enzyme Inhibitors; Isoflurophate; Male; Nerve Agents; Nerve Degeneration; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley

Topics: Amidines; Animals; Benzylamines; Biomarkers; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Inflammation Mediators; Liver; Liver Diseases; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Pulse Wave Analysis; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Vascular Stiffness

Topics: Acute Kidney Injury; Amidines; Animals; Benzylamines; Biomarkers; Blood Pressure; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Injections, Intraperitoneal; Kidney; Male; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Rats, Sprague-Dawley; Time Factors

Topics: Amidines; Animals; Apoptosis; Benzylamines; Cardiotonic Agents; Caspase 3; Disease Models, Animal; Enzyme Inhibitors; Isoquinolines; Male; Myocardial Infarction; Myocardium; Nitric Oxide Synthase Type II; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Ventricular Function

Topics: Alzheimer Disease; Amidines; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Benzylamines; Brain; Diflunisal; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Male; Maze Learning; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate

Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male; Neurons; Nitric Oxide Synthase Type II; Rats, Sprague-Dawley; Status Epilepticus

Topics: Amidines; Animals; Aqueous Humor; Benzylamines; Diabetic Retinopathy; Disease Models, Animal; Electroretinography; Enzyme Inhibitors; Guanidines; Intraocular Pressure; Intravitreal Injections; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Rabbits; Retina; Vitreous Body

Topics: Amidines; Animals; Arginine; Benzylamines; Disease Models, Animal; Hippocampus; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxadiazoles; Rats; Rats, Wistar; Soluble Guanylyl Cyclase; Stress, Psychological; Swimming; Time Factors

Topics: Amidines; Animals; Benzylamines; Blood Pressure; Chemokines; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fluid Therapy; Glutathione Transferase; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Adhesion Molecule-1; Isoenzymes; Liver; Liver Diseases; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Tyrosine; Wounds and Injuries

Topics: Acute Kidney Injury; Amidines; Anesthesia, General; Animals; Benzylamines; Biomarkers; Creatinine; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Fluid Therapy; Glomerular Filtration Rate; Hemodynamics; Kidney; Lipopolysaccharides; Male; Microcirculation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitroglycerin; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Wistar; Renal Circulation; RNA, Messenger; Time Factors

Topics: Amidines; Animals; Antioxidants; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Kidney; Kidney Diseases; Male; Melatonin; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reperfusion Injury

Topics: Amidines; Animals; Benzylamines; Bone Marrow; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Eosinophils; Female; Hypersensitivity; Integrin alpha4beta1; Leukocyte Count; Lung; Macrophage-1 Antigen; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Ovalbumin; Th2 Cells

Topics: alpha-Synuclein; Amidines; Animals; Animals, Genetically Modified; Benzylamines; Disease Models, Animal; Injections, Intraperitoneal; Lewy Bodies; Lipopolysaccharides; Mice; NADPH Oxidases; Nerve Degeneration; Neurodegenerative Diseases; Nitric Oxide Synthase Type II; Onium Compounds; Oxidative Stress; Parkinson Disease; Substantia Nigra

Topics: Acetylcholine; Amidines; Animals; Benzylamines; Diet, High-Fat; Disease Models, Animal; Endothelium; Enzyme Inhibitors; Fatty Liver; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Liver Circulation; Male; Metformin; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Non-alcoholic Fatty Liver Disease; Phosphorylation; Rats; Rats, Wistar; Up-Regulation; Vasodilation; Vasodilator Agents

Topics: Adaptive Immunity; Adoptive Transfer; Amidines; Animals; Antigen Presentation; Benzylamines; Cells, Cultured; Disease Models, Animal; Glycoproteins; Granuloma; Granulomatous Disease, Chronic; Humans; Interferon-gamma; Macrophages, Peritoneal; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Th1 Cells

Topics: Acetates; Amidines; Animals; Anti-Inflammatory Agents; Benzylamines; Chronic Disease; Cyclopropanes; Cytokines; Dexamethasone; Disease Models, Animal; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Lung; Male; Ovalbumin; Pneumonia; Quinolines; Statistics, Nonparametric; Sulfides

Topics: Amidines; Animals; Arginine; Benzylamines; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Guanylate Cyclase; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pilocarpine; Receptors, Cytoplasmic and Nuclear; Seizures; Soluble Guanylyl Cyclase

Topics: Adolescent; Adult; Amidines; Animals; Benzylamines; Blood Proteins; Case-Control Studies; Disease Models, Animal; Disease Vectors; Enzyme Inhibitors; Female; Hantavirus Pulmonary Syndrome; Humans; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Male; Mice; Mice, Inbred NZB; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Orthohantavirus; Peromyscus; Reactive Nitrogen Species; Reactive Oxygen Species; Sin Nombre virus; Tyrosine

Topics: Acidosis; Amidines; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Female; Hindlimb; Humans; Melanoma; Melphalan; Nitric Oxide; Rats; Rats, Nude; Regional Blood Flow; Skin Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Topics: Acidosis; Amidines; Animals; Benzylamines; Blood Gas Analysis; Disease Models, Animal; Drug Evaluation, Preclinical; Endotoxemia; Hemodynamics; Ileum; Intestinal Mucosa; Laser-Doppler Flowmetry; Microcirculation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prospective Studies; Random Allocation; Spectrophotometry; Swine

Topics: Amidines; Animals; Benzylamines; Bronchi; Cytokines; Dexamethasone; Dextrans; Disease Models, Animal; Enzyme Inhibitors; Eosinophilia; Eosinophils; Inflammation; Lung; Male; Neutrophils; Nitric Oxide Synthase; Protein Isoforms; Rats; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger

Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Endotoxemia; Energy Metabolism; Female; Hemodynamics; Intestinal Mucosa; Lipopolysaccharides; Liver Circulation; Male; Niacinamide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerase Inhibitors; Prospective Studies; Pulmonary Circulation; Random Allocation; Splanchnic Circulation; Swine; Time Factors

Topics: Amidines; Animals; Benzylamines; Blood Pressure; Breath Tests; Disease Models, Animal; Drug Evaluation, Preclinical; Endotoxemia; Escherichia coli Infections; Lipopolysaccharides; Luminescent Measurements; Lung; Male; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Prospective Studies; Rabbits; Random Allocation; Rats; Species Specificity

Topics: Amidines; Animals; Benzylamines; Cardiotonic Agents; Disease Models, Animal; Enzyme Inhibitors; Heart; Heart Function Tests; Lipopolysaccharides; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Sepsis

Topics: Amidines; Animals; Benzylamines; Creatine Kinase; Disease Models, Animal; Immunohistochemistry; Kidney; Liver; Multiple Organ Failure; Nitric Oxide; Nitric Oxide Synthase; Pancreas; Protein-Tyrosine Kinases; Rats; Shock, Hemorrhagic; Tyrphostins

Topics: Amidines; Animals; Annexins; Astrocytes; Benzylamines; Blood-Brain Barrier; Cell Count; Cell Death; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Female; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Guanidines; Immunoglobulin G; Immunohistochemistry; Laminectomy; Motor Neurons; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligodeoxyribonucleotides, Antisense; Organic Chemicals; Peroxidase; Phosphopyruvate Hydratase; Propidium; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries

Topics: Amidines; Androstadienes; Animals; Apoptosis; Benzylamines; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Ginkgolides; Glucosamine; Lactones; Lipopolysaccharides; Mucins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Porphyromonas gingivalis; Rats; Rats, Sprague-Dawley; Saliva; Salivary Glands; Sublingual Gland; Tritium; Tumor Necrosis Factor-alpha; Up-Regulation; Wortmannin

Topics: Adenosine Triphosphate; Amidines; Amino Acid Transport System X-AG; Animals; Benzylamines; Brain; Cerebral Infarction; Cytoprotection; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Stroke; Treatment Outcome

Topics: Amidines; Animals; Benzylamines; Brain Injuries; Calcium; Disease Models, Animal; Enzyme Inhibitors; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Time Factors

Topics: Amidines; Analysis of Variance; Animals; Anticoagulants; Benzylamines; Blotting, Western; Brain; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Edetic Acid; Enzyme Inhibitors; Inhibitory Concentration 50; Ischemic Attack, Transient; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors

Topics: Amidines; Animals; Benzylamines; Creatinine; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Kidney Tubules; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tyrosine

Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Hemodynamics; Humans; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Sepsis; Shock, Septic

Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Epinephrine; Hemoglobins; Male; Microcirculation; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Rats; Rats, Wistar; Shock, Septic

Topics: Amidines; Animals; Benzylamines; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Hyperalgesia; Inflammation; Inflammation Mediators; Male; MAP Kinase Signaling System; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase Type II; Nociceptors; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord

Topics: Aldehydes; Amidines; Animals; Antineoplastic Agents; Benzylamines; Cisplatin; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kidney; Kidney Diseases; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Tyrosine

Topics: Aldehydes; Amidines; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzylamines; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hypertension; Losartan; Male; Malondialdehyde; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Tiopronin; Up-Regulation; Ventricular Function, Left

Topics: Acute Disease; Amidines; Animals; Antioxidants; Benzylamines; Carrageenan; Disease Models, Animal; Drug Administration Schedule; Edema; Enzyme Inhibitors; Free Radical Scavengers; Inflammation; Inflammation Mediators; Injections; Injections, Intraperitoneal; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Pleura; Pleurisy; Rats; Rats, Wistar; Superoxides; Thiourea

Topics: Amidines; Animals; Benzylamines; Chemokine CXCL2; Chemokines; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Glomerular Mesangium; Glomerulonephritis; Interleukin-1; Kidney Glomerulus; Lysine; Mutagenesis, Site-Directed; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins

Topics: Amidines; Animals; Benzylamines; Blotting, Western; Colitis; Colon; Disease Models, Animal; Drug Administration Schedule; Enzyme Activation; Enzyme Inhibitors; Female; Injections, Intraperitoneal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid

Topics: Acetophenones; Amidines; Animals; Antioxidants; Benzylamines; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibitors; Eosinophils; Hypersensitivity; Immunoglobulin E; Immunohistochemistry; Interferon-gamma; Interleukin-4; Interleukin-5; Lung; Male; Mice; Mice, Inbred BALB C; Neutrophils; Nitric Oxide Synthase; Ovalbumin; Specific Pathogen-Free Organisms; Tyrosine

Topics: Amidines; Animals; Benzylamines; Colitis, Ulcerative; Colon; Dextran Sulfate; Digestive System; Digestive System Physiological Phenomena; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Humans; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NADPH Oxidases; Neutrophil Infiltration; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphoproteins; Reactive Oxygen Species; Specific Pathogen-Free Organisms; Superoxide Dismutase; Superoxides; Time Factors; Tumor Necrosis Factor-alpha

Topics: Aging; Amidines; Animals; Animals, Newborn; Apoptosis; Benzylamines; Cell Count; Crosses, Genetic; Diabetic Retinopathy; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Ischemia; Mice; Mice, Inbred Strains; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Proteins; Retina; Retinal Diseases; Retinal Vein Occlusion; Tyrosine

Topics: Animals; Asthma; Cells, Cultured; Cytokines; Disease Models, Animal; Female; HSP90 Heat-Shock Proteins; I-kappa B Kinase; Imines; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Ovalbumin; S-Nitroso-N-Acetylpenicillamine; Signal Transduction

Topics: Animals; Annexin A5; Apoptosis; Cells, Cultured; Cognition Disorders; Disease Models, Animal; Gene Expression Regulation; Hypoxia; Imines; Lipid Peroxidation; Malondialdehyde; Maze Learning; Microglia; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase Type II; Oxygen; Rats; Rats, Sprague-Dawley; Tyrosine

Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Imines; Indazoles; Infusions, Intravenous; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke

Topics: Animals; Arginase; Arginine; Blotting, Western; Cardiac Pacing, Artificial; Disease Models, Animal; Enzyme Inhibitors; Heart Failure; Heart Rate; Imines; Male; Microscopy, Confocal; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Protein Processing, Post-Translational; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stroke Volume; Superoxides; Up-Regulation; Ventricular Function, Left

Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Cell Division; Disease Models, Animal; Enzyme Inhibitors; Imines; Immunohistochemistry; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pancreatic Elastase; Rats; Rats, Wistar

Topics: Animals; Disease Models, Animal; Female; Gastric Juice; Gastric Mucosa; Imines; Lipopolysaccharides; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats

Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Imines; Male; Mice; Mice, Inbred mdx; Muscle Relaxation; Muscle, Smooth; Muscular Dystrophy, Duchenne; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Organ Culture Techniques; Oxadiazoles; Quinoxalines; Receptors, Vasoactive Intestinal Peptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach; Vasoactive Intestinal Peptide