n-(3-(aminomethyl)benzyl)acetamidine has been researched along with Disease Models, Animal in 55 studies
N-(3-(aminomethyl)benzyl)acetamidine: structure in first source
N-[3-(aminomethyl)benzyl]acetamidine : An aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acidosis enhances the antitumor effect of melphalan." | 7.71 | Acidosis plus melphalan induces nitric oxide-mediated tumor regression in an isolated limb perfusion human melanoma xenograft model. ( Bauer, TW; Buerk, DG; Fraker, DL; Kelley, ST; Menon, C, 2002) |
| "Both Melatonin and 1400W were efficient in ameliorating experimental I/R injury of the kidneys." | 5.35 | Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. ( Akgul, EO; Cayci, T; Cetiner, S; Ersoz, N; Guven, A; Korkmaz, A; Oztas, E; Turk, E; Uysal, B, 2009) |
| " In this study, we examined the role of NO in lipopolysaccharide (LPS)-induced inflammation in an ovalbumin (OVA)-challenged mouse asthma model." | 3.81 | Nitric oxide suppresses LPS-induced inflammation in a mouse asthma model by attenuating the interaction of IKK and Hsp90. ( Chiang, CP; Huang, CF; Lee, MY; Liu, HY; Sun, GH; Sun, KH; Tang, SJ; Tsou, YC, 2015) |
| "The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice." | 3.79 | Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice. ( Cavalcante Melo, FH; de Carvalho Lima, CN; de França Fonteles, MM; Freire Vasconcelos, L; Leite Dias, M; Moura Rocha, NF; Rodrigues Carvalho, AM; Soares Lopes, K; Vasconcelos Rios, ER, 2013) |
| "The administration of a HFD induces insulin resistance in the liver sinusoidal endothelium, which is mediated, at least in part, through iNOS upregulation and can be prevented by the administration of metformin." | 3.77 | Insulin resistance and liver microcirculation in a rat model of early NAFLD. ( Abraldes, JG; Bosch, J; García-Pagán, JC; La Mura, V; Pasarín, M; Rodríguez-Vilarrupla, A, 2011) |
| "Acidosis enhances the antitumor effect of melphalan." | 3.71 | Acidosis plus melphalan induces nitric oxide-mediated tumor regression in an isolated limb perfusion human melanoma xenograft model. ( Bauer, TW; Buerk, DG; Fraker, DL; Kelley, ST; Menon, C, 2002) |
| " It was found that in the carrageenin-induced pleurisy, a single intrapleural injection of the selective inducible NO inhibitors S-(2-aminoethyl) isothiourea (AE-ITU; 3 and 10 mg/kg) and N-(3-(aminomethyl)-benzyl) acetamidine (1400W; 10 mg/kg) or the selective endothelial cell NOS inhibitor L-N(5)(1-iminoethyl)-ornithine (10 mg/kg) not only exacerbated inflammation at the very early stages of the lesion (1-6 h), but also prevented inflammatory resolution." | 3.71 | Nitric oxide synthase inhibitors have opposite effects on acute inflammation depending on their route of administration. ( Gilroy, DW; Paul-Clark, MJ; Tomlinson, A; Willis, D; Willoughby, DA, 2001) |
| "4 mg) caused no significant toxic ocular effects in rabbit eyes." | 1.46 | TOWARDS A TREATMENT FOR DIABETIC RETINOPATHY: Intravitreal Toxicity and Preclinical Safety Evaluation of Inducible Nitric Oxide Synthase Inhibitors. ( Bennett, LD; Birch, DG; Carr, BC; Emigh, CE; Nguyen, C; Pansick, AD, 2017) |
| "Although trauma-hemorrhage produces tissue hypoxia, systemic inflammatory response and organ dysfunction, the mechanisms responsible for these alterations are not clear." | 1.35 | Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsu, JT; Kan, WH; Raju, R; Schwacha, MG, 2008) |
| "1." | 1.35 | Effects of 1400W and/or nitroglycerin on renal oxygenation and kidney function during endotoxaemia in anaesthetized rats. ( Dieterich, HJ; Goedhart, PT; Ince, C; Johannes, T; Klingel, K; Mik, EG; Nohé, B; Unertl, KE; Zanke, C, 2009) |
| "Both Melatonin and 1400W were efficient in ameliorating experimental I/R injury of the kidneys." | 1.35 | Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. ( Akgul, EO; Cayci, T; Cetiner, S; Ersoz, N; Guven, A; Korkmaz, A; Oztas, E; Turk, E; Uysal, B, 2009) |
| "Treatment of hemodynamic instability in septic shock often demands the administration of vasopressor agents, although these may have deleterious effects on microcirculatory homeostasis." | 1.33 | Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock. ( Boer, R; Ghofrani, HA; Grimminger, F; Lehner, M; Maring, D; Mayer, K; Pullamsetti, SS; Rosengarten, B; Schermuly, RT; Schudt, C; Seeger, W; Weissmann, N, 2006) |
| " These data suggest that the compound has been administered using an appropriate dosing regimen for iNOS inhibition in the rat lung." | 1.32 | Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation. ( Battram, CH; Belvisi, MG; Birrell, MA; Foster, ML; Haddad, el-B; McCluskie, K; Webber, SE; Yacoub, MH, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 32 (58.18) | 29.6817 |
| 2010's | 20 (36.36) | 24.3611 |
| 2020's | 3 (5.45) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Hurst, J | 1 |
| Mueller-Buehl, AM | 1 |
| Hofmann, L | 1 |
| Kuehn, S | 1 |
| Herms, F | 1 |
| Schnichels, S | 1 |
| Joachim, SC | 1 |
| Zhang, Z | 1 |
| Payne, K | 1 |
| Pallone, TL | 1 |
| Staunton, CA | 1 |
| Barrett-Jolley, R | 1 |
| Djouhri, L | 1 |
| Thippeswamy, T | 3 |
| Wang, B | 1 |
| Han, S | 1 |
| Putra, M | 2 |
| Sharma, S | 2 |
| Gage, M | 1 |
| Gasser, G | 1 |
| Hinojo-Perez, A | 1 |
| Olson, A | 1 |
| Gregory-Flores, A | 1 |
| Puttachary, S | 2 |
| Wang, C | 1 |
| Anantharam, V | 1 |
| Davies, AL | 1 |
| Desai, RA | 1 |
| Bloomfield, PS | 1 |
| McIntosh, PR | 1 |
| Chapple, KJ | 1 |
| Linington, C | 1 |
| Fairless, R | 1 |
| Diem, R | 1 |
| Kasti, M | 1 |
| Murphy, MP | 1 |
| Smith, KJ | 1 |
| Chen, TH | 2 |
| Liao, FT | 2 |
| Yang, YC | 2 |
| Wang, JJ | 2 |
| Wang, J | 1 |
| Hao, L | 1 |
| Wang, Y | 1 |
| Qin, W | 1 |
| Wang, X | 1 |
| Zhao, T | 1 |
| Liu, Y | 1 |
| Sheng, L | 1 |
| Du, Y | 1 |
| Zhang, M | 1 |
| Lu, Q | 1 |
| Maher, A | 1 |
| El-Sayed, NS | 1 |
| Breitinger, HG | 1 |
| Gad, MZ | 1 |
| Verma, S | 1 |
| Yang, Y | 2 |
| Thippeswamy, A | 1 |
| Luo, D | 1 |
| Carr, BC | 1 |
| Emigh, CE | 1 |
| Bennett, LD | 1 |
| Pansick, AD | 1 |
| Birch, DG | 1 |
| Nguyen, C | 1 |
| Sales, AJ | 1 |
| Hiroaki-Sato, VA | 1 |
| Joca, SR | 1 |
| Kan, WH | 1 |
| Hsu, JT | 1 |
| Schwacha, MG | 1 |
| Choudhry, MA | 1 |
| Raju, R | 1 |
| Bland, KI | 1 |
| Chaudry, IH | 1 |
| Johannes, T | 1 |
| Mik, EG | 1 |
| Klingel, K | 1 |
| Goedhart, PT | 1 |
| Zanke, C | 1 |
| Nohé, B | 1 |
| Dieterich, HJ | 1 |
| Unertl, KE | 1 |
| Ince, C | 2 |
| Ersoz, N | 1 |
| Guven, A | 1 |
| Cayci, T | 1 |
| Uysal, B | 1 |
| Turk, E | 1 |
| Oztas, E | 1 |
| Akgul, EO | 1 |
| Korkmaz, A | 1 |
| Cetiner, S | 1 |
| Pelaquini, EH | 1 |
| Guimarães, Lde A | 1 |
| Benetti, LR | 1 |
| Fernandes, LG | 1 |
| Tamashiro, WM | 1 |
| Conran, N | 1 |
| Ferreira, HH | 1 |
| Gao, HM | 1 |
| Zhang, F | 1 |
| Zhou, H | 1 |
| Kam, W | 1 |
| Wilson, B | 1 |
| Hong, JS | 1 |
| Pasarín, M | 1 |
| Abraldes, JG | 1 |
| Rodríguez-Vilarrupla, A | 1 |
| La Mura, V | 1 |
| García-Pagán, JC | 1 |
| Bosch, J | 1 |
| Lewis, CJ | 1 |
| Cobb, BA | 1 |
| Souza, FC | 1 |
| Gobbato, NB | 1 |
| Maciel, RG | 1 |
| Prado, CM | 1 |
| Martins, MA | 1 |
| Leick, EA | 1 |
| Tibério, IF | 1 |
| Vasconcelos Rios, ER | 1 |
| Moura Rocha, NF | 1 |
| Rodrigues Carvalho, AM | 1 |
| Freire Vasconcelos, L | 1 |
| Leite Dias, M | 1 |
| de Carvalho Lima, CN | 1 |
| Soares Lopes, K | 1 |
| Cavalcante Melo, FH | 1 |
| de França Fonteles, MM | 1 |
| Davis, IC | 1 |
| Zajac, AJ | 1 |
| Nolte, KB | 1 |
| Botten, J | 1 |
| Hjelle, B | 1 |
| Matalon, S | 1 |
| Kelley, ST | 1 |
| Menon, C | 1 |
| Buerk, DG | 1 |
| Bauer, TW | 1 |
| Fraker, DL | 1 |
| Pittner, A | 1 |
| Nalos, M | 1 |
| Asfar, P | 1 |
| Georgieff, M | 2 |
| Brückner, UB | 1 |
| Radermacher, P | 2 |
| Fröba, G | 1 |
| Birrell, MA | 1 |
| McCluskie, K | 1 |
| Haddad, el-B | 1 |
| Battram, CH | 1 |
| Webber, SE | 1 |
| Foster, ML | 1 |
| Yacoub, MH | 1 |
| Belvisi, MG | 1 |
| Stehr, A | 1 |
| Ploner, F | 1 |
| Tugtekin, I | 1 |
| Matejovic, M | 1 |
| Theisen, M | 1 |
| Zülke, C | 1 |
| Jauch, KW | 1 |
| Bachetti, T | 1 |
| Pasini, E | 1 |
| Suzuki, H | 1 |
| Ferrari, R | 1 |
| Price, S | 1 |
| Mitchell, JA | 1 |
| Anning, PB | 1 |
| Evans, TW | 1 |
| McDonald, M | 1 |
| Abdelrahman, M | 1 |
| Cuzzocrea, S | 1 |
| Thiemermann, C | 1 |
| Pearse, DD | 1 |
| Chatzipanteli, K | 1 |
| Marcillo, AE | 1 |
| Bunge, MB | 1 |
| Dietrich, WD | 1 |
| Slomiany, BL | 1 |
| Slomiany, A | 1 |
| Pérez-Asensio, FJ | 1 |
| Hurtado, O | 1 |
| Burguete, MC | 1 |
| Moro, MA | 2 |
| Salom, JB | 1 |
| Lizasoain, I | 2 |
| Torregrosa, G | 1 |
| Leza, JC | 2 |
| Alborch, E | 1 |
| Castillo, J | 1 |
| Knowles, RG | 1 |
| Lorenzo, P | 2 |
| Jafarian-Tehrani, M | 2 |
| Louin, G | 2 |
| Royo, NC | 1 |
| Besson, VC | 1 |
| Bohme, GA | 1 |
| Plotkine, M | 2 |
| Marchand-Verrecchia, C | 1 |
| Lerouet, D | 1 |
| Palmier, B | 1 |
| Bonnefont-Rousselot, D | 1 |
| Margaill, I | 1 |
| Mark, LA | 1 |
| Robinson, AV | 1 |
| Schulak, JA | 1 |
| Spiel, AO | 1 |
| Mayr, FB | 1 |
| Pullamsetti, SS | 1 |
| Maring, D | 1 |
| Ghofrani, HA | 1 |
| Mayer, K | 1 |
| Weissmann, N | 1 |
| Rosengarten, B | 1 |
| Lehner, M | 1 |
| Schudt, C | 1 |
| Boer, R | 1 |
| Grimminger, F | 1 |
| Seeger, W | 1 |
| Schermuly, RT | 1 |
| Tang, Q | 1 |
| Svensson, CI | 1 |
| Fitzsimmons, B | 1 |
| Webb, M | 1 |
| Yaksh, TL | 1 |
| Hua, XY | 1 |
| Chirino, YI | 1 |
| Trujillo, J | 1 |
| Sánchez-González, DJ | 1 |
| Martínez-Martínez, CM | 1 |
| Cruz, C | 1 |
| Bobadilla, NA | 1 |
| Pedraza-Chaverri, J | 1 |
| Matsuhisa, S | 1 |
| Otani, H | 1 |
| Okazaki, T | 1 |
| Yamashita, K | 1 |
| Akita, Y | 1 |
| Sato, D | 1 |
| Moriguchi, A | 1 |
| Imamura, H | 1 |
| Iwasaka, T | 1 |
| Paul-Clark, MJ | 1 |
| Gilroy, DW | 1 |
| Willis, D | 1 |
| Willoughby, DA | 1 |
| Tomlinson, A | 1 |
| Walpen, S | 1 |
| Beck, KF | 1 |
| Schaefer, L | 1 |
| Raslik, I | 1 |
| Eberhardt, W | 1 |
| Schaefer, RM | 1 |
| Pfeilschifter, J | 1 |
| Menchén, LA | 1 |
| Colón, AL | 1 |
| Menchén, P | 1 |
| Alvarez, E | 1 |
| Muijsers, RB | 1 |
| van Ark, I | 1 |
| Folkerts, G | 1 |
| Koster, AS | 1 |
| van Oosterhout, AJ | 1 |
| Postma, DS | 1 |
| Nijkamp, FP | 1 |
| Krieglstein, CF | 1 |
| Cerwinka, WH | 1 |
| Laroux, FS | 1 |
| Salter, JW | 1 |
| Russell, JM | 1 |
| Schuermann, G | 1 |
| Grisham, MB | 1 |
| Ross, CR | 1 |
| Granger, DN | 1 |
| Sennlaub, F | 1 |
| Courtois, Y | 1 |
| Goureau, O | 1 |
| Lee, MY | 1 |
| Sun, KH | 1 |
| Chiang, CP | 1 |
| Huang, CF | 1 |
| Sun, GH | 1 |
| Tsou, YC | 1 |
| Liu, HY | 1 |
| Tang, SJ | 1 |
| Shi, Q | 1 |
| Liu, X | 1 |
| Wang, N | 1 |
| Zheng, X | 2 |
| Ran, J | 1 |
| Liu, Z | 1 |
| Fu, J | 1 |
| Zheng, J | 1 |
| Liu, K | 1 |
| Li, Q | 1 |
| Zhang, L | 1 |
| Heusch, P | 1 |
| Aker, S | 1 |
| Boengler, K | 1 |
| Deindl, E | 1 |
| van de Sand, A | 1 |
| Klein, K | 1 |
| Rassaf, T | 1 |
| Konietzka, I | 1 |
| Sewell, A | 1 |
| Menazza, S | 1 |
| Canton, M | 1 |
| Heusch, G | 1 |
| Di Lisa, F | 1 |
| Schulz, R | 1 |
| Sigala, F | 1 |
| Papalambros, E | 1 |
| Kotsinas, A | 1 |
| Andreadou, I | 1 |
| Sigalas, P | 1 |
| Kremastinos, D | 1 |
| Bastounis, E | 1 |
| Gorgoulis, VG | 1 |
| Robinson, EK | 1 |
| Kennison, SD | 1 |
| Suliburk, JW | 1 |
| Mercer, DW | 1 |
| Mulè, F | 1 |
| Zizzo, MG | 1 |
| Amato, A | 1 |
| Feo, S | 1 |
| Serio, R | 1 |
1 trial available for n-(3-(aminomethyl)benzyl)acetamidine and Disease Models, Animal
| Article | Year |
|---|---|
Neurological deficits caused by tissue hypoxia in neuroinflammatory disease.
Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental | 2013 |
54 other studies available for n-(3-(aminomethyl)benzyl)acetamidine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
iNOS-inhibitor driven neuroprotection in a porcine retina organ culture model.
Topics: Amacrine Cells; Amidines; Animals; Apoptosis; Benzylamines; Cell Hypoxia; Disease Models, Animal; Hu | 2020 |
Adaptive responses of rat descending vasa recta to ischemia.
Topics: Adaptation, Physiological; Amidines; Angiotensin II; Animals; Arterioles; Benzylamines; Constriction | 2018 |
Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model.
Topics: Amidines; Animals; Benzylamines; Cytokines; Disease Models, Animal; Male; Neuralgia; Nitric Oxide; N | 2018 |
Inhibition of Inducible Nitric Oxide Synthase Attenuates Deficits in Synaptic Plasticity and Brain Functions Following Traumatic Brain Injury.
Topics: Amidines; Animals; Benzylamines; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Enzyme In | 2018 |
Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.
Topics: Amidines; Animals; Benzylamines; Brain; Disease Models, Animal; Enzyme Inhibitors; Isoflurophate; Ma | 2020 |
Inhibition of inducible nitric oxide synthesis ameliorates liver ischemia and reperfusion injury induced transient increase in arterial stiffness.
Topics: Amidines; Animals; Benzylamines; Biomarkers; Cytoprotection; Disease Models, Animal; Enzyme Inhibito | 2014 |
Inhibition of inducible nitric oxide synthase ameliorates myocardial ischemia/reperfusion injury - induced acute renal injury.
Topics: Acute Kidney Injury; Amidines; Animals; Benzylamines; Biomarkers; Blood Pressure; Cytoprotection; Di | 2014 |
Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis.
Topics: Amidines; Animals; Apoptosis; Benzylamines; Cardiotonic Agents; Caspase 3; Disease Models, Animal; E | 2015 |
Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: modulation by NOS inhibitors.
Topics: Alzheimer Disease; Amidines; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2014 |
1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy.
Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male; | 2016 |
TOWARDS A TREATMENT FOR DIABETIC RETINOPATHY: Intravitreal Toxicity and Preclinical Safety Evaluation of Inducible Nitric Oxide Synthase Inhibitors.
Topics: Amidines; Animals; Aqueous Humor; Benzylamines; Diabetic Retinopathy; Disease Models, Animal; Electr | 2017 |
Participation of hippocampal nitric oxide synthase and soluble guanylate cyclase in the modulation of behavioral responses elicited by the rat forced swimming test.
Topics: Amidines; Animals; Arginine; Benzylamines; Disease Models, Animal; Hippocampus; Male; Nitric Oxide; | 2017 |
Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury.
Topics: Amidines; Animals; Benzylamines; Blood Pressure; Chemokines; Cytokines; Disease Models, Animal; Enzy | 2008 |
Effects of 1400W and/or nitroglycerin on renal oxygenation and kidney function during endotoxaemia in anaesthetized rats.
Topics: Acute Kidney Injury; Amidines; Anesthesia, General; Animals; Benzylamines; Biomarkers; Creatinine; D | 2009 |
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS.
Topics: Amidines; Animals; Antioxidants; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Kidney; Ki | 2009 |
Role of the Mac-1 and VLA-4 integrins, and concomitant Th2-cytokine production, in nitric oxide modulated eosinophil migration from bone marrow to lungs in allergic mice.
Topics: Amidines; Animals; Benzylamines; Bone Marrow; Chemotaxis, Leukocyte; Cytokines; Disease Models, Anim | 2011 |
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.
Topics: alpha-Synuclein; Amidines; Animals; Animals, Genetically Modified; Benzylamines; Disease Models, Ani | 2011 |
Insulin resistance and liver microcirculation in a rat model of early NAFLD.
Topics: Acetylcholine; Amidines; Animals; Benzylamines; Diet, High-Fat; Disease Models, Animal; Endothelium; | 2011 |
Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.
Topics: Adaptive Immunity; Adoptive Transfer; Amidines; Animals; Antigen Presentation; Benzylamines; Cells, | 2011 |
Effects of corticosteroid, montelukast and iNOS inhibition on distal lung with chronic inflammation.
Topics: Acetates; Amidines; Animals; Anti-Inflammatory Agents; Benzylamines; Chronic Disease; Cyclopropanes; | 2013 |
Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice.
Topics: Amidines; Animals; Arginine; Benzylamines; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Gu | 2013 |
Elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndrome.
Topics: Adolescent; Adult; Amidines; Animals; Benzylamines; Blood Proteins; Case-Control Studies; Disease Mo | 2002 |
Acidosis plus melphalan induces nitric oxide-mediated tumor regression in an isolated limb perfusion human melanoma xenograft model.
Topics: Acidosis; Amidines; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Benzylamines; Disease Mod | 2002 |
Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia.
Topics: Acidosis; Amidines; Animals; Benzylamines; Blood Gas Analysis; Disease Models, Animal; Drug Evaluati | 2003 |
Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation.
Topics: Amidines; Animals; Benzylamines; Bronchi; Cytokines; Dexamethasone; Dextrans; Disease Models, Animal | 2003 |
Effect of combining nicotinamide as a PARS-inhibitor with selective iNOS blockade during porcine endotoxemia.
Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, | 2003 |
Species-specific modulation of the nitric oxide pathway after acute experimentally induced endotoxemia.
Topics: Amidines; Animals; Benzylamines; Blood Pressure; Breath Tests; Disease Models, Animal; Drug Evaluati | 2003 |
Type II nitric oxide synthase activity is cardio-protective in experimental sepsis.
Topics: Amidines; Animals; Benzylamines; Cardiotonic Agents; Disease Models, Animal; Enzyme Inhibitors; Hear | 2003 |
Tyrphostin reduces the organ injury in haemorrhagic shock: role of inducible nitric oxide synthase.
Topics: Amidines; Animals; Benzylamines; Creatine Kinase; Disease Models, Animal; Immunohistochemistry; Kidn | 2003 |
Comparison of iNOS inhibition by antisense and pharmacological inhibitors after spinal cord injury.
Topics: Amidines; Animals; Annexins; Astrocytes; Benzylamines; Blood-Brain Barrier; Cell Count; Cell Death; | 2003 |
Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation.
Topics: Amidines; Androstadienes; Animals; Apoptosis; Benzylamines; Cell Survival; Cells, Cultured; Disease | 2004 |
Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia.
Topics: Adenosine Triphosphate; Amidines; Amino Acid Transport System X-AG; Animals; Benzylamines; Brain; Ce | 2005 |
1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats.
Topics: Amidines; Animals; Benzylamines; Brain Injuries; Calcium; Disease Models, Animal; Enzyme Inhibitors; | 2005 |
Lack of iNOS induction in a severe model of transient focal cerebral ischemia in rats.
Topics: Amidines; Analysis of Variance; Animals; Anticoagulants; Benzylamines; Blotting, Western; Brain; Cal | 2005 |
Inhibition of nitric oxide synthase reduces renal ischemia/reperfusion injury.
Topics: Amidines; Animals; Benzylamines; Creatinine; Disease Models, Animal; Endothelins; Enzyme Inhibitors; | 2005 |
NO-synthase inhibition in sepsis.
Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Hemodynamics; Humans; Ni | 2006 |
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Epinephrine; Hemoglobins | 2006 |
Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation.
Topics: Amidines; Animals; Benzylamines; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Dr | 2007 |
Selective iNOS inhibition reduces renal damage induced by cisplatin.
Topics: Aldehydes; Amidines; Animals; Antineoplastic Agents; Benzylamines; Cisplatin; Disease Models, Animal | 2008 |
Angiotensin II type 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in Dahl salt-sensitive rat heart.
Topics: Aldehydes; Amidines; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzylamines; D | 2008 |
Nitric oxide synthase inhibitors have opposite effects on acute inflammation depending on their route of administration.
Topics: Acute Disease; Amidines; Animals; Antioxidants; Benzylamines; Carrageenan; Disease Models, Animal; D | 2001 |
Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis.
Topics: Amidines; Animals; Benzylamines; Chemokine CXCL2; Chemokines; Disease Models, Animal; Enzyme Inhibit | 2001 |
N-(3-(aminomethyl)benzyl)acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats.
Topics: Amidines; Animals; Benzylamines; Blotting, Western; Colitis; Colon; Disease Models, Animal; Drug Adm | 2001 |
Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice.
Topics: Acetophenones; Amidines; Animals; Antioxidants; Benzylamines; Bronchial Hyperreactivity; Bronchoalve | 2001 |
Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide.
Topics: Amidines; Animals; Benzylamines; Colitis, Ulcerative; Colon; Dextran Sulfate; Digestive System; Dige | 2001 |
Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy.
Topics: Aging; Amidines; Animals; Animals, Newborn; Apoptosis; Benzylamines; Cell Count; Crosses, Genetic; D | 2002 |
Nitric oxide suppresses LPS-induced inflammation in a mouse asthma model by attenuating the interaction of IKK and Hsp90.
Topics: Animals; Asthma; Cells, Cultured; Cytokines; Disease Models, Animal; Female; HSP90 Heat-Shock Protei | 2015 |
1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia.
Topics: Animals; Annexin A5; Apoptosis; Cells, Cultured; Cognition Disorders; Disease Models, Animal; Gene E | 2017 |
The dynamic detection of NO during stroke and reperfusion in vivo.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Imines; Indazoles; Infusions, Intra | 2009 |
Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation.
Topics: Animals; Arginase; Arginine; Blotting, Western; Cardiac Pacing, Artificial; Disease Models, Animal; | 2010 |
Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Cell Division; Disease Models, Ani | 2005 |
Rat gastric injury after lipopolysaccharide: role of inducible nitric oxide synthase.
Topics: Animals; Disease Models, Animal; Female; Gastric Juice; Gastric Mucosa; Imines; Lipopolysaccharides; | 2005 |
Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Imines; Male; Mice; Mice, Inbred mdx; Muscle Rel | 2006 |