n-(2-propynyl)-2-(5-benzyloxy-indolyl)-methylamine and Disease-Models--Animal

n-(2-propynyl)-2-(5-benzyloxy-indolyl)-methylamine has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for n-(2-propynyl)-2-(5-benzyloxy-indolyl)-methylamine and Disease-Models--Animal

Article	Year
Neuroprotective aspects of a novel MAO-B inhibitor PF9601N. Neurobiology (Budapest, Hungary), 2000, Volume: 8, Issue:3-4 PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than l-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57Bl/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound. Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Indoles; Male; Methylamines; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinsonian Disorders; Selegiline	2000

Article

Year

Neuroprotective aspects of a novel MAO-B inhibitor PF9601N.

Neurobiology (Budapest, Hungary), 2000, Volume: 8, Issue:3-4

PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than l-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57Bl/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Indoles; Male; Methylamines; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinsonian Disorders; Selegiline

2000