n-(2-methylbenzyl)linoleamide and Colonic-Neoplasms

n-(2-methylbenzyl)linoleamide has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for n-(2-methylbenzyl)linoleamide and Colonic-Neoplasms

Article	Year
[Potential cytostatic effect of the maleimide derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1-H-pyrrol-2,5-dione]. Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:8 The cytostatic/cytotoxic effects of the maleimide derivative 1-(4-Cl-Benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione (MI-1) have been estimated on epithelial derived human cell cultures (Colo 205, MCF-7, and Hela). The anticancer and toxic effects of MI-1 have been investigated on DMH-induced cancer development and normal colon morphology in rats. The results showed that the compound studied has low cytotoxicity but produces a strong antiproliferative effect on cell cultures and partially suppresses colon cancer development in DMH-induced model. The MI-1 effect on normal colon mucosa is insignificant, and no destructive changes have been detected in the intestine of rats. This maleimide derivate can be considered as a promising anticancer drug. Topics: Aniline Compounds; Animals; Antineoplastic Agents; Colonic Neoplasms; Cytotoxins; Dimenhydrinate; Drug Screening Assays, Antitumor; Humans; Linoleic Acids; Male; Maleimides; Polyunsaturated Alkamides; Pyrroles; Rats	2013

Article

Year

[Potential cytostatic effect of the maleimide derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1-H-pyrrol-2,5-dione].

Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:8

The cytostatic/cytotoxic effects of the maleimide derivative 1-(4-Cl-Benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione (MI-1) have been estimated on epithelial derived human cell cultures (Colo 205, MCF-7, and Hela). The anticancer and toxic effects of MI-1 have been investigated on DMH-induced cancer development and normal colon morphology in rats. The results showed that the compound studied has low cytotoxicity but produces a strong antiproliferative effect on cell cultures and partially suppresses colon cancer development in DMH-induced model. The MI-1 effect on normal colon mucosa is insignificant, and no destructive changes have been detected in the intestine of rats. This maleimide derivate can be considered as a promising anticancer drug.

Topics: Aniline Compounds; Animals; Antineoplastic Agents; Colonic Neoplasms; Cytotoxins; Dimenhydrinate; Drug Screening Assays, Antitumor; Humans; Linoleic Acids; Male; Maleimides; Polyunsaturated Alkamides; Pyrroles; Rats

2013