n-(2-methoxybenzyl)-n-(4-phenoxypyridin-3-yl)acetamide and Arthritis--Rheumatoid

Reumatoid Arthritis (RA) is an autoimmune disorder characterized by peripheral joint inflammation. Recently, an engagement of the brain immune system has been proposed. The aim with the current investigation was to study the glial cell activation marker translocator protein (TSPO) in a well characterized cohort of RA patients and to relate it to disease activity, peripheral markers of inflammation and autonomic activity. Fifteen RA patients and fifteen healthy controls matched for age, sex and TSPO genotype (rs6971) were included in the study. TSPO was measured using Positron emission tomography (PET) and the radioligand [

Topics: Acetamides; Adult; Arthritis, Rheumatoid; Biomarkers; Carbon Radioisotopes; Cerebral Cortex; Disease Progression; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Protein Binding; Pyridines; Receptors, GABA