n-(2-methoxybenzyl)-n-(4-phenoxypyridin-3-yl)acetamide and Alcoholism

Neuroinflammation appears to contribute to neurotoxicity observed with heavy alcohol consumption. To assess whether chronic alcohol results in neuroinflammation we used PET and [

Topics: Acetamides; Alcoholism; Animals; Brain; Carrier Proteins; Central Nervous System Depressants; Cholesterol; Ethanol; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Protein Binding; Pyridines; Radiopharmaceuticals; Rats, Wistar; Receptors, GABA; Receptors, GABA-A

Repeated withdrawal from alcohol is clinically associated with progressive cognitive impairment. Microglial activation occurring during pre-clinical models of alcohol withdrawal is associated with learning deficits. We investigated whether there was microglial activation in recently detoxified alcohol-dependent patients (ADP), using [

Topics: Acetamides; Alcoholism; Astrocytes; Carbon Radioisotopes; Case-Control Studies; Drug Contamination; Female; Hippocampus; Humans; Male; Microglia; Middle Aged; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Receptors, GABA

Neuroinflammation may be a critical component of the neurobiology of alcohol use disorders, yet the exact nature of this relationship is not well understood. This work compared the brain and peripheral immune profile of alcohol-dependent subjects and controls. Brain levels of 18-kDa translocator protein (TSPO), a marker of microglial activation and neuroinflammation, were measured with [

Topics: Acetamides; Adult; Alcoholism; Brain; Brain Mapping; Carbon Radioisotopes; Cells, Cultured; Cytokines; Female; Humans; Inflammation; Lipopolysaccharides; Male; Microglia; Monocytes; Neuroimaging; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Receptors, GABA; Severity of Illness Index