Page last updated: 2024-08-23

n-(2-hydroxypropyl)methacrylamide and Neoplasms

n-(2-hydroxypropyl)methacrylamide has been researched along with Neoplasms in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.70)18.2507
2000's4 (10.81)29.6817
2010's31 (83.78)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Dai, X; Duan, Z; Gong, Q; Gu, L; Gu, Z; Li, X; Luo, K; Luo, Q; Tian, X; Zhang, H; Zhu, H1
Chytil, P; Etrych, T; Filippov, SK; Kikhney, A; Niebuur, BJ; Papadakis, CM; Svergun, DI; Wieland, DCF; Zhang, X1
Barz, M; Baues, M; Gremse, F; Jahnen-Dechent, W; Kiessling, F; Koynov, K; Lammers, T; Negwer, I; Pechar, M; Pola, R; Storm, G; Theek, B; Weber, B1
Carlisle, R; Cawood, R; Coussios, CC; Graham, S; Laga, R; Mo, S; Myers, R; Seymour, L; Ulbrich, K1
Huang, Y; Li, L; Sun, W; Zhang, Z1
Etrych, T; Hovorka, O; Jelínková, M; Kovár, M; Pechar, M; Ríhová, B; Stastný, M; Ulbrich, K1
Etrych, T; Fang, J; Hackbarth, S; Islam, W; Maeda, H; Röder, B; Šubr, V1
Chytil, P; Etrych, T; Haratake, M; Koziolová, E; Maeda, H; Nakamura, H1
Chytil, P; Etrych, T; Fang, J; Maeda, H; Nakamura, H; Ohkubo, M; Ulbrich, K1
Etrych, T; Laga, R; Ríhová, B; Subr, V; Ulbrich, K1
Huang, Y; Li, L; Xu, X; Yang, Y; Zhou, Z1
Guan, S; Huang, Y; Li, L; Yang, Q; Zhang, Z; Zhong, J; Zhou, Z; Zhu, X1
Apte, RN; David, A; Golan, M; Raviv, L; Shamay, Y; Voronov, E1
Chuang, VT; Fang, J; Ikeda, M; Ishima, Y; Kinoshita, R; Kodama, A; Kragh-Hansen, U; Maeda, H; Maruyama, T; Nakamura, H; Otagiri, M; Tanaka, R; Watanabe, H1
Gong, Q; Guan, P; Li, X; Luo, K; Luo, Q; Sun, L; Wei, X; Wu, M; Zhu, H1
Kopeček, J; Wang, J; Yang, J; Zhang, L; Zhang, R1
David, A; Feinshtein, V; Golan, M1
Braunová, A; Černoch, P; Cuchalová, L; Etrych, T; Filippov, S; Hvězdová, Z; Janoušková, O; Kostka, L; Laga, R; Pechar, M; Šírová, M; Sivák, L1
Chytil, P; Etrych, T; Lidický, O; Říhová, B; Šírová, M; Strohalm, J; Tomala, J1
Huang, Y; Li, L; Wu, L; Yang, Q; Zhou, Z1
Hennink, WE; Huber, PE; Lammers, T; Peschke, P; Storm, G; Subr, V; Ulbrich, K1
Hovorka, O; Pechar, M; Pola, R; Ríhová, B; Studenovský, M; Ulbrich, K; Vetvicka, D1
Liu, XM; Miller, SC; Wang, D1
Kovár, M; Ríhová, B1
Kopecek, J; Kopecková, P1
Ghandehari, H; Pike, DB1
Lammers, T1
Huang, F; McCormick, CL; York, AW1
McEwan, J; McTavish, K; Russell-Jones, G1
Bachtarzi, H; Fisher, KD; Seymour, LW; Stevenson, M; Šubr, V; Ulbrich, K1
Hennink, WE; Huber, PE; Kiessling, F; Lammers, T; Peschke, P; Storm, G; Subr, V; Ulbrich, K1
Alonso, CM; Boyle, RW; Bullous, AJ1
Khambati, H; Kolhatkar, R; Lote, A1
Hennink, WE; Huis In 't Veld, R; Kiessling, F; Lammers, T; Storm, G1
Fang, J; Hitaka, Y; Liao, L; Maeda, H; Nakamura, H; Subr, V; Tsukigawa, K; Ulbrich, K1
Kubácková, K; Ríhová, B1
Ríhová, B1

Reviews

8 review(s) available for n-(2-hydroxypropyl)methacrylamide and Neoplasms

ArticleYear
Beyond oncology--application of HPMA copolymers in non-cancerous diseases.
    Advanced drug delivery reviews, 2010, Feb-17, Volume: 62, Issue:2

    Topics: Acrylamides; Animals; Arthritis, Rheumatoid; Humans; Nanomedicine; Neoplasms; Osteoporosis; Polymers

2010
Immunogenicity and immunomodulatory properties of HPMA-based polymers.
    Advanced drug delivery reviews, 2010, Feb-17, Volume: 62, Issue:2

    Topics: Acrylamides; Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; Humans; Immunologic Factors; Neoplasms; Polymers

2010
HPMA copolymer-cyclic RGD conjugates for tumor targeting.
    Advanced drug delivery reviews, 2010, Feb-17, Volume: 62, Issue:2

    Topics: Acrylamides; Animals; Antineoplastic Agents; Drug Delivery Systems; Humans; Neoplasms; Polymers; Recombinant Fusion Proteins

2010
Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations.
    Advanced drug delivery reviews, 2010, Feb-17, Volume: 62, Issue:2

    Topics: Acrylamides; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Combined Modality Therapy; Humans; Nanomedicine; Neoplasms; Polymers

2010
Photosensitiser-antibody conjugates for photodynamic therapy.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2011, Volume: 10, Issue:5

    Topics: Acrylamides; Antibodies; Carbodiimides; Fullerenes; Humans; Isothiocyanates; Neoplasms; Photochemotherapy; Photosensitizing Agents; Polyglutamic Acid; Polyvinyl Alcohol

2011
Active tumor targeting of nanomaterials using folic acid, transferrin and integrin receptors.
    Current drug discovery technologies, 2011, Volume: 8, Issue:3

    Topics: Acrylamides; Animals; Antineoplastic Agents; Dendrimers; Drug Delivery Systems; Folic Acid; Humans; Integrin alphaVbeta3; Liposomes; Nanoparticles; Neoplasms; Transferrin

2011
Clinical implications of N-(2-hydroxypropyl)methacrylamide copolymers.
    Current pharmaceutical biotechnology, 2003, Volume: 4, Issue:5

    Topics: Acrylamides; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Drug Carriers; Humans; Molecular Structure; Neoplasms; Treatment Outcome

2003
Antibody-targeted polymer-bound drugs.
    Folia microbiologica, 1995, Volume: 40, Issue:4

    Topics: Acrylamides; Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antineoplastic Agents; Chlorophyllides; Clinical Trials as Topic; Cyclosporine; Daunorubicin; Doxorubicin; Histocompatibility Antigens Class II; Humans; Immune System Diseases; Immunoconjugates; Immunosuppressive Agents; Lysosomes; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Polymethacrylic Acids; Porphyrins; Radiation-Sensitizing Agents; T-Lymphocyte Subsets; Thy-1 Antigens; Tissue Distribution

1995

Other Studies

29 other study(ies) available for n-(2-hydroxypropyl)methacrylamide and Neoplasms

ArticleYear
Synergistic Therapy of a Naturally Inspired Glycopolymer-Based Biomimetic Nanomedicine Harnessing Tumor Genomic Instability.
    Advanced materials (Deerfield Beach, Fla.), 2021, Volume: 33, Issue:45

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biomimetic Materials; Cell Line, Tumor; Chlorophyll; DNA Damage; Drug Carriers; Genomic Instability; Humans; Light; Mice; Nanomedicine; Nanostructures; Neoplasms; Photochemotherapy; Phthalazines; Piperazines; Polymethacrylic Acids; Polysaccharides; Reactive Oxygen Species

2021
Macromolecular pHPMA-Based Nanoparticles with Cholesterol for Solid Tumor Targeting: Behavior in HSA Protein Environment.
    Biomacromolecules, 2018, 02-12, Volume: 19, Issue:2

    Topics: Cholesterol; Doxorubicin; Drug Delivery Systems; Humans; Nanoparticles; Neoplasms; Polymethacrylic Acids; Serum Albumin, Human

2018
Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors.
    Journal of controlled release : official journal of the Controlled Release Society, 2018, 07-28, Volume: 282

    Topics: Animals; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; Permeability; Polymethacrylic Acids; Proteins; Tissue Distribution; Up-Regulation

2018
Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Jul-28, Volume: 210

    Topics: Adenoviridae; Animals; Cell Line, Tumor; Female; Gold; Green Fluorescent Proteins; Humans; Liver; Metal Nanoparticles; Mice, Inbred BALB C; Mice, Nude; Nanomedicine; Neoplasms; Oncolytic Virotherapy; Polyethylene Glycols; Polymethacrylic Acids; Ultrasonics

2015
Time-staggered delivery of docetaxel and H1-S6A,F8A peptide for sequential dual-strike chemotherapy through tumor priming and nuclear targeting.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, 06-28, Volume: 232

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Survival; Docetaxel; Female; HeLa Cells; Humans; Mice, Nude; Neoplasms; Peptides; Polymethacrylic Acids; Proto-Oncogene Proteins c-myc; Taxoids; Tumor Burden

2016
Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes.
    Journal of controlled release : official journal of the Controlled Release Society, 2001, Jul-06, Volume: 74, Issue:1-3

    Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Drug Carriers; Hydrazones; Lysosomes; Methacrylates; Mice; Molecular Weight; Neoplasms; Oligopeptides; Polymethacrylic Acids; Spleen; Tumor Cells, Cultured

2001
Singlet oxygen phosphorescence detection in vivo identifies PDT-induced anoxia in solid tumors.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2019, Jun-12, Volume: 18, Issue:6

    Topics: Acrylamides; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Hypoxia; Kinetics; Luminescence; Mice; Molecular Structure; Neoplasms; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen; Structure-Activity Relationship

2019
Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid.
    Molecular pharmaceutics, 2019, 08-05, Volume: 16, Issue:8

    Topics: Acrylamides; Antineoplastic Agents; Doxorubicin; Drug Carriers; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Neoplasms; Spheroids, Cellular

2019
Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage.
    Journal of controlled release : official journal of the Controlled Release Society, 2014, Jan-28, Volume: 174

    Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; HeLa Cells; Humans; Male; Mice; Neoplasms; Polymers; Tissue Distribution; Tumor Burden

2014
Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid tumours.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Jul-16, Volume: 58

    Topics: Acrylamides; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; Drug Stability; Female; Hydrazones; Hydrogen-Ion Concentration; Mice; Mice, Inbred C57BL; Neoplasms

2014
Tumor targeting by pH-sensitive, biodegradable, cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles.
    Biomaterials, 2014, Volume: 35, Issue:24

    Topics: Acrylamides; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Biocompatible Materials; Cell Line, Tumor; Cross-Linking Reagents; Doxorubicin; Endocytosis; Female; Fluorescein-5-isothiocyanate; Humans; Hydrogen-Ion Concentration; Liver; Mice; Micelles; Microscopy, Electron, Transmission; Neoplasms; Polymers; Sitosterols; Tissue Distribution; Tumor Burden; Xenograft Model Antitumor Assays

2014
A smart polymeric platform for multistage nucleus-targeted anticancer drug delivery.
    Biomaterials, 2015, Volume: 65

    Topics: Acrylamides; Amino Acid Sequence; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Nucleus; Cell-Penetrating Peptides; Delayed-Action Preparations; Drug Delivery Systems; HeLa Cells; Humans; Hydrogen-Ion Concentration; Male; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasms; Nuclear Localization Signals; Peptides; Proto-Oncogene Proteins c-myc

2015
Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer-drug conjugates.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Nov-10, Volume: 217

    Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Doxorubicin; E-Selectin; Female; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasms; Peptides; Polymers; Tumor Burden

2015
S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Nov-10, Volume: 217

    Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Kidney; Liposomes; Liver; Male; Mice; Mice, Inbred BALB C; Micelles; Neoplasms; Nitroso Compounds; Permeability; Polyethylene Glycols; Protein Multimerization; Protoporphyrins; Serum Albumin; Serum Albumin, Human; Tumor Burden

2015
Enzyme- and pH-Sensitive Branched Polymer-Doxorubicin Conjugate-Based Nanoscale Drug Delivery System for Cancer Therapy.
    ACS applied materials & interfaces, 2016, 05-11, Volume: 8, Issue:18

    Topics: Acrylamides; Animals; Doxorubicin; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Mice; Neoplasms; Polymers

2016
Indium-based and iodine-based labeling of HPMA copolymer-epirubicin conjugates: Impact of structure on the in vivo fate.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, 08-10, Volume: 235

    Topics: Acrylamides; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Epirubicin; Female; Humans; Indium Radioisotopes; Iodine Radioisotopes; Mice, Nude; Neoplasms; Staining and Labeling

2016
Conjugates of HA2 with octaarginine-grafted HPMA copolymer offer effective siRNA delivery and gene silencing in cancer cells.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2016, Volume: 109

    Topics: A549 Cells; Acrylamides; Cell Line, Tumor; Cytoplasm; Endosomes; Female; Fluorescein-5-isothiocyanate; Gene Expression Regulation, Neoplastic; Gene Silencing; Gene Transfer Techniques; Humans; Microscopy, Confocal; Neoplasms; Oligopeptides; Ovarian Neoplasms; Peptides; Polymers; Real-Time Polymerase Chain Reaction; RNA; RNA Interference; RNA, Small Interfering; Surface Properties

2016
Tumor-targeted micelle-forming block copolymers for overcoming of multidrug resistance.
    Journal of controlled release : official journal of the Controlled Release Society, 2017, 01-10, Volume: 245

    Topics: Acrylamides; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Inbred C57BL; Micelles; Neoplasms; Polymers; Propylene Glycols; Tumor Burden

2017
The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel.
    Journal of controlled release : official journal of the Controlled Release Society, 2017, 01-28, Volume: 246

    Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Docetaxel; Doxorubicin; Drug Carriers; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms; Taxoids

2017
Subcellular co-delivery of two different site-oriented payloads for tumor therapy.
    Nanoscale, 2017, Jan-26, Volume: 9, Issue:4

    Topics: Acrylamides; Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; DNA Damage; Docetaxel; Drug Delivery Systems; Humans; Male; Mice; Mice, Inbred BALB C; Micelles; Neoplasms; NIH 3T3 Cells; Organosilicon Compounds; Polymers; Taxoids; Tretinoin; Xenograft Model Antitumor Assays

2017
Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers.
    Biomaterials, 2009, Volume: 30, Issue:20

    Topics: Acrylamides; Animals; Antineoplastic Agents; Apoptosis; Biocompatible Materials; Deoxycytidine; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Gemcitabine; Male; Materials Testing; Molecular Structure; Neoplasm Transplantation; Neoplasms; Neovascularization, Physiologic; Polymers; Rats; Tissue Distribution

2009
HPMA-copolymer conjugates targeted to tumor endothelium using synthetic oligopeptides.
    Journal of drug targeting, 2009, Volume: 17, Issue:10

    Topics: Acrylamides; Animals; Apoptosis; Cell Line; Cell Line, Tumor; Drug Delivery Systems; Endothelium, Vascular; Humans; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Neoplasms; Neovascularization, Pathologic; Oligopeptides; Time Factors

2009
HPMA copolymers: origins, early developments, present, and future.
    Advanced drug delivery reviews, 2010, Feb-17, Volume: 62, Issue:2

    Topics: Acrylamides; Animals; Antineoplastic Agents; Drug Discovery; Forecasting; History, 20th Century; History, 21st Century; Humans; Neoplasms; Polymers

2010
Rational design of targeted cancer therapeutics through the multiconjugation of folate and cleavable siRNA to RAFT-synthesized (HPMA-s-APMA) copolymers.
    Biomacromolecules, 2010, Feb-08, Volume: 11, Issue:2

    Topics: Acrylamides; Acrylic Resins; Antineoplastic Agents; Drug Delivery Systems; Drug Design; Folic Acid; Humans; Neoplasms; Organometallic Compounds; RNA, Small Interfering

2010
Preliminary studies on the selective accumulation of vitamin-targeted polymers within tumors.
    Journal of drug targeting, 2011, Volume: 19, Issue:2

    Topics: Acrylamides; Animals; Biotin; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Mice; Microscopy, Fluorescence; Neoplasms; Neoplasms, Experimental; Tissue Distribution; Vitamin B 12; Vitamins

2011
Targeting adenovirus gene delivery to activated tumour-associated vasculature via endothelial selectins.
    Journal of controlled release : official journal of the Controlled Release Society, 2011, Mar-10, Volume: 150, Issue:2

    Topics: Acrylamides; Adenoviridae; Animals; Antibodies, Monoclonal; Bacterial Proteins; Cell Line, Tumor; Cells, Cultured; E-Selectin; Endothelial Cells; Endothelium, Vascular; Female; Gene Transfer Techniques; Hep G2 Cells; Humans; Luciferases, Firefly; Membrane Glycoproteins; Mice; Mice, Nude; Neoplasms; P-Selectin; Platelet Endothelial Cell Adhesion Molecule-1; Selectins; Transduction, Genetic; Tumor Necrosis Factor-alpha; Umbilical Cord; Viral Load; Xenograft Model Antitumor Assays

2011
HPMA-based polymer therapeutics improve the efficacy of surgery, of radiotherapy and of chemotherapy combinations.
    Nanomedicine (London, England), 2010, Volume: 5, Issue:10

    Topics: Acrylamides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Humans; Nanomedicine; Neoplasms; Polymers

2010
Macromolecular nanotheranostics for multimodal anticancer therapy.
    Nanoscale, 2011, Oct-05, Volume: 3, Issue:10

    Topics: Acrylamides; Animals; Antineoplastic Agents; Doxorubicin; Drug Carriers; Gadolinium; Humans; Iodine Radioisotopes; Mice; Nanomedicine; Neoplasms; Tissue Distribution

2011
Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo.
    Journal of controlled release : official journal of the Controlled Release Society, 2013, Feb-10, Volume: 165, Issue:3

    Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; HeLa Cells; Humans; Light; Male; Mice; Micelles; Neoplasms; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Burden

2013