n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Status Epilepticus in 4 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The COX-2 inhibitor celecoxib decreased neuronal excitability and prevented epileptogenesis in pilocarpine-induced status epilepticus rats." | 7.74 | Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats. ( Lei, GF; Liu, CX; Sun, RP; Yang, L; Zhang, HJ, 2008) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 5.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "The COX-2 inhibitor celecoxib decreased neuronal excitability and prevented epileptogenesis in pilocarpine-induced status epilepticus rats." | 3.74 | Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats. ( Lei, GF; Liu, CX; Sun, RP; Yang, L; Zhang, HJ, 2008) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 1.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "Epileptic seizures drive expression of the blood-brain barrier efflux transporter P-glycoprotein via a glutamate/cyclooxygenase-2 mediated signalling pathway." | 1.36 | COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. ( Aronica, E; Edelbroek, PM; Gorter, JA; Holtman, L; Pekcec, A; Potschka, H; Schlichtiger, J; van Vliet, EA; Zibell, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trandafir, CC | 1 |
| Pouliot, WA | 1 |
| Dudek, FE | 1 |
| Ekstrand, JJ | 1 |
| Zhang, HJ | 1 |
| Sun, RP | 1 |
| Lei, GF | 1 |
| Yang, L | 1 |
| Liu, CX | 1 |
| Zibell, G | 2 |
| Unkrüer, B | 1 |
| Pekcec, A | 2 |
| Hartz, AM | 1 |
| Bauer, B | 1 |
| Miller, DS | 1 |
| Potschka, H | 2 |
| van Vliet, EA | 1 |
| Schlichtiger, J | 1 |
| Edelbroek, PM | 1 |
| Holtman, L | 1 |
| Aronica, E | 1 |
| Gorter, JA | 1 |
4 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Status Epilepticus
| Article | Year |
|---|---|
Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diazepam; Disease Models, A | 2015 |
Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats.
Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models | 2008 |
Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition.
Topics: Animals; Arachidonic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barr | 2009 |
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2010 |