n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Seizures in 6 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Injection of kainic acid (KA) into the brain causes severe seizures with hippocampal neuron loss." | 3.73 | Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region. ( Maehara, M; Matsumura, K; Sugiura, H; Takemiya, T; Yamagata, K; Yasuda, S, 2006) |
| "In the KA-induced seizure model, i." | 1.42 | Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. ( Chan, JY; Chang, AY; Chao, YM; Ho, YH; Lin, YT; Wu, CW, 2015) |
| "Epileptic seizures drive expression of the blood-brain barrier efflux transporter P-glycoprotein via a glutamate/cyclooxygenase-2 mediated signalling pathway." | 1.36 | COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. ( Aronica, E; Edelbroek, PM; Gorter, JA; Holtman, L; Pekcec, A; Potschka, H; Schlichtiger, J; van Vliet, EA; Zibell, G, 2010) |
| "Kainic acid (KA)-induced seizure in rat involves eicosanoid production in the brain, but their production mechanism and biological functions are poorly understood." | 1.33 | Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2. ( Kishimoto, K; Kita, Y; Shimizu, T; Yoshikawa, K, 2006) |
| "COX-2 selective inhibitors induced the seizure at earlier onset and more severe mortality within the first hour than indomethacin and aspirin." | 1.30 | Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus. ( Baik, EJ; Kim, EJ; Lee, SH; Moon, C, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ho, YH | 1 |
| Lin, YT | 1 |
| Wu, CW | 1 |
| Chao, YM | 1 |
| Chang, AY | 1 |
| Chan, JY | 1 |
| van Vliet, EA | 1 |
| Zibell, G | 1 |
| Pekcec, A | 1 |
| Schlichtiger, J | 1 |
| Edelbroek, PM | 1 |
| Holtman, L | 1 |
| Aronica, E | 1 |
| Gorter, JA | 1 |
| Potschka, H | 1 |
| Yuhas, Y | 1 |
| Weizman, A | 1 |
| Vanichkin, A | 1 |
| Ashkenazi, S | 1 |
| Yoshikawa, K | 1 |
| Kita, Y | 1 |
| Kishimoto, K | 1 |
| Shimizu, T | 1 |
| Takemiya, T | 1 |
| Maehara, M | 1 |
| Matsumura, K | 1 |
| Yasuda, S | 1 |
| Sugiura, H | 1 |
| Yamagata, K | 1 |
| Baik, EJ | 1 |
| Kim, EJ | 1 |
| Lee, SH | 1 |
| Moon, C | 1 |
6 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Seizures
| Article | Year |
|---|---|
Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.
Topics: Animals; Cyclic N-Oxides; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammation; Interleukin-1b | 2015 |
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2010 |
Involvement of prostaglandins in an animal model of Shigella-related seizures.
Topics: Animals; Chi-Square Distribution; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Disease Models | 2005 |
Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2.
Topics: Animals; Arachidonic Acids; Brain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; | 2006 |
Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Ex | 2006 |
Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus.
Topics: Animals; Aspirin; Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibito | 1999 |