n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Lung Neoplasms in 28 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gemcitabine is a chemotherapeutic drug widely used in the treatment of non-small cell lung carcinoma, especially in advanced lung adenocarcinoma." | 7.74 | NS-398 enhances the efficacy of gemcitabine against lung adenocarcinoma through up-regulation of p21WAF1 and p27KIP1 protein. ( Chen, XJ; Qu, X; Xiao, W; Zhou, SY, 2008) |
| "Gemcitabine is a chemotherapeutic drug widely used in the treatment of non-small cell lung carcinoma, especially in advanced lung adenocarcinoma." | 3.74 | NS-398 enhances the efficacy of gemcitabine against lung adenocarcinoma through up-regulation of p21WAF1 and p27KIP1 protein. ( Chen, XJ; Qu, X; Xiao, W; Zhou, SY, 2008) |
| "Lung cancer is one of the most common causes of cancer-related mortality throughout the world, and the incidence continues to increase." | 2.42 | COX-2 inhibitor as a radiation enhancer: new strategies for the treatment of lung cancer. ( Choy, H; Pyo, H; Saha, D, 2003) |
| "Lung cancer is frequently complicated by pulmonary infections which may impair prognosis of this disease." | 1.39 | Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation. ( Banat, GA; Dahlem, G; Eul, B; Fink, L; Goldmann, T; Grandel, U; Grimminger, F; Hattar, K; Lang, DS; Savai, R; Schermuly, RT; Schmall, A; Seeger, W; Sibelius, U; Subtil, FS; Vollmer, E; Wilhelm, J, 2013) |
| "NS-398 suppressed the growth of colon cancer cells, independent of COX-2 expression." | 1.33 | Autocrine vascular endothelial growth factor/vascular endothelial growth factor receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon cancer cells. ( Choi, CW; Kim, BS; Kim, JS; Kim, SJ; Kim, YH; Lee, YJ; Seo, JH; Shin, SW; Yoon, JH, 2005) |
| "As indomethacin was more effective we used it in mechanistic studies." | 1.32 | Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways. ( Bradbury, DA; Knox, AJ; Pang, L; Sánchez-Alcázar, JA, 2003) |
| " NNK increased plasma prostaglandin E2 (PGE2) basal levels by 413%, whereas ASA attenuated this elevation in a dose-response manner (r2 = 0." | 1.30 | Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398. ( Castonguay, A; Rioux, N, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 19 (67.86) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, GB | 1 |
| Fang, HY | 1 |
| Tao, DY | 1 |
| Chen, XP | 1 |
| Cao, FL | 1 |
| Ramer, R | 3 |
| Walther, U | 2 |
| Borchert, P | 1 |
| Laufer, S | 1 |
| Linnebacher, M | 2 |
| Hinz, B | 3 |
| Huang, RY | 1 |
| Li, SS | 1 |
| Guo, HZ | 1 |
| Huang, Y | 1 |
| Zhang, X | 1 |
| Li, MY | 1 |
| Chen, GG | 1 |
| Zeng, X | 1 |
| Hattar, K | 2 |
| Franz, K | 1 |
| Ludwig, M | 1 |
| Sibelius, U | 2 |
| Wilhelm, J | 2 |
| Lohmeyer, J | 1 |
| Savai, R | 2 |
| Subtil, FS | 2 |
| Dahlem, G | 2 |
| Eul, B | 2 |
| Seeger, W | 2 |
| Grimminger, F | 2 |
| Grandel, U | 2 |
| Emmrich, K | 1 |
| Mittag, N | 1 |
| Qiu, R | 1 |
| Chen, J | 1 |
| Sima, J | 1 |
| Shen, X | 1 |
| Liu, D | 1 |
| Shen, J | 1 |
| Schmall, A | 1 |
| Lang, DS | 1 |
| Goldmann, T | 1 |
| Fink, L | 1 |
| Schermuly, RT | 1 |
| Banat, GA | 1 |
| Vollmer, E | 1 |
| Heinemann, K | 1 |
| Merkord, J | 1 |
| Rohde, H | 1 |
| Salamon, A | 1 |
| Liu, LT | 1 |
| Chang, HC | 4 |
| Chiang, LC | 1 |
| Hung, WC | 4 |
| Sánchez-Alcázar, JA | 1 |
| Bradbury, DA | 1 |
| Pang, L | 1 |
| Knox, AJ | 1 |
| Nakata, H | 2 |
| Uemura, Y | 2 |
| Kobayashi, M | 2 |
| Harada, R | 1 |
| Taguchi, H | 2 |
| Saha, D | 1 |
| Pyo, H | 1 |
| Choy, H | 1 |
| Martey, CA | 1 |
| Pollock, SJ | 1 |
| Turner, CK | 1 |
| O'Reilly, KM | 1 |
| Baglole, CJ | 1 |
| Phipps, RP | 1 |
| Sime, PJ | 1 |
| Fang, KM | 1 |
| Shu, WH | 1 |
| Wang, JJ | 1 |
| Mak, OT | 1 |
| Han, S | 2 |
| Roman, J | 2 |
| Kim, SJ | 1 |
| Seo, JH | 1 |
| Lee, YJ | 1 |
| Yoon, JH | 1 |
| Choi, CW | 1 |
| Kim, BS | 1 |
| Shin, SW | 1 |
| Kim, YH | 1 |
| Kim, JS | 1 |
| Liu, GS | 1 |
| Liu, LF | 1 |
| Lin, CJ | 1 |
| Tseng, JC | 1 |
| Chuang, MJ | 1 |
| Lam, HC | 1 |
| Lee, JK | 1 |
| Yang, LC | 1 |
| Chan, JH | 1 |
| Howng, SL | 1 |
| Tai, MH | 1 |
| Kudryavtsev, IA | 1 |
| Gudkova, MV | 1 |
| Pavlova, OM | 1 |
| Oreshkin, AE | 1 |
| Myasishcheva, NV | 1 |
| Duan, W | 1 |
| Zhang, L | 1 |
| Kubota, T | 1 |
| Saito, T | 1 |
| Bandobashi, K | 1 |
| Chen, XJ | 1 |
| Xiao, W | 1 |
| Qu, X | 1 |
| Zhou, SY | 1 |
| Pan, MR | 3 |
| Chuang, LY | 3 |
| Rioux, N | 2 |
| Castonguay, A | 2 |
| Marrogi, A | 1 |
| Pass, HI | 1 |
| Khan, M | 1 |
| Metheny-Barlow, LJ | 1 |
| Harris, CC | 1 |
| Gerwin, BI | 1 |
| Lee, TH | 1 |
| Yao, R | 1 |
| You, M | 1 |
1 review available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Lung Neoplasms
| Article | Year |
|---|---|
COX-2 inhibitor as a radiation enhancer: new strategies for the treatment of lung cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Cyclooxygenase 2 | 2003 |
27 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Lung Neoplasms
| Article | Year |
|---|---|
COX-2 potentiates cisplatin resistance of non-small cell lung cancer cells by promoting EMT in an AKT signaling pathway-dependent manner.
Topics: Antineoplastic Agents; Apoptosis; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cispl | 2019 |
Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib.
Topics: Anilides; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Celecoxib; Cell Line, Tu | 2013 |
Thromboxane A2 exerts promoting effects on cell proliferation through mediating cyclooxygenase-2 signal in lung adenocarcinoma cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenocarcinoma; Adenocarcinoma o | 2014 |
Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Communication; Cell Growth Processes; Cell Line, Tumor; Cocultu | 2014 |
Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway.
Topics: A549 Cells; Anilides; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 | 2016 |
NS398 induces apoptosis in non-small cell lung cancer cells.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Growth Processes; Cell Line, Tumor; Cyclo | 2012 |
Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyc | 2013 |
COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.
Topics: Anilides; Animals; Antineoplastic Agents; Apoptosis; Cannabidiol; Cell Line, Tumor; Cell Nucleus; Ce | 2013 |
Induction of RECK by nonsteroidal anti-inflammatory drugs in lung cancer cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Base Sequence; DNA Primers; Fluorescent A | 2002 |
Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways.
Topics: Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspases; C | 2003 |
Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
Topics: Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoproston | 2003 |
Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.
Topics: Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fibroblas | 2004 |
Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549.
Topics: Apoptosis; Cell Line, Tumor; Cyclooxygenase Inhibitors; Humans; Lung Neoplasms; Mitochondria; Nitrob | 2004 |
COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cyclooxygenase Inhibitors; Extracellular Signal-Regul | 2005 |
Autocrine vascular endothelial growth factor/vascular endothelial growth factor receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Caco-2 Cells; Carcinoma, Non-Small-Cell Lung; Cell Line, T | 2005 |
Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma: involvement of alpha-melanocyte-stimulating hormone-mediated inhibition of the nuclear factor kappaB/cyclooxygenase-2 pathway.
Topics: Adenoviridae; alpha-MSH; Animals; Cell Adhesion; Cell Movement; Cyclooxygenase 2; Cyclooxygenase 2 I | 2006 |
COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals.
Topics: Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase Inhibitors; Flavonoids; | 2006 |
Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenocarcinoma; Arachidonate Lipoxygenases; Arachidonic | 2005 |
Cyclooxygenase inhibitors not inhibit resting lung cancer A549 cell proliferation.
Topics: Antineoplastic Agents; Aspirin; Cell Proliferation; Cell Survival; Cyclooxygenase 1; Cyclooxygenase | 2006 |
Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on lung cancer: roles of cyclooxygenase-2.
Topics: Antibodies; Apoptosis; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Granulocyte Co | 2007 |
NS-398 enhances the efficacy of gemcitabine against lung adenocarcinoma through up-regulation of p21WAF1 and p27KIP1 protein.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cyclin- | 2008 |
The nonsteroidal anti-inflammatory drug NS398 reactivates SPARC expression via promoter demethylation to attenuate invasiveness of lung cancer cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransfer | 2008 |
Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Biotransformation; Carcinogens; Cell Division; Cyclooxyge | 1998 |
Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor.
Topics: Adult; Aged; Amidines; Anti-Inflammatory Agents, Non-Steroidal; Asbestos; Benzylamines; Cell Divisio | 2000 |
Induction of p27(KIP1) as a mechanism underlying NS398-induced growth inhibition in human lung cancer cells.
Topics: Antineoplastic Agents; Cell Cycle Proteins; Cell Division; Cyclin G; Cyclin G1; Cyclin-Dependent Kin | 2000 |
Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis.
Topics: Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Chemoprevention; Cycl | 2000 |
Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Culture Media, Conditioned; Cyclooxygenase Inhibitors; Dino | 2001 |