n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Invasiveness, Neoplasm in 23 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These data indicated that P38 in the pancreatic cancer cells was non‑specifically activated by NS‑398." | 1.43 | NS-398 promotes pancreatic cancer cell invasion by CD147 and MMP-2 via the activation of P38. ( Gao, FH; Liu, H; Tang, MC; Xu, XF; Zhao, Y; Zhou, YQ, 2016) |
| "Periostin mRNA in gastric cancer cells was silenced using small interfering RNA (siRNA) techniques and periostin gene expression was evaluated by quantitative reverse transcription-polymerase chain reaction." | 1.37 | Enhanced proliferation, invasion, and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin. ( Liu, BA; Liu, Y, 2011) |
| "Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood." | 1.34 | Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. ( Choe, M; Choi, EM; Ha, KS; Han, JA; Kim, H; Kim, JI; Kim, SR; Kim, SS; Kim, YM; Lee, EJ; Park, JH, 2007) |
| "Invasive behaviors of the malignant colon cancer cell line HT-29 were investigated in this study." | 1.33 | Effect of NS-398 on colon cancer cells. ( Han, LH; Jia, XQ; Meng, FL; Wang, JH; Yan, M; Zhang, SZ; Zhong, N, 2005) |
| "Worldwide oral squamous cell carcinoma (OSCC) represents about 5." | 1.33 | Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion. ( Hart, IR; Marshall, JF; McCulloch, D; Nystrom, ML; Speight, PM; Thomas, GJ; Violette, SM; Weinreb, PH, 2006) |
| "Two human colorectal cancer cell lines, LS174T and HT29, were challenged with MMP inhibitor (doxycycline), selective COX-2 inhibitor (NS-398), or a combination of these agents to evaluate cancer cell proliferation and invasion." | 1.32 | Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells. ( Dhar, DK; Fujii, T; Nagasue, N; Ono, T; Onoda, T; Yamanoi, A, 2004) |
| "In the present study, human oral squamous cell carcinoma (OSCC) cell lines NA and HSC-4 were used to evaluate the effects of NS-398, a selective inhibitor of COX-2, and COX-2 antisense oligonucleotide (COX-2 AS) on the invasion activity of OSCC cells." | 1.32 | Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44. ( Hatori, M; Ito, D; Ito, H; Kinugasa, Y; Kurihara, Y; Nagumo, M, 2004) |
| "DU-145 and PC-3 human prostate cancer cell lines were used to test the effect of inhibitors of PLA2, COX, or LOX on the invasion of prostate tumor cells through Matrigel in vitro using the Boyden chamber assay and fibroblast-conditioned medium as the chemoattractant." | 1.31 | Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. ( Attiga, FA; Fernandez, PM; Manyak, MJ; Patierno, SR; Weeraratna, AT, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (56.52) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Zhang, X | 1 |
| Feng, L | 1 |
| Lemay, R | 1 |
| Lepage, M | 1 |
| Tremblay, L | 1 |
| Therriault, H | 1 |
| Charest, G | 1 |
| Paquette, B | 1 |
| Dinicola, S | 1 |
| Masiello, MG | 1 |
| Proietti, S | 1 |
| Coluccia, P | 1 |
| Fabrizi, G | 1 |
| Catizone, A | 1 |
| Ricci, G | 1 |
| de Toma, G | 1 |
| Bizzarri, M | 1 |
| Cucina, A | 1 |
| Lin, J | 1 |
| Wu, H | 1 |
| Shi, H | 1 |
| Pan, W | 1 |
| Yu, H | 1 |
| Zhu, J | 1 |
| Qiu, X | 1 |
| Cheng, JC | 1 |
| Chang, HM | 1 |
| Leung, PC | 1 |
| Liu, H | 1 |
| Xu, XF | 1 |
| Zhao, Y | 1 |
| Tang, MC | 1 |
| Zhou, YQ | 1 |
| Gao, FH | 1 |
| Li, Z | 1 |
| You, K | 1 |
| Li, J | 1 |
| Wang, Y | 1 |
| Xu, H | 1 |
| Gao, B | 1 |
| Wang, J | 1 |
| Ding, Q | 1 |
| Bai, YF | 1 |
| Wang, YQ | 1 |
| An, RH | 1 |
| Silva, HC | 1 |
| Alves, V | 1 |
| Nogueira, LA | 1 |
| Rosa, MS | 1 |
| Carvalho, L | 1 |
| Regateiro, F | 1 |
| Liu, Y | 1 |
| Liu, BA | 1 |
| Nithipatikom, K | 1 |
| Isbell, MA | 1 |
| Lindholm, PF | 1 |
| Kajdacsy-Balla, A | 1 |
| Kaul, S | 1 |
| Campell, WB | 1 |
| Yao, M | 1 |
| Lam, EC | 1 |
| Kelly, CR | 1 |
| Zhou, W | 1 |
| Wolfe, MM | 1 |
| Onoda, T | 1 |
| Ono, T | 1 |
| Dhar, DK | 1 |
| Yamanoi, A | 1 |
| Fujii, T | 1 |
| Nagasue, N | 1 |
| Holzer, RG | 1 |
| Ryan, RE | 1 |
| Tommack, M | 1 |
| Schlekeway, E | 1 |
| Jorcyk, CL | 1 |
| Jia, XQ | 1 |
| Zhong, N | 1 |
| Han, LH | 1 |
| Wang, JH | 1 |
| Yan, M | 1 |
| Meng, FL | 1 |
| Zhang, SZ | 1 |
| Kinugasa, Y | 1 |
| Hatori, M | 1 |
| Ito, H | 1 |
| Kurihara, Y | 1 |
| Ito, D | 1 |
| Nagumo, M | 1 |
| Nystrom, ML | 1 |
| McCulloch, D | 1 |
| Weinreb, PH | 1 |
| Violette, SM | 1 |
| Speight, PM | 1 |
| Marshall, JF | 1 |
| Hart, IR | 1 |
| Thomas, GJ | 1 |
| Lee, EJ | 1 |
| Choi, EM | 1 |
| Kim, SR | 1 |
| Park, JH | 1 |
| Kim, H | 1 |
| Ha, KS | 1 |
| Kim, YM | 1 |
| Kim, SS | 1 |
| Choe, M | 1 |
| Kim, JI | 1 |
| Han, JA | 1 |
| Pan, MR | 1 |
| Chang, HC | 1 |
| Chuang, LY | 1 |
| Hung, WC | 1 |
| Attiga, FA | 1 |
| Fernandez, PM | 1 |
| Weeraratna, AT | 1 |
| Manyak, MJ | 1 |
| Patierno, SR | 1 |
| Joki, T | 1 |
| Heese, O | 1 |
| Nikas, DC | 1 |
| Bello, L | 1 |
| Zhang, J | 1 |
| Kraeft, SK | 1 |
| Seyfried, NT | 1 |
| Abe, T | 1 |
| Chen, LB | 1 |
| Carroll, RS | 1 |
| Black, PM | 1 |
| Denkert, C | 1 |
| Köbel, M | 1 |
| Berger, S | 1 |
| Siegert, A | 1 |
| Leclere, A | 1 |
| Trefzer, U | 1 |
| Hauptmann, S | 1 |
| Abiru, S | 1 |
| Nakao, K | 1 |
| Ichikawa, T | 1 |
| Migita, K | 1 |
| Shigeno, M | 1 |
| Sakamoto, M | 1 |
| Ishikawa, H | 1 |
| Hamasaki, K | 1 |
| Nakata, K | 1 |
| Eguchi, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Double Blind, Placebo Controlled Trial of Doxycycline in Lymphangioleiomyomatosis.[NCT00989742] | Phase 4 | 24 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| A Prospective Randomized Control Trial of the Effect of Sorafenib Combined With Aspirin in Preventing the Recurrence in High-risk Patients With Hepatocellular Carcinoma[NCT02748304] | 52 participants (Actual) | Interventional | 2016-04-30 | Terminated (stopped due to The enrollment of this study was slow. With the approval of lenvatinib in HCC,many patients choose the new drug, so subsequent enrollment may be more difficult.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Ghrelin Regulates Cyclooxygenase-2 Expression and Promotes Gastric Cancer Cell Progression.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Computational Biology; Cyclooxygenase 2; Cyclooxygenase | 2021 |
Tumor Cell Invasion Induced by Radiation in Balb/C Mouse is Prevented by the Cox-2 Inhibitor NS-398.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cyclooxygenase 2 Inhibitors; Drug Screening Assays, Antitu | 2017 |
Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement.
Topics: Antigens, CD; Antineoplastic Agents; beta Catenin; Caco-2 Cells; Cadherins; Carcinogens; Cell Moveme | 2018 |
Combined inhibition of epidermal growth factor receptor and cyclooxygenase-2 leads to greater anti-tumor activity of docetaxel in advanced prostate cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Proliferation; Cyclooxygen | 2013 |
COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion.
Topics: Cadherins; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regul | 2014 |
NS-398 promotes pancreatic cancer cell invasion by CD147 and MMP-2 via the activation of P38.
Topics: Basigin; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Humans; Imidazoles; MAP Kinase Sig | 2016 |
Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Centella; Cyclooxygenase 2; Di | 2016 |
TGF-beta1 reverses inhibition of COX-2 with NS398 and increases invasion in prostate cancer cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; D | 2010 |
Impairment of breast cancer cell invasion by COX-2-specific inhibitor NS398: roles of CXCR4 and of uPA system.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cyclooxygenase 2; Cyclooxygenase Inhib | 2012 |
Enhanced proliferation, invasion, and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin.
Topics: Animals; Apoptosis; Cell Adhesion Molecules; Cell Dedifferentiation; Cell Line, Tumor; Cyclooxygenas | 2011 |
Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion.
Topics: 6-Ketoprostaglandin F1 alpha; Adenocarcinoma; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; | 2002 |
Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer.
Topics: Animals; Blotting, Western; Cell Division; Cell Movement; Colorectal Neoplasms; Cyclooxygenase 2; Cy | 2004 |
Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells.
Topics: Adenocarcinoma; Anti-Bacterial Agents; Apoptosis; Blotting, Western; Cell Division; Cell Line, Tumor | 2004 |
Oncostatin M stimulates the detachment of a reservoir of invasive mammary carcinoma cells: role of cyclooxygenase-2.
Topics: Adenocarcinoma; Animals; Cell Adhesion; Cell Line, Tumor; Collagen; Contraindications; Cyclooxygenas | 2004 |
Effect of NS-398 on colon cancer cells.
Topics: Actins; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2005 |
Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44.
Topics: Carcinoma, Squamous Cell; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloox | 2004 |
Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cell | 2006 |
Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells.
Topics: Bone Neoplasms; Celecoxib; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenase 2; Cy | 2007 |
The nonsteroidal anti-inflammatory drug NS398 reactivates SPARC expression via promoter demethylation to attenuate invasiveness of lung cancer cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransfer | 2008 |
Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
Topics: 3T3 Cells; Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cell M | 2000 |
Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398.
Topics: Adult; Animals; Apoptosis; Astrocytoma; Brain; Brain Neoplasms; Cell Division; Cell Movement; Cocult | 2000 |
Expression of cyclooxygenase 2 in human malignant melanoma.
Topics: Biocompatible Materials; Cell Division; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyc | 2001 |
Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma, Hepatocellular; Cyclooxygenase 2; Cyclo | 2002 |