n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Inflammation in 53 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, a series of novel thiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives bearing naproxen was synthesized and evaluated for their in vivo analgesic and anti-inflammatory properties in acute experimental pain and inflammation models." | 3.81 | Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies. ( Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A, 2015) |
| " Inflammation was assessed by measurement of nitrites (nitrite, a breakdown product of nitric oxide), prostaglandin-E(2) levels and cellular infiltration in the pouch fluid exudates." | 3.76 | Modulation of the cyclooxygenase pathway via inhibition of nitric oxide production contributes to the anti-inflammatory activity of kaempferol. ( Adhyapak, AA; Ashfaque, SM; Benade, VS; Hebballi, V; Khan, FR; Kulkarni, NM; Mahat, MY; Patil, BM; Thippeswamy, BS; Tubachi, S; Vishwakarma, SL, 2010) |
| " The finding that LSS-dependent reduction of TNF-alpha generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398, the nonselective COX inhibitor aspirin, or the specific prostacyclin receptor (IP) antagonist RO3244794 illuminates the central role played by LSS-induced COX-2-dependent prostacyclin in restraining endothelial inflammation." | 3.75 | Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. ( Dercho, RA; Di Francesco, A; Di Francesco, L; Dovizio, M; Evangelista, V; Pandolfi, A; Patrignani, P; Piccoli, A; Salvatore, T; Seta, F; Totani, L, 2009) |
| " In contrast, levels of prostaglandin D2, and 15deoxy delta(12-14)prostaglandin J2 were high at 2 hours, decreased as inflammation increased, but were increased again at 48 hours." | 3.70 | Inducible cyclooxygenase may have anti-inflammatory properties. ( Chivers, J; Colville-Nash, PR; Gilroy, DW; Paul-Clark, MJ; Willis, D; Willoughby, DA, 1999) |
| "It is known that cerebral ischemia can cause brain inflammation and adiposome can serve as a depot of inflammatory mediators." | 1.51 | Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke. ( Chang, YJ; Hsu, SL; Hsueh, CM; Liao, LY; Lin, CH; Tung, CW; Yang, TY, 2019) |
| "Postoperative cerebral edema is a devastating complication in neurosurgical patients." | 1.46 | Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury. ( Gren, ECK; Hayes, WK; Kelln, W; Kim, CH; Lekic, T; McBride, DW; Person, CE; Sherchan, P; Tang, J; Zhang, JH, 2017) |
| "In the KA-induced seizure model, i." | 1.42 | Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. ( Chan, JY; Chang, AY; Chao, YM; Ho, YH; Lin, YT; Wu, CW, 2015) |
| "Treatment with valdecoxib (5 or 10 mg/kg, p." | 1.37 | Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice. ( Gupta, A; Kulkarni, SK; Kumar, A, 2011) |
| "Inflammation is a physiological response to tissue trauma or infection, but leukocytes, which are the effector cells of the inflammatory process, have powerful tissue remodelling capabilities." | 1.35 | Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. ( Calder, PC; Grimble, RF; Madden, J; Maskrey, BH; Nash, GB; O'Donnell, VB; Rainger, GE; Tull, SP; Yates, CM, 2009) |
| "Pretreatment with indomethacin completely reversed both of the therapeutic effects of dalteparin, whereas pretreatment with NS-398, a selective inhibitor of cyclooxygenase-2, did not." | 1.33 | Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats. ( Harada, N; Okajima, K; Uchiba, M, 2006) |
| "Inflammation is often accompanied with hyperalgesia." | 1.32 | Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia. ( Ibuki, T; Kobayashi, S; Matsumura, K; Nozaki, T; Tanaka, Y; Yamazaki, Y, 2003) |
| "Following trauma, increased prostaglandin E2 (PGE2) levels may be important in immunodysregulation." | 1.31 | Blocking prostaglandin E2 after trauma attenuates pro-inflammatory cytokines and improves survival. ( Concannon, EM; Daly, JM; Mackrell, PJ; Naama, HA; Schaefer, PA; Shaftan, GW; Stapleton, PP; Strong, VE, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (11.32) | 18.2507 |
| 2000's | 23 (43.40) | 29.6817 |
| 2010's | 23 (43.40) | 24.3611 |
| 2020's | 1 (1.89) | 2.80 |
| Authors | Studies |
|---|---|
| Molina, P | 1 |
| Tárraga, A | 1 |
| Gonzalez-Tejero, A | 1 |
| Rioja, I | 1 |
| Ubeda, A | 1 |
| Terencio, MC | 1 |
| Alcaraz, MJ | 1 |
| Tran, TD | 1 |
| Park, H | 1 |
| Kim, HP | 2 |
| Ecker, GF | 1 |
| Thai, KM | 1 |
| Wiegard, A | 1 |
| Hanekamp, W | 1 |
| Griessbach, K | 1 |
| Fabian, J | 1 |
| Lehr, M | 1 |
| Kang, SM | 1 |
| Lee, J | 1 |
| Jin, JH | 1 |
| Kim, M | 1 |
| Lee, S | 2 |
| Lee, HH | 2 |
| Shin, JS | 2 |
| Lee, KT | 3 |
| Lee, JY | 1 |
| Sarigol, D | 1 |
| Uzgoren-Baran, A | 1 |
| Tel, BC | 1 |
| Somuncuoglu, EI | 1 |
| Kazkayasi, I | 1 |
| Ozadali-Sari, K | 1 |
| Unsal-Tan, O | 1 |
| Okay, G | 1 |
| Ertan, M | 1 |
| Tozkoparan, B | 1 |
| Farag, AK | 1 |
| Elkamhawy, A | 1 |
| Londhe, AM | 1 |
| Pae, AN | 1 |
| Roh, EJ | 1 |
| Marín-Ocampo, L | 1 |
| Veloza, LA | 1 |
| Abonia, R | 1 |
| Sepúlveda-Arias, JC | 1 |
| Hassan, AHE | 1 |
| Yoo, SY | 1 |
| Lee, KW | 1 |
| Yoon, YM | 1 |
| Ryu, HW | 1 |
| Jeong, Y | 1 |
| Kang, SY | 1 |
| Kim, SY | 1 |
| Park, BY | 1 |
| Lee, YS | 1 |
| Qi, Z | 1 |
| Lan, C | 1 |
| Xiaofang, J | 1 |
| Juanjuan, T | 1 |
| Cheng, F | 1 |
| Ting, H | 1 |
| Erxia, S | 1 |
| Zi, L | 1 |
| Labrecque, J | 1 |
| Michaud, A | 1 |
| Gauthier, MF | 1 |
| Pelletier, M | 1 |
| Julien, F | 1 |
| Bouvet-Bouchard, L | 1 |
| Tchernof, A | 1 |
| Lin, CH | 1 |
| Liao, LY | 1 |
| Yang, TY | 1 |
| Chang, YJ | 1 |
| Tung, CW | 1 |
| Hsu, SL | 1 |
| Hsueh, CM | 1 |
| Morell, M | 1 |
| Camprubí-Robles, M | 1 |
| Culler, MD | 1 |
| de Lecea, L | 1 |
| Delgado, M | 1 |
| Ho, YH | 1 |
| Lin, YT | 1 |
| Wu, CW | 1 |
| Chao, YM | 1 |
| Chang, AY | 1 |
| Chan, JY | 1 |
| Totoson, P | 1 |
| Maguin-Gaté, K | 1 |
| Nappey, M | 1 |
| Wendling, D | 1 |
| Demougeot, C | 1 |
| Ou, HL | 1 |
| Sun, D | 1 |
| Peng, YC | 1 |
| Wu, YL | 1 |
| Kohi, S | 1 |
| Sato, N | 2 |
| Koga, A | 1 |
| Matayoshi, N | 1 |
| Hirata, K | 1 |
| Kim, CH | 1 |
| McBride, DW | 1 |
| Sherchan, P | 1 |
| Person, CE | 1 |
| Gren, ECK | 1 |
| Kelln, W | 1 |
| Lekic, T | 2 |
| Hayes, WK | 1 |
| Tang, J | 2 |
| Zhang, JH | 2 |
| Di Francesco, L | 1 |
| Totani, L | 1 |
| Dovizio, M | 1 |
| Piccoli, A | 1 |
| Di Francesco, A | 1 |
| Salvatore, T | 1 |
| Pandolfi, A | 1 |
| Evangelista, V | 1 |
| Dercho, RA | 1 |
| Seta, F | 1 |
| Patrignani, P | 1 |
| Tull, SP | 1 |
| Yates, CM | 1 |
| Maskrey, BH | 1 |
| O'Donnell, VB | 1 |
| Madden, J | 1 |
| Grimble, RF | 1 |
| Calder, PC | 1 |
| Nash, GB | 1 |
| Rainger, GE | 1 |
| Fathali, N | 1 |
| Ostrowski, RP | 1 |
| Jadhav, V | 1 |
| Tong, W | 1 |
| Strauss, KI | 1 |
| Chan, MM | 1 |
| Moore, AR | 2 |
| Mahat, MY | 1 |
| Kulkarni, NM | 1 |
| Vishwakarma, SL | 1 |
| Khan, FR | 1 |
| Thippeswamy, BS | 1 |
| Hebballi, V | 1 |
| Adhyapak, AA | 1 |
| Benade, VS | 1 |
| Ashfaque, SM | 1 |
| Tubachi, S | 1 |
| Patil, BM | 1 |
| Lin, IC | 1 |
| Kuo, CD | 1 |
| Järvelä, JT | 1 |
| Ruohonen, S | 1 |
| Kukko-Lukjanov, TK | 1 |
| Plysjuk, A | 1 |
| Lopez-Picon, FR | 1 |
| Holopainen, IE | 1 |
| Gupta, A | 1 |
| Kumar, A | 1 |
| Kulkarni, SK | 1 |
| Yang, C | 1 |
| Ling, H | 1 |
| Zhang, M | 1 |
| Yang, Z | 1 |
| Wang, X | 1 |
| Zeng, F | 1 |
| Wang, C | 1 |
| Feng, J | 1 |
| Gong, W | 1 |
| Zhang, JL | 1 |
| Yan, XJ | 1 |
| Zhou, Q | 1 |
| Wang, ZY | 1 |
| Yi, TN | 1 |
| Paris, D | 1 |
| Townsend, KP | 1 |
| Obregon, DF | 1 |
| Humphrey, J | 1 |
| Mullan, M | 1 |
| Ibuki, T | 1 |
| Matsumura, K | 1 |
| Yamazaki, Y | 1 |
| Nozaki, T | 1 |
| Tanaka, Y | 1 |
| Kobayashi, S | 1 |
| Isoda, K | 1 |
| Koide, H | 1 |
| Kojima, M | 1 |
| Arita, E | 1 |
| Ikkaku, M | 1 |
| Higashiyama, S | 1 |
| Tashiro, F | 1 |
| Yamato, E | 1 |
| Miyazaki, J | 1 |
| Kawase, M | 1 |
| Yagi, K | 1 |
| Kim, H | 1 |
| Rhee, SH | 1 |
| Kokkotou, E | 1 |
| Na, X | 1 |
| Savidge, T | 1 |
| Moyer, MP | 1 |
| Pothoulakis, C | 1 |
| LaMont, JT | 1 |
| Sheu, ML | 1 |
| Chao, KF | 1 |
| Sung, YJ | 1 |
| Lin, WW | 1 |
| Lin-Shiau, SY | 1 |
| Liu, SH | 1 |
| Ferrario, A | 1 |
| Fisher, AM | 1 |
| Rucker, N | 1 |
| Gomer, CJ | 1 |
| Kozar, RA | 1 |
| Zou, L | 1 |
| Weatherall, JM | 1 |
| Attuwaybi, B | 1 |
| Moore-Olufemi, SD | 1 |
| Weisbrodt, NW | 1 |
| Moore, FA | 1 |
| Colville-Nash, PR | 2 |
| Gilroy, DW | 2 |
| Willis, D | 2 |
| Paul-Clark, MJ | 2 |
| Willoughby, DA | 2 |
| Blais, V | 1 |
| Turrin, NP | 1 |
| Rivest, S | 1 |
| Ha, H | 1 |
| Lee, JH | 1 |
| Kim, HN | 1 |
| Kim, HM | 1 |
| Kwak, HB | 1 |
| Kim, HH | 1 |
| Lee, ZH | 1 |
| Harada, N | 1 |
| Okajima, K | 1 |
| Uchiba, M | 1 |
| Sharma-Walia, N | 1 |
| Raghu, H | 1 |
| Sadagopan, S | 1 |
| Sivakumar, R | 1 |
| Veettil, MV | 1 |
| Naranatt, PP | 1 |
| Smith, MM | 1 |
| Chandran, B | 1 |
| Flora, G | 1 |
| Pu, H | 1 |
| Hennig, B | 1 |
| Toborek, M | 1 |
| Huang, CC | 1 |
| Chen, PC | 1 |
| Huang, CW | 1 |
| Yu, J | 1 |
| Mathias, JR | 1 |
| Dodd, ME | 1 |
| Walters, KB | 1 |
| Rhodes, J | 1 |
| Kanki, JP | 1 |
| Look, AT | 1 |
| Huttenlocher, A | 1 |
| Li, W | 1 |
| Liu, Y | 1 |
| Mukhtar, MM | 1 |
| Gong, R | 1 |
| Pan, Y | 1 |
| Rasool, ST | 1 |
| Gao, Y | 1 |
| Kang, L | 1 |
| Hao, Q | 1 |
| Peng, G | 1 |
| Chen, Y | 1 |
| Chen, X | 1 |
| Wu, J | 1 |
| Zhu, Y | 1 |
| Masferrer, JL | 1 |
| Zweifel, BS | 1 |
| Manning, PT | 1 |
| Hauser, SD | 1 |
| Leahy, KM | 1 |
| Smith, WG | 1 |
| Isakson, PC | 1 |
| Seibert, K | 1 |
| Futaki, N | 1 |
| Arai, I | 1 |
| Hamasaka, Y | 1 |
| Takahashi, S | 1 |
| Higuchi, S | 1 |
| Otomo, S | 1 |
| Harada, Y | 1 |
| Hatanaka, K | 1 |
| Kawamura, M | 1 |
| Saito, M | 1 |
| Ogino, M | 1 |
| Majima, M | 1 |
| Ohno, T | 1 |
| Ogino, K | 1 |
| Yamamoto, K | 1 |
| Taketani, Y | 1 |
| Yamamoto, S | 1 |
| Katori, M | 1 |
| Niki, H | 2 |
| Tominaga, Y | 1 |
| Watanabe-Kobayashi, M | 1 |
| Mue, S | 1 |
| Ohuchi, K | 2 |
| Hamilton, LC | 1 |
| Mitchell, JA | 1 |
| Tomlinson, AM | 1 |
| Warner, TD | 1 |
| Chivers, J | 1 |
| Strong, VE | 1 |
| Mackrell, PJ | 1 |
| Concannon, EM | 1 |
| Naama, HA | 1 |
| Schaefer, PA | 1 |
| Shaftan, GW | 1 |
| Stapleton, PP | 1 |
| Daly, JM | 1 |
| Ghosh, AK | 1 |
| Hirasawa, N | 1 |
| Kwak, WJ | 1 |
| Han, CK | 1 |
| Son, KH | 1 |
| Chang, HW | 1 |
| Kang, SS | 1 |
| Park, BK | 1 |
1 review available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Inflammation
| Article | Year |
|---|---|
Anti-inflammatory activity of triazine derivatives: A systematic review.
Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Structure-Activity Relationship; Triazines | 2019 |
52 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Inflammation
| Article | Year |
|---|---|
Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives.
Topics: Alkaloids; Animals; Brassicaceae; Cells, Cultured; Chromatography, Thin Layer; Dinoprostone; Free Ra | 2001 |
Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.
Topics: Animals; Cell Line; Chalcone; Chalcones; Chemistry, Pharmaceutical; Cyclooxygenase 2; Dinoprostone; | 2009 |
Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1.
Topics: Cell Line, Tumor; Enzyme Inhibitors; Humans; Inflammation; Inhibitory Concentration 50; Intramolecul | 2012 |
Synthesis and PGE₂ production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells.
Topics: Animals; Dinoprostone; Inflammation; Intramolecular Oxidoreductases; Macrophages; Mice; Prostaglandi | 2014 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; D | 2015 |
Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Survival; Dose-Respons | 2017 |
Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Discovery; | 2019 |
Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation.
Topics: Animals; Cyclooxygenase 2; Dinoprostone; Immunity; Inflammation; Liver; Mice; Mice, Inbred C57BL; Ni | 2022 |
Interleukin-1β and prostaglandin-synthesizing enzymes as modulators of human omental and subcutaneous adipose tissue function.
Topics: Adipocytes; Adipogenesis; Aldehyde Reductase; Cell Differentiation; Cyclooxygenase 2; Cyclooxygenase | 2019 |
Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke.
Topics: Anilides; Animals; Animals, Newborn; Brain Ischemia; Cell Death; Culture Media, Serum-Free; Cyclooxy | 2019 |
Cortistatin attenuates inflammatory pain via spinal and peripheral actions.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Disease Models, Anima | 2014 |
Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.
Topics: Animals; Cyclic N-Oxides; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammation; Interleukin-1b | 2015 |
Endothelial Dysfunction in Rheumatoid Arthritis: Mechanistic Insights and Correlation with Circulating Markers of Systemic Inflammation.
Topics: Acetylcholine; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Chemokines; Cycl | 2016 |
Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1β-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells.
Topics: Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Gene Expression Regu | 2016 |
KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer.
Topics: Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation | 2017 |
Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury.
Topics: Animals; Body Water; Brain; Brain Edema; Crotalus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Di | 2017 |
Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Atherosclerosis; Benzofurans; Cells, Cultured; Cyclooxygenase | 2009 |
Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment.
Topics: Cell Adhesion; Cells, Cultured; Chemokine CCL2; Chemokine CXCL1; Chemokine CXCL2; Chromatography, Li | 2009 |
Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury.
Topics: Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Body Weight; Brain; Cyclooxygenase 2 | 2010 |
COX2 inhibitors for acquired brain injuries: is the time ripe?
Topics: Animals; Animals, Newborn; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Hypoxia-Isc | 2010 |
Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyclooxygenase Inhibitors | 2010 |
Modulation of the cyclooxygenase pathway via inhibition of nitric oxide production contributes to the anti-inflammatory activity of kaempferol.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colchicine; Dexamethasone; Dinoprostone; Exudates an | 2010 |
Pro-inflammatory effects of commercial alpha-lactalbumin on RAW 264.7 macrophages is due to endotoxin contamination.
Topics: Animals; Blotting, Western; Cell Survival; Cyclooxygenase 2; Dinoprostone; Drug Contamination; Endot | 2010 |
Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death.
Topics: Animals; Cell Culture Techniques; Cell Death; Cyclooxygenase 2 Inhibitors; Dinoprostone; Excitatory | 2011 |
Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Catatonia; Cyclooxygenase 2 Inhibitors; | 2011 |
Oxidative stress mediates chemical hypoxia-induced injury and inflammation by activating NF-κb-COX-2 pathway in HaCaT cells.
Topics: Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; | 2011 |
Lipopolysaccharide initiates a bypass feedback loop of epidermal growth factor receptor signaling by HPS70-induced COX-2 in H22 hepatocarcinoma cells.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclooxygenase | 2011 |
Pro-inflammatory effect of freshly solubilized beta-amyloid peptides in the brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cattle; Cells, Cultured; Cyclooxygenase 2; | 2002 |
Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia.
Topics: Animals; Brain; Carrageenan; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; | 2003 |
Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPbeta gene.
Topics: Adenoviridae; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromodeoxyuridine; Carbon | 2005 |
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.
Topics: Animals; Bacterial Toxins; Cell Line; Colon; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Dose-Respon | 2005 |
Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the up-regulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chromones; Cyclooxygenase 2; Dose-Response Relationshi | 2005 |
Celecoxib and NS-398 enhance photodynamic therapy by increasing in vitro apoptosis and decreasing in vivo inflammatory and angiogenic factors.
Topics: Animals; Apoptosis; Celecoxib; Cyclooxygenase Inhibitors; Dihematoporphyrin Ether; Dinoprostone; Dru | 2005 |
Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion.
Topics: Active Transport, Cell Nucleus; Animals; Cell Nucleus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyg | 2005 |
Prostaglandin F2alpha produced by inducible cyclooxygenase may contribute to the resolution of inflammation.
Topics: Analysis of Variance; Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprost; Inflammation; | 2005 |
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli.
Topics: Animals; Blood-Brain Barrier; Brain; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase I | 2005 |
alpha-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis.
Topics: Animals; Antioxidants; Blotting, Western; Bone and Bones; Bone Marrow Cells; Bone Resorption; Carrie | 2006 |
Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anticoagulants; Calcium; Cyclooxygenase 2 Inhibitors; Daltepa | 2006 |
Cyclooxygenase 2 induced by Kaposi's sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression.
Topics: Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial | 2006 |
Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain.
Topics: Animals; Astrocytes; Brain; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, | 2006 |
Aristolochic Acid induces heart failure in zebrafish embryos that is mediated by inflammation.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aristolochic Acids; Cyclooxygenase 2; Cyclooxygen | 2007 |
Live imaging of chronic inflammation caused by mutation of zebrafish Hai1.
Topics: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Epit | 2007 |
Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection.
Topics: Adult; Aspirin; Cell Line, Tumor; Cytokines; Female; Humans; Inflammation; Influenza A virus; Interl | 2008 |
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dexa | 1994 |
Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation.
Topics: 6-Ketoprostaglandin F1 alpha; Air Sacs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageena | 1993 |
Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Azo Compounds; Blotting, Western; C | 1996 |
Possible participation of cyclooxygenase-2 in the recurrence of allergic inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cycloo | 1997 |
Synergy between cyclo-oxygenase-2 induction and arachidonic acid supply in vivo: consequences for nonsteroidal antiinflammatory drug efficacy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Celecoxib; Cyclooxygenase 2; Cyc | 1999 |
Inducible cyclooxygenase may have anti-inflammatory properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; C | 1999 |
Blocking prostaglandin E2 after trauma attenuates pro-inflammatory cytokines and improves survival.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cyclooxygenase 2; Cyclooxygenase 2 In | 2000 |
Cyclooxygenase-2-mediated angiogenesis in carrageenin-induced granulation tissue in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen | 2000 |
Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation.
Topics: Animals; Biflavonoids; Blotting, Western; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dinoproston | 2002 |