n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Gastric Ulcer in 22 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanism of indomethacin-induced gastric ulcer healing by ellagic acid (EA) in experimental mice model is described in our study." | 7.78 | Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation. ( Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Chattopadhyay, S; Das, S; Saha, A, 2012) |
| "To investigate the possible role of cyclooxygenase-2 (COX-2) inhibitor NS-398 in formation and healing of acetic acid-induced gastric ulcer in rats." | 7.71 | [Effects of cyclooxygenase-2 on formation and healing of acetic acid-induced gastric ulcer in rats]. ( Shen, X, 2001) |
| " at an effective anti-inflammatory dose to rats with pre-existing acetic acid-induced gastric ulcer, NS-398 caused a statistically significant delay of ulcer healing." | 7.70 | Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats. ( Dyer, RD; Gilbertsen, RB; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B; Schrier, D; Song, Y, 1998) |
| "The mechanism of indomethacin-induced gastric ulcer healing by ellagic acid (EA) in experimental mice model is described in our study." | 3.78 | Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation. ( Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Chattopadhyay, S; Das, S; Saha, A, 2012) |
| "To investigate the possible role of cyclooxygenase-2 (COX-2) inhibitor NS-398 in formation and healing of acetic acid-induced gastric ulcer in rats." | 3.71 | [Effects of cyclooxygenase-2 on formation and healing of acetic acid-induced gastric ulcer in rats]. ( Shen, X, 2001) |
| "To elucidate the role of cyclooxygenase (COX)-2 in ulcer healing, we compared the effects of NS-398 (COX-2-selective inhibitor) and indomethacin (nonselective COX inhibitor) on the healing of acetic acid-induced gastric ulcers in rats." | 3.70 | Role of cyclooxygenase-2 in the healing of gastric ulcers in rats. ( Okabe, S; Shigeta, J; Takahashi, S, 1998) |
| "Effects of selective cyclooxygenase-2 (COX-2) inhibitors (NS-398) and nitric oxide (NO) -releasing aspirin (NO-ASA) on gastric ulcerogenic and healing responses were examined in comparison with nonselective COX inhibitors such as indomethacin and aspirin (ASA)." | 3.70 | Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach. ( Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1998) |
| " at an effective anti-inflammatory dose to rats with pre-existing acetic acid-induced gastric ulcer, NS-398 caused a statistically significant delay of ulcer healing." | 3.70 | Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats. ( Dyer, RD; Gilbertsen, RB; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B; Schrier, D; Song, Y, 1998) |
| "Both, nitric oxide-releasing aspirin and naproxen dose-dependently attenuated ethanol-induced damage and produced a significant rise in gastric blood flow but did not delay healing of gastric ulcers while native aspirin and naproxen had no influence on ethanol-induced gastric damage but significantly prolonged ulcer healing, reduced gastric blood flow and suppressed mucosal generation of prostaglandin E2." | 3.70 | Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs. ( Brzozowski, T; Drozdowicz, D; Hahn, E; Konturek, PC; Konturek, SJ; Kwiecień, S; Pajdo, R; Pawlik, M; Ptak, A; Sliwowski, Z, 2000) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| "In vehicle-treated rats, gastric ulcers healed progressively and at day 14 the healing was completed, accompanied by a significant rise in the GBF at ulcer margin." | 1.31 | Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. ( Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z, 2001) |
| "Since assessment of the acute gastrotoxicity of nonsteroidal antiinflammatory drugs (NSAIDs) in rats requires high doses of the drugs, we sought to establish an experimental model with which this adverse NSAID effect can be estimated at therapy-relevant doses." | 1.31 | Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses. ( Cabré, F; Holzer, P; Jocic, M; Mauléon, D, 2001) |
| "Pretreatment with indomethacin (10 mg kg[-1], s." | 1.30 | Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs. ( Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 9 (40.91) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, Y | 3 |
| Connor, DT | 2 |
| Doubleday, R | 2 |
| Sorenson, RJ | 2 |
| Sercel, AD | 2 |
| Unangst, PC | 2 |
| Roth, BD | 2 |
| Gilbertsen, RB | 3 |
| Chan, K | 2 |
| Schrier, DJ | 2 |
| Guglietta, A | 3 |
| Bornemeier, DA | 2 |
| Dyer, RD | 3 |
| Beylin, VG | 1 |
| Abdel-Aziz, M | 1 |
| Beshr, EA | 1 |
| Abdel-Rahman, IM | 1 |
| Ozadali, K | 1 |
| Tan, OU | 1 |
| Aly, OM | 1 |
| Chatterjee, A | 1 |
| Chatterjee, S | 1 |
| Das, S | 1 |
| Saha, A | 1 |
| Chattopadhyay, S | 1 |
| Bandyopadhyay, SK | 1 |
| Komori, M | 1 |
| Tsuji, S | 2 |
| Sun, WH | 2 |
| Tsujii, M | 2 |
| Kawai, N | 2 |
| Yasumaru, M | 2 |
| Kakiuchi, Y | 2 |
| Kimura, A | 2 |
| Sasaki, Y | 2 |
| Higashiyama, S | 1 |
| Kawano, S | 2 |
| Hori, M | 2 |
| Netzer, P | 1 |
| Halter, F | 1 |
| Ma, TY | 1 |
| Hoa, N | 1 |
| Nguyen, N | 1 |
| Nakamura, T | 1 |
| Tarnawski, AS | 1 |
| Futaki, N | 1 |
| Yoshikawa, K | 1 |
| Hamasaka, Y | 1 |
| Arai, I | 1 |
| Higuchi, S | 1 |
| Iizuka, H | 1 |
| Otomo, S | 1 |
| Mizuno, H | 1 |
| Sakamoto, C | 2 |
| Matsuda, K | 1 |
| Wada, K | 2 |
| Uchida, T | 1 |
| Noguchi, H | 1 |
| Akamatsu, T | 2 |
| Kasuga, M | 1 |
| Hirata, T | 1 |
| Ukawa, H | 2 |
| Yamakuni, H | 2 |
| Kato, S | 2 |
| Takeuchi, K | 3 |
| Shigeta, J | 1 |
| Takahashi, S | 1 |
| Okabe, S | 1 |
| Lesch, CA | 1 |
| Schrier, D | 1 |
| Kraus, ER | 1 |
| Sanchez, B | 1 |
| Horie-Sakata, K | 1 |
| Shimada, T | 1 |
| Hiraishi, H | 1 |
| Terano, A | 1 |
| Brzozowski, T | 3 |
| Konturek, PC | 3 |
| Konturek, SJ | 3 |
| Sliwowski, Z | 3 |
| Drozdowicz, D | 3 |
| Stachura, J | 1 |
| Pajdo, R | 3 |
| Hahn, EG | 2 |
| Godessart, N | 1 |
| Salcedo, C | 1 |
| Fernández, AG | 1 |
| Palacios, JM | 1 |
| Gunawan, ES | 1 |
| Iijima, H | 1 |
| Okuda, Y | 1 |
| Kwiecień, S | 1 |
| Ptak, A | 2 |
| Pawlik, M | 1 |
| Hahn, E | 1 |
| Araki, H | 1 |
| Umeda, M | 1 |
| Komoike, Y | 1 |
| Suzuki, K | 1 |
| Holzer, P | 1 |
| Jocic, M | 1 |
| Cabré, F | 1 |
| Mauléon, D | 1 |
| Shen, X | 1 |
| Miyake, K | 1 |
| Tsukui, T | 1 |
| Tatsuguchi, A | 1 |
| Futagami, S | 1 |
| Hiratsuka, T | 1 |
| Shinoki, K | 1 |
| Iizumi, T | 1 |
| Kobayashi, M | 1 |
22 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Gastric Ulcer
| Article | Year |
|---|---|
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cycl | 1999 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan | 1999 |
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.
Topics: Animals; Anisoles; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxyg | 2014 |
Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation.
Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors | 2012 |
Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats.
Topics: Animals; Antibodies; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibit | 2002 |
Interaction of hepatocyte growth factor and non-steroidal anti-inflammatory drugs during gastric epithelial wound healing.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Culture Techniques; Cell Division; Ce | 2003 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |
Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice.
Topics: Acetic Acid; Acids; Animals; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 | 1997 |
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas | 1997 |
Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.
Topics: Animals; Cyclooxygenase 2; Dinoprostone; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandi | 1998 |
Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclo | 1998 |
Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; C | 1998 |
Role of cyclooxygenase 2 in hepatocyte growth factor-mediated gastric epithelial restitution.
Topics: Animals; Cell Line; Cell Movement; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 1998 |
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 1999 |
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 1999 |
Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase 1; Cycl | 2000 |
Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclo | 2000 |
Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice.
Topics: Adaptation, Physiological; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; C | 2001 |
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cycloo | 2001 |
Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2001 |
[Effects of cyclooxygenase-2 on formation and healing of acetic acid-induced gastric ulcer in rats].
Topics: Acetic Acid; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dino | 2001 |
Irritant-induced cyclooxygenase-2 is involved in the defense mechanism of the gastric mucosa in mice.
Topics: Animals; Central Nervous System Depressants; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In | 2002 |