n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Edema in 20 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, a series of novel thiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives bearing naproxen was synthesized and evaluated for their in vivo analgesic and anti-inflammatory properties in acute experimental pain and inflammation models." | 3.81 | Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies. ( Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A, 2015) |
| "60 μmol/cm²) exhibited topical antiedematous properties comparable to those of indomethacin (ID₅₀ 0." | 3.77 | Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. ( Atanasov, AG; Bauer, J; Bauer, R; Baumgartner, L; Bodensieck, A; Dirsch, VM; Fakhrudin, N; Favero, GD; Heiss, EH; Ladurner, A; Loggia, RD; Ponti, C; Rollinger, JM; Schwaiger, S; Sosa, S; Stuppner, H; Tubaro, A; Werz, O; Widowitz, U, 2011) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| "Its role as a mediator of hyperalgesia (clinically defined as an augmented sensitivity to painful stimuli) is not known." | 1.35 | Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. ( Cuzzocrea, S; Di Paola, R; Esposito, E; Matuschak, GM; Mazzon, E; Ndengele, MM; Salvemini, D, 2008) |
| "Atopic dermatitis is a chronic inflammatory disease characterized by severe pruritus, and cutaneous barrier disruption by scratching contributes to further aggravation of the condition." | 1.34 | Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice. ( Arai, I; Futaki, N; Hashimoto, Y; Honma, Y; Nakaike, S; Sakurai, T; Sugimoto, M, 2007) |
| "Pretreatment with indomethacin completely reversed both of the therapeutic effects of dalteparin, whereas pretreatment with NS-398, a selective inhibitor of cyclooxygenase-2, did not." | 1.33 | Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats. ( Harada, N; Okajima, K; Uchiba, M, 2006) |
| "Pretreatment with indomethacin (10 mg kg[-1], s." | 1.30 | Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs. ( Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 10 (50.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, JJ | 1 |
| Anderson, GD | 1 |
| Burton, EG | 1 |
| Cogburn, JN | 1 |
| Collins, JT | 1 |
| Garland, DJ | 1 |
| Gregory, SA | 1 |
| Huang, HC | 1 |
| Isakson, PC | 1 |
| Koboldt, CM | 1 |
| Song, Y | 2 |
| Connor, DT | 2 |
| Doubleday, R | 2 |
| Sorenson, RJ | 2 |
| Sercel, AD | 2 |
| Unangst, PC | 2 |
| Roth, BD | 2 |
| Gilbertsen, RB | 2 |
| Chan, K | 2 |
| Schrier, DJ | 2 |
| Guglietta, A | 2 |
| Bornemeier, DA | 2 |
| Dyer, RD | 2 |
| Beylin, VG | 1 |
| Inagaki, M | 1 |
| Tsuri, T | 1 |
| Jyoyama, H | 1 |
| Ono, T | 1 |
| Yamada, K | 1 |
| Kobayashi, M | 1 |
| Hori, Y | 1 |
| Arimura, A | 1 |
| Yasui, K | 1 |
| Ohno, K | 1 |
| Kakudo, S | 1 |
| Koizumi, K | 1 |
| Suzuki, R | 1 |
| Kawai, S | 1 |
| Kato, M | 1 |
| Matsumoto, S | 1 |
| Molina, P | 1 |
| Aller, E | 1 |
| Lorenzo, A | 1 |
| López-Cremades, P | 1 |
| Rioja, I | 1 |
| Ubeda, A | 1 |
| Terencio, MC | 1 |
| Alcaraz, MJ | 2 |
| Baumgartner, L | 1 |
| Sosa, S | 1 |
| Atanasov, AG | 1 |
| Bodensieck, A | 1 |
| Fakhrudin, N | 1 |
| Bauer, J | 1 |
| Favero, GD | 1 |
| Ponti, C | 1 |
| Heiss, EH | 1 |
| Schwaiger, S | 1 |
| Ladurner, A | 1 |
| Widowitz, U | 1 |
| Loggia, RD | 1 |
| Rollinger, JM | 1 |
| Werz, O | 1 |
| Bauer, R | 1 |
| Dirsch, VM | 1 |
| Tubaro, A | 1 |
| Stuppner, H | 1 |
| Abdel-Aziz, M | 1 |
| Beshr, EA | 1 |
| Abdel-Rahman, IM | 1 |
| Ozadali, K | 1 |
| Tan, OU | 1 |
| Aly, OM | 1 |
| Sarigol, D | 1 |
| Uzgoren-Baran, A | 1 |
| Tel, BC | 1 |
| Somuncuoglu, EI | 1 |
| Kazkayasi, I | 1 |
| Ozadali-Sari, K | 1 |
| Unsal-Tan, O | 1 |
| Okay, G | 1 |
| Ertan, M | 1 |
| Tozkoparan, B | 1 |
| Devesa, I | 1 |
| Riguera, R | 1 |
| Ferrándiz, ML | 1 |
| Harada, N | 1 |
| Okajima, K | 1 |
| Uchiba, M | 1 |
| Pesce, C | 1 |
| Grattarola, M | 1 |
| Menini, S | 1 |
| Fiallo, P | 1 |
| Sugimoto, M | 2 |
| Arai, I | 3 |
| Futaki, N | 3 |
| Hashimoto, Y | 2 |
| Honma, Y | 2 |
| Nakaike, S | 2 |
| Guindon, J | 1 |
| LoVerme, J | 1 |
| De Léan, A | 1 |
| Piomelli, D | 1 |
| Beaulieu, P | 1 |
| Park, H | 1 |
| Kim, YH | 1 |
| Chang, HW | 1 |
| Kim, HP | 1 |
| Sakurai, T | 1 |
| Ndengele, MM | 1 |
| Cuzzocrea, S | 1 |
| Esposito, E | 1 |
| Mazzon, E | 1 |
| Di Paola, R | 1 |
| Matuschak, GM | 1 |
| Salvemini, D | 1 |
| Yoshikawa, K | 1 |
| Hamasaka, Y | 1 |
| Higuchi, S | 1 |
| Iizuka, H | 1 |
| Otomo, S | 1 |
| Huff, R | 1 |
| Collins, P | 1 |
| Kramer, S | 1 |
| Seibert, K | 1 |
| Koboldt, C | 1 |
| Gregory, S | 1 |
| Isakson, P | 1 |
| Buritova, J | 1 |
| Chapman, V | 1 |
| Honoré, P | 1 |
| Besson, JM | 1 |
| Hirata, T | 1 |
| Ukawa, H | 1 |
| Yamakuni, H | 1 |
| Kato, S | 1 |
| Takeuchi, K | 1 |
20 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Edema
| Article | Year |
|---|---|
1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyc | 1995 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cycl | 1999 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan | 1999 |
Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Blood Platelet | 2000 |
Solid-phase synthesis and inhibitory effects of some pyrido[1,2-c]pyrimidine derivatives on leukocyte formations and experimental inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; E | 2001 |
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Austria; Benzofurans; | 2011 |
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.
Topics: Animals; Anisoles; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxyg | 2014 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; D | 2015 |
A new pyrazolo pyrimidine derivative inhibitor of cyclooxygenase-2 with anti-angiogenic activity.
Topics: Angiogenesis Inhibitors; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloo | 2004 |
Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anticoagulants; Calcium; Cyclooxygenase 2 Inhibitors; Daltepa | 2006 |
Cyclooxygenase 2 expression in vessels and nerves in reversal reaction leprosy.
Topics: Blood Vessels; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Endothelium; Eosine Yellowish-( | 2006 |
COX-1 inhibition enhances scratching behaviour in NC/Nga mice with atopic dermatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carrageenan; Cyclooxygenase 1; | 2006 |
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Capsaicin; Chromatography, High | 2006 |
Anti-inflammatory activity of the synthetic C-C biflavonoids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biflavonoids; Blotting, Western; Carrageenan; Cell | 2006 |
Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2007 |
Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Synergism; | 2008 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |
A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2).
Topics: Animals; Cyclooxygenase Inhibitors; Edema; Humans; Isoenzymes; Male; Mice; Nitrobenzenes; Prostaglan | 1995 |
Selective cyclooxygenase-2 inhibition reduces carrageenan oedema and associated spinal c-Fos expression in the rat.
Topics: Animals; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Foot; Hind | 1996 |
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas | 1997 |