n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Disease Models, Animal in 68 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The COX-2 inhibitor celecoxib decreased neuronal excitability and prevented epileptogenesis in pilocarpine-induced status epilepticus rats." | 7.74 | Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats. ( Lei, GF; Liu, CX; Sun, RP; Yang, L; Zhang, HJ, 2008) |
| "To investigate the possible role of cyclooxygenase-2 (COX-2) inhibitor NS-398 in formation and healing of acetic acid-induced gastric ulcer in rats." | 7.71 | [Effects of cyclooxygenase-2 on formation and healing of acetic acid-induced gastric ulcer in rats]. ( Shen, X, 2001) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 5.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| " In this study, NS-398, a specific COX-2 inhibitor, and indomethacin, a COX-1 and COX-2 inhibitor, were administered 24 h after chloroform dosing to determine their effect on liver injury in Sprague-Dawley rats." | 5.32 | Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. ( Begay, CK; Gandolfi, AJ, 2003) |
| " In this study, a series of novel thiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives bearing naproxen was synthesized and evaluated for their in vivo analgesic and anti-inflammatory properties in acute experimental pain and inflammation models." | 3.81 | Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies. ( Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A, 2015) |
| "The COX-2 inhibitor celecoxib decreased neuronal excitability and prevented epileptogenesis in pilocarpine-induced status epilepticus rats." | 3.74 | Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats. ( Lei, GF; Liu, CX; Sun, RP; Yang, L; Zhang, HJ, 2008) |
| "In this study, using rat carrageenin-induced pleurisy, we found that treatment of rats with either indomethacin or NS-398 suppressed the pleurisy at 2 h but significantly exacerbated this reaction at 48 h." | 3.71 | Role of cyclopentenone prostaglandins in rat carrageenin pleurisy. ( Di Rosa, M; Ialenti, A; Ianaro, A; Maffia, P; Pisano, B, 2001) |
| "To investigate the possible role of cyclooxygenase-2 (COX-2) inhibitor NS-398 in formation and healing of acetic acid-induced gastric ulcer in rats." | 3.71 | [Effects of cyclooxygenase-2 on formation and healing of acetic acid-induced gastric ulcer in rats]. ( Shen, X, 2001) |
| "In this model of chronic inflammation, aspirin, more selective for the inhibition of COX-1 is more effective than the selective COX-2 inhibitors nimesulide and NS-398 at inhibiting granuloma dry weight, vascularity and COX activity." | 3.70 | Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation. ( Gilroy, DW; Tomlinson, A; Willoughby, DA, 1998) |
| "There are many parallels between ADPKD and clear-cell renal cell carcinoma (ccRCC); however, few studies have addressed the mechanisms linking them." | 1.62 | NS398 as a potential drug for autosomal-dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models. ( Chen, S; Fu, L; Huang, L; Mao, Z; Mei, C; Ruan, M; Xu, D; Yang, B; Zhang, Q; Zhou, S, 2021) |
| "Postoperative cerebral edema is a devastating complication in neurosurgical patients." | 1.46 | Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury. ( Gren, ECK; Hayes, WK; Kelln, W; Kim, CH; Lekic, T; McBride, DW; Person, CE; Sherchan, P; Tang, J; Zhang, JH, 2017) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 1.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "Lung cancer is frequently complicated by pulmonary infections which may impair prognosis of this disease." | 1.39 | Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation. ( Banat, GA; Dahlem, G; Eul, B; Fink, L; Goldmann, T; Grandel, U; Grimminger, F; Hattar, K; Lang, DS; Savai, R; Schermuly, RT; Schmall, A; Seeger, W; Sibelius, U; Subtil, FS; Vollmer, E; Wilhelm, J, 2013) |
| "Epileptic seizures drive expression of the blood-brain barrier efflux transporter P-glycoprotein via a glutamate/cyclooxygenase-2 mediated signalling pathway." | 1.36 | COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. ( Aronica, E; Edelbroek, PM; Gorter, JA; Holtman, L; Pekcec, A; Potschka, H; Schlichtiger, J; van Vliet, EA; Zibell, G, 2010) |
| "VEGF may play a role in ovarian cancer progression in the hen and the proliferation of ascites cells can be decreased by targeting the COX-1 but not COX-2 pathway." | 1.35 | VEGF expression and the effect of NSAIDs on ascites cell proliferation in the hen model of ovarian cancer. ( Giles, JR; Johnson, PA; Urick, ME, 2008) |
| " Pharmacological agents that inhibit COX-2 have been found to be neuroprotective in a number of injury models, and long-term administration of these drugs has been shown to induce plastic changes in the brain." | 1.34 | Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke. ( Kolb, B; Silasi, G, 2007) |
| " Platelet aggregation induced by ADP and dosing of prostanoid products 6-keto-PGF1alpha, TXB2, PGE2 and LTB4 were also performed." | 1.34 | Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. ( Aguejouf, O; Belon, P; Desplat, V; Doutremepuich, C; Eizayaga, FX, 2007) |
| "IL-1beta-induced hyperalgesia was blocked by pretreatment with IL-1 receptor antagonist." | 1.33 | Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats. ( Ahn, DK; Bae, YC; Chae, JM; Choi, HS; Kwon, OW; Kyung, HM; Park, HS; Youn, DH, 2005) |
| "Acute colitis is characterized by an extensive disturbance of microcirculation together with signs of systemic inflammatory response syndrome." | 1.33 | Selective COX-2 inhibition reduces leukocyte sticking and improves the microcirculation in TNBS colitis. ( Anderson, T; Buhr, HJ; Kruschewski, M; Loddenkemper, C, 2006) |
| "We studied the effects of inhibitors of COX-2 (NS398) and iNOS (aminoguanidine) alone or in combination with olfactory ensheathing cell (OEC) grafts after spinal cord injury in the rat." | 1.33 | Effects of COX-2 and iNOS inhibitors alone or in combination with olfactory ensheathing cell grafts after spinal cord injury. ( Casas, C; Forés, J; García-Alías, G; Guzmán-Lenis, MS; López-Vales, R; Navarro, X; Verdú, E, 2006) |
| " In this study, NS-398, a specific COX-2 inhibitor, and indomethacin, a COX-1 and COX-2 inhibitor, were administered 24 h after chloroform dosing to determine their effect on liver injury in Sprague-Dawley rats." | 1.32 | Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. ( Begay, CK; Gandolfi, AJ, 2003) |
| "Inflammation is often accompanied with hyperalgesia." | 1.32 | Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia. ( Ibuki, T; Kobayashi, S; Matsumura, K; Nozaki, T; Tanaka, Y; Yamazaki, Y, 2003) |
| "Immune function after experimental hemorrhagic shock and subsequent sepsis may be gender-related, with enhanced immunity and better survival in females." | 1.32 | Inhibition of cyclooxygenase-2 by NS-398 following hemorrhage and subsequent sepsis: no beneficial effects in either gender. ( Brötzmann, K; Kahlke, V; Schafmayer, C; Schröder, J; Seidel, M; Stapela, S, 2004) |
| "Using a murine model of metastatic breast cancer, we show that PGE(2) levels are positively correlated with increased tumorigenic and metastatic potential." | 1.31 | Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. ( Dorsey, R; Fulton, AM; Kundu, N; Yang, Q, 2001) |
| "This hyperalgesia was observed only in the period before the development of fever which started 120-135 min after the LPS injection." | 1.31 | Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats. ( Abe, M; Hori, T; Oka, T; Takahashi, S, 2001) |
| " Animals were dosed daily, p." | 1.30 | The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis-induced monoarticular arthritis in the rat. ( Gilroy, DW; Greenslade, K; Seed, MP; Tomlinson, A; Willoughby, DA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (5.88) | 18.2507 |
| 2000's | 41 (60.29) | 29.6817 |
| 2010's | 19 (27.94) | 24.3611 |
| 2020's | 4 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Sarigol, D | 1 |
| Uzgoren-Baran, A | 1 |
| Tel, BC | 1 |
| Somuncuoglu, EI | 1 |
| Kazkayasi, I | 1 |
| Ozadali-Sari, K | 1 |
| Unsal-Tan, O | 1 |
| Okay, G | 1 |
| Ertan, M | 1 |
| Tozkoparan, B | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Chen, S | 1 |
| Huang, L | 1 |
| Zhou, S | 1 |
| Zhang, Q | 1 |
| Ruan, M | 1 |
| Fu, L | 1 |
| Yang, B | 1 |
| Xu, D | 1 |
| Mei, C | 1 |
| Mao, Z | 1 |
| Chen, J | 1 |
| Cai, S | 1 |
| Li, R | 1 |
| Xie, J | 1 |
| Yang, F | 1 |
| Liu, T | 1 |
| Wang, Z | 1 |
| Liu, P | 1 |
| Hu, M | 1 |
| Lu, S | 1 |
| Lyu, Z | 1 |
| Kou, Y | 1 |
| Sun, Y | 2 |
| Zhao, X | 1 |
| Liu, F | 1 |
| Tian, J | 1 |
| Huxtable, AG | 1 |
| Kopp, E | 1 |
| Dougherty, BJ | 1 |
| Watters, JJ | 1 |
| Mitchell, GS | 1 |
| Nakamura, H | 1 |
| Kunitsugu, I | 1 |
| Fukuda, K | 1 |
| Matsuzaki, M | 1 |
| Sano, M | 1 |
| Morell, M | 1 |
| Camprubí-Robles, M | 1 |
| Culler, MD | 1 |
| de Lecea, L | 1 |
| Delgado, M | 1 |
| Mazzarella, G | 1 |
| Bergamo, P | 1 |
| Maurano, F | 1 |
| Luongo, D | 1 |
| Rotondi Aufiero, V | 1 |
| Bozzella, G | 1 |
| Palmieri, G | 1 |
| Troncone, R | 1 |
| Auricchio, S | 1 |
| David, C | 1 |
| Rossi, M | 1 |
| Trandafir, CC | 1 |
| Pouliot, WA | 1 |
| Dudek, FE | 1 |
| Ekstrand, JJ | 1 |
| Araújo-Santos, T | 1 |
| Prates, DB | 1 |
| França-Costa, J | 1 |
| Luz, NF | 1 |
| Andrade, BB | 1 |
| Miranda, JC | 1 |
| Brodskyn, CI | 1 |
| Barral, A | 1 |
| Bozza, PT | 1 |
| Borges, VM | 1 |
| Ahmed, M | 1 |
| Hussain, AR | 1 |
| Siraj, AK | 1 |
| Uddin, S | 1 |
| Al-Sanea, N | 1 |
| Al-Dayel, F | 1 |
| Al-Assiri, M | 1 |
| Beg, S | 1 |
| Al-Kuraya, KS | 1 |
| Zhang, R | 1 |
| Liu, Z | 1 |
| Zhang, H | 1 |
| Zhang, Y | 3 |
| Lin, D | 1 |
| Yu, J | 1 |
| Lin, X | 1 |
| Tang, W | 1 |
| Kim, CH | 1 |
| McBride, DW | 1 |
| Sherchan, P | 1 |
| Person, CE | 1 |
| Gren, ECK | 1 |
| Kelln, W | 1 |
| Lekic, T | 1 |
| Hayes, WK | 1 |
| Tang, J | 1 |
| Zhang, JH | 3 |
| Urick, ME | 1 |
| Giles, JR | 1 |
| Johnson, PA | 1 |
| Zhang, HJ | 1 |
| Sun, RP | 1 |
| Lei, GF | 1 |
| Yang, L | 1 |
| Liu, CX | 1 |
| Varga, H | 1 |
| Pardutz, A | 1 |
| Vamos, E | 1 |
| Bohar, Z | 1 |
| Bago, F | 1 |
| Tajti, J | 1 |
| Bari, F | 2 |
| Vecsei, L | 1 |
| Novak, ML | 1 |
| Billich, W | 1 |
| Smith, SM | 1 |
| Sukhija, KB | 1 |
| McLoughlin, TJ | 1 |
| Hornberger, TA | 1 |
| Koh, TJ | 1 |
| Foreman, JE | 1 |
| Sorg, JM | 1 |
| McGinnis, KS | 1 |
| Rigas, B | 1 |
| Williams, JL | 1 |
| Clapper, ML | 1 |
| Gonzalez, FJ | 1 |
| Peters, JM | 1 |
| Nasrallah, R | 1 |
| Robertson, SJ | 1 |
| Hébert, RL | 1 |
| Jadhav, V | 2 |
| Ostrowski, RP | 1 |
| Tong, W | 1 |
| Matus, B | 1 |
| Jesunathadas, R | 1 |
| van Vliet, EA | 1 |
| Zibell, G | 1 |
| Pekcec, A | 1 |
| Schlichtiger, J | 1 |
| Edelbroek, PM | 1 |
| Holtman, L | 1 |
| Aronica, E | 1 |
| Gorter, JA | 1 |
| Potschka, H | 1 |
| Belin de Chantemèle, EJ | 1 |
| Vessières, E | 1 |
| Guihot, AL | 1 |
| Toutain, B | 1 |
| Loufrani, L | 2 |
| Henrion, D | 2 |
| Medeiros, R | 1 |
| Figueiredo, CP | 1 |
| Pandolfo, P | 1 |
| Duarte, FS | 1 |
| Prediger, RD | 1 |
| Passos, GF | 1 |
| Calixto, JB | 1 |
| Mu, L | 1 |
| Sun, B | 1 |
| Wang, J | 1 |
| Xie, X | 1 |
| Li, N | 1 |
| Zhang, J | 2 |
| Kong, Q | 1 |
| Liu, Y | 1 |
| Han, Z | 1 |
| Wang, G | 1 |
| Fu, Z | 1 |
| Yu, B | 1 |
| Li, G | 1 |
| Li, H | 1 |
| Brenhouse, HC | 1 |
| Andersen, SL | 1 |
| Ayer, R | 1 |
| Sugawara, T | 1 |
| Barasch, N | 1 |
| Li, RC | 1 |
| Sapirstein, A | 1 |
| Hattar, K | 1 |
| Savai, R | 1 |
| Subtil, FS | 1 |
| Wilhelm, J | 1 |
| Schmall, A | 1 |
| Lang, DS | 1 |
| Goldmann, T | 1 |
| Eul, B | 1 |
| Dahlem, G | 1 |
| Fink, L | 1 |
| Schermuly, RT | 1 |
| Banat, GA | 1 |
| Sibelius, U | 1 |
| Grimminger, F | 1 |
| Vollmer, E | 1 |
| Seeger, W | 1 |
| Grandel, U | 1 |
| Mijovic, JE | 1 |
| Zakar, T | 1 |
| Zaragoza, DB | 1 |
| Olson, DM | 1 |
| Hartner, A | 1 |
| Cordasic, N | 1 |
| Goppelt-Struebe, M | 1 |
| Veelken, R | 1 |
| Hilgers, KF | 1 |
| Begay, CK | 1 |
| Gandolfi, AJ | 1 |
| Salzberg-Brenhouse, HC | 1 |
| Chen, EY | 1 |
| Emerich, DF | 1 |
| Baldwin, S | 1 |
| Hogeland, K | 1 |
| Ranelli, S | 1 |
| Lafreniere, D | 1 |
| Perdomo, B | 1 |
| Novak, L | 1 |
| Kladis, T | 1 |
| Fu, K | 1 |
| Basile, AS | 1 |
| Kordower, JH | 1 |
| Bartus, RT | 1 |
| Tunçtan, B | 1 |
| Altug, S | 1 |
| Uludag, O | 1 |
| Demirkay, B | 1 |
| Abacioglu, N | 1 |
| Ibuki, T | 1 |
| Matsumura, K | 1 |
| Yamazaki, Y | 1 |
| Nozaki, T | 1 |
| Tanaka, Y | 1 |
| Kobayashi, S | 1 |
| Yoshida, S | 1 |
| Amano, H | 1 |
| Hayashi, I | 1 |
| Kitasato, H | 1 |
| Kamata, M | 1 |
| Inukai, M | 1 |
| Yoshimura, H | 1 |
| Majima, M | 1 |
| Quadros, A | 1 |
| Patel, N | 1 |
| Crescentini, R | 1 |
| Crawford, F | 1 |
| Paris, D | 1 |
| Mullan, M | 1 |
| Yao, M | 1 |
| Lam, EC | 1 |
| Kelly, CR | 1 |
| Zhou, W | 1 |
| Wolfe, MM | 1 |
| Kahlke, V | 1 |
| Seidel, M | 1 |
| Stapela, S | 1 |
| Brötzmann, K | 1 |
| Schafmayer, C | 1 |
| Schröder, J | 1 |
| Gendron, TF | 1 |
| Brunette, E | 1 |
| Mealing, GA | 1 |
| Nguyen, A | 1 |
| Tauskela, JS | 1 |
| Morley, P | 1 |
| Lui, PW | 1 |
| Lee, CH | 1 |
| Oka, T | 2 |
| Shearer, T | 1 |
| Azuma, M | 1 |
| Wu Chen, R | 1 |
| Rose, ME | 1 |
| Graham, SH | 1 |
| Mochizuki, M | 1 |
| Ishii, Y | 1 |
| Itoh, K | 1 |
| Iizuka, T | 1 |
| Morishima, Y | 1 |
| Kimura, T | 1 |
| Kiwamoto, T | 1 |
| Matsuno, Y | 1 |
| Hegab, AE | 1 |
| Nomura, A | 1 |
| Sakamoto, T | 1 |
| Uchida, K | 1 |
| Yamamoto, M | 1 |
| Sekizawa, K | 1 |
| Ahn, DK | 1 |
| Chae, JM | 1 |
| Choi, HS | 1 |
| Kyung, HM | 1 |
| Kwon, OW | 1 |
| Park, HS | 1 |
| Youn, DH | 1 |
| Bae, YC | 1 |
| Yuhas, Y | 1 |
| Weizman, A | 1 |
| Vanichkin, A | 1 |
| Ashkenazi, S | 1 |
| Hiratsuka, T | 1 |
| Futagami, S | 1 |
| Tatsuguchi, A | 1 |
| Suzuki, K | 1 |
| Shinji, Y | 1 |
| Kusunoki, M | 1 |
| Shinoki, K | 1 |
| Nishigaki, H | 1 |
| Fujimori, S | 1 |
| Wada, K | 1 |
| Miyake, K | 1 |
| Gudis, K | 1 |
| Tsukui, T | 1 |
| Sakamoto, C | 1 |
| Jiang, X | 1 |
| Shi, E | 1 |
| Nakajima, Y | 1 |
| Sato, S | 1 |
| Hiraga, T | 1 |
| Myoui, A | 1 |
| Choi, ME | 1 |
| Yoshikawa, H | 1 |
| Yoneda, T | 1 |
| Poplawski, C | 1 |
| Sosnowski, D | 1 |
| Szaflarska-Popławska, A | 1 |
| Sarosiek, J | 1 |
| McCallum, R | 1 |
| Bartuzi, Z | 1 |
| Kruschewski, M | 1 |
| Anderson, T | 1 |
| Buhr, HJ | 1 |
| Loddenkemper, C | 1 |
| López-Vales, R | 1 |
| García-Alías, G | 1 |
| Guzmán-Lenis, MS | 1 |
| Forés, J | 1 |
| Casas, C | 1 |
| Navarro, X | 1 |
| Verdú, E | 1 |
| Silasi, G | 1 |
| Kolb, B | 1 |
| Birkenmeier, K | 1 |
| Staudt, A | 1 |
| Schunck, WH | 1 |
| Janke, I | 1 |
| Labitzke, C | 1 |
| Prange, T | 1 |
| Trimpert, C | 1 |
| Krieg, T | 1 |
| Landsberger, M | 1 |
| Stangl, V | 1 |
| Felix, SB | 1 |
| Institoris, A | 1 |
| Farkas, E | 1 |
| Berczi, S | 1 |
| Sule, Z | 1 |
| Eizayaga, FX | 1 |
| Aguejouf, O | 1 |
| Desplat, V | 1 |
| Belon, P | 1 |
| Doutremepuich, C | 1 |
| Gilroy, DW | 2 |
| Tomlinson, A | 2 |
| Willoughby, DA | 2 |
| Shoup, M | 1 |
| He, LK | 1 |
| Liu, H | 1 |
| Shankar, R | 1 |
| Gamelli, R | 1 |
| Greenslade, K | 1 |
| Seed, MP | 1 |
| Brzozowski, T | 1 |
| Konturek, PC | 1 |
| Konturek, SJ | 1 |
| Sliwowski, Z | 1 |
| Drozdowicz, D | 1 |
| Stachura, J | 1 |
| Pajdo, R | 1 |
| Hahn, EG | 1 |
| Liu, XH | 1 |
| Kirschenbaum, A | 1 |
| Yao, S | 1 |
| Lee, R | 1 |
| Holland, JF | 1 |
| Levine, AC | 1 |
| Kim, TI | 1 |
| Lee, YC | 1 |
| Lee, KH | 1 |
| Han, JH | 1 |
| Chon, CY | 1 |
| Moon, YM | 1 |
| Kang, JK | 1 |
| Park, IS | 1 |
| Kundu, N | 1 |
| Yang, Q | 1 |
| Dorsey, R | 1 |
| Fulton, AM | 1 |
| Abe, M | 1 |
| Hori, T | 1 |
| Takahashi, S | 1 |
| Ianaro, A | 1 |
| Ialenti, A | 1 |
| Maffia, P | 1 |
| Pisano, B | 1 |
| Di Rosa, M | 1 |
| Matrougui, K | 1 |
| Lévy, BI | 1 |
| Shen, X | 1 |
68 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Disease Models, Animal
| Article | Year |
|---|---|
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; D | 2015 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
NS398 as a potential drug for autosomal-dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Computational Biology; Cyclooxygenase Inhi | 2021 |
Blockade of Cycloxygenase-2 ameliorates sepsis induced immune-suppression by regulating myeloid-derived suppressor cells.
Topics: Animals; CD4-Positive T-Lymphocytes; Cecum; Cyclooxygenase 2 Inhibitors; Cytokines; Disease Models, | 2022 |
Naoxintong restores ischemia injury and inhibits thrombosis via COX2-VEGF/ NFκB signaling.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease M | 2021 |
Cyclooxygenase enzyme activity does not impair respiratory motor plasticity after one night of intermittent hypoxia.
Topics: Animals; Carbon Dioxide; CD11b Antigen; Cyclooxygenase Inhibitors; Disease Models, Animal; Hypoxia; | 2018 |
Diverse stage-dependent effects of glucocorticoids in a murine model of viral myocarditis.
Topics: Acute Disease; Animals; Coxsackievirus Infections; Cyclooxygenase Inhibitors; Dexamethasone; Disease | 2013 |
Cortistatin attenuates inflammatory pain via spinal and peripheral actions.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Disease Models, Anima | 2014 |
Gliadin intake alters the small intestinal mucosa in indomethacin-treated HLA-DQ8 transgenic mice.
Topics: Animals; Apoptosis; Caspase 3; Celiac Disease; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diseas | 2014 |
Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diazepam; Disease Models, A | 2015 |
Prostaglandin E2/leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Female; | 2014 |
Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Colorectal | 2015 |
The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis.
Topics: Animals; Choroid; Choroidal Neovascularization; Cyclooxygenase Inhibitors; Disease Models, Animal; F | 2016 |
Inhibition of cyclooxygenase-2 by NS398 attenuates noise-induced hearing loss in mice.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Gene Expressio | 2016 |
Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury.
Topics: Animals; Body Water; Brain; Brain Edema; Crotalus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Di | 2017 |
VEGF expression and the effect of NSAIDs on ascites cell proliferation in the hen model of ovarian cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascites; Aspirin; Cell Growth Processes; Chickens; | 2008 |
Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats.
Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models | 2008 |
Selective inhibition of cyclooxygenase-2 attenuates nitroglycerin-induced calmodulin-dependent protein kinase II alpha in rat trigeminal nucleus caudalis.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Arteries; Cerebrovascular Circ | 2009 |
COX-2 inhibitor reduces skeletal muscle hypertrophy in mice.
Topics: Animals; Carrier Proteins; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diseas | 2009 |
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Coloni | 2009 |
Chronic COX inhibition reduces diabetes-induced hyperfiltration, proteinuria, and renal pathological markers in 36-week B6-Ins2(Akita) mice.
Topics: Albuminuria; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Body Weight; Creatinine; | 2009 |
Cyclo-oxygenase-2 mediates hyperbaric oxygen preconditioning-induced neuroprotection in the mouse model of surgical brain injury.
Topics: Animals; Brain Edema; Brain Injuries; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, A | 2009 |
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2010 |
Cyclooxygenase-2 preserves flow-mediated remodelling in old obese Zucker rat mesenteric arteries.
Topics: Acetylcholine; Age Factors; Animals; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Di | 2010 |
The role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive decline induced by beta-amyloid peptide.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Antibodies; Cognition Disorders; CREB-Binding | 2010 |
Activation of the receptor for advanced glycation end products (RAGE) exacerbates experimental autoimmune myasthenia gravis symptoms.
Topics: Animals; Autoantibodies; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokine | 2011 |
Nonsteroidal anti-inflammatory treatment prevents delayed effects of early life stress in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dis | 2011 |
The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage.
Topics: Animals; Brain Edema; Brain Injuries; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Resp | 2011 |
Inhibition of cytosolic phospholipase A(2) alpha protects against focal ischemic brain damage in mice.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Body Temp | 2012 |
Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyc | 2013 |
Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice.
Topics: Animals; Disease Models, Animal; Female; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Nitrobenzen | 2002 |
Role of macula densa cyclooxygenase-2 in renovascular hypertension.
Topics: Animals; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; D | 2003 |
Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Cyclooxygenase In | 2003 |
Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2003 |
Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; | 2003 |
Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia.
Topics: Animals; Brain; Carrageenan; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; | 2003 |
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inh | 2003 |
Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Brain; Cy | 2003 |
Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer.
Topics: Animals; Blotting, Western; Cell Division; Cell Movement; Colorectal Neoplasms; Cyclooxygenase 2; Cy | 2004 |
Inhibition of cyclooxygenase-2 by NS-398 following hemorrhage and subsequent sepsis: no beneficial effects in either gender.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinopr | 2004 |
Opposing effects of cyclooxygenase-2 selective inhibitors on oxygen-glucose deprivation-induced neurotoxicity.
Topics: Animals; Calcium; Canada; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Cyclooxyge | 2004 |
Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hindli | 2004 |
Involvement of cyclooxygenase-2 in rat models of conjunctivitis.
Topics: Animals; Capillary Permeability; Carrageenan; Conjunctivitis; Cyclooxygenase 1; Cyclooxygenase 2; Cy | 2004 |
Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo.
Topics: Animals; Cell Survival; Cells, Cultured; Cyclin D1; Cyclooxygenase 2; Disease Models, Animal; DNA Fr | 2004 |
Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury.
Topics: Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dise | 2005 |
Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats.
Topics: Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relation | 2005 |
Involvement of prostaglandins in an animal model of Shigella-related seizures.
Topics: Animals; Chi-Square Distribution; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Disease Models | 2005 |
COX-1 and COX-2 conversely promote and suppress ischemia-reperfusion gastric injury in mice.
Topics: Alanine; Animals; Blotting, Western; Celiac Artery; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygena | 2005 |
COX-2 mediates morphine-induced delayed cardioprotection via an iNOS-dependent mechanism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cardiotonic Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 2006 |
Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer.
Topics: Animals; Apoptosis; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cyclooxygena | 2006 |
Role of bile acids, prostaglandins and COX inhibitors in chronic esophagitis in a mouse model.
Topics: Animals; Bile Acids and Salts; Chronic Disease; Cyclooxygenase Inhibitors; Dinoprostone; Disease Mod | 2006 |
Selective COX-2 inhibition reduces leukocyte sticking and improves the microcirculation in TNBS colitis.
Topics: Animals; Colitis; Colon; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Immunohistochemistry; | 2006 |
Effects of COX-2 and iNOS inhibitors alone or in combination with olfactory ensheathing cell grafts after spinal cord injury.
Topics: Animals; Brain Tissue Transplantation; Cell Transplantation; Cyclooxygenase 2 Inhibitors; Disease Mo | 2006 |
Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke.
Topics: Animals; Brain Ischemia; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; D | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenas | 2007 |
Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats.
Topics: Animals; Astrocytes; Brain Ischemia; Carotid Stenosis; Cyclooxygenase Inhibitors; Disease Models, An | 2007 |
Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dinopros | 2007 |
Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation.
Topics: Air; Air Sacs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Croton Oil; Cyclooxygenase | 1998 |
Cyclooxygenase-2 inhibitor NS-398 improves survival and restores leukocyte counts in burn infection.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; Burns; Cyclooxygenase Inhibi | 1998 |
The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis-induced monoarticular arthritis in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Bone and Bones; Cartilage, | 1998 |
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 1999 |
Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth of prostate cancer in vivo.
Topics: Animals; Apoptosis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diseas | 2000 |
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Chronic Disease; Cycloox | 2001 |
Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer.
Topics: Animals; Breast Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2001 |
Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats.
Topics: Animals; Bacterial Infections; Body Temperature; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2001 |
Role of cyclopentenone prostaglandins in rat carrageenin pleurisy.
Topics: Active Transport, Cell Nucleus; Animals; Carrageenan; Cyclooxygenase Inhibitors; Disease Models, Ani | 2001 |
High NaCl intake decreases both flow-induced dilation and pressure-induced myogenic tone in resistance arteries from normotensive rats: involvement of cyclooxygenase-2.
Topics: Animals; Arginine; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2001 |
[Effects of cyclooxygenase-2 on formation and healing of acetic acid-induced gastric ulcer in rats].
Topics: Acetic Acid; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dino | 2001 |