n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Colorectal Neoplasms in 19 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of our study was to characterize the effects of two COX-2 selective inhibitors, NS-398 and nimesulide, on colorectal cancer cell proliferation, and to describe the molecular mechanisms involved." | 7.72 | Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines. ( Blottière, HM; Bonnet, C; Bouancheau, D; Broquet, A; Buecher, B; Denis, MG; Galmiche, JP; Heymann, MF; Jany, A, 2003) |
| "Indomethacin-induced G(1) arrest and apoptosis of human colorectal cancer (CRC) cells is associated with a dose-dependent decrease in beta-catenin protein levels." | 7.71 | Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. ( Albanese, C; D'Amico, M; Hawcroft, G; Hull, MA; Markham, AF; Pestell, RG, 2002) |
| "Generally, colorectal cancers are resistant to anticancer drugs." | 5.37 | HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. ( Beneytout, JL; Cook-Moreau, J; Delage, C; Leger, DY; Liagre, B; Limami, Y; Mousseau, Y; Pinon, A; Simon, A, 2011) |
| "The aim of our study was to characterize the effects of two COX-2 selective inhibitors, NS-398 and nimesulide, on colorectal cancer cell proliferation, and to describe the molecular mechanisms involved." | 3.72 | Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines. ( Blottière, HM; Bonnet, C; Bouancheau, D; Broquet, A; Buecher, B; Denis, MG; Galmiche, JP; Heymann, MF; Jany, A, 2003) |
| "Indomethacin-induced G(1) arrest and apoptosis of human colorectal cancer (CRC) cells is associated with a dose-dependent decrease in beta-catenin protein levels." | 3.71 | Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. ( Albanese, C; D'Amico, M; Hawcroft, G; Hull, MA; Markham, AF; Pestell, RG, 2002) |
| "We assessed 15-LOX-1 protein expression and enzymatic activity, 13-S-HODE levels, and 15-LOX-1 inhibition in association with cellular growth inhibition and apoptosis induced by NSAIDs (primarily sulindac and NS-398) in two colorectal cancer cell lines (RKO and HT-29)." | 3.70 | 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. ( Brenner, DE; Chen, D; Fischer, SM; Lee, JJ; Lippman, SM; Lotan, R; Newman, RA; Shureiqi, I; Yang, P, 2000) |
| "Generally, colorectal cancers are resistant to anticancer drugs." | 1.37 | HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. ( Beneytout, JL; Cook-Moreau, J; Delage, C; Leger, DY; Liagre, B; Limami, Y; Mousseau, Y; Pinon, A; Simon, A, 2011) |
| "Two human colorectal cancer cell lines, LS174T and HT29, were challenged with MMP inhibitor (doxycycline), selective COX-2 inhibitor (NS-398), or a combination of these agents to evaluate cancer cell proliferation and invasion." | 1.32 | Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells. ( Dhar, DK; Fujii, T; Nagasue, N; Ono, T; Onoda, T; Yamanoi, A, 2004) |
| "NSAIDs act on human colorectal cancer cells via different mechanisms." | 1.31 | The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. ( Hawcroft, G; Hull, MA; Smith, ML, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 14 (73.68) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, M | 1 |
| Hussain, AR | 1 |
| Siraj, AK | 1 |
| Uddin, S | 1 |
| Al-Sanea, N | 1 |
| Al-Dayel, F | 1 |
| Al-Assiri, M | 1 |
| Beg, S | 1 |
| Al-Kuraya, KS | 1 |
| Réti, A | 1 |
| Pap, E | 1 |
| Adleff, V | 1 |
| Jeney, A | 1 |
| Kralovánszky, J | 1 |
| Budai, B | 1 |
| Galamb, O | 1 |
| Spisák, S | 1 |
| Sipos, F | 1 |
| Tóth, K | 1 |
| Solymosi, N | 1 |
| Wichmann, B | 1 |
| Krenács, T | 1 |
| Valcz, G | 1 |
| Tulassay, Z | 1 |
| Molnár, B | 1 |
| Limami, Y | 1 |
| Pinon, A | 1 |
| Leger, DY | 1 |
| Mousseau, Y | 1 |
| Cook-Moreau, J | 1 |
| Beneytout, JL | 1 |
| Delage, C | 1 |
| Liagre, B | 1 |
| Simon, A | 1 |
| Smartt, HJ | 1 |
| Elder, DJ | 4 |
| Hicks, DJ | 1 |
| Williams, NA | 1 |
| Paraskeva, C | 4 |
| Buecher, B | 1 |
| Broquet, A | 1 |
| Bouancheau, D | 1 |
| Heymann, MF | 1 |
| Jany, A | 1 |
| Denis, MG | 1 |
| Bonnet, C | 1 |
| Galmiche, JP | 1 |
| Blottière, HM | 1 |
| Yao, M | 1 |
| Lam, EC | 1 |
| Kelly, CR | 1 |
| Zhou, W | 1 |
| Wolfe, MM | 1 |
| Onoda, T | 1 |
| Ono, T | 1 |
| Dhar, DK | 1 |
| Yamanoi, A | 1 |
| Fujii, T | 1 |
| Nagasue, N | 1 |
| Zhang, ZH | 1 |
| Ouyang, Q | 2 |
| Gan, HT | 1 |
| Daouphars, M | 1 |
| Koufany, M | 1 |
| Benani, A | 1 |
| Marchal, S | 1 |
| Merlin, JL | 1 |
| Netter, P | 1 |
| Jouzeau, JY | 1 |
| Leung, E | 1 |
| McArthur, D | 1 |
| Morris, A | 1 |
| Williams, N | 1 |
| Hara, A | 1 |
| Yoshimi, N | 1 |
| Niwa, M | 1 |
| Ino, N | 1 |
| Mori, H | 1 |
| Crew, TE | 2 |
| Smith, ML | 1 |
| Hawcroft, G | 2 |
| Hull, MA | 2 |
| Halton, DE | 2 |
| Shureiqi, I | 1 |
| Chen, D | 1 |
| Lee, JJ | 1 |
| Yang, P | 1 |
| Newman, RA | 1 |
| Brenner, DE | 1 |
| Lotan, R | 1 |
| Fischer, SM | 1 |
| Lippman, SM | 1 |
| D'Amico, M | 1 |
| Albanese, C | 1 |
| Markham, AF | 1 |
| Pestell, RG | 1 |
| Qiu, C | 1 |
| Playle, LC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Double Blind, Placebo Controlled Trial of Doxycycline in Lymphangioleiomyomatosis.[NCT00989742] | Phase 4 | 24 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Colorectal Neoplasms
| Article | Year |
|---|---|
Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Colorectal | 2015 |
Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Pro | 2010 |
Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor.
Topics: Adenocarcinoma; Adenoma; Cluster Analysis; Colon; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; | 2010 |
HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death.
Topics: Apoptosis; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Resistance, Neo | 2011 |
Increased NF-kappaB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells.
Topics: Apoptosis; Blotting, Western; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; C | 2003 |
Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines.
Topics: Adenocarcinoma; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Division; Colorectal Neoplas | 2003 |
Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer.
Topics: Animals; Blotting, Western; Cell Division; Cell Movement; Colorectal Neoplasms; Cyclooxygenase 2; Cy | 2004 |
Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells.
Topics: Adenocarcinoma; Anti-Bacterial Agents; Apoptosis; Blotting, Western; Cell Division; Cell Line, Tumor | 2004 |
Targeting cyclooxygenase-2 with sodium butyrate and NSAIDs on colorectal adenoma/carcinoma cells.
Topics: Adenoma; Apoptosis; Butyrates; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase Inhibitors; | 2004 |
Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; | 2005 |
Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression.
Topics: Analysis of Variance; Blotting, Western; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Cy | 2008 |
Apoptosis induced by NS-398, a selective cyclooxygenase-2 inhibitor, in human colorectal cancer cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Colorectal Neoplasms; Cyclooxygen | 1997 |
A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Butyrates; Color | 2000 |
The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; beta Catenin; Cell Division; Colorectal | 2000 |
Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug NS-398.
Topics: Adenoma; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Carcinoma; Col | 2000 |
15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Arachidonate 15-Lipoxygenase; Blot | 2000 |
Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.
Topics: Acetylcysteine; beta Catenin; Blotting, Western; Colorectal Neoplasms; Cyclin D1; Cytoskeletal Prote | 2002 |
[Study on the effect of COX-2's selective inhibitor on human colorectal adenoma cells proliferation].
Topics: Adenoma; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose | 2001 |
The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Butadienes; Cell Division; Colorectal Neoplasms; | 2002 |