n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Cirrhosis in 5 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " It remains unclear, however, whether ATRA affects cyclooxygenase-2 (COX-2; an enzyme involved in prostaglandin production), PGE2, and thromboxane A2 (TXA2) (metabolic products of COX-2) by a transforming growth factor-β/Smad-signaling pathway, which plays important roles in mesangial-cell proliferation and renal fibrosis." | 3.80 | Effects of all-trans retinoic acid on signal pathway of cyclooxygenase-2 and Smad3 in transforming growth factor-β-stimulated glomerular mesangial cells. ( Chen, X; Fan, Y; Guo, N; Han, J; Yang, B; Zhang, L, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chi, YC | 1 |
| Shi, CL | 1 |
| Zhou, M | 1 |
| Liu, Y | 1 |
| Zhang, G | 1 |
| Hou, SA | 1 |
| Han, J | 1 |
| Zhang, L | 1 |
| Chen, X | 1 |
| Yang, B | 1 |
| Guo, N | 1 |
| Fan, Y | 1 |
| Zhang, R | 1 |
| Liu, Z | 1 |
| Zhang, H | 1 |
| Zhang, Y | 1 |
| Lin, D | 1 |
| LaPointe, MC | 1 |
| Mendez, M | 1 |
| Leung, A | 1 |
| Tao, Z | 1 |
| Yang, XP | 1 |
| Shen, W | 1 |
| Li, Y | 1 |
| Tang, Y | 1 |
| Cummins, J | 1 |
| Huard, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients[NCT05637216] | Phase 2 | 40 participants (Anticipated) | Interventional | 2023-08-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Cirrhosis
| Article | Year |
|---|---|
Selective cyclooxygenase-2 inhibitor NS-398 attenuates myocardial fibrosis in mice after myocardial infarction via Snail signaling pathway.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Fibrosis; Male; Mice; Mice, Inbred C57BL; Myocardial Infarctio | 2017 |
Effects of all-trans retinoic acid on signal pathway of cyclooxygenase-2 and Smad3 in transforming growth factor-β-stimulated glomerular mesangial cells.
Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Di | 2014 |
The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis.
Topics: Animals; Choroid; Choroidal Neovascularization; Cyclooxygenase Inhibitors; Disease Models, Animal; F | 2016 |
Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse.
Topics: Animals; Cardiomegaly; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhib | 2004 |
NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cell Culture Techniques; Cell Differentiation; C | 2005 |