n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Cancer of Colon in 39 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the primary adenoma cells and HT-29 cells in an attempt to know whether NaBT and two NSAIDs (aspirin and NS-398) could be used as effective adjuvant for reducing cell proliferation, and to explore the possible mechanisms therein involved." | 3.72 | [Effects of NaBT and NSAIDs on colorectal adenoma-carcinoma cells]. ( Gan, H; Ouyang, Q; Zhang, Z, 2003) |
| "Adenocarcinoma cells HT-29 were used to investigate whether butyrates and non-steroidal anti-inflammatory agents (NSAIDs, aspirin and NS-398) would be effective adjuvants for inducing apoptosis and to probe its possible mechanisms." | 3.71 | [The effects of butyrates and non-steroidal anti-inflammatory agents on HT-29 colonic carcinoma cells]. ( Gan, H; Ouyang, Q; Zhang, Z, 2002) |
| "Human colon cancer cell line Caco-2 exposed to a hypertonic environment responded with marked VEGF and PGE₂ production." | 1.37 | Hypertonic stress induces VEGF production in human colon cancer cell line Caco-2: inhibitory role of autocrine PGE₂. ( Diaz, BL; Gentile, LB; Piva, B, 2011) |
| "Human colon cancer cells SW480 were divided into two groups: SW480 cells in experimental group were treated with NS398 in different concentrations(25 micromol/L, 50 micromol/L, 100 micromol/L and 200 micromol/L) for 48 h or 72 h." | 1.36 | [Effect of COX-2 inhibitor on the expression of BCL-3 and cyclin D1 in human colon cancer cell line SW480]. ( Ni, SM; Wang, SM; Wu, X; Yang, G; Ye, M, 2010) |
| "Invasive behaviors of the malignant colon cancer cell line HT-29 were investigated in this study." | 1.33 | Effect of NS-398 on colon cancer cells. ( Han, LH; Jia, XQ; Meng, FL; Wang, JH; Yan, M; Zhang, SZ; Zhong, N, 2005) |
| "Sulindac sulfide treatment was associated with activation of ERKp44/42 and p38 MAPK in a dosage- and time-dependent manner, and also activated upstream MEK." | 1.33 | Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells. ( Sinicrope, FA; Sun, Y, 2005) |
| " This study was designed to determine if the addition of NS-398 to NPe6-induced PDT in single or fractionated dosing would result in greater tumor kill." | 1.33 | Killing tumor cells: the effect of photodynamic therapy using mono-L-aspartyl chlorine and NS-398. ( Fromm, D; Harvey, EH; Kessel, D; Webber, J, 2005) |
| "Compared to colon cancer cells, prostate cancer cells expressed lower levels of COX-2, produced less PGE2, and were resistant to selective COX-2 inhibition." | 1.33 | Resistance of prostate cancer cell lines to COX-2 inhibitor treatment. ( Barry, JM; Beer, TM; Corless, CL; Gantner, M; Garzotto, M; Loos, J; Wagner, M; Weksler, N, 2005) |
| "NS-398 suppressed the growth of colon cancer cells, independent of COX-2 expression." | 1.33 | Autocrine vascular endothelial growth factor/vascular endothelial growth factor receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon cancer cells. ( Choi, CW; Kim, BS; Kim, JS; Kim, SJ; Kim, YH; Lee, YJ; Seo, JH; Shin, SW; Yoon, JH, 2005) |
| "Using a human colon cancer cell line, LoVo cells, we performed immunoprecipitation analysis, followed by Western blot analysis." | 1.33 | Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. ( Kitayama, J; Mori, K; Nagawa, H; Shida, D; Watanabe, T; Yamaguchi, H; Yamashita, H, 2005) |
| "Human colon cancer cells of the line SW480 were cultured and then divided into 2 groups: experimental group and control group." | 1.33 | [Molecular mechanism of cyclooxygenase-2 inhibitor in inhibition of proliferation of colon cancer cells by modulating Stat5 signal transduction pathway]. ( Cui, ZR; Du, RY; Ma, XT; Wang, S; Yu, LW; Zhang, H, 2005) |
| "Human colon cancer Caco-2 cells were treated with either: placebo, IND (0." | 1.33 | Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells. ( Chai, J; Huang, RH; Tarnawski, AS, 2006) |
| "The mechanism of NS-398 against colon cancer may be independent upon the expression levels of COX-2 mRNA and PGE2 of colon cancer." | 1.32 | [Effects of selective cyclooxygenase-2 inhibitor NS-398 on 5-fluorouracil chemotherapy and progression of colon cells: an experimental study]. ( Cui, ZR; Liang, B; Wang, S; Ye, YJ; Zhang, H; Zhang, YC, 2004) |
| "NSAIDs can induce apoptosis in colon cancer cells via up-regulation of 15-LOX-1 in the absence of COX-2." | 1.31 | 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. ( Chen, D; Fischer, SM; Lippman, SM; Lotan, R; Newman, RA; Shureiqi, I; Yang, P, 2000) |
| "In three selected colon cancer cell lines, NS398-induced apoptosis was mediated by the release of cytochrome c from mitochondria and, consequently, by the activation of caspase-9 and caspase-3 and by the cleavage of poly(ADP-ribose) polymerase." | 1.31 | Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. ( Li, M; Wu, X; Xu, XC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (10.26) | 18.2507 |
| 2000's | 29 (74.36) | 29.6817 |
| 2010's | 6 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huh, JE | 1 |
| Kang, JW | 1 |
| Nam, D | 1 |
| Baek, YH | 1 |
| Choi, DY | 1 |
| Park, DS | 1 |
| Lee, JD | 1 |
| Dinicola, S | 1 |
| Masiello, MG | 1 |
| Proietti, S | 1 |
| Coluccia, P | 1 |
| Fabrizi, G | 1 |
| Catizone, A | 1 |
| Ricci, G | 1 |
| de Toma, G | 1 |
| Bizzarri, M | 1 |
| Cucina, A | 1 |
| Foreman, JE | 1 |
| Sorg, JM | 1 |
| McGinnis, KS | 1 |
| Rigas, B | 1 |
| Williams, JL | 1 |
| Clapper, ML | 1 |
| Gonzalez, FJ | 1 |
| Peters, JM | 1 |
| Réti, A | 1 |
| Pap, E | 1 |
| Zalatnai, A | 1 |
| Jeney, A | 1 |
| Kralovánszky, J | 1 |
| Budai, B | 1 |
| Liu, JP | 2 |
| Wei, HB | 2 |
| Zheng, ZH | 2 |
| Guo, WP | 2 |
| Fang, JF | 2 |
| Wang, SM | 1 |
| Ye, M | 1 |
| Ni, SM | 1 |
| Wu, X | 2 |
| Yang, G | 1 |
| Banu, NA | 1 |
| Daly, RS | 1 |
| Buda, A | 2 |
| Moorghen, M | 2 |
| Baker, J | 1 |
| Pignatelli, M | 2 |
| Gentile, LB | 1 |
| Piva, B | 1 |
| Diaz, BL | 1 |
| Yao, M | 1 |
| Song, DH | 1 |
| Rana, B | 1 |
| Wolfe, MM | 1 |
| Sun, Y | 3 |
| Tang, XM | 1 |
| Half, E | 2 |
| Kuo, MT | 1 |
| Sinicrope, FA | 3 |
| Zhang, Z | 4 |
| Ouyang, Q | 2 |
| Gan, H | 2 |
| Massoumi, R | 1 |
| Nielsen, CK | 1 |
| Azemovic, D | 1 |
| Sjölander, A | 1 |
| Zhang, YC | 1 |
| Wang, S | 3 |
| Zhang, H | 3 |
| Ye, YJ | 1 |
| Liang, B | 1 |
| Cui, ZR | 2 |
| Nishikawa, M | 1 |
| Stapleton, PP | 1 |
| Freeman, TA | 1 |
| Gaughan, JP | 1 |
| Matsuda, T | 1 |
| Daly, JM | 1 |
| Jia, XQ | 1 |
| Zhong, N | 1 |
| Han, LH | 1 |
| Wang, JH | 1 |
| Yan, M | 1 |
| Meng, FL | 1 |
| Zhang, SZ | 1 |
| Harvey, EH | 1 |
| Webber, J | 1 |
| Kessel, D | 1 |
| Fromm, D | 1 |
| Wagner, M | 1 |
| Loos, J | 1 |
| Weksler, N | 1 |
| Gantner, M | 1 |
| Corless, CL | 1 |
| Barry, JM | 1 |
| Beer, TM | 1 |
| Garzotto, M | 1 |
| Kim, SJ | 1 |
| Seo, JH | 1 |
| Lee, YJ | 1 |
| Yoon, JH | 1 |
| Choi, CW | 1 |
| Kim, BS | 1 |
| Shin, SW | 1 |
| Kim, YH | 1 |
| Kim, JS | 1 |
| Gao, XQ | 1 |
| Han, JX | 1 |
| Huang, HY | 1 |
| Song, B | 1 |
| Zhu, B | 1 |
| Song, CZ | 1 |
| Yoshii, M | 1 |
| Jikuhara, A | 1 |
| Mori, S | 1 |
| Iwagaki, H | 1 |
| Takahashi, HK | 1 |
| Nishibori, M | 1 |
| Tanaka, N | 1 |
| Shida, D | 1 |
| Kitayama, J | 1 |
| Yamaguchi, H | 1 |
| Yamashita, H | 1 |
| Mori, K | 1 |
| Watanabe, T | 1 |
| Nagawa, H | 1 |
| Ma, XT | 1 |
| Yu, LW | 1 |
| Du, RY | 1 |
| Huang, RH | 1 |
| Chai, J | 1 |
| Tarnawski, AS | 1 |
| Saito, H | 1 |
| Inagaki, Y | 1 |
| Tsunenari, T | 1 |
| Ura, M | 1 |
| Mizuno, H | 1 |
| Fujimoto-Ouchi, K | 1 |
| Onuma, E | 1 |
| Sato, K | 1 |
| Ogata, E | 1 |
| Yamada-Okabe, H | 1 |
| Banu, N | 1 |
| Chell, S | 1 |
| Elder, D | 1 |
| Paraskeva, C | 2 |
| Qualtrough, D | 1 |
| Ye, Y | 1 |
| Bai, Z | 1 |
| Tsuji, S | 1 |
| Kawano, S | 1 |
| Sawaoka, H | 1 |
| Takei, Y | 1 |
| Kobayashi, I | 1 |
| Nagano, K | 1 |
| Fusamoto, H | 1 |
| Kamada, T | 1 |
| Yoshimi, N | 2 |
| Kawabata, K | 1 |
| Hara, A | 2 |
| Matsunaga, K | 2 |
| Yamada, Y | 2 |
| Mori, H | 2 |
| Elder, DJ | 1 |
| Halton, DE | 1 |
| Hague, A | 1 |
| Shimizu, M | 1 |
| Fujii, K | 1 |
| DuBois, RN | 2 |
| Shureiqi, I | 1 |
| Chen, D | 1 |
| Lotan, R | 1 |
| Yang, P | 1 |
| Newman, RA | 1 |
| Fischer, SM | 1 |
| Lippman, SM | 1 |
| Li, M | 1 |
| Xu, XC | 1 |
| Kishimoto, Y | 1 |
| Yashima, K | 1 |
| Morisawa, T | 1 |
| Shiota, G | 1 |
| Kawasaki, H | 1 |
| Hasegawa, J | 1 |
39 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Cancer of Colon
| Article | Year |
|---|---|
Melittin suppresses VEGF-A-induced tumor growth by blocking VEGFR-2 and the COX-2-mediated MAPK signaling pathway.
Topics: Animals; Apoptosis; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Rela | 2012 |
Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement.
Topics: Antigens, CD; Antineoplastic Agents; beta Catenin; Caco-2 Cells; Cadherins; Carcinogens; Cell Moveme | 2018 |
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Coloni | 2009 |
Co-inhibition of cyclooxygenase-2 and dihydropyrimidine dehydrogenase by non-steroidal anti-inflammatory drugs in tumor cells and xenografts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Colonic Neoplasms; Cyclooxygena | 2009 |
Celecoxib increases retinoid sensitivity in human colon cancer cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Celecoxib; Cell Line, Tumor; Colonic Neop | 2010 |
[Effect of COX-2 inhibitor on the expression of BCL-3 and cyclin D1 in human colon cancer cell line SW480].
Topics: B-Cell Lymphoma 3 Protein; Cell Line, Tumor; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2 Inhibito | 2010 |
[Celecoxib increased cellular ATRA sensitivity of human colon cancer cell lines through COX-2-independent mechanisms].
Topics: Antineoplastic Agents; Apoptosis; Celecoxib; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyc | 2009 |
Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Apoptosis; beta Catenin; Bromodeoxyuridine; Carcinogens; Ce | 2011 |
Hypertonic stress induces VEGF production in human colon cancer cell line Caco-2: inhibitory role of autocrine PGE₂.
Topics: Caco-2 Cells; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Humans; | 2011 |
COX-2 selective inhibition reverses the trophic properties of gastrin in colorectal cancer.
Topics: Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Cyclooxygena | 2002 |
Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase Inhibitors; Caspases; Colonic Neoplasms; | 2002 |
[Effects of NaBT and NSAIDs on colorectal adenoma-carcinoma cells].
Topics: Adenocarcinoma; Adenoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Butyrates; Cel | 2003 |
Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin.
Topics: Caco-2 Cells; Carcinoma; Cell Adhesion; Colitis; Collagen Type I; Colonic Neoplasms; Cyclooxygenase | 2003 |
[Effects of selective cyclooxygenase-2 inhibitor NS-398 on 5-fluorouracil chemotherapy and progression of colon cells: an experimental study].
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; C | 2004 |
NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model.
Topics: Animals; Apoptosis; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase | 2004 |
Effect of NS-398 on colon cancer cells.
Topics: Actins; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2005 |
Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase Inhibitors; Dr | 2005 |
Killing tumor cells: the effect of photodynamic therapy using mono-L-aspartyl chlorine and NS-398.
Topics: Animals; Colonic Neoplasms; Cyclooxygenase Inhibitors; Drug Administration Schedule; Drug Synergism; | 2005 |
Resistance of prostate cancer cell lines to COX-2 inhibitor treatment.
Topics: Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclo | 2005 |
Autocrine vascular endothelial growth factor/vascular endothelial growth factor receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Caco-2 Cells; Carcinoma, Non-Small-Cell Lung; Cell Line, T | 2005 |
Effect of NS398 on metastasis-associated gene expression in a human colon cancer cell line.
Topics: Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase Inhibitors; Gene Expression Regulation, Neoplast | 2005 |
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxyg | 2005 |
Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells.
Topics: Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Induction; | 2005 |
[Molecular mechanism of cyclooxygenase-2 inhibitor in inhibition of proliferation of colon cancer cells by modulating Stat5 signal transduction pathway].
Topics: Apoptosis; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Hum | 2005 |
Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caco-2 Cells; Caspases; Colonic | 2006 |
Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells.
Topics: Antibodies; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inh | 2007 |
Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid hormone-related protein in colon 26 carcinoma.
Topics: Animals; Becaplermin; Biomarkers, Tumor; Cachexia; Calcium; Colonic Neoplasms; Cyclooxygenase 2; Cyc | 2007 |
Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Base Sequence; Cell Line, Tumor; Cell Movement; Colo | 2007 |
The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway.
Topics: Amyloid Precursor Protein Secretases; Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Trans | 2008 |
Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines.
Topics: Cell Division; Cell Line; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In | 1996 |
Inhibitory effect of NS-398, a selective cyclooxygenase-2 inhibitor, on azoxymethane-induced aberrant crypt foci in colon carcinogenesis of F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Colon; Colonic Neoplasms; | 1997 |
Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Cell Division; Colonic | 1997 |
Chemopreventive effect of N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide (NS-398), a selective cyclooxygenase-2 inhibitor, in rat colon carcinogenesis induced by azoxymethane.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Body Weight; Carcinogens; Chemopreve | 1999 |
Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Norther | 2000 |
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antioxidants; Antithrombins; Apoptos | 2000 |
Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway.
Topics: Apoptosis; Caspase 3; Caspase 9; Caspases; Cell Survival; Colonic Neoplasms; Cyclooxygenase 2; Cyclo | 2001 |
Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apopt | 2001 |
Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane.
Topics: Animals; Azoxymethane; Carcinogens; Carcinoma; Colonic Neoplasms; Cyclooxygenase Inhibitors; Genes, | 2002 |
[The effects of butyrates and non-steroidal anti-inflammatory agents on HT-29 colonic carcinoma cells].
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Butyrates; Colonic Neop | 2002 |