n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Breast Cancer in 13 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bone is the most common site for breast cancer spread." | 1.48 | The therapeutic effect of miR-125b is enhanced by the prostaglandin endoperoxide synthase 2/cyclooxygenase 2 blockade and hampers ETS1 in the context of the microenvironment of bone metastasis. ( Bendinelli, P; Desiderio, MA; Maroni, P; Matteucci, E, 2018) |
| "Aromatase levels in breast cancer cells are enhanced by prostaglandins and reduced by COX inhibitors." | 1.33 | Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. ( Brueggemeier, RW; Diaz-Cruz, ES; Landini, S; Su, B, 2006) |
| "Treatment of MDA-MB-231 breast cancer cells with NS-398 (a COX-2 inhibitor) or ciglitazone (CGZ, a PPARgamma-ligand) significantly inhibited cell proliferation and markedly increased apoptotic rates." | 1.32 | Inhibition of cyclooxygenase-2 and activation of peroxisome proliferator-activated receptor-gamma synergistically induces apoptosis and inhibits growth of human breast cancer cells. ( Badawi, AF; Badr, MZ; Michael, MS, 2003) |
| "Using a murine model of metastatic breast cancer, we show that PGE(2) levels are positively correlated with increased tumorigenic and metastatic potential." | 1.31 | Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. ( Dorsey, R; Fulton, AM; Kundu, N; Yang, Q, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (84.62) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, B | 3 |
| Diaz-Cruz, ES | 2 |
| Landini, S | 2 |
| Brueggemeier, RW | 3 |
| Wang, M | 1 |
| Lacy, G | 1 |
| Gao, M | 1 |
| Miller, KD | 1 |
| Sledge, GW | 1 |
| Zheng, QH | 1 |
| Tian, R | 1 |
| Darby, MV | 1 |
| Maroni, P | 1 |
| Bendinelli, P | 1 |
| Matteucci, E | 1 |
| Desiderio, MA | 1 |
| Zatelli, MC | 2 |
| Molè, D | 1 |
| Tagliati, F | 2 |
| Minoia, M | 1 |
| Ambrosio, MR | 1 |
| degli Uberti, E | 1 |
| Silva, HC | 1 |
| Alves, V | 1 |
| Nogueira, LA | 1 |
| Rosa, MS | 1 |
| Carvalho, L | 1 |
| Regateiro, F | 1 |
| Michael, MS | 1 |
| Badr, MZ | 1 |
| Badawi, AF | 1 |
| Totzke, G | 1 |
| Schulze-Osthoff, K | 1 |
| Jänicke, RU | 1 |
| Simeone, AM | 1 |
| Li, YJ | 1 |
| Broemeling, LD | 1 |
| Johnson, MM | 1 |
| Tuna, M | 1 |
| Tari, AM | 1 |
| Hiraga, T | 1 |
| Myoui, A | 1 |
| Choi, ME | 1 |
| Yoshikawa, H | 1 |
| Yoneda, T | 1 |
| Luchin, A | 1 |
| Leoni, S | 1 |
| Piccin, D | 1 |
| Bondanelli, M | 1 |
| Rossi, R | 1 |
| degli Uberti, EC | 1 |
| Kundu, N | 1 |
| Yang, Q | 1 |
| Dorsey, R | 1 |
| Fulton, AM | 1 |
13 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Breast Cancer
| Article | Year |
|---|---|
Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition.
Topics: Aniline Compounds; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cyclooxygena | 2006 |
Synthesis of carbon-11 labeled sulfonanilide analogues as new potential PET agents for imaging of aromatase in breast cancer.
Topics: Adult; Anilides; Aromatase Inhibitors; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Cyc | 2007 |
Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification.
Topics: Anilides; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Screening A | 2008 |
The therapeutic effect of miR-125b is enhanced by the prostaglandin endoperoxide synthase 2/cyclooxygenase 2 blockade and hampers ETS1 in the context of the microenvironment of bone metastasis.
Topics: Adenocarcinoma; Animals; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Femal | 2018 |
Cyclo-oxygenase 2 modulates chemoresistance in breast cancer cells involving NF-kappaB.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, West | 2009 |
Impairment of breast cancer cell invasion by COX-2-specific inhibitor NS398: roles of CXCR4 and of uPA system.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cyclooxygenase 2; Cyclooxygenase Inhib | 2012 |
Inhibition of cyclooxygenase-2 and activation of peroxisome proliferator-activated receptor-gamma synergistically induces apoptosis and inhibits growth of human breast cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Caspases; Cell Cycle; Cell Divis | 2003 |
Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; A | 2003 |
Cyclooxygenase-2 is essential for HER2/neu to suppress N- (4-hydroxyphenyl)retinamide apoptotic effects in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygena | 2004 |
Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer.
Topics: Animals; Apoptosis; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cyclooxygena | 2006 |
Suppression of aromatase in human breast cells by a cyclooxygenase-2 inhibitor and its analog involves multiple mechanisms independent of cyclooxygenase-2 inhibition.
Topics: Aromatase; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colforsin; Cyclooxygenase 2 Inhib | 2008 |
Cyclooxygenase-2 inhibitors prevent the development of chemoresistance phenotype in a breast cancer cell line by inhibiting glycoprotein p-170 expression.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2007 |
Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer.
Topics: Animals; Breast Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2001 |