n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Brain Ischemia in 8 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels." | 7.73 | Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005) |
| " We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels." | 3.73 | Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005) |
| "It is known that cerebral ischemia can cause brain inflammation and adiposome can serve as a depot of inflammatory mediators." | 1.51 | Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke. ( Chang, YJ; Hsu, SL; Hsueh, CM; Liao, LY; Lin, CH; Tung, CW; Yang, TY, 2019) |
| " Pharmacological agents that inhibit COX-2 have been found to be neuroprotective in a number of injury models, and long-term administration of these drugs has been shown to induce plastic changes in the brain." | 1.34 | Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke. ( Kolb, B; Silasi, G, 2007) |
| "Focal cerebral ischemia was produced by permanent occlusion of the middle cerebral artery (MCA) in mice." | 1.30 | The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene. ( Iadecola, C; Nagayama, M; Nagayama, T; Niwa, K; Ross, ME, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, CH | 1 |
| Liao, LY | 1 |
| Yang, TY | 1 |
| Chang, YJ | 1 |
| Tung, CW | 1 |
| Hsu, SL | 1 |
| Hsueh, CM | 1 |
| Varga, DP | 1 |
| Puskás, T | 1 |
| Menyhárt, Á | 1 |
| Hertelendy, P | 1 |
| Zölei-Szénási, D | 1 |
| Tóth, R | 1 |
| Ivánkovits-Kiss, O | 1 |
| Bari, F | 3 |
| Farkas, E | 3 |
| Sugimoto, K | 1 |
| Iadecola, C | 2 |
| Sasaki, T | 1 |
| Kitagawa, K | 1 |
| Sugiura, S | 1 |
| Omura-Matsuoka, E | 1 |
| Tanaka, S | 1 |
| Yagita, Y | 1 |
| Okano, H | 1 |
| Matsumoto, M | 1 |
| Hori, M | 1 |
| Domoki, F | 1 |
| Kis, B | 1 |
| Nagy, K | 1 |
| Busija, DW | 1 |
| Silasi, G | 1 |
| Kolb, B | 1 |
| Institoris, A | 1 |
| Berczi, S | 1 |
| Sule, Z | 1 |
| Nagayama, M | 1 |
| Niwa, K | 1 |
| Nagayama, T | 1 |
| Ross, ME | 1 |
8 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Brain Ischemia
| Article | Year |
|---|---|
Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke.
Topics: Anilides; Animals; Animals, Newborn; Brain Ischemia; Cell Death; Culture Media, Serum-Free; Cyclooxy | 2019 |
Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Laser-Dopple | 2016 |
Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia.
Topics: Acute Disease; Animals; Body Temperature; Body Weight; Brain Ischemia; Cyclooxygenase 2; Cyclooxygen | 2003 |
Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Differentiation; Cell Division; Cyclooxygenase 2; Cyclooxy | 2003 |
Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Blood Pressure; Brain Ischemia; Cells, Cultured; Cerebrovascu | 2005 |
Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke.
Topics: Animals; Brain Ischemia; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; D | 2007 |
Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats.
Topics: Animals; Astrocytes; Brain Ischemia; Carotid Stenosis; Cyclooxygenase Inhibitors; Disease Models, An | 2007 |
The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene.
Topics: Animals; Brain Ischemia; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; G | 1999 |