n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Brain Inflammation in 7 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacological agents that inhibit COX-2 have been found to be neuroprotective in a number of injury models, and long-term administration of these drugs has been shown to induce plastic changes in the brain." | 1.34 | Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke. ( Kolb, B; Silasi, G, 2007) |
| "The possible role of COX-2 in modulating brain inflammation was examined utilizing NS-398, a COX-2 selective inhibitor." | 1.31 | Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. ( Daeschner, JC; Hansen, JT; Kerry O'Banion, M; Kyrkanides, S; Moore, AH; Olschowka, JA; Williams, JP, 2002) |
| "In Escherichia coli-induced brain inflammation, cyclooxygenase-2 was induced not only on brain arterioles at 3 h, but also on infiltrating neutrophils at 9 h post-intracerebral injection." | 1.30 | TNFalpha-induced cyclooxygenase 2 not only increases the vasopermeability of blood-brain barrier but also enhances the neutrophil survival in Escherichia coli-induced brain inflammation. ( Hsu, HP; Lei, HY; Tsao, N, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thirumangalakudi, L | 1 |
| Rao, HV | 1 |
| Grammas, P | 1 |
| Kyrkanides, S | 1 |
| Moore, AH | 1 |
| Olschowka, JA | 1 |
| Daeschner, JC | 1 |
| Williams, JP | 1 |
| Hansen, JT | 1 |
| Kerry O'Banion, M | 1 |
| Silasi, G | 1 |
| Kolb, B | 1 |
| Caso, JR | 1 |
| Pradillo, JM | 1 |
| Hurtado, O | 1 |
| Lorenzo, P | 1 |
| Moro, MA | 1 |
| Lizasoain, I | 1 |
| Kunz, A | 1 |
| Abe, T | 1 |
| Hochrainer, K | 1 |
| Shimamura, M | 1 |
| Anrather, J | 1 |
| Racchumi, G | 1 |
| Zhou, P | 1 |
| Iadecola, C | 1 |
| Tsao, N | 1 |
| Hsu, HP | 1 |
| Lei, HY | 1 |
| Brian, JE | 1 |
| Faraci, FM | 1 |
| Moore, SA | 1 |
7 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Brain Inflammation
| Article | Year |
|---|---|
Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cells, Cultured; Cerebral Cortex; Cyclo | 2009 |
Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury.
Topics: Animals; Animals, Newborn; Astrocytes; Brain; Cell Culture Techniques; Chemokine CCL2; Chemokine CXC | 2002 |
Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke.
Topics: Animals; Brain Ischemia; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; D | 2007 |
Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke.
Topics: Animals; Brain Chemistry; Brain Damage, Chronic; Cerebral Infarction; Cyclooxygenase 2; Cyclooxygena | 2007 |
Nuclear factor-kappaB activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion.
Topics: Amino Acid Sequence; Animals; CD36 Antigens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Encephal | 2008 |
TNFalpha-induced cyclooxygenase 2 not only increases the vasopermeability of blood-brain barrier but also enhances the neutrophil survival in Escherichia coli-induced brain inflammation.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 1999 |
COX-2-dependent delayed dilatation of cerebral arterioles in response to bradykinin.
Topics: Animals; Arterioles; Bradykinin; Cerebrovascular Circulation; Cyclooxygenase 2; Cyclooxygenase 2 Inh | 2001 |