n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Arthritis, Rheumatoid in 12 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To understand the involvement of osteoclastogenesis inhibitory factor (OCIF), also called osteoprotegerin (OPG), in the pathogenesis of bone destruction in rheumatoid arthritis (RA), we investigated the cytokine network involved in the production of OCIF by human fibroblast-like synovial (HFLS) cells from a patient with RA." | 7.71 | Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor. ( Higashio, K; Nakagawa, N; Tsuda, E; Yano, K; Yasuda, H, 2001) |
| "To understand the involvement of osteoclastogenesis inhibitory factor (OCIF), also called osteoprotegerin (OPG), in the pathogenesis of bone destruction in rheumatoid arthritis (RA), we investigated the cytokine network involved in the production of OCIF by human fibroblast-like synovial (HFLS) cells from a patient with RA." | 3.71 | Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor. ( Higashio, K; Nakagawa, N; Tsuda, E; Yano, K; Yasuda, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Farag, AK | 1 |
| Elkamhawy, A | 1 |
| Londhe, AM | 1 |
| Lee, KT | 1 |
| Pae, AN | 1 |
| Roh, EJ | 1 |
| Totoson, P | 1 |
| Maguin-Gaté, K | 1 |
| Nappey, M | 1 |
| Wendling, D | 1 |
| Demougeot, C | 1 |
| Yasuda, T | 1 |
| Chan, MM | 1 |
| Moore, AR | 1 |
| Shibata-Nozaki, T | 1 |
| Ito, H | 1 |
| Mitomi, H | 1 |
| Akaogi, J | 1 |
| Komagata, T | 1 |
| Kanaji, T | 1 |
| Maruyama, T | 1 |
| Mori, T | 1 |
| Nomoto, S | 1 |
| Ozaki, S | 1 |
| Yamada, H | 1 |
| Han, JH | 1 |
| Roh, MS | 1 |
| Park, CH | 1 |
| Park, KC | 1 |
| Cho, KH | 1 |
| Kim, KH | 1 |
| Eun, HC | 1 |
| Chung, JH | 1 |
| Onodera, M | 1 |
| Horiuchi, Y | 1 |
| Nakahama, K | 1 |
| Muneta, T | 1 |
| Mano, Y | 1 |
| Morita, I | 1 |
| Jüngel, A | 1 |
| Distler, O | 1 |
| Schulze-Horsel, U | 1 |
| Huber, LC | 1 |
| Ha, HR | 1 |
| Simmen, B | 1 |
| Kalden, JR | 1 |
| Pisetsky, DS | 1 |
| Gay, S | 1 |
| Distler, JH | 1 |
| Kotake, S | 1 |
| Udagawa, N | 1 |
| Takahashi, N | 1 |
| Matsuzaki, K | 1 |
| Itoh, K | 1 |
| Ishiyama, S | 1 |
| Saito, S | 1 |
| Inoue, K | 1 |
| Kamatani, N | 1 |
| Gillespie, MT | 1 |
| Martin, TJ | 1 |
| Suda, T | 1 |
| Manabe, N | 1 |
| Oda, H | 1 |
| Nakamura, K | 1 |
| Kuga, Y | 1 |
| Uchida, S | 1 |
| Kawaguchi, H | 1 |
| Di Battista, JA | 1 |
| Fahmi, H | 1 |
| He, Y | 1 |
| Zhang, M | 1 |
| Martel-Pelletier, J | 1 |
| Pelletier, JP | 1 |
| Yano, K | 1 |
| Nakagawa, N | 1 |
| Yasuda, H | 1 |
| Tsuda, E | 1 |
| Higashio, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Project Arthritis Recovering Quality of Life Through Education - Hip[NCT04018690] | 48 participants (Anticipated) | Interventional | 2019-09-01 | Not yet recruiting | |||
| The Effect of Tocilizumab (Anti-interleukin-6) Treatment on microRNA Expression and Adipokine Levels in Rheumatoid Arthritis Patients[NCT03149796] | 80 participants (Actual) | Observational | 2011-03-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Survival; Dose-Respons | 2017 |
Endothelial Dysfunction in Rheumatoid Arthritis: Mechanistic Insights and Correlation with Circulating Markers of Systemic Inflammation.
Topics: Acetylcholine; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Chemokines; Cycl | 2016 |
Hyaluronan inhibits prostaglandin E2 production via CD44 in U937 human macrophages.
Topics: Animals; Arthritis, Rheumatoid; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone | 2010 |
Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyclooxygenase Inhibitors | 2010 |
Endogenous prostaglandin E2 inhibits aberrant overgrowth of rheumatoid synovial tissue and the development of osteoclast activity through EP4 receptor.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relat | 2011 |
Selective COX-2 inhibitor, NS-398, inhibits the replicative senescence of cultured dermal fibroblasts.
Topics: Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Cellular Senescence; Cyclooxygenase 2; C | 2004 |
Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenas | 2004 |
Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1.
Topics: Arachidonic Acids; Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibito | 2007 |
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.
Topics: Animals; Antigens, CD; Arthritis, Rheumatoid; Bone Marrow Cells; Carrier Proteins; Cell Division; Co | 1999 |
Involvement of fibroblast growth factor-2 in joint destruction of rheumatoid arthritis patients.
Topics: Animals; Arthritis, Rheumatoid; Bone Resorption; Calcium; Cell Differentiation; Coculture Techniques | 1999 |
Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas | 2001 |
Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor.
Topics: Arthritis, Rheumatoid; Bone Resorption; Cells, Cultured; Culture Media, Conditioned; Dinoprostone; F | 2001 |