n-(2-amino-5-fluorobenzyl)-4-(n-(pyridine-3-acrylyl)aminomethyl)benzamide has been researched along with Colonic-Neoplasms* in 3 studies
3 other study(ies) available for n-(2-amino-5-fluorobenzyl)-4-(n-(pyridine-3-acrylyl)aminomethyl)benzamide and Colonic-Neoplasms
| Article | Year |
|---|---|
Discovery of novel cyclin-dependent kinase (CDK) and histone deacetylase (HDAC) dual inhibitors with potent in vitro and in vivo anticancer activity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Cyclin-Dependent Kinases; Drug Discovery; Drug Screening Assays, Antitumor; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Protein Kinase Inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Drug Design; Drug Screening Assays, Antitumor; Female; Histone Deacetylases; Humans; Male; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Molecular Docking Simulation; Neoplasms, Experimental; Protein Kinase Inhibitors; Purines; Structure-Activity Relationship | 2020 |
Design, synthesis and biological evaluation of 4-piperazinyl-containing Chidamide derivatives as HDACs inhibitors.
The synthesis and biological evaluation of a variety of 4-piperazinyl-containing Chidamide derivatives is described. Some of these compounds were shown to inhibit HDAC1 with IC Topics: Administration, Oral; Aminopyridines; Animals; Antineoplastic Agents; Benzamides; Binding Sites; Catalytic Domain; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Design; Drug Screening Assays, Antitumor; Female; Half-Life; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mice; Molecular Docking Simulation; Piperazines; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous | 2017 |