n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride has been researched along with Adrenocortical Carcinoma in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burns, VE; Kerppola, TK | 1 |
| Cheng, Y; Kerppola, RE; Kerppola, TK | 1 |
| Crudo, V; Hammer, GD; Hunt, SW; LaPensee, CR; Mann, JE; Rainey, WE | 1 |
3 other study(ies) available for n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride and Adrenocortical Carcinoma
| Article | Year |
|---|---|
ATR-101 inhibits cholesterol efflux and cortisol secretion by ATP-binding cassette transporters, causing cytotoxic cholesterol accumulation in adrenocortical carcinoma cells.
Topics: Adenosine Triphosphate; Adrenocortical Carcinoma; Antineoplastic Agents; ATP-Binding Cassette Transporters; Caspase 3; Caspase 7; Cell Line, Tumor; Cholesterol; Humans; Hydrocortisone; Phenylurea Compounds | 2017 |
ATR-101 disrupts mitochondrial functions in adrenocortical carcinoma cells and in vivo.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Guinea Pigs; Humans; Membrane Potential, Mitochondrial; Mice, SCID; Mitochondria; Phenylurea Compounds; Rats, Sprague-Dawley; Reactive Oxygen Species; Tumor Burden | 2016 |
ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Dogs; Humans; Membrane Potential, Mitochondrial; Phenylurea Compounds; Sterol O-Acyltransferase | 2016 |